3-Phenyl-substituted imidazo[1,5-a]quinoxalin-4-ones and imidazo[1,5- a]quinoxaline ureas that have high affinity at the GABA(A)/benzodiazepine receptor complex

Journal of Medicinal Chemistry

Volumn 39, Issue 19, 1996, Pages 3820-3836

  Jacobsen, E Jon ^a   Stelzer, Lindsay S ^a   Belonga, Kenneth L ^a   Carter, Donald B ^a   Im, Wha Bin ^a   Sethy, Vimala H ^a   Tang, Andrew H ^a   Von Voigtlander, Philip F ^a   Petke, James D ^b  

^a Pharmacia and Upjohn ^*  (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BENZODIAZEPINE RECEPTOR; FLUMAZENIL; FLUNITRAZEPAM; IMIDAZO[1,5 A]QUINOXALINE DERIVATIVE; PENTETRAZOLE; QUINOXALINE DERIVATIVE; TRIAZOLAM; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CEREBELLUM; CHLORIDE CURRENT; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; RAT; SEIZURE; SUBCUTANEOUS DRUG ADMINISTRATION; TRANQUILIZING ACTIVITY;

ANIMALS; ANTICONVULSANTS; BENZODIAZEPINES; CELL MEMBRANE; CEREBRAL CORTEX; DRUG SYNERGISM; ETHANOL; IMIDAZOLES; LIGANDS; MALE; MICE; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; PENTYLENETETRAZOLE; QUINOXALINES; RATS; RECEPTORS, GABA; SEIZURES; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTANCE-RELATED DISORDERS;

EID: 0029795527     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm960070+     Document Type: Article

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