Effect of the pregnane-related GABA-active steroid alphaxalone on mice performance in the staircase test

Brain Research

Volumn 765, Issue 1, 1997, Pages 129-134

  Pick, Chaim G ^a   Peter, Yakov ^a   Paz, Lior ^a   Schreiber, Shaul ^b   Gavish, Moshe ^c   Weizman, Ronit ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

Alphaxalone; Alprazolam; Anxiolytic; Flumazenil; GABA(A) receptor; Muscimol; Neuroactive steroid; Staircase test

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; ALFAXALONE; ALPRAZOLAM; FLUMAZENIL;

ANIMAL EXPERIMENT; ANXIETY NEUROSIS; ARTICLE; DRUG EFFECT; DRUG RECEPTOR BINDING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TASK PERFORMANCE;

ALPRAZOLAM; ANESTHETICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CORTICOSTERONE; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA AGONISTS; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; MALE; MICE; MICE, INBRED ICR; MUSCIMOL; PREGNANEDIONES; PREGNANES; PREGNENOLONE; PSYCHOMOTOR PERFORMANCE; RECEPTORS, GABA-A;

EID: 0030758499     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00540-4     Document Type: Article

References (19)

1. Belzung C., Misslin R., Vogel E. The benzodiazepine receptor inverse agonist β-CCM and Ro 15-3505 both reverse the anxiolytic effects of ethanol in mice. Life Sci. 42:1988;1765-1772.
2. Britton K.T., Page M., Baldwin H., Koob G.F. Anxiolytic activity of the steroid anesthetic alphaxalone. J. Pharmacol. Exp. Ther. 258:1991;124-129.
3. Britton K.T., McLeod S., Koob G.F., Hauger R. Pregnane steroid alphaxalone attenuates anxiogenic behavioral effects of corticotropin releasing factor and stress. Pharmacol. Biochem. Behav. 41:1992;399-403.
4. Deutsch S.I., Mastropolo J., Hitri A. GABA-active steroids: endogenous modulators of GABA-gated chloride ion conductance. Clin. Neuropharmacol. 15:1992;352-364.
5. Emmanouil D.E., Quock R.M. Effects of benzodiazepine agonist, inverse agonist and antagonist drugs in the mouse staircase test. Psychopharmacology. 102:1990;95-97.
6. Green C.J., Halsey M.J., Precious S., Wardley-Smith B. Alphaxalone-alphadolone anesthesia in laboratory animals. Lab. Animal. 12:1978;85-89.
7. Harrison N.L., Majewska M.D., Harrington J.W., Baker J.L. Structure-activity relationship for steroid interaction with the γ-animobutyric acid receptor complex. J. Pharmacol. Exp. Ther. 241:1987;346-353.
8. K.G. Lloyd, P.L. Moreseli, Psychopharmacology of GABA-ergic Drugs, in: H.Y. Meltzer (Ed.), Psychopharmacology, The Third Generation of Progress, Raven Press, New York, 1987, pp. 173-179.
9. Majewska M.D. Steroid and brain activity, essential dialogue between body and mind. Biochem. Pharmacol. 36:1987;3781-3788.
10. Majewska M.D., Harrison N.L., Schwartz R.D., Barker J.L., Paul S.M. Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor. Science. 232:1986;1004-1007.
11. Morrow A.L., Pace J.R., Purdy R.H., Paul S.M. Characterization of steroid interactions with γ-aminobutyric acid receptor-gated chloride channels: evidence of multiple steroid recognition sites. Mol. Pharmacol. 37:1990;263-270.
12. Paul S.M., Purdy R.H. Neuroactive steroids. FASEB J. 6:1992;2311-2322.
13. A receptor by depressant barbiturates and pregnane steroids. Br. J. Pharmacol. 94:1988;1257-1269.
14. C.G. Pick, J. Peter, J. Terkel, M. Gavish, R. Weizman, Effect of the neuroactive steroid α-THDOC on staircase test behavior in mice, Psychopharmacology 128 (1997) 61-67.
15. Pollard G.T., Howard J.L. The staircase test: some evidence of nonspecificity for anxiolytics. Psychopharmacology. 89:1986;14-19.
16. Quock R.M., Klauenberg B.J., Hurt W.D., Merritt J.H. Influence of microwave exposure on chlorodiazepoxide effects in the mouse staircase test. Pharmacol. Biochem. Behav. 47:1994;845-849.
17. Simiand J., Keane P.E., Morre M. The staircase test in mice: a simple and efficient procedure for primary screening of anxiolytic agents. Psychopharmacology. 84:1984;48-53.
18. Stephenson F.A. Understanding the GABA receptor: a chemically gated ion channel. Biochem. J. 249:1988;21-32.
19. Steru L., Thierry B., Chermat R., Millet B., Simon P., Porslt R.D. Comparing benzodiazepines using the staircase test in mice. Psychopharmacology. 92:1987;106-109.