Intra-Amygdala Administration of Polyamines Modulates Fear Conditioning in Rats

Journal of Neuroscience

Volumn 24, Issue 9, 2004, Pages 2328-2334

  Rubin, Maribel A ^a   Berlese, Daiane B ^a   Stiegemeier, Juliano A ^a   Volkweis, Márcio A ^a   Oliveira, Denise M ^a   Dos Santos, Telma L B ^a   Fenili, Ana C ^a   Mello, Carlos F ^a  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

Author keywords

Amygdala; Arcaine; Fear conditioning; Learning; Memory; Polyamines; Spermidine

Indexed keywords

ARCAINE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; POLYAMINE; SPERMIDINE;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUDITORY NERVOUS SYSTEM; BINDING SITE; CONDITIONED REFLEX; CONDITIONING; CONTROLLED STUDY; FEAR; LEARNING; MALE; MEMORY; NONHUMAN; PRIORITY JOURNAL; RAT;

AMYGDALA; ANIMALS; BEHAVIOR, ANIMAL; BIGUANIDES; BIOGENIC POLYAMINES; CATHETERIZATION; CONDITIONING, CLASSICAL; DRUG ADMINISTRATION ROUTES; FEAR; MALE; MAZE LEARNING; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SPATIAL BEHAVIOR; SPERMIDINE;

EID: 1542317047     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1622-03.2004     Document Type: Article

References (53)

1. Anderson DJ, Crossland J, Shaw GG (1975) The actions of spermidine and spermine on the central nervous system. Neuropharmacology 14:571-577.
2. Antoniadis E, McDonald RJ (2000) Amygdala, hippocampus and discriminative fear conditioning to context. Behav Brain Res 108:1-19.
3. Barros DM, Izquierdo LA, Mello e Souza T, Ardenghi PG, Pereira P, Medina JH, Izquierdo I (2000) Molecular signalling pathways in the cerebral cortex are required for retrieval of one-trial avoidance learning in rats. Behav Brain Res 114:183-192.
4. Cahill L, Weinberger NM, Roozendaal B, McGaugh JL (1999) Is the amygdala a locus of "conditioned fear"? Some questions and caveats. Neuron 23:227-228.
5. Campeau S, Miserendino MJD, Davis M (1992) Intra-amygdala infusions of the N-methyl-D-aspartate receptor antagonist AP5 blocks acquisition but not expression of fear-potentiated startle to an auditory conditioned stimulus. Behav Neurosci 106:569-574.
6. Conway EC (1998) Brain lesions and delayed water maze learning deficits after intracerebroventricular spermine. Brain Res 800:10-20.
7. Falls WA, Miserendino MJD, Davis M (1992) Extinction of fear-potentiated startle: blockade by infusion of an NMDA antagonist into the amygdala. J Neurosci 12:854-863.
8. Fanselow MS (1985) Odors released by stressed rats produce opioid analgesia in unstressed rats. Behav Neurosci 99:589-592.
9. Fanselow MS, Kim JJ (1994) Acquisition of contextual Pavlovian fear conditioning is blocked by application of an NMDA receptor antagonist D,L-2-amino-5-phosphonovaleric acid to the basolateral amygdala. Behav Neurosci 108:210-212.
10. Fanselow MS, Kim JJ, Landeira-Fernandez J (1991) Anatomically selective blockade of Pavlovian fear conditioning by application of na NMDA antagonist to the amygdala and periaqueductal gray. Soc Neurosci Abstr 17:659.
11. Fanselow MS, Kim JJ, Yipp J, DeOca B (1994) Differential effects of the N-methyl-D-aspartate antagonist DL-2-amino-5-phosphonovalerate on acquisition of fear of auditory and contextual cues. Behav Neurosci 108:235-240.
12. Fendt M (2001) Injections of the NMDA receptor antagonist aminophos-phonopentanoic acid into the lateral nucleus of the amygdala block the expression of fear-potentiated startle and freezing. J Neurosci 21:4111-4115.
13. 1A receptor modulation of anxiety in two ethological animal tests. J Neurosci 16:4810-4815.
14. Gold PE, Buskirk RV (1976) Enhancement and impairment of memory processes with post-trial injections of adrenocorticotrophic hormone. Behav Biol 16:387-400.
15. Goosens KA, Maren S (2001) Contextual and auditory fear conditioning are mediated by the lateral, basal, and central amygdaloid nuclei in rats. Learn Mem 8:148-155.
16. Halonen T, Sivenius J, Miettinen R, Halmekyto M, Kauppinen R, Sinervirta R, Alakuijala L, Alhonen L, MacDonald E, Janne J, Riekkinen PJ (1993) Elevated seizure threshold and impaired spatial learning in transgenic mice with putrescine overproduction in the brain. Eur J Neurosci 5:1233-1239.
17. Hunskaar S, Berge O-G, Hole K (1986) A modified hot-plate test sensitivie to mild analgesics. Behav Brain Res 21:101-108.
18. Jensen TS, Smith DF (1982) Effect of emotions on nociceptive thresholds in rats. Physiol Behav 28:597-599.
19. Kim M, Campeau S, Falls WA, Davis M (1993) Infusion of the non-NMDA receptor antagonist CNQX into the amygdala blocks the expression of fear-potentiated startle. Behav Neural Biol 59:5-8.
20. Kishi A, Ohno M, Watanabe S (1998a) Concurrent activation of hippocampal glycine and polyamine sites of the N-methyl-D-aspartate receptor synergistically reverses working memory deficits in rats. Neurosci Lett 257:131-134.
21. Kishi A, Ohno M, Watanabe S (1998b) Spermidine, a polyamine site agonist, attenuates working memory deficits caused by blockade of hippocampal muscarinic receptors and mGluRs in rats. Brain Res 793:311-314.
22. Lee H, Kim JJ (1998) Amygdalar NMDA receptors are critical for new fear learning in previously fear-conditioned rats. J Neurosci 18:8444-8454.
23. Lester LS, Fanselow MS (1985) Exposure to a cat produces opioid analgesia in rats. Behav Neurosci 99:756-759.
24. Maren S (2000) Does the basolateral amygdala store memories for emotional events? Reply. Trends Neurosci 8:345-346.
25. Maren S, Aharonov G, Stote DL, Fanselow MS (1996) N-methyl-D-aspartate receptor in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats. Behav Neurosci 110:1365-1374.
26. McGurk JF, Bennet MVL, Zukin RS (1990) Polyamines potentiate responses of N-methyl-D-aspartate receptors expressed in Xenopus oocytes. Proc Natl Acad Sci USA 87:9971-9974.
27. Meyer RC, Knox J, Purwin DA, Purwin A, Spangler EL, Ingran DK (1998) Combined stimulation of the glycine and polyamines sites of the NMDA blockade-induced learning deficits of rats in a 14-unit T-maze. Psychopharmacology 135:290-295.
28. Mikolajczak P, Okuliez-Kozaryn I, Kaminska E, Niedopad L, Polanska A, Gebka J (2002) Effects of acamprosate and some polyamine site ligands of NMDA receptor on short-term memory in rats. Eur J Pharmacol 444:83-96.
29. Miserendino MJD, Sananes CB, Melia KR, Davis M (1990) Blocking of acquisition but not expression of conditioned fear-potentiated startle by NMDA antagonists in the amygdala. Nature 345:716-718.
30. Netto CA, Siegfried B, Izquierdo I (1987) Analgesia induced by exposure to a novel environment in rats: effect of concurrent and post-training stressful stimulation. Behav Neural Biol 48:304-309.
31. Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, Ed 2. San Diego: Academic.
32. Pellegrini-Giampietro DE (2003) An activity-dependent spermidine-mediated mechanism that modulates glutamate transmission. Trends Neurosci 26:9-11.
33. 3H] MK-801 binding to the N-methyl-D-aspartate receptor ion channel complex by L-glutamate, glycine, and polyamines. J Neurochem 51:830-836.
34. Rock DM, Macdonald RL (1995) Polyamine regulation of N-methyl-D-aspartate receptor channels. Annu Rev Pharmacol Toxicol 35:463-482.
35. Roesler R, Viana MRM, de Paris F, Quevedo J (1999) Memory-enhancing treatments do not reverse the impairment of inhibitory avoidance retention induced by NMDA receptor blockade. Neurobiol Learn Mem 72:252-258.
36. Rogan MT, Stäubli UV, LeDoux JE (1997) AMPA receptor facilitation accelerates fear learning without altering the level of conditioned fear acquired. J Neurosci 17:5928-5935.
37. Rubin MA, Boemo RL, Jurach A, Rojas DB, Zanolla GR, Obregon ADC, Souza DO, Mello CF (2000) Intrahippocampal spermidine administration improves inhibitory avoidance performance in rats. Behav Pharmacol 11:57-62.
38. Rubin MA, Stiegemeier JA, Volkweis MA, Oliveira DM, Fenili AC, Boemo RL, Jurach A, Mello CF (2001) Intra-amygdala spermidine administration improves inhibitory avoidance performance in rats. Eur J Pharmacol 423:35-39.
39. 3H]N-(1-[thienyl]cyclohexyl) piperidine binding to the N-methyl-D-aspartate receptor ionophore complex. Mol Pharmacol 37:572-577.
40. Shimada A, Spangler EL, London ED, Ingram DK (1994) Spermidine potentiates dizocilpine-induced impairment of learning performance by rats in a 14-unit T-maze. Eur J Pharmacol 262:293-300.
41. Snow AE, Tucker SM, Dewey WL (1982) The role of neurotransmitters in stress-induced antinociception (SAI). Pharmacol Biochem Behav 16:47-50.
42. Sprosen T, Woodruff GN (1990) Polyamines potentiate NMDA induced whole-cell currents in cultured striatal neurons. Eur J Pharmacol 179:477-478.
43. Tang YP, Wang H, Feng R, Kyin M, Tsien JZ (2001) Differential effects of enrichment on learning and memory function in NR2B transgenic mice. Neuropharmacology 41:779-790.
44. Vazdarjanova A (2000) Does the basolateral amygdala store memories for emotional events? Trends Neurosci 23:345.
45. Walker DL, Davis M (2000) Involvement of NMDA receptors within the amygdala in short- versus long-term memory for fear conditioning as assessed with fear-potentiated startle. Behav Neurosci 114:1019-1033.
46. Walker DL, Davis M (2002) The role of amygdala glutamate receptors in fear learning, fear-potentiated startle, and extinction. Pharmacol Biochem Behav 71:379-392.
47. Walker DL, Ressler KJ, Lu K-T, Davis M (2002) Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. J Neurosci 22:2343-2351.
48. Wilensky AE, Schafe GE, LeDoux JE (2000) The amygdala modulates memory consolidation of fear-motivated inhibitory avoidance learning but not classical fear conditioning. J Neurosci 20:7059-7066.
49. Williams K (1997) Interactions of polyamines with ion channels. Biochem J 325:289-297.
50. Williams K, Dawson VL, Romano C, Dichter MA, Molinoff PB (1990) Characterization of polyamines having agonist, antagonist, and inverse agonist effects at the polyamine recognition site of the NMDA receptor. Neuron 5:199-208.
51. Williams K, Romano C, Dichter MA, Molinoff PB (1991) Modulation of the NMDA receptor by polyamines. Life Sci 48:469-498.
52. Yeomens DC, Proudfit HK (1996) Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: electrophysiological evidence. Pain 68:141-150.
53. Yeomens DC, Pirec V, Proudfit HK (1996) Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: behavioral evidence. Pain 68:133-140.