An assessment of anxiolytic drug screening tests: Hormetic dose responses predominate

Critical Reviews in Toxicology

Volumn 38, Issue 6, 2008, Pages 489-542

  Calabrese, Edward J ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Anxiety; Anxiolytic; Biphasic; Conflict test; Depression; Dose response; Elevated plus maze test; Forced swimming test; Four plates test; GABA; Hole board test; Hormesis; Light dark test; Open field test; Partial agonist; Social interaction test; Staircase test

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 1 METHYL 3 INDOLECARBOXYLIC ACID [1 [2 (METHYLSULFONYLAMINO)ETHYL] 4 PIPERIDINYLMETHYL] ESTER; 1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; 2 AMINO 7 PHOSPHONOHEPTANOIC ACID; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 (2 CHLORO 4 METHOXY 5 METHYLPHENYL) N [2 CYCLOPROPYL 1 (3 FLUORO 4 METHYLPHENYL)ETHYL] 5 METHYL N (2 PROPYNYL) 2 THIAZOLAMINE; 4 (2 FLUOROPHENYL) 6 METHYL 2 (1 PIPERAZINYL)THIENO[2,3 D]PYRIMIDINE; 5 HYDROXYTRYPTOPHAN; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; 8 AMINO 7 CHLORO 1,4 BENZODIOXAN 5 CARBOXYLIC ACID 1 BUTYL 4 PIPERIDINYLMETHYL ESTER; ALNESPIRONE; ANXIOLYTIC AGENT; BUSPIRONE; CANNABIDIOL; CARTAZOLATE; CHLORDIAZEPOXIDE; CLONAZEPAM; CR 1795; CYCLOSERINE; DIAZEPAM; DRUG RECEPTOR; GEPIRONE; GIRISOPAM; GRANISETRON; GUANABENZ; IPSAPIRONE; ITRIGLUMIDE; MDL 7005EF; METHYLENE BLUE; MOTILIN; N BENZYL N2 [4 HYDROXY 1 [(1 METHYL 1H INDOL 3 YL)CARBONYL]PROLYL] N METHYL 3 (2 NAPHTHYL)ALANINAMIDE; N METHYL BETA CARBOLINE 3 CARBOXAMIDE; N(G) NITROARGININE METHYL ESTER; NERISOPAM; NKP 608; ONDANSETRON; PENTETRAZOLE; PERICIAZINE; PRASTERONE; PRAZOSIN; ROTIGOTINE; SAREDUTANT; SUBSTANCE P; TACHYKININ RECEPTOR; TROPISETRON; U 97775; U P7775; UNINDEXED DRUG; WAY 102635;

ANIMAL BEHAVIOR; CHRONIC STRESS; COLD STRESS; DEPRESSION; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG MEGADOSE; DRUG POTENCY; DRUG RESPONSE; DRUG SCREENING; EXPERIMENTAL ANIMAL; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; EXPERIMENTAL RAT; EXPERIMENTAL TEST; EXPERIMENTATION; EXPLORATORY BEHAVIOR; FORCED SWIMMING TEST; GERBIL; HORMESIS; HUMAN; IMMOBILIZATION STRESS; INSTRUMENTAL CONDITIONING; LABORATORY DIAGNOSIS; LEARNED HELPLESSNESS; LIGHT DARK CYCLE; LOCOMOTION; LOW DRUG DOSE; MAZE TEST; MOTOR PERFORMANCE; MOUSE STRAIN; NONHUMAN; OPEN FIELD TEST; PREDICTION; PROTEIN FAMILY; QUANTITATIVE ANALYSIS; REVIEW; RODENT; ROTAROD TEST; SCREENING TEST; SOCIAL INTERACTION; TASK PERFORMANCE;

ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; MICE; RATS;

ANIMALIA;

EID: 46949108881     PISSN: 10408444     EISSN: 15476898     Source Type: Journal    
DOI: 10.1080/10408440802014238     Document Type: Review

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