High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the γ-aminobutyric acid A/benzodiazepine receptor complex

Journal of Medicinal Chemistry

Volumn 39, Issue 1, 1996, Pages 158-175

  Jacobsen, E Jon ^a   TenBrink, Ruth E ^a   Stelzer, Lindsay S ^a   Belonga, Kenneth L ^a   Carter, Donald B ^a   Im, Haesook K ^a   Im, Wha Bin ^a   Sethy, Vimala H ^a   Tang, Andy H ^a   VonVoigtlander, Philip F ^a   Petke, James D ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (5 CYCLOPROPYL 1,2,4 OXADIAZOL 3 YL) 5 [(DIMETHYLAMINO)CARBONYL] 4,5 DIHYDROIMIDAZO[1,5 A]QUINOXALINE; 4 AMINOBUTYRIC ACID A RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; ABECARNIL; ALCOHOL; ALPIDEM; BENZODIAZEPINE; BENZODIAZEPINE RECEPTOR; BRETAZENIL; DIAZEPAM; FLUMAZENIL; PANADIPLON; PARTIAL AGONIST; PAZINACLONE; PENTETRAZOLE; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; TRIAZOLAM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ANXIETY NEUROSIS; ARTICLE; BINDING AFFINITY; CHLORIDE CURRENT; CONFLICT; CONTROLLED STUDY; CONVULSION; DRUG ANTAGONISM; DRUG DEPENDENCE; DRUG EFFICACY; DRUG POTENTIATION; ELECTRIC SHOCK; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LICKING; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PUNISHMENT; RAT; RECEPTOR AFFINITY; SEIZURE THRESHOLD; SUBCUTANEOUS DRUG ADMINISTRATION; TRANQUILIZING ACTIVITY;

ANIMALS; ANXIETY; BENZODIAZEPINES; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING, COMPETITIVE; BRAIN; CHLORIDES; FLUNITRAZEPAM; GABA AGONISTS; GABA ANTAGONISTS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; OXADIAZOLES; PENTYLENETETRAZOLE; QUINOXALINES; RATS; RECEPTORS, GABA-A;

EID: 0030051558     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm940765f     Document Type: Article

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