Rhodococcus equi-infected macrophages are recognized and killed by CD8 + T lymphocytes in a major histocompatibility complex class I-unrestricted fashion

Infection and Immunity

Volumn 72, Issue 12, 2004, Pages 7073-7083

  Patton, Kristin M ^a   McGuire, Travis C ^a   Fraser, Darrilyn G ^a,b   Hines, Stephen A ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

^b Athens Technical College   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; BACTERIAL ANTIGEN; CD1 ANTIGEN; CD2 ANTIGEN; CD3 ANTIGEN; CD8 ANTIGEN; EQUINE LEUKOCYTE ANTIGEN A; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; ARTICLE; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; CELL STIMULATION; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; HORSE; IMMUNOCOMPETENCE; LYMPHOCYTE COUNT; LYMPHOCYTE DEPLETION; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PLASMID; PRIORITY JOURNAL; RHODOCOCCUS EQUI; T LYMPHOCYTE; TARGET CELL DESTRUCTION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD2; ANTIGENS, CD3; CD8-POSITIVE T-LYMPHOCYTES; CYTOTOXICITY, IMMUNOLOGIC; HISTOCOMPATIBILITY ANTIGENS CLASS I; HORSES; MACROPHAGES; RHODOCOCCUS EQUI; VIRULENCE;

EID: 9244233349     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.72.12.7073-7083.2004     Document Type: Article

References (50)

1. Alvarez, B., C. Sanchez, R. Bullido, A. Marina, J. Lunney, F. Alonso, A. Ezquerra, and J. Dominguez. 2000. A porcine cell surface receptor identified by monoclonal antibodies to SWC3 is a member of the signal regulatory protein family and associates with protein-tyrosine phosphatase SHP-1. Tissue Antigens 55:342-351.
2. Batuwangala, T., D. Shepherd, S. D. Gadola, K. J. Gibson, N. R. Zaccai, A. R. Fersht, G. S. Besra, V. Cerundolo, and E. Y. Jones. 2004. The crystal structure of human CD1b with a bound bacterial glycolipid. J. Immunol. 172:2382-2388.
3. Beckman, E. M., S. A. Porcelli, C. T. Morita, S. M. Behar, S. T. Furlong, and M. B. Brenner. 1994. Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells. Nature 372:691-694.
4. Blanchard-Channell, M., P. F. Moore, and J. L. Stott. 1994. Characterization of monoclonal antibodies specific for equine homologues of CD3 and CD5. Immunology 82:548-554.
5. Brigl, M., and M. B. Brenner. 2004. CD1: antigen presentation and T cell function. Annu. Rev. Immunol. 22:817-890.
6. Byrne, B. A., J. F. Prescott, G. H. Palmer, S. Takai, V. M. Nicholson, D. C. Alperin, and S. A. Hines. 2001. Virulence plasmid of Rhodococcus equi contains inducible gene family encoding secreted proteins. Infect. Immun. 69:650-656.
7. Capdevila, J. A., S. Bujan, J. Gavalda, A. Ferrer, and A. Pahissa. 1997. Rhodococcus equi pneumonia in patients infected with the human immunodeficiency virus. Report of 2 cases and review of the literature. Scand. J. Infect. Dis. 29:535-541.
8. Davis, W. C., J. E. Davis, and M. Hamilton. 1995. Use of monoclonal antibodies and flow cytometry to cluster and analyse leukocyte differentiation molecules, p. 149. In W. C. Davis (ed.), Monoclonal antibody protocols. Humana Press, Inc., Totowa, N.J.
9. De La Barrera, S. S., M. Finiasz, A. Prias, M. Aleman, P. Barrionuevo, S. Fink, M. C. Franco, E. Abbate, and M. D. C. Sasiain. 2003. Specific lytic activity against mycobacterial antigens is inversely correlated with the severity of tuberculosis. Clin. Exp. Immunol. 132:450-461.
10. De Libero, G., A. Donda, L. Mori, V. Manolova, and A. Shamshiev. 2001. Immunity to glycolipid antigens in microbial infections. J. Biol. Regul. Homeost. Agents 15:249-256.
11. De Libero, G., I. Flesch, and S. H. Kaufmann. 1988. Mycobacteria-reactive Lyt-2+ T cell lines. Eur. J. Immunol. 18:59-66.
12. Fraser, D. G., and E. Bailey. 1996. Demonstration of three DRB loci in a domestic horse family. Immunogenetics 44:441-445.
13. Gansert, J. L., V. Kiessler, M. Engele, F. Wittke, M. Rollinghoff, A. M. Krensky, S. A. Porcelli, R. L. Modlin, and S. Stenger. 2003. Human NKT cells express granulysin and exhibit antimycobacterial activity. J. Immunol. 170:3154-3161.
14. Garton, N. J., M. Gilleron, T. Brando, H. H. Dan, S. Giguere, G. Puzo, J. F. Prescott, and I. C. Sutcliffe. 2002. A novel lipoarabinomannan from the equine pathogen Rhodococcus equi. Structure and effect on macrophage cytokine production. J. Biol. Chem. 277:31722-31733.
15. Giguere, S., M. K. Hondalus, J. A. Yager, P. Darrah, D. M. Mosser, and J. F. Prescott. 1999. Role of the 85-kilobase plasmid and plasmid-encoded virulence-associated protein A in intracellular survival and virulence of Rhodococcus equi. Infect. Immun. 67:3548-3557.
16. Hines, M. T., K. M. Paasch, D. C. Alperin, G. H. Palmer, N. C. Westhoff, and S. A. Hines. 2001. Immunity to Rhodococcus equi: antigen-specific recall responses in the lungs of adult horses. Vet. Immunol. Immunopathol. 79: 101-114.
17. + T lymphocytes. Clin. Diagn. Lab. Immunol. 10:208-215.
18. Hirsh, D. C., and D. C. Zee. 1999. Veterinary microbiology. Blackwell Science, Inc., Malden, Mass.
19. Hondalus, M. K., and D. M. Mosser. 1994. Survival and replication of Rhodococcus equi in macrophages. Infect. Immun. 62:4167-4175.
20. Jullien, D., S. Stenger, W. A. Ernst, and R. L. Modlin. 1997. CD1 presentation of microbial nonpeptide antigens to T cells. J. Clin. Investig. 99:2071-2074.
21. Kanaly, S. T., S. A. Hines, and G. H. Palmer. 1995. Cytokine modulation alters pulmonary clearance of Rhodococcus equi and development of granulomatous pneumonia. Infect. Immun. 63:3037-3041.
22. Kanaly, S. T., S. A. Hines, and G. H. Palmer. 1993. Failure of pulmonary clearance of Rhodococcus equi infection in CD4+ T-lymphocyte-deficient transgenic mice. Infect. Immun. 61:4929-4932.
23. + Th1 cell line to nude mice effects clearance of Rhodococcus equi from the lung. Infect. Immun. 64:1126-1132.
24. Kasuga-Aoki, H., S. Takai, Y. Sasaki, S. Tsubaki, H. Madarame, and A. Nakane. 1999. Tumour necrosis factor and interferon-gamma are required in host resistance against virulent Rhodococcus equi infection in mice: cytokine production depends on the virulence levels of R. equi. Immunology 96:122-127.
25. Kohler, A. K., D. M. Stone, M. T. Hines, B. A. Byrne, D. C. Alperin, L. K. Norton, and S. A. Hines. 2003. Rhodococcus equi secreted antigens are immunogenic and stimulate a type 1 recall response in the lungs of horses immune to R. equi infection. Infect. Immun. 71:6329-6337.
26. + T cells in tuberculosis. Am. J. Respir. Crit. Care Med. 166:1116-1121.
27. Lopez, A. M., M. T. Hines, G. H. Palmer, D. C. Alperin, and S. A. Hines. 2002. Identification of pulmonary T-lymphocyte and serum antibody isotype responses associated with protection against Rhodococcus equi. Clin. Diagn. Lab. Immunol. 9:1270-1276.
28. Lunn, D. P., M. A. Holmes, D. F. Antczak, N. Agerwal, J. Baker, S. Bendali-Ahcene, M. Blanchard-Channell, K. M. Byrne, K. Cannizzo, W. Davis, M. J. Hamilton, D. Hannant, T. Kondo, J. H. Kydd, M. C. Monier, P. F. Moore, T. O'Neil, B. R. Schram, A. Sheoran, J. L. Stott, T. Sugiura, and K. E. Vagnoni. 1998. Report of the Second Equine Leucocyte Antigen Workshop, Squaw Valley, California, July 1995. Vet. Immunol. Immunopathol. 62:101-143.
29. Macias, J., J. A. Pineda, F. Borderas, J. A. Gallardo, J. Delgado, M. Leal, A. Sanchez-Quijano, and E. Lissen. 1997. Rhodococcus or mycobacterium? An example of misdiagnosis in HIV infection. AIDS 11:253-254.
30. Madarame, H., S. Takai, C. Matsumoto, K. Minamiyama, Y. Sasaki, S. Tsubaki, Y. Hasegawa, and A. Nakane. 1997. Virulent and avirulent Rhodococcus equi infection in T-cell deficient athymic nude mice: pathologic, bacteriologic and immunologic responses. FEMS Immunol. Med. Microbiol. 17:251-262.
31. McGuire, T. C., D. G. Fraser, and R. H. Mealey. 2002. Cytotoxic T lymphocytes and neutralizing antibody in the control of equine infectious anemia virus. Viral Immunol. 15:521-531.
32. McGuire, T. C., S. R. Leib, R. H. Mealey, D. G. Fraser, and D. J. Prieur. 2003. Presentation and binding affinity of equine infectious anemia virus CTL envelope and matrix protein epitopes by an expressed equine classical MHC class I molecule. J. Immunol. 171:1984-1993.
33. + cytotoxic T lymphocytes from horses with equine infectious anemia virus recognize Env and Gag/PR proteins. J. Virol. 68:1459-1467.
34. Nordmann, P., E. Ronco, and C. Nauciel. 1992. Role of T-lymphocyte subsets in Rhodococcus equi infection. Infect. Immun. 60:2748-2752.
35. Ottenhoff, T. H., and T. Mutis. 1995. Role of cytotoxic cells in the protective immunity against and immunopathology of intracellular infections. Eur. J. Clin. Investig. 25:371-377.
36. Pathan, A. A., K. A. Wilkinson, P. Klenerman, H. McShane, R. N. Davidson, G. Pasvol, A. V. Hill, and A. Lalvani. 2001. Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment. J. Immunol. 167:5217-5225.
37. Pathan, A. A., K. A. Wilkinson, R. J. Wilkinson, M. Latif, H. McShane, G. Pasvol, A. V. Hill, and A. Lalvani. 2000. High frequencies of circulating IFN-gamma-secreting CD8 cytotoxic T cells specific for a novel MHC class I-restricted Mycobacterium tuberculosis epitope in M. tuberculosis-infected subjects without disease. Eur. J. Immunol. 30:2713-2721.
38. Raabe, M. R., C. J. Issel, and R. C. Montelaro. 1998. Equine monocyte-derived macrophage cultures and their applications for infectivity and neutralization studies of equine infectious anemia virus. J. Virol. Methods 71: 87-104.
39. Ross, T. L., G. A. Balson, J. S. Miners, G. D. Smith, P. E. Shewen, J. F. Prescott, and J. A. Yager. 1996. Role of CD4+, CD8+ and double negative T-cells in the protection of SCID/beige mice against respiratory challenge with Rhodococcus equi. Can. J. Vet. Res. 60:186-192.
40. + T cells participate in the memory immune response to Mycobacterium tuberculosis. Infect. Immun. 69:4320-4328.
41. Shinkai, K., and R. M. Locksley. 2000. CD1, tuberculosis, and the evolution of major histocompatibility complex molecules. J. Exp. Med. 191:907-914.
42. Sutcliffe, I. C. 1997. Macroamphiphilic cell envelope components of Rhodococcus equi and closely related bacteria. Vet. Microbiol. 56:287-299.
43. Takai, S. 1997. Epidemiology of Rhodococcus equi infections: a review. Vet. Microbiol. 56:167-176.
44. Takai, S., S. A. Hines, T. Sekizaki, V. M. Nicholson, D. A. Alperin, M. Osaki, D. Takamatsu, M. Nakamura, K. Suzuki, N. Ogino, T. Kakuda, H. Dan, and J. F. Prescott. 2000. DNA sequence and comparison of virulence plasmids from Rhodococcus equi ATCC 33701 and 103. Infect. Immun. 68:6840-6847.
45. Takai, S., C. Kobayashi, K. Murakami, Y. Sasaki, and S. Tsubaki. 1999. Live virulent Rhodococcus equi, rather than killed or avirulent, elicits protective immunity to R. equi infection in mice. FEMS Immunol. Med. Microbiol. 24:1-9.
46. Terasaki, P., D. Bernoco, M. Park, G. Ozturk, and Y. Iwaki. 1978. Microdroplet testing for HLA-A, -B, -C and -D antigens. The Philip Levine Award Lecture. Am. J. Clin. Pathol. 69:103-120.
47. Tumas, D. B., A. L. Brassfield, A. S. Travenor, M. T. Hines, W. C. Davis, and T. C. McGuire. 1994. Monoclonal antibodies to the equine CD2 T lymphocyte marker, to a pan-granulocyte/monocyte marker and to a unique pan-B lymphocyte marker. Immunobiology 192:48-64.
48. Ulrichs, T., D. B. Moody, E. Grant, S. H. Kaufmann, and S. A. Porcelli. 2003. T-cell responses to CD1-presented lipid antigens in humans with Mycobacterium tuberculosis infection. Infect. Immun. 71:3076-3087.
49. Viveiros, M. M., and D. F. Antczak. 1999. Characterization of equine natural killer and IL-2 stimulated lymphokine activated killer cell populations. Dcv. Comp. Immunol. 23:521-532.
50. + CTL recognizing mycobacterial peptides. Scand. J. Immunol. 45:521-526.