Mechanism of human S-adenosylmethionine decarboxylase proenzyme processing as revealed by the structure of the S68A mutant

Biochemistry

Volumn 42, Issue 8, 2003, Pages 2386-2395

  Tolbert, William D ^a   Zhang, Yang ^a   Cottet, Sarah E ^a   Bennett, Eric M ^a   Ekstrom, Jennifer L ^a   Pegg, Anthony E ^b   Ealick, Steven E ^a  

^a Department of Molecular Biology and Genetics   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; ENZYMES; HYDROGEN BONDS;

PROTEIN PRECURSORS;

BIOCHEMISTRY;

ADENOSYLMETHIONINE DECARBOXYLASE; ALANINE; ASPARTATE DECARBOXYLASE; CARBON; CARBONYL DERIVATIVE; CARBOXYLYASE; ENZYME PRECURSOR; HISTIDINE; HISTIDINE DECARBOXYLASE; OXAZOLIDINE DERIVATIVE; OXYOXAZOLIDINE; POLYAMINE; PROTEIN PRECURSOR; PROTON; SERINE; SPERMIDINE; SPERMINE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME MECHANISM; ENZYME SYNTHESIS; GENE MUTATION; HUMAN; HUMAN CELL; HYDROGEN BOND; MUTAGENESIS; OBSERVATION; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN STRUCTURE; REACTION ANALYSIS; STRAIN DIFFERENCE; X RAY ANALYSIS;

ADENOSYLMETHIONINE DECARBOXYLASE; ALANINE; BINDING SITES; BUFFERS; CATALYSIS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENZYME PRECURSORS; GLUTAMINE; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; OXAZOLES; OXYGEN; PROTEIN PROCESSING, POST-TRANSLATIONAL; PUTRESCINE; SERINE; TROMETHAMINE;

EID: 0037418569     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0268854     Document Type: Article

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