Hormetic dose-response relationships in immunology: Occurrence, quantitative features of the dose response, mechanistic foundations, and clinical implications

Critical Reviews in Toxicology

Volumn 35, Issue 2-3, 2005, Pages 89-295

  Calabrese, Edward J ^a  

^a UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

Cytokines; Dose Response; Hormesis; Immune Stimulation; Inhibitory; Interleukins; J Shaped; Lymphocyte stimulation; Metals; Opioids; Stimulatory; U Shaped

Indexed keywords

ADRENALIN; ALPHA ENDORPHIN; ATRIAL NATRIURETIC FACTOR; BETA CAROTENE; BETA ENDORPHIN; BOMBESIN; CARBON MONOXIDE; CHOLECYSTOKININ; COMPLEMENT COMPONENT C5; CORTICOSTERONE; CORTICOTROPIN; CYTOKINE; DOPAMINE; ENDOTHELIN 1; ENDOTHELIN 3; ESTRADIOL; ESTRONE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMIN; HISTAMINE; HUMAN GROWTH HORMONE; HYDROGEN PEROXIDE; INTERLEUKIN 1; INTERLEUKIN 10; ISOPRENALINE; METAL; OPIATE; RETINOIC ACID DERIVATIVE; UNINDEXED DRUG; XENOBIOTIC AGENT;

ANTIBODY RESPONSE; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; CANCER CELL DESTRUCTION; CELL LINE; CELL MIGRATION; CYTOKINE PRODUCTION; DOSE RESPONSE; DOSIMETRY; DRUG MEGADOSE; ENZYME INHIBITION; FEEDBACK SYSTEM; HORMESIS; HUMAN; IMMUNOLOGY; IMMUNOSTIMULATION; LOW DRUG DOSE; LYMPHOCYTE ACTIVATION; NONHUMAN; PLAQUE FORMING CELL; POLLUTANT; PUBLICATION; QUANTITATIVE ANALYSIS; REVIEW; T LYMPHOCYTE; XENOBIOTIC METABOLISM;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; META-ANALYSIS; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; TERMINOLOGY;

EID: 15344338506     PISSN: 10408444     EISSN: None     Source Type: Journal    
DOI: 10.1080/10408440590917044     Document Type: Review

References (308)

1. Aarbiou, J., Verhoosel, R.M., van Weterin, S., de Boer, W.I., van Krieken, J.H.J.M., Litvinov, S.V., Rabe, K.F., and Hiemstra, RS. (2004). Neutrophil defensins enhance lung epithelial wound closure and mucin gene expression in vitro. Am. J. Respir. Cell Mol. Biol. 30:193-201.
2. Adolfs, M.J.P., Beusenberg, F.D., and Bonta, I.L. (1989). PAF-acether modifies human peritoneal macrophage cAMP levels in a biphasic fashion. Agents Actions 26:119-120.
3. Alobaidi, T., Naccache, P.H., and Sha'afi, R.I. (1981). Calmodulin antagonists modulate rabbit neutrophil degranulation, aggregation and stimulated oxygen consumption. Biochim. Biophys. Acta 675:316-321.
4. Anderson, R.E., and Lefkovits, I. (1979). In vitro evaluation of radiation-induced augmentation of the immune response. Am. J. Pathol. 97(3):456-472.
5. Anderson, R.E., and Troup, G.M. (1982). Effects of irradiation upon the response of murine spleen cells to mitogens. Am. J. Pathol. 109:169-178.
6. Anderson, R., and Van Rensburg, A.J. (1979). The in vitro effects of propranolol and atenolol on neutrophil motility and post-phagocytic metabolic activity. Immunology 37:15-24.
7. Anderson, R.S., Brubacher, L.L., Calvo, L.M.R., Burreson, E.M., and Unger, M.A. (1997). Effect of in vitro exposure to tributyltin on generation of oxygen metabolites by oyster hemocytes. Environ. Res. 74:84-90.
8. Anderson, R.S., Mora, L.M., and Thomson, S.A. (1994). Modulation of oyster (Crassostrea virginica) hemocyte immune function by copper, as measured by luminol enhanced chemiluminescence. Comp. Biochem. Physiol. 108C(2):215-220.
9. Andersson, J.A., Uddman, R., Cardell, L.-O. (2002). Hemin, a heme oxygenase substrate analog, both inhibits and enhances neutrophil random migration and chemotaxis. Allergy 57:1008-1012.
10. Anel, A., Halmos, T., Torres, J.M., Pineiro, A., Antonakis, K., and Uriel, J. (1990). Cytotoxicity of chlorambucil and chlorambucil-fatty acid conjugates against human lymphomas and normal human peripheral blood lymphocytes. Biochem. Pharmacol. 40(6):1193-1200.
11. 1-proteinase inhibitor on chemotaxis and chemokinesis on polymorphonuclear leukocytes: Its possible role in regulatory polymorphonuclear leukocyte recruitment in human subjects. J. Lab. Clin. Med. 122(3):333-340.
12. Badger, A.M., Brown, A.E., and Poste, G. (1983). The effect of cimetidine on antibody synthesis in vitro and in vivo. Immunology 48:151-155.
13. Baier-Anderson, C., and Anderson, R.S. (1998). Evaluation of the immunotoxicity of chlorothalonil to striped bass phagocytes following in vitro exposure. Environ. Toxicol. Chem. 17(8):1546-1551.
14. Bellavite, P., Chirumbolo, S., Lippi, G., Guzzo, P., and Santonastaso, C. (1993). Homologous priming in chemotactic peptide-stimulated neutrophils. Cell Biochem. Func. 11:93-100.
15. Belokrylov, G.A., Popova, O.Y., Derevnina, O.N., Molchanova, I.V., and Sorochinskaya, E.I. (1998). Immuno-, phagocytosis-modulating, and antitoxic properties of amino acids and peptide preparations. Drug Dev. Indus. Pharmacy 24:115-127.
16. Benacerraf, B., Biozzi, G., Halpern, B.N., and Stiffel, C. (1957). In: Physiopathology of the Reticulo-endothelial System, B.N. Halpern, B. Benacerraf, and J.F. Delafresnaye, eds. Blackwell, Oxford, p. 52.
17. 3+) on histamine release from human adenoidal and cutaneous mast cells. Agents Actions C1:C321-C324.
18. Beusenberg, F.D., van Schaik, A., van Amsterdam, J.G.C., and Bonta, I.L. (1991). Involvement of eicosanoids in platelet-activating factor-induced modulation of adenylyl cyclase activity in alveolar macrophages. J. Lipid Mediators 3:301-310.
19. Beusenberg, F.D., van Amsterdam, J.G.C., Hoogsteden, H.C., Hekking, P.R.M., Brouwers, J.W., Schermers, H.P., and Bonta, I.L. (1992). Stimulation of cyclic AMP production in human alveolar macrophages induced by inflammatory mediators and β-sympathicomimetics. Eur. J. Pharmacol., Environ. Toxicol. Pharmacol. Section 228:57-62.
20. Beusenberg, F.D., Bonta, I.L., and van Amsterdan, J.G.C. (1994). Cyclic-AMP level and eicosanoid release from alveolar macrophages are differentially affected by high and low dose of platelet activating factor. Biochem. Pharmacol. 47:588-590.
21. Bilbey, D.L.H., and Nicol, T. (1958). Effect of various natural steroids on the phagocytic activity of the reticuloendothelial system. Nature 182:674.
22. Bluestein, H.G., Weisman, M.H., Zvaifler, N.J., and Shapiro, R.F. (1979). Lymphocyte alteration by procainamide: Relation to drug-induced lupus erythematosus syndrome. Lancet 816-819.
23. Bonnet, M., Lespinats, G., and Burtin, C. (1984). Histamine and serotonin suppression of lymphocyte response to phytohemagglutinin and allogeneic cells. Cell Immunol. 83:280-291.
24. Boogaerts, M.A., Mabrain, S., Meeus, P., Van Hove, L., and Verhoef, G.E.G. (1990). in vitro modulation of normal and diseased human neutrophil function by pentoxifylline. Blut 61:60-65.
25. Boorman, G.A., Luster, M.I., Dean, J.H., and Luebke, R.W. (1982). Effect of indomethacin on the bone marrow and immune system of the mouse. J. Clin. Lab. Immunol. 7:119-126.
26. Boorman, G.A., Luster, M.I., Dean, J.H., and Wilson, R.E. (1980). The effect of adult exposure to diethylstilbestrol in the mouse on macrophage function and numbers. J. Reticuloendothelial Soc. 28(6):547-560.
27. Borella, P., Manni, S., and Giardino, A. (1990). Cadmium, nickel, chromium and lead accumulate in human lymphocytes and interfere with PHA-induced proliferation. J. Trace Elem. Electrolytes Health Dis. 4:87-95.
28. Bozelka, B.E., Gaumer, H.R., Nordberg, J., and Salvaggio, I.E. (1983). Asbestos induced alterations of human lymphoid cell mitogenic responses. Environ. Res. 30:281-290.
29. Bramm, E., Binderup, L., and Arrigoni-Martelli, E. (1979). Delayed hypersensitivity to tuberculin in rats: Effects of antirheumatic drugs. Acta Pharmacol. Toxicol. 44:75-80.
30. Brandt, L. (1971). Enhancing effect of clofazimine (B663) on the phagocytosis of neutrophilic leucocytes in vitro. Scand. J. Haematol. 8:265-269.
31. Brattig, N.W., Diao, G.-J., Berg, P.A. (1984). Immunoenhancing effect of flavonoid compounds on lymphocyte proliferation and immunoglobulin synthesis. Eur. J. Immunopharm. 6:205-215.
32. Brousseau, P., Pellerin, J., Morin, Y., Cyr, D., Blakley, B., Boermans, H., and Fournier, M. (2000). Flow cytometry as a tool to monitor the disturbance of phagocytosis in the clam Mya arenaria hemocytes following in vitro exposure to heavy metals. Toxicology 142:145-156.
33. Bryant, H.U., Holaday, J.W., and Bernton, E.W. (1989). Cysteamine produces dose-related bi-directional immunomodulatory effects in mice. J. Pharm. Exp. Ther. 249:424-429.
34. Burchiel, S.W., and Melmon, K.L. (1981). The role of cyclic AMP in immunoregulation. In: Suppressor Cells in Human Disease (J.S. Goodwin). New York, Marcel Dekker, pp. 31-64.
35. Cahalon, L., Lider, O., Schor, H., Avron, A., Gilat, D., Hershkovitz, R., Margalit, R., Eshel, A., Shoseyev, O., and Cohen, I.R. (1997). Heparin disaccharides inhibit tumor necrosis factor-α production by macrophages and arrest immune inflammation in rodents. Int. Immunol. 9:1517-1522.
36. Calabrese, E.J. (2001). Apoptosis: Biphasic dose responses. Crit. Rev. Toxicol. 31(4&5):607-613.
37. Calabrese, E.J., and Baldwin, L.A. (2003). The hormetic dose-response model is more common than the threshold model in toxicology. Toxicol. Sci. 71:246-250.
38. Calabrese, E.J., and Baldwin, L.A. (2001). The frequency of U-shaped dose-responses in the toxicological literature. Toxicol. Sci. 62:330-338.
39. Calabrese, E.J., and Baldwin, L.A. (2001a). Agonist concentration gradients as a generalizable regulatory implementation strategy. Crit. Rev. Toxicol. 31:471-473.
40. Calabrese, E.J., and Baldwin, L.A. (2000a). Chemical hormesis: Its historical foundations as a biological hypothesis. Hum. Exp. Toxicol. 19:2-31.
41. Calabrese, E.J., and Baldwin, L.A. (2000b). The marginalization of hormesis. Hum. Exp. Toxicol. 19:32-40.
42. Calabrese, E.J., and Baldwin, L.A. (2000c). Radiation hormesis: Its historical foundations as a biological hypothesis. Hum. Exp. Toxicol. 19:41-75.
43. Calabrese, E.J., and Baldwin, L.A. (2000d). Radiation hormesis: the demise of a legitimate hypothesis. Hum. Exp. Toxicol. 19:76-84.
44. Calabrese, E.J., and Baldwin, L.A. (2000e). Tales of two similar hypotheses: The risk and fall of chemical and radiation hormesis. Hum. Exp. Toxicol. 19:85-97.
45. Calvo, C.-F., Chavanel, G., and Senik, A. (1992). Substance P enhances IL-2 expression in activated human T-cells. J. Immunol. 148:3498-3504.
46. Chen, M.G., and Schooley, J.C. (1970). Effect of ionizing radiation and vinblastine on the proliferation of peritoneal macrophage precursors in the mouse. Radiat. Res. 41:623-636.
47. Christin, M.S., Menard, L., Gendron, A.D., Ruby, S., Cyr, D., Marcogliese, D.J., Rollins-Smith, L., and Fournier, M. (2004). Effects of agricultural pesticides on the immune system of Xenopus laevis and Rana pipiens. Aquat. Toxicol. 67:33-43.
48. Clarke, B.L., Moore, D.R., and Blalock, J.E. (1994). Adrenocorticotropic hormone stimulates a transient calcium uptake in rat lymphocytes. Endocrinology 135:1780-1786.
49. Cleary, S.F., Liu, L.-M., and Merchant, R.E. (1990). In vitro lymphocyte proliferation induced by radio-frequency electromagnetic radiation under isothermal conditions. Bioelectromagnetics 11:47-56.
50. Clerici, M., Cogliati, M., Rizzardini, G., Colombo, F., Fossati, S., Rhodes, J., Bray, D., and Piconi, S. (2000). In vitro immunomodulatory properties of tucaresol in HIV infection. Clin. Immunol. 97(3):211-220.
51. Coles, J.A., Parley, S.R., and Pipe, R.K. (1995). Alteration of the immune response of the common marine mussel Mytilus edulis resulting from exposure to cadmium. Dis. Aquat. Organisms 22: 59-65.
52. 2-adrenergic agonist, modulates proliferation of rat thymocytes in vivo and in vitro. Methods Find. Exp. Clin. Pharmacol. 22(7):557-562.
53. Colic, M., Vucevic, D., Kilibarda, V., Radicevic, N., and Savic, M. (2002). Modulatory effects of garlic extracts on proliferation of T-lymphocytes in vitro stimulated with concanavalin A. Phytomedicine 9:117-124.
54. Conning, D.M., and Heppleston, A.G. (1966). Reticuloendothelial activity and local particle disposal - A comparison of influence of modifying agents. Br. J. Exp. Pathol. 47:388.
55. Contrino, J., Marucha, P., Ribaudo, R., Ference, R., Bigazzi, P.E., and Kreutzer, D.L. (1988). Effects of mercury on human polymorphonuclear leukocyte function in vitro. Amer. J. Pathol. 132(1): 110-118.
56. Contrino, J., Kosuda, L.L., Marucha, P., Kreutzer, D.L., and Bigazzi, P.E. (1992). The in vitro effects of mercury on peritoneal leukocytes (PMN and macrophages) from inbred Brown Norway and Lewis rats. Int. J. Immunopharm. 14(6):1051-1059.
57. Crabbe, J. (1956). Enhancing action of small doses of cortisone on macrophage phagocytosis of staphylococci in rabbits. Acta Endocrinol 21:41-46.
58. Csaba, G., and Lantos, T. (1973). Effect of hormones on protozoa. Studies on the phagocytotic effects of histamine, 5-hydroxytryptamine and indoleacetic acid in Tetrahymena pyriformis. Cytobiology 7:361-365.
59. 2-adrenergic agonist, on rat spleen cells in culture. J. Neuroimmunol. 113:19-29.
60. De Jesus, S., and Renaud, F.L. (1989). Phagocytosis in Tetrahymena thermophila: Naloxone-reversible inhibition by opiates. Camp. Biochem. Physiol. 92C:139-142.
61. De la Fuente, M., Carrasco, M., Del Rio, M., and Hernanz, A. (1998). Modulation of murine lymphocyte functions by sulfated cholecystokinin octapeptide. Neuropeptides 32(3):225-233.
62. De la Fuente, M., del Rio, M., Ferrandez, M.D., and Hernanz, A. (1991). Modulation of phagocytic function in murine peritoneal macrophages by bombesin, gastrin-releasing peptide and neuromedin C. Immunology 73:205-211.
63. Dieter, M.P., Luster, M.I., Boorman, G.A., Jameson, C.W., Dean, J.H., and Cox, J.W. (1983). Immunological and biochemical responses in mice treated with mercuric chloride. Toxicol. Appl. Pharmacol. 68:218-228.
64. DiGioacchino, M., Sabbioni, E., DiGiampaolo, L., Schiavone, C., Di Sciascio, M.B., Reale, M., Verna, N., Qiao, N., Paganelli, R., Conti, P., and Boscolo, P. (2002). In vitro effects of vanadate on human immune functions. Ann. Clin. Lab. Sci. 32:148-154.
65. Dubois, C., Bissonnette, E., and Rola-Pleszczynski, M. (1989). Platelet-activating factor (PAF) enhances tumor necrosis factor production by alveolar macrophages. J. Immunol. 143:964-970.
66. Edgar, V., Genaro, A.M., Cremaschi, G., and Sterin-Borda, L. (1998). Fluoxetine action on murine T-lymphocyte proliferation: participation of PKC activation and calcium mobilization. Cell. Signal 10:721-726.
67. Egorin, M.J., Litvin, F., Felsted, R.L., and Bachur, N.R. (1978). Phytohemagglutinin isolectin stimulation of human lympocytes cultured in serum free medium. Life Sci. 23(3):237-246.
68. Eisemann, K., Totola, A., Jurcic, K., Pettit, G.R., and Wagner, H. (1995). Bryostatins 1,2 and 5 activate human granulocytes and lymphocytes in vitro and in vivo studies. Pharm. Pharmacol. Lett. 1:45-48.
69. Elferink, J.G.R., and de Koster, B.M. (2000). Inhibition of interleukin-8-activated human neutrophil chemotaxis by thapsigargin in a calcium- and cyclic AMP-dependent way. Biochem. Pharmacol. 59:369-375.
70. Elferink, J.G.R., and de Koster, B.M. (1998). The effect of thimerosal on neutrophil migration: a comparison with the effect on calcium mobilization and CD11B expression. Biochem. Pharmacol. 55:305-312.
71. Elferink, J.G.R., and de Koster, B.M. (1998a). N-Acetylcysteine causes a transcient stimulation of neutrophil migration. Immunopharmacology 38:229-236.
72. Elferink, J.G.R., and de Koster, B.M. (1996). Modulation of human neutrophil chemotaxis by the endothelin-B receptor agonist sarafotoxin S6c. Chemi. Biol. Interact 101:165-174.
73. Elferink, J.G.R., and de Koster, B.M. (1995). Stimulation and inhibition of neutrophil chemotaxis by endothelin-3. J. Cardiovasc. Pharmacol. 26:8142-8144.
74. Elferink, J.G.R., and de Koster, B.M. (1995a). Atrial natriuretic factor stimulates migration by human neutrophils. Eur. J. Pharm. 288:335-340.
75. Elferink, J.G.R., and de Koster, B.M. (1994). Endothelin-induced activation of neutrophil migration. Biochem. Pharmacol. 48(5):865-871.
76. Elferink, J.G.R. and de Koster, B.M. (1993). Modulation of neutrophil migration by captopril. Naunyn-Schmiedeberg's Arch. Pharmacol. 347:562-567.
77. Elferink, J.G.R., and de Koster, B.M. (1993a). Differential stimulation of neutrophil functions by pyrithioxine. Int. J. Immunopharm. 15(5):641-646.
78. Elferink, J.G.R., and de Koster, B.M. (1992). N-Methyl-N′-nitroso- N-nitrosoguanidine: The effect on migration and cGMP level of neutrophils. Toxicology 73:45-52.
79. Elferink, J.G.R., Daha, M.R., and de Koster, B.M. (1997). A cyclic GMP- and G-kinase-dependent effect of azathioprine on migration by human neutrophils. Cell. Mol. Life Sci. 53:593-599.
80. Elferink, J.F.R., Huizinga, T.W.J., and de Koster, B.M. (1997a). The effect of pentoxifylline on human neutrophil migration: A possible role for cyclic nucleotides. Biochem. Pharmacol. 54: 475-480.
81. Elferink, J.F.R., and VanUffelen, B.E. (1996). The role of cyclic nucleotides in neutrophil migration. Gen. Pharm. 27(2):387-393.
82. Elsasser-Beile, U., Voss, M., Schuhle, R., and Wetterauer, U. (2000). Biological effects of natural and recombinant mistletoe lectin and an aqueous mistletoe extract on human monocytes and lymphocytes in vitro. J. Clin. Lab. Anal. 14:256-259.
83. Evans, D.L., Miller, D.M., Jacobsen, K.L., and Bush, P.B. (1987). Modulation of immune responses in mice by d-limonene. J. Toxicol. Env. Health 20:51-66.
84. Faccioli, L.H., Souza, G.E.P., Cunha, F.Q., Poole, S., and Ferreira, S.H. (1990). Recombinant interleukin-1 and tumor necrosis factor induce neutrophil "in vivo" by indirect mechanisms. Agents Actions 30:344-349.
85. Falchetti, R., Fuggetta, M.P., Lanzilli, G., Tricarico, M., and Ravagnan, G. (2001). Effects of resveratrol on human immune cell function. Life Sci. 70:81-96.
86. Falk, W., Goodwin, R.H.J., and Leonard, E.J. (1980). A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte migration. J. Immunol. Methods 33(3):239-247.
87. Fan, F., Wierda, D., and Rozman, K.K. (1996). Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on humoral and cell-mediated immunity in Sprague-Dawley rats. Toxicology 106:221-228.
88. Fasanmade, A.A., and Jusko, W.J. (1995). Effect of halofantrine and its desbutyl metabolite on lymphocyte proliferation dynamics. Life Sci. 57(14):175-180.
89. Fauci, A.S., Pratt, K.R., and Whalen, G. (1978). Activation of human B lymphocytes. VIII. Differential radiosensitivity of subpopulations of lymphoid cells involved in the polyclonally-induced PFC responses of peripheral blood B lymphocytes. Immunology 35:715-720.
90. Filkins, J.P., and Di Luzio, N.R. (1966). Effects of gelatin and heparin on intravascular phagocytosis. J. Reticuloendothelial Soc. 3:471-485.
91. Fink, R., Ehrhardt, R., and Dancygier, H. (1988). Bombesin and its analogues inhibit interleukin-2-induced proliferation of CTLL-2 cells. Regul. Peptides 23:323-330.
92. Finocchiaro, L.M.E., Polack, E., Nahmod, V.E., and Glikin, G.C. (1995). Sensitivity of human peripheral blood mononuclear leukocytes to visible light. Life Sci. 57(11):1097-1110.
93. Flynn, A. (1984). Stimulation of interleukin-1 production from placental monocytes. Lymphokine Res. 3:1-5.
94. Foris, G., Medgyesi, G.A., and Hauck, M. (1986). Bidirectional effect of met-enkephalin on macrophage effector functions. Mol. Cell. Biochem. 69:127-137.
95. Fournier, M., Cyr, D., Blakley, B., Boermans, H., and Brousseau, P. (2000). Phagocytosis as a biomarker of immunotoxicity in wildlife species exposed to environmental xenobiotics. Am. Zool. 40:412-420.
96. Franchimont, D., Martens, H., Hagelstein, M.-T., Louis, E., Dewe, W., Chrousos, O.P., Belaiche, J., and Geenen, V. (1999). Tumor necrosis factor α decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: Potential regulation of the glucocorticoid receptor. J. Clin. Endocrin. Metab. 84(8):2834-2839.
97. Friedman, E.M., Coe, C.L., and Ershler, W.B. (1994). Bidirectional effects of interleukin-1 on immune responses in Rhesus monkeys. Brain Behav. Immun. 8:87-99.
98. Friedman, H., Lee, I., and Walz, D.T. (1982). Effects of histamine receptor antagonists metiamide and cimetidine on antibody formation in vitro by murine cells (41335). Proc. Soc. Exp. Biol. Med. 169:222-225.
99. Fujimaki, H. (1987). Comparison of the effect of cadmium on lymphocytes of young and adult mice. J. Environ. Path. Toxicol. Oncol. (JEPTO) 7:39-46.
100. Fujimaki, H., Murakami, M., and Kubota, K. (1982). In vitro evaluation of cadmium-induced augmentation of the antibody response. Toxicol. Appl. Pharmacol. 62:288-293.
101. Gallo, R.C., Whang-Peng, J., and Perry, S. (1969). Isopentenyladenosine stimulates and inhibits mitosis of human lymphocytes treated with phytohemagglutinin. Science 165:400-402.
102. Garry, V.F., and Uyeki, E.M. (1972). Effects of phenothiazines on the development of antibody-producing cell in vitro. Biochem. Pharmacol. 21:2801-2804.
103. Gelfand, E.W., Dosch, H-M., Hastings, D., and Shore, A. (1979). Lithium: A modulator of cyclic AMP-dependent events in lymphocytes? Science 203(26):365-367.
104. Germuth, F.G. (1956). The role of adrenocortical steroids in infection, immunity and hypersensitivity. Pharmacol. Rev. 8:1-24.
105. Ghazanfari, T., Hassan, Z.M., Ebtekar, M., Ahmadiani, A., Naderig, G., and Azar, A. (2000). Garlic induces a shift in cytokine pattern in Leshmania major infected BALB/C mice. Scand. J. Immunol. 52:491-495.
106. Glasky, A., Pfadenhauer, E.H., Settineri, R., and Ginsberg, T. (1975). Isoprinosine, a purine derivative metabolic, immunological and antiviral effects, pp. 157-171. In: R. Pickering, B. Pollera, I. Porter, and H. Meuwissen (eds.), Combined Immunodeficiency Disease and Adenosine Deaminase Deficiency. Academic Press, New York.
107. Goldenberg, G.J. (1974). Drug-induced stimulation of nitrogen mustard and choline transport and other systems in L5178Y lymphoblasts in vitro. Cancer Res. 34:2511-2516.
108. Gordon, P., Ronsen, B., and Brown, E.R. (1974). Antiherpes virus action of isoprinosine. Antimicrob. Agents Chemother. 5:153-160.
109. Gratas, C., Menot, M.L., Dresch, C., and Chomienne, C. (1993). Retinoid acid supports granulocytic but not erythroid differentiation of myeloid progenitors in normal bone marrow cells. Leukemia 7(8):1156-1162.
110. Madden, J.W., Englard, A., Sadlik, J.R., and Hadden, E.M. (1979). The comparative effects of isoprinosine, levamisole, muramyl dipeptide and SM1213 on lymphocyte and macrophage proliferation and activation in vitro. Int. J. Immunopharm. 1:17-27.
111. Hadden, J.W., Hadden, E.M., and Coffey, R.G. (1976). Isoprinosine augmentation of phytohemagglutinin-induced lymphocyte proliferation. Infect. Immun. 13(2):382-387.
112. Hadden, J.W., Coffey, R.G., Hadden, E.M., Lopez-Corrales, E., and Sunshine, G.H. (1975). Effects of levamisole and imidazole on lymphocyte proliferation and cyclic nucleotide levels. Cell. Immunol. 20:98-103.
113. Hafstrom, I., Uden, A.-M., and Palmblad, J. (1983). Modulation of neutrophil functions by auranofin. Scand. J. Rheumatol. 12:97-105.
114. Hallengren, B., and Forsgren, A. (1978). Effect of alcohol on chemotaxis, adherence and phagocytosis of human polymorphonuclear leucocytes. Acta. Med. Scand. 204:43-48.
115. Hardt, T.J., and Ritschel, W.A. (1983). The effect of coumarin and 7-hydroxycoumarin on in vitro macrophage phagocytosis of latex particles. Methods Find. Exp. Clin. Pharmacol. 5(1):39-42.
116. Harris, G., Browne, C., and Cramp, W.A. (1981). The response of rabbit spleen explants to ionizing radiation. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 39(1):9-19.
117. Hashimoto, S., Shirato, H., Hosokawa, M., Nishioka, T., Kuramitsu, Y., Matushita, K., Kobayashi, M., and Miyasaka, K. (1999). The suppression of metastases and the change in host immune response after low-dose total-body irradiation in tumor-bearing rats. Rad. Res. 151:717-724.
118. Heil, T.L., Volkmann, K.R., Wataha, J.C., and Lockwood, P.E. (2002). Human peripheral blood monocytes versus THP-1 monocytes for in vitro biocompatibility testing of dental material components. J. Oral Rehab. 29:401-407.
119. Heller, J.H. ( 1957). In: Physiopathology of the Reticuloendothelial System, B.N. Halpern, B. Benacerraf, and J.F. Delafresnaye, eds. Blackwell, Oxford, p. 43.
120. Hill, H.R., Augustine, N.H., Newton, J.A., Shigeoka, O., Morris, E., and Sacchi, F. (1987). Correction of a developmental defect in neutrophil activation and movement. Am. J. Pathol. 128:307-314.
121. Hill, H.R., Estensen, R.D., Quie, P.G., Hogan, N.A., and Goldberg, N. (1975). Modulation of human neutrophil chemotactic response by cyclic 3′, 5′-guanosine monophosphate and cyclic 3′,5′-adenosine monophosphate. Metabolism 24(3):447-446.
122. Hinton, D.M., Jessop, J.J., Arnold, A., Albert, R.H., and Hines, F.A. (1987). Evaluation of immunotoxicity in a subchronic feeding study of triphenyl phosphate. Toxicol. Ind. Health 3(1):71-89.
123. Hirano, T., Oka, K., and Tamaki, T. (1995). Gramicidin as a potential immunosuppressant for organ transplantation: Suppression of human lymphocyte blastogenesis in vitro and prolongation of heart allograft survival in the rat. J. Pharmacol. Exp. Ther. 273:223-229.
124. Hirata, A.A., and Redlich, M. (1962). Effect of colchicines on antibody response in hamsters. Proc. Soc. Exp. Biol. Med. 109:628-630.
125. Hoffsten, P.E., and Dixon, F.J. (1974). Effect of irradiation and cyclophosphamide on anti-KLH antibody formation in mice. J. Immunol. 112:564-572.
126. House, R.V., Thomas, P.T., and Bhargava, H.N. (1995). Selective modulation of immune function resulting from in vitro exposure to methylenedioxymethamphetamine (Ecstasy). Toxicology 96: 59-69.
127. House, R.V., Thomas, P.T., and Bhargava, H.N. (1996). A comparative study of immunomodulation produced by in vitro exposure to delta opioid receptor agonist peptides. Peptides 17(1):75-81.
128. Howard, H.L., McLaughlin-Taylor, E., and Hill, R.L. (1990). The effect of mouse euthanasia technique on subsequent lymphocyte proliferation and cell mediated lympholysis assays. Lab. Anim. Sci. 40:510-514.
129. Ichimura, K., and Ohmachi, K. (1971). Effects of chlorpromazine on reticuloendothelial phagocytosis and antibody formation in mice. J. Reticuloendothial Soc. 10:239-250.
130. Ikeda, T., Morishita, N., and Morimoto, T. (1982-1983). Modification of immune response by cinnarizine. J. Immunopharmacol. 4(3):209-221.
131. Ikeda, T., Nakakuma, H., Shionoya, H., Kawaguchi, T., Yamatsu, K., and Takatsuki, K. (1992). Ganglioside-induced inhibition of in vivo immune response in mice. Life Sci. 51(11):847-851.
132. 1A receptors. Cell Immunol. 163:1-9.
133. Ishii, K., Muto, N., and Yamamoto, I. (1990). Augmentation in mitogen-induced proliferation of rat splenocytes by whole body x-irradiation. Nihon Igaku Hao Shasen Gakkai 50(10):1262-1267.
134. Ishizuka, M., Braun, W., and Matsumoto, T. (1971). Cyclic AMP and immune responses. I. Influence of poly A:U and cAMP on antibody formation in vitro. J. Immunol. 107(4):1027-1035.
135. James, S.J., Enger, S.M., Peterson, W.J., and Makinodan, T. (1990). Immune potentiation after fractionated exposure to very low doses of ionizing radiation and/or caloric restriction in autoimmune-prone and normal C57B1/6 mice. Clin. Immunol. Immunopathol. 55(3):427-437.
136. Jawetz, E. (1954). Effect of cortisone on therapeutic efficacy of antibiotics in experimental infections. A.M.A. Arch. Internal. Med. 93:850-862.
137. Johnson, B.H., Dean, R.R., Moran, S.M., and Thompson, E.B. (1992). Glucocorticoid, interleukin-2, and prostaglandin interactions in a clonal human leukemic T-cell line. J. Ster. Biochem. Molecul. Biol. 42(1):1-9.
138. Jones, R.J., Sharkis, J.J., Miller, C.B., Rowinsky, E.K., Burke, P.J., and May, W.S. (1990). Bryostatin-1, a unique biological response modifier-antileukemic activity in vitro. Blood 75(6):1319-1323.
139. Kalashnikov, S.V., Kalashnikova, E.A., and Kokarovtseva, S.N. (2002). Immunomodulating effects of tofixopam (Grandaxin®) and diazepam in vitro. Med. Inflamm. 11:53-59.
140. Kanangat, S., Meduri, G.U., Tolley, E.A., Patterson, D.R., Meduri, C.U., Pak, C., Griffin, J.P., Bronze, M.S., and Schaberg, D.R. (1999). Effects of cytokines and endotoxin on the intracellular growth of bacteria. Infect. Immun. 67:2834-2840.
141. Rarsten, S., Schafer, G., and Schauder, P. (1994). Cytokine production and DNA synthesis by human peripheral lymphocytes in response to palmitic, stearic, oleic, and linoleic acid. J. Cell. Physiol. 161:15-22.
142. Kass, E.H., and Finland, M. (1953). Adrenocortical hormones in infection and immunity. Ann. Rev. Microbiol. 7:361-388.
143. Kenny, J.F., Pangburn, P.C., and Trail, G. (1976). Effect of estradiol on immune competence: In vivo and in vitro studies. Infec. Immun. 13(3):448-456.
144. Kensler, T.W., and Mueller, G.C. (1978). Effects of hexachlorocyclohexane isomers on the mitogenic response of bovine lymphocytes. Biochem. Pharmacol. 27:667-671.
145. Klein, C.L., Kohler, H., and Kirkpatrick, C.J. (1994). Increased adhesion and activation of polymorphonuclear neutrophil granulocytes to endothelial cells under heavy metal exposure in vitro. Pathobiology 62:90-98.
146. Kohidai, L., Vakkuri, O., Keresztesi, M., Pallinger, E., Leppaluoto, J., and Csaba, G. (2002). Impact of melatonin on the cell division, phagocytosis and chemotaxis of Tetrahymena pyriformis. Acta Protozool. 41:85-89.
147. Koller, L.D., and Roan, J.G. (1980). Effects of lead, cadmium and methylmercury on immunological memory. J. Environ. Pathol. Toxicol. 4:47-52.
148. Kowalski, J. (1998). Immunomodulatory action of class μ-, δ- and Kκ opioid receptor agonists in mice. Neuropeptides 32(4):301-306.
149. Kownarski, E., Liehl, E., Aschauer, H., and Uhrich, S. (1990). Inhibition of chemotactic migration of human neutrophillic granulocytes by recombinant human granulocyte-macrophage colony-stimulating factor. Immunopharmacology 19:139-143.
150. Kristiansen, J.E., Sebbesen, O., Frimodt-Moller, N., Aaes-Jorgensen, T., and Hvidberg, E.F. (1988). Synergy between a non-neuroleptic thioxanthene Stereo-isomer and penicillin in vivo. Acta Pathol. Microbiol. Immunol. Scand. 96:1079-1084.
151. Kut, J.L., Young, M.R.I., Crayton, J.W., Wright, M.A., and Young, M.E. (1992). Regulation of murine T-lymphocyte function by spleen cell-derived and exogenous serotonin. Immunopharmacol. Immunotoxicol. 14(4):783-796.
152. Lander, H.M., Levine, D.M., and Novogrodsky, A. (1992). Stress stimuli-induced lymphocyte activation. Cell. Immunol. 145:146-155.
153. Landsman, T., Leitner, G., Robinzon, B., and Heller, E.D. (2001). Immunology and Molecular Biology. Effect of gonadal steroids on proliferative responses and subset alterations in cultured chicken lymphocytes. Poult. Sci. 80:1329-1338.
154. Lang, D.S., Meier, K.L., and Luster, M.I. (1993). Comparative effects of immunotoxic chemicals on in vitro proliferative responses of human and rodent lymphocytes. Fundam. Appl. Toxicol. 21:535-545.
155. Lawrence, D.A. (1981). In vivo and in vitro effects of lead on humoral and cell-mediated immunity. Infect. Immun. 31(1):136-143.
156. Lawrence, D.A. (1981a). Heavy metal modulation of lymphocyte activities. I. In vitro effects of heavy metals on primary humoral immune responses. Toxicol. Appl. Pharmacol. 57:439-451.
157. Lebrec, H., Blot, C., Pequet, S., Roger, R., Bohuon, C., and Pallard, M. (1994). Immunotoxicological investigation using pharmaceutical drugs: in vivo evaluation of immune effects. Fundam. Appl. Toxicol. 23:159-168.
158. Lee, M.-G., Li, S., Jarvis, B.B., and Pestka, J.J. (1999). Effects of satratoxins and other macrocyclic trichothecenes on IL-2 production and viability of EL-4 thymoma cells. Toxicol. Env. Health A, 57:459-474.
159. Legrand-Poels, S., Maniglia, S., Boelaert, J.R., and Piette, J. (1997). Activation of the transcription factor NF-kB in lipopolysaccharide-stimulated U937 cells. Biochem. Pharmacol. 53:339-346.
160. Li, W.-I., and Yan, W.-C. (1992). Immunostimulatory factor(s) in the porcine uterine fluids. Life Sci. 52:73-84.
161. Linner, K.M., Nicol, S.E., and Sharp, B.M. (1993). IL-1β modulates the concanavalin-A-induced expression of proenkephalin A mRNA in murine thymocytes. J. Pharmacol. Exper. Ther. 267(3):1566-1572.
162. Liu, S.-Z. (2003). Nonlinear dose-response relationships in the immune system following exposure to ionizing radiation: mechanisms and Implications. NonLin. Biol. Toxicol. Med. 1:71-92.
163. Liu, S.-Z. (1992). Overview lecture. Multilevel mechanisms of stimulatory effect of low dose radiation on immunity. In: Low Dose Irradiation and Biological Defense Mechanisms. (T. Sugahara, L.A. Sagan, and T. Aoyama, Eds.), pp. 225-232.
164. Liu, S.-Z., Zhang, Y.-C., Mu, Y., Su, X., and Liu, J.-X. (1996). Thymocyte apoptosis in response to low-dose radiation. Mut. Res. 358:185-191.
165. Liu, S.Z., Cai, L., and Sun, J.B. (1990). Effect of low-dose radiation on repair of DNA and chromosome damage. Acta. Biol. Hung. 41(1-3):149-157.
166. Liu, S.Z., Cai, L., and Sun, S.Q. (1992). Induction of a cytogenetic adaptive response by exposure of rabbits to very low dose-rate γ-radiation. Int. J. Radiat. Biol. 62(2):187-190.
167. Liu, S.Z., Liu, W.H., and Sun, J.B. (1987). Radiation hormesis: Its expression in the immune system. Health Phys. 52(5):579-583.
168. Lohr, K.M., Feix, J.B., and Kurth, C. (1984). Chlorpromazine inhibits neutrophil chemotaxis beyond the chemotactic receptor-ligand interaction. J. Infect. Dis. 150:643-652.
169. Los, M., Droge, W., Stricker, K., Baeuerle, P.A., and Schulze-Osthoff, K. (1995). Hydrogen peroxide as a potent activator of T lymphocyte functions. Eur. J. Immunol. 15:159-165.
170. Luebke, R.W., Copeland, C.B., and Andrews, D.L. (1995). Short Communication. Host resistance to Trichinella spiralis infection in rats exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Fund. Appl. Toxicol. 24:285-289.
171. Lurie, M.B. (1960). The reticuloendothelial system, cortisone, and thyroid function - Their relation to native resistance to infection. Ann. NY Acad. Sci. 88:83-98.
172. Lurie, M.B., Zappasodi, P., Dannenberg, A.M., and Schwartz, I.B. (1951).Constitutional factors in resistance to infection - The effect of cortisone on the pathogenesis of tuberculosis. Science 113:234-237.
173. Luster, M.I., Boorman, G.A., Harris, M.W., and Moore, J.A. (1980). Laboratory studies on polybrominated biphenyl-induced immune alterations following low-level chronic or pre/postnatal exposure. Int. J. Immunopharmac.
174. Luster, M.I., Boorman, G.A., Dean, J.H., Harris, M.W., Luebke, R.W., Padarathsingh, M.L., and Moore, J.A. (1980a). Examination of bone marrow, immunologic parameters and host susceptibility following pre- and postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Int. J. Immunopharm. 2:301-310.
175. Luster, M.I., Dean, J.H., Boorman, G.A., Dieter, M.P., and Hayes, H.T. (1982). Immune functions in methyl and ethyl carbamate treated mice. Clin. Exp. Immunol. 50:223-230.
176. Luster, M.I., Portier, C., Pait, D.G., Rosenthal, G.J., Germolec, D.R., Corsini, E., Blaylock, B.L., Pollock, P., Kouchi, Y., Graig, W., White, K.L., Munson, A.E., and Comment, C.E. (1993). Risk assessment in immunotoxicology. II. Relationships between immune and host resistance tests. Fundam. Appl. Toxicol. 21:71-82.
177. MacKinney, A.A., and Vyas, R. ( 1973). The assay of diphenylhydantoin effects on growing human lymphocytes. Pharmacol. Exper. Ther. 186(1):37-43.
178. MacManus, J.P., and Whitfield, J.F. (1969). Stimulation of DNA synthesis and mitotic activity of thymic lymphocytes by cyclic adenosine 3′,5′-monophosphate. Exp. Cell Res. 58(1):188-191.
179. Majeski, J.A., McClellan, M.A., and Alexander, J.W. (1976). Effect of antibiotics on the in vitro neutrophil chemotactic response. Am. Surg. 42:785-788.
180. Mannerstrom, M., Maenpaa, H., Toimela, T., Salminen, L., and Tahti, H. (2001). The phagocytosis of rod outer segments is inhibited by selected drugs in retinal pigment epithelial cell cultures. Pharmacol. Toxicol. 88:27-33.
181. Mazumder, S., Nath, I., and Dhar, M.M. (1993). Immunomodulation of human T cell responses with receptor selective enkephalins. Immunol. Lett. 35:33-38.
182. McCabe, M., Maguire, D., and Nowak, M. (1983). The effects of arsenic compounds on human and bovine lymphocyte mitogenesis in vitro. Environ. Res. 31:323-331.
183. 3H]-thymidine incorporation in CD3e mAb- and CD28 mAb-activated splenocytes and thymocytes. Immunopharmacol. 48:101-115.
184. 1 on immunoglobulin production: A role for Smad3 in IgA production in vitro. Int. Immunopharmacol. 3:1761-1774.
185. Meduri, G.U., Kanangat, S., Bronze, M., Patterson, D.R., Meduri, C.U., Pak, C., Tolley, E.A., and Schaberg, D.R. (2001). Effects of methyl-prednisolone on intracellular bacterial growth. Clin. Diag. Lab. Immunol. 8:1156-1163.
186. Meduri, G.U., Kanangat, S., Stefan, J., Tolley, E., and Schaberg, D. (1999). Cytokine IL-1β, IL-6, and TNF-α enhance in vitro growth of bacteria. Am. J. Respir. Crit. Care Med. 160:961-967.
187. Mendenhall, C.L., Theus, S.A., Roselle, G.A., Grossman, C.J., and Rouster, S.D. (1997). Biphasic in vivo immune function after low-versus high-dose alcohol consumption. Alcohol 14(3):255-260.
188. Meng, Z.Q. (1993). Effects of arsenic on DNA synthesis in human lymphocytes stimulated by phytohemagglutinin. Biol. Trace Elem. Res. 39:73-80.
189. Meng, Z., and Meng, N. (1994). Effects of inorganic arsenicals on DNA synthesis in unsensitized human blood lymphocytes in vitro. Biol. Trace Elem. Res. 42:201-208.
190. Metcalf, J.F., and Wilson, G.B. (1987). Use of mitogen-induced lymphocyte transformation to assess toxicity of aminoglycosides. JEPTO 7(4):27-38.
191. Misra, R.R., and Bloom, S.E. (1991). Roles of dosage, pharmacokinetics, and cellular sensitivity to damage in the selective toxicity of cyclophosphamide towards B and T cells in development. Toxicology 66:239-256.
192. Miyamoto, H., Sugawara, I., Azuma, A., Saito, Y., Kohno, N., and Kudoh, S. (2002). Differential secretion of cytokines and adhesion molecules by HUVEC stimulated with low concentrations of bleomycin. Cell. Immunol. 219:73-81.
193. Monobe, M., and Ando, K. (2002). Drinking beer reduces radiation-induced chromosome aberrations in human lymphocytes. J. Rad. Res. 43:237-245.
194. Mosmann, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65:55-63.
195. Muscoplat, C.C., Rakich, P.M., Thoen, C.O., and Johnson, D.W. (1978). Enhancement of lymphocyte blastogenic and delayed hypersensitivity skin responses by indomethacin. Infect. Immun. 20(3): 627-631.
196. 3 and retinoic acid on normal human pluripotent (CPU-mix), erythroid (BFU-E), and myeloid (CFU-C) progenitor cell growth and differentiation patterns. Exp. Hematol. 14:60-65.
197. Narasimhan, T.R., Craig, A., Arellano, L., Harper, N., Howie, L., Menache, M., Birnbaum, L., and Safe, S. (1994). Relative sensitivities of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Cyp1a-1 and Cyp1a-2 gene expression and immunotoxicity in female B6C3F1 mice. Fundam. Appl. Toxicol. 23:598-607.
198. Nicholl, D.S., Daniels, H.M., Thabrew, M.I., Grayer, R.J., Simmonds, M.S.J., and Hughes, R.D. (2001). In vitro studies on the immunomodulatory effects of extract of Osbeckia aspera. J. Ethnopharmacol. 78:39-44.
199. Nicol, T., Bilbey, D.L.J., Charles, L.M., Cordingley, J.L., and Vernon-Roberts, B. (1964). Oestrogen-Natural stimulant of body defence. J. Endocrinol. 30:277.
200. Nicol, T., Snell, R.S., and Bilbey, D.L.H. (1956). Effect of cortisone on the defence mechanisms of the body. Br. Med. J. 2:800-801.
201. Nicol, T., Vernon-Roberts, B., and Quantock, D.C. (1965). Influence of various hormones on reticulo-endothelial system - Endocrine control of body defence. J. Endocrinol. 33:365.
202. Nicol, T., Quantock, D.C., and Vernon-Roberts, B. (1967). In: The Reticuloendothelial System and Atherosclerosis (N.R. DiLuzio and P. Paoletti, eds.). Plenum Press, New York, p. 221.
203. Nio, D.A., Moylan, R.N., and Roche, J.K. (1993). Modulation of T lymphocyte function by neuropeptides. J. Immunol. 150(12):5281-5288.
204. Nordlind, K. (1982). Effect of metal allergens on the DNA synthesis of unsensitized guinea pig lymphoid cells cultured in vitro. Int. Archs Allergy Appl. Immunol. 69:12-17.
205. Nordlind, K., and Henze, A. (1984). Stimulating effect of mercuric chloride and nickel sulfate on DNA synthesis of thymocytes and peripheral blood lymphocytes in children. Int. Atch. Allergy Appl. Immun. 73:162-165.
206. Nothnick, W.B., and Soloway, P.D. (1998). Novel implications in the development of endometriosis: Biphasic effect of macrophage activation on peritoneal tissue expression of tissue inhibitor of metalloproteinase-2. Am. J. Reprod. Immunol. 40:364-369.
207. Oben, J.A., and Foreman, J.C. (1988). Stimulatory effects of anti-rheumatic drugs on human neutrophil functions. Immunopharmacology 16:157-165.
208. Oben, J.A., Wallace, G.R., Chain, B.M., and Foreman, J.C. (1989). The stimulation of IL-2 production by anti-rheumatic drugs. Immunology 67:328-332.
209. 1. J. Immunol. 144:1909-1913.
210. O'Flaherty, J.T., Jacobson, D.P., and Redman, J.F. (1989). Bidirectional effects of protein kinase C activators. J. Biol. Chem. 264:6836-6843.
211. Okabe, N., Inoue, K., and Mori, R. (1983). Effects of antithyroid drugs on lymphocyte proliferation responses to lectins: Relationship between insulin autoimmune syndrome and methimazole. J. Clin. Lab. Immunol. 11:167-171.
212. Okabe, N., Mori, R., Miake, S., and Inoue, K. (1984). Effects of antithyroid drugs on Con A-induced suppressor cell activity. J. Clin. Lab. Immunol. 13:167-169.
213. Oleson, D.R., and Johnson, D.R. (1988). Regulation of human natural cytotoxicity by enkephalins and selective opiate agonists. Brain Behav. Immun. 2:171-186.
214. 2+/calmodulin during activation of rat neutrophils by polychlorinated biphenyls. Biochem. Pharmacol. 62:1125-1132.
215. Omara, P.O., Blakley, B.R., Bernier, J., and Fournier, M. (1997). Immunomodulatory and protective effects of N-acetylcysteine in mitogen-activated murine splenocytes in vitro. Toxicology 116:219-226.
216. Otsuka, F., and Ohsawa, M. (1991). Differential susceptibility of T- and B-lymphocyte proliferation to cadmium: Relevance to zinc requirement in T-lymphocyte proliferation. Chem. Biol. Interact. 78:193-205.
217. Ozaki, Y., and Kume, S. (1984). Enhancement of chemiluminescence of the neutrophils by low concentrations of tribluoperazine. Biochem. Biophys. Res. Common. 118(1):53-59.
218. Pabst, H.F., and Crawford, J. (1975). L-Tetramisole enhancement of human lymphocyte response to antigen. Clin. Exp. Immunol. 21:468-473.
219. Panush, R.S., and Ossakow, S.J. (1979). Effects of acetaminophen on normal human peripheral blood lymphocytes: Enhancement of mitogen-and antigen-stimulated incorporation of tritiated thymidine. Clin. Exp. Immunol. 38:539-548.
220. Patke, C.L., Green, C.G., and Shearer, W.T. (1994). Differential effects of interleukin-2 and interleukin-4 on immunomodulatory role of platelet-activating factor in human B cells. Clin. Diag. Lab. Immunol. 1:424-432.
221. ras. Int. Immunol. 16:275-281.
222. Pfeifer, R.W., and Patterson, R.M. (1986). Modulation of lectin-stimulated lymphocyte agglutination and mitogenesis by estrogen metabolites: Effects on early events of lymphocyte activation. Arch. Toxicol. 58:157-164.
223. Phoon, M.C., Desbordes, C., Howe, J., and Chow, V.T.K. (2001). Linoleic and linolelaidic acids differentially influence proliferation and apoptosis of molt-4 leukaemia cells. Cell Biol. Int. 25(8):777-784.
224. Plotnikoff, N.P., and Miller, G.C. (1983). Enkephalins as immunomodulators. Int. J. Immunopharm. 5(5):437-441.
225. Pruett, S.B., Ensley, O.K., and Crittenden, P.L. (1993). The role of chemical-induced stress responses in immunosuppression: A review of quantitative associations and cause-effect relationships between chemical-induced stress responses and immunosuppression. J. Toxicol. Environ. Health 39:163-192.
226. Quinones-Maldonado, V., and Renaud, R.L. (1987). Effect of biogenic amines on phagocytosis in Tetrahymena thermophila. J. Protozool. 34(4):435-38.
227. Rahman, A., and Parker, R.S. (2001). Carotenoid photodegradation products and proliferation of murine lymphoid cell line. Nutr. Res. 21:735-745.
228. Rameshwar, P., Gascon, P., and Ganea, D. (1992). Immunoregulatory effects of neuropeptides. Stimulation of interleukin-2 production by substance P. J. Neuroimmunol. 37:65-74.
229. Rana, R., Vitale, M., Mazzotti, G., Manzoli, L., and Papa, S. (1990). Radiosensitivity of human natural killer cells: binding and cytotoxic activities of natural killer cell subsets. Radiat. Res. 124:96-102.
230. Rechnitzer, C., Kristiansen, J.E., and Kharazmi, A. (1985). In vitro modulation of human neutrophil chemotaxis by cis(z)- and trans(e)-clopenthixol, and chlorpromazine. Acta Pathol. Microbiol. Immunol. Scand. C 93:199-203.
231. Renoux, G., and Renoux, M. (1974). Modulation of immune reactivity by phenylimidothiazole salts in mice immunized by sheep red blood cells. J. Immunol. 113(3):779-790.
232. Rice, C.D., and Weeks, B.A. (1989). Influence of tributyltin on in vitro activation of oyster toadfish macrophages. J. Aquat. Anim. Health 1:62-68.
233. Rio, B., Lautraite, S., and Parent-Massin, D. (1997). In vitro toxicity of trichothecenes on human erythroblastic progenitors. Hum. Exp. Toxicol. 16:673-679.
234. Rivkin, I., and Becker, E.L. (1976). Effect of exogenous cyclic AMP and other adenine nucleotides on neutrophil chemotaxis and motility. Int. Arch. Allergy Appl. Immunol. 50:95-102.
235. Robinson, H.J. (1953). In: The Suprarenal Cortex. (J.M. Yoffey, ed.). Butterworth, Washington, DC, p. 105.
236. Robinson, H.J. (1956). Adrenal cortical hormones and infection. Pediatrics 17:770-780.
237. Robinson, H.J., Mason, R.C., and Smith, A.L. (1953). Beneficial effects of cortisone on survival of rats infected with d-pneumoniae. Proc. Soc. Exp. Biol. Med. 84:312-314.
238. Roch-Arveiller, M., Huy, D.P., Maman, L., Giroud, J.-P., and Sorenson, J.R.J. (1990). Non-steroidal anti-inflammatory drug-copper complex modulation of polymorphonuclear leukocyte migration. Biochem. Pharmacol. 39:569-574.
239. Rogers, A., and Eastell, R. (2001). The effect of 17β-estradiol on production of cytokines in cultures of peripheral blood. Bone, 29: 30-34.
240. Roszell, L.E., and Anderson, R.S. (1993). In vitro immunomodulation by pentachlorophenol in phagocytes from an estuarine teleost, Fundulus heteroclitus, as measured by chemiluminescence activity. Arch. Environ. Contam. Toxicol. 25:492-496.
241. Ruhl, A., Franzke, S., and Stremmel, W. (2001). IL-1β and IL-10 have dual effects on enteric glial cell proliferation. Neurogastroenterol. Motil. 13:89-94.
242. Sahney, N.N., Summersgill, J.T., Ramirez, J.A., and Miller, R.D. (2001). Inhibition of oxidative burst and chemotaxis in human phagocytes by Legionella pneumophila zinc metalloprotease. J. Med. Microbiol. 50:517-525.
243. Sakamoto, K., Myojin, M., Hosoi, Y., Ogawa, Y., Nemoto, K., Takai, Y., Kakuto, Y., Yamada, S., and Watabe, N. (1997). Fundamental and clinical studies on cancer control with total or upper half body irradiation. J. Jpn. Soc. Ther. Radiat. Oncol. 9:161-175.
244. Salaman, A., Roman, M., Renaud, F.L., and Silva, W.I. (1990). Effect of chronic opioid treatment on phagocytosis in Tetrahymena. Neuropeptides 16:115-120.
245. Sambani, C., Thomou, H., and Kitsiou, P. (1996). Stimulatory effect of low dose X-irradiation on the expression of the human T lymphocyte CD2 surface antigen. Int. J. Radiat. Biol. 70:711-717.
246. Sauve, S., Brousseau, P., Pellerin, J., Morin, Y., Senecal, L., Goudreau, P., and Fournier, M. (2002). Phagocytic activity of marine and freshwater bivalves: In vitro exposure of hemocytes to metals (Ag, Cd, Hg and Zn). Aquatic Toxicol. 58:189-200.
247. Schlagel, C.T., and Ahmed, A. (1982). Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes. J. Immunol. 129:1530-1533.
248. Schettini, G., Florio, T., Meucci, O., Landolfi, E., Grimaldi, M., Lombardi, G., Scala, G., and Leong, D. (1990). Interleukin-1-beta modulation of prolactin secretion from rat anterior-pituitary cells-Involvement of adenylate-cyclase activity and calcium mobilization. Endocrinology 126:1435-1441.
249. Seve, M., Favier, A., Osman, M., Hernandey, B., Vaitaitis, G., Flores, N.C., McCord, J.M., and Flores, S.C. (1999). The human immunodeficiency virus-1-tat protein increases cell proliferation, alters sensitivity to zinc chelator-induced apoptosis, and changes Sp1 DNA binding in Hera cells. Arch. Biochem. Biophys. 36: 165-172.
250. Shifrine, M., Fisher, G.L., and Taylor, N.J. (1984). Effect of trace elements found in coal fly ash, on lymphocyte blastogenesis. J. Environ. Path. Toxicol. Oncol. (JEPTO) 5-4(5):15-24.
251. Simoens, J., and Rosenthal, M. (1977). Levamisole in the modulation of the immune response: the current experimental and clinical state. J. Reticuloendothel. Soc. 3:175.
252. Siwicki, A.K. (1989). Immunostimulating influence of levamisole on non-specific immunity in carp (Cyprinus carpio). Dev. Comp. Immunol. 13:87-91.
253. Siwicki, A.K., and Cossarini-Dunier, M. (1990). Effect of levamisole on the lymphocyte and macrophage activity in carp (Cyprinus carpio). Ann. Rech. Vet. 21:95-100.
254. Siwicki, A.K., and Dunier, M. (1994). Effects of lindane exposure on rainbow trout (Oncorhynchus mykiss) immunity. II. In vitro restoration of antibody-secreting cells and lymphocyte proliferation activity by nitrogranulogen after in vivo immunosuppression due to lindane. Ecotoxicol. Environ. Safety 27:316-323.
255. Siwicki, A.K., Anderson, D.P., and Dixon, O.W. (1990). In vitro immunostimulation of rainbow trout (Oncorhynchus mykiss) spleen cells with levamisole. Dev. Comp. Immunol. 14:231-237.
256. 1 1. Vet. Immunol. Immunopathol. 34:81-96.
257. Smialowicz, R.J., Riddly, M.M., Roger,s, R.R., Copeland, C.B., Leubke, R.W., and Andrews, D.L. (1991). Evaluation of the immunotoxicity of orally administered 2-methoxyacetic acid in Fischer 344 rats. Fundam. Appl. Toxicol. 17:771-781.
258. Snell, J.F. (1960a). The reticuloendothelial system. 1. Chemical methods of stimulation of the reticuloendothelial system. Ann. NY Acad. Sci. 88:56-77.
259. Snell, J.F. (1960b). In: Reticuloendothelial Structure and Function. (J.H. Heller, Ed.). Ronald Press, New York, p. 321.
260. Snijdewint, F.G.M., Kapsenberg, M.L., Wauben-Penris, P.J.J., and Box, J.D. (1995). Corticosteroids class-dependently inhibit in vitro Th1-and Th2-type cytokine productions. Immunopharmacology 29:93-101.
261. Sperber, K., Quaraishi, H., Kalb, T.H., Panja, A., Stecher, V., and Mayer, L. (1993). Selective regulation of cytokine secretion by hydroxychloroquine: Inhibition of interleukin 1 alpha (IL-1-α) and IL-6 in human monocytes and T cells. J. Rheumatol. 20:803-808.
262. Spieker-Polet, H., and Polet, H. (1981). Requirement of a combination of a saturated and an unsaturated free fatty acid and a fatty acid carrier protein for in vitro growth of lymphocytes. J. Immunol. 126:949-954.
263. Sredni, B., Kalechman, Y., Albeck, M., Gross, O., Aurbach, D., Sharon, P., Sehgal, S.N., Gurwith, M.J., and Michlin, H. (1990). Cytokine secretion effected by synergism of the immunomodulator AS101 and the protein kinase C inducer bryostatin. Immunology 70:473-477.
264. Stanulis, E.D., Jordan, S.D., Rosecrans, J.A., and Holsapple, M.P. (1997). Disruption of Th1/Th2 cytokine balance by cocaine is mediated by corticosterone. Immunopharmacol. 37:25-33.
265. Stanulis, E.D., Matulka, R.A., Jordan, S.D., Rosecrans, J.A., and Holsapple, M.P. (1997a). Role of corticosterone in the enhancement of the antibody response after acute cocaine administration. J. Pharmacol. Exp. Ther. 280(1):284-291.
266. Stefulj, J., Cicin-Sain, L., Schauenstein, K., and Jernej, B. (2001). Serotonin and immune response: effect of the amine on in vitro proliferation of rat lymphocytes. Neuroimmunomodulation 9:103-108.
267. Sterzl, J. (1980). Immunopharmacology and its toxicological problems. Arch. Toxicol. Suppl. 4:109-119.
268. Stiles, D.P. (1980). Clinical laboratory methods of detecting cellular immune function. In: Basic and Clinical Immunology. H.H. Fudenberg, O.P. Stites, J.L. Caldwell, and i.V. Wells (eds.). Lange Medical, Los Altos, CA, pp. 382-397.
269. Sullivan, G.W., Carper, H.T., and Mandell, G.L. (1992). Pentoxifylline modulates activation of human neutrophils by amphotericin B in vitro. Antimicrobial Agents Chemother. 36:408-416.
270. Suzuki, S., and Huchet, R. (1981). Mechanism of histamine-induced inhibition of lymphocyte response to mitogens in mice. Cell. Immunol. 62:396-405.
271. Swain, S.D., Siemsen, D.W., Hanson, A.J., and Quinn, M.T. Activation-induced mobilization of secretory vesicles in bovine neutrophils. Am. J. Vet. Res. 62:1776-1781.
272. Takamizawa, A., Koyama, S., Sato, E., Masubuchi, T., Kubo, K., Sekiguchi, M., Nagai, S., and Izumi, T. (1999). Bleomycin stimulated lung fibroblasts to release neutrophil and monocyte chemotactic activity. J. Immunol. 162:6200-6208
273. Tarr, M.J., and Olsen, R.G. (1985). Species variation in susceptibility to methylnitrosourea-induced immunosuppression. J. Environ. Path. Toxicol. Oncol. (JEPTO) 6(2):261-270.
274. Tarr, M.J., Olsen, R.G., and Jacobs, D.L. (1982). In vivo and in vitro effects of 1,1-dimethylhydrazine on selected immune functions. Immunopharmacology 4:139-147.
275. 2+, protein kinase C, and lipoxygenase products. Am. Rev. Respir. Dis. 144:272-277.
276. Thomas, L. (1952). The effects of cortisone and adrenocorticotropic hormone on infection. Ann. Rev. Med. 3:1-24.
277. Thong, Y.-H., and Ferrante, A. (1980). Effect of tetracycle treatment on immunological responses in mice. Clin. Exp. Immunol. 39:728-732.
278. Thurman, G.B., Simms, B.C., Goldstein, A.L., and Kilian, D.J. (1978). The effects of organic compounds used in the manufacture of plastics on the responsivity of murine and human lymphocytes. Toxicol. Appl. Pharmacol. 44:617-641.
279. Tomei, E.Z., and Renaud, F.L. (1997). Effect of morphine of Fc-mediated phagocytosis by murine macrophages in vitro. J. Neuroimmunol. 74:111-116.
280. Ushio, H., Nohara, K., and Fujimaki, H. (1999). Effect of environmental pollutants on the production of pro-inflammatory cytokines by normal human dermal keratinocytes. Toxicol. Lett. 105:17-24.
281. Uyeki, E.M., and Llacer, V. (1969). Effect of antibiotics on antibody-forming cells in vitro. Biochem. Pharmacol. 18:948-951.
282. 2 integrin-blocking in ICAM-1-mediated neutrophil migration in ulcerative colitis. Scand. J. Gastroenterol. 6:621-629.
283. Van Dijk, H., and Voermans, G.A.G.M. (1978). Immunostimulating properties of the cytostatic drug 6-thioguanine. Chapter 10. In: The Pharmacology of Immunoregulation: Present Concepts as a Basis for the Development of Immunopharmacological Agents: Proceedings of the Rhône-Poulenc Round Table Conference, held in Paris, November 30th-December 2, 1977. pp. 301-304.
284. 2. Cell. Immunol. 37:142-150.
285. Van Uffelen, B.E., de Koster, B.M., VanSteveninck, J., and Elferink, J.G.R. (1996). Carbon monoxide enhances human neutrophil migration in a cyclic GMP-dependent way. Biochem. Biophy. Res. Comm. 226:21-26.
286. VanUffelen, B.E., de Koster, B.M., Van den Broek, P.J.A., VanSteveninck, J., and Elferink, J.G.R. (1996a). Modulation of neutrophil migration by exogenous gaseous nitric oxide. J. Leukocyte Biol. 60:94-100.
287. VanUffelen, B.E., Van der Zee, J., de Koster, B.M., VanSteveninck, J., and Elferink, J.G.R. (1998). Sodium azide enhances neutrophil migration and exocytosis: Involvement of nitric oxide, cyclic GMP and calcium. Life Sci. 63(8):645-657.
288. Vernon-Roberts, B. (1969). The effects of steroid hormones on macrophage activity. Int. Rev. Cytol. 25:131-159.
289. Voccia, I., Krzystyniak, K., Dunier, M., Flipo, D., and Fournier, M. (1994). In vitro mercury-related cytotoxicity and functional impairment of the immune cells of rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 29:37-48.
290. Vos, J.G., Moore, J.A., and Zinkl, J.G. (1973). Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the immune system of laboratory animals. Environ. Health Perspect. 5:149-162.
291. Wagner, H., Kreher, B., and Jurcic, K. (1988). In vitro stimulation of human granulocytes and lymphocytes by pico- and femtogram quantities of cytostatic agents. Arzneim-Fursch/Drug Res. 38: 273-275.
292. Wang, J.M., Colella, S., Allavena, P., and Mantovani, A. (1987). Chemotactic activity of human recombinant granulocyte-macrophage colony-stimulating factor. Immunology 60:439-444.
293. Wermerskirchen, A.S., LaTocha, D.H., and Clarke, B.L. (2000). Adrenocorticotropic hormone controls Concanavalin A activation of rat lymphocytes by modulating IL-2 production. Life Sci. 67:2177-2187.
294. Whitfield, J.F., MacManus, J.P., and Rixon, R.H. (1970). Cyclic AMP-mediated stimulation of thymocyte proliferation by low concentrations of cortisol (34967). Proc. Soc. Exp. Biol. Med. 134:1170-1174.
295. Whitnall, M.H., Perlstein, R.S., Mougey, E.H., and Neta, R. (1992). Effects of interleukin-1 on the stress-responsive and -nonresponsive subtypes of corticotropin-releasing hormone neurosecretory axons. Endocrinology 131:37-44.
296. Wiedermann, C.J., Reinisch, N., and Braunsteiner, H. (1993). Stimulation of monocyte chemotaxis by human growth hormone and its deactivation by somatostatin. Blood 82:954-960.
297. Williamson, S.A., Knight, R.A., Lightman, S.L., and Hobbs, J.R. (1987). Differential effects of β-endorphin fragments on human natural killing. Brain Behav. Immun. 1:329-335.
298. Williamson, S.A., Knight, R.A., Lightman, S.L., and Hobbs, J.R. (1988). Effects of beta endorphin on specific immune responses in man. Immunology 65:47-51.
299. Wilmer, J.L., and Bloom, S.E. (1991). A cytogenetic approach for detecting the selective toxicity of drugs in avian embryonic B and T lymphocytes. Mutat. Res. 253:161-172.
300. Wilmer, J.L., Colvin, O.M., and Bloom, S.E. ( 1992). Cytogenetic mechanisms in the selective toxicity of cyclophosphamide analogs and metabolites towards avian embryonic B lymphocytes in vivo. Mutat. Res. 268:115-130.
301. Wright, D.G., Kirkpatrick, C.H., and Gallin, J.I. (1977). Effects of levamisole on normal and abnormal leukocyte locomotion. J. Clin. Invest. 59:941-950.
302. Wyle, F.A. and Kent, J.R. (1977). Immunosuppression by sex steroid hormones. I. The effect upon PHA- and PPD-stimulated lymphocytes. Clin. Exp. Immunol. 27:407-415.
303. Xie, X., Thorlacius, H., Raud, J., Hedquist, P., and Lindbom, L. (1997). Inhibitory effect of locally administered heparin on leukocyte rolling and chemoattractant-induced firm adhesion in rat mesenteric venules in vivo. Br. J. Pharm. 122:906-910.
304. 2) on the proliferation of human lymphocytes. Scand. J. Rheumatol. 20:8-15.
305. Zaitsev, S.V., Khegai, L.A., Kim, B.B., Gavrilova, E.M., Yanovsky, O.G., and Zakharova, L.A. (1992). Involvement of opioid receptors in Met-enkephalin modulation of blast-transformation of mouse splenocytes. Immunology Letters 32:27-30.
306. 2]methionine enkephalinamide. FEBS 291(1):84-86.
307. Zdolsek, J.M., Soder, O., and Hultman, P. (1994). Mercury induces in vivo and in vitro secretion of interleukin-1 in mice. Immunopharmacology 28:201-208.
308. Zhang, L.-H., Longley, R.E., and Koehn, F.E. (1997). Antiproliferative and immunosuppressive properties of microcolin A, a marine-derived lipopeptide. Life Sci. 60(10):751-762.