In silico chemical library screening and experimental validation of a novel 9-aminoacridine based lead-inhibitor of human S-adenosylmethionine decarboxylase

Journal of Chemical Information and Modeling

Volumn 47, Issue 5, 2007, Pages 1897-1905

  Brooks, Wesley H ^a   McCloskey, Diane E ^b   Daniel, Kenyon G ^a   Ealick, Steven E ^c   Secrist III, John A ^d   Waud, William R ^d   Pegg, Anthony E ^b   Guida, Wayne C ^a,e  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c Department of Obstetrics Gynecology   (United States)

^d SOUTHERN RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOSYNTHESIS; COMPUTATIONAL METHODS; ENZYME INHIBITION; TUMORS; VIRTUAL REALITY;

CHEMICAL LIBRARY SCREENING; POLYAMINES; VIRTUAL SCREENING;

AMINES;

ADENOSYLMETHIONINE DECARBOXYLASE; AMINOACRIDINE; CARBON DIOXIDE; ENZYME INHIBITOR; RECOMBINANT PROTEIN;

ARTICLE; CHEMISTRY; COMPUTER; COMPUTER PROGRAM; COMPUTER SIMULATION; DRUG ANTAGONISM; DRUG SCREENING; HUMAN; REPRODUCIBILITY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ADENOSYLMETHIONINE DECARBOXYLASE; AMINACRINE; CARBON DIOXIDE; COMPUTER SIMULATION; COMPUTERS; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35248880204     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci700005t     Document Type: Article

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