Amelioration of experimental autoimmune encephalomyelitis in IL-4Rα-/- mice implicates compensatory up-regulation of Th2-type cytokines

American Journal of Pathology

Volumn 173, Issue 1, 2008, Pages 119-129

  Gaupp, Stefanie ^a,b   Cannella, Barbara ^a   Raine, Cedric S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 4 RECEPTOR ALPHA; INTERLEUKIN 6;

ACUTE DISEASE; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOCYTOCHEMISTRY; MOUSE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; REMYELINIZATION; TH2 CELL; UPREGULATION;

EID: 46749155914     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2008.071156     Document Type: Article

References (53)

1. Frohman EM, Racke MK, Raine CS: Multiple sclerosis - the plaque and its pathogenesis. N Engl J Med 2006, 354:942-955
2. Sospedra M, Martin R: Antigen-specific therapies in multiple sclerosis. Int Rev Immunol 2005, 24:393-413
3. Lafaille JJ, Keere FV, Hsu AL, Baron JL, Haas W, Raine CS, Tonegawa S: Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J Exp Med 1997, 186:307-312
4. Genain CP, Abel K, Belmar N, Villinger F, Rosenberg DP, Linington C, Raine CS, Hauser SL: Late complications of immune deviation therapy in a nonhuman primate. Science 1996, 274:2054-2057
5. Olsson T: Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T-cell autoimmunity in experimental autoimmune encephalomyelitis and multiple sclerosis. Immunol Rev 1995, 144:245-268
6. Bettelli E, Das MP, Howard ED, Weiner HL, Sobel RA, Kuchroo VK: IL-10 is critical in the regulation of autoimmune encephalomyelitis as demonstrated by studies of IL-10- and IL-4-deficient and transgenic mice. J Immunol 1998, 161:3299-3306
7. Hsieh CS, Heimberger AB, Gold JS, O'Garra A, Murphy KM: Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system. Proc Natl Acad Sci USA 1992, 89:6065-6069
8. Fiorentino DF, Zlotnik A, Vieira P, Mosmann TR, Howard M, Moore KW, O'Garra A: IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J Immunol 1991, 146:3444-3451
9. Racke MK, Bonomo A, Scott DE, Cannella B, Levine A, Raine CS, Shevach EM, Rocken M: Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J Exp Med 1994, 180:1961-1966
10. Falcone M, Rajan AJ, Bloom BR, Brosnan CF: A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice. J Immunol 1998, 160:4822-4830
11. Furlan R, Poliani PL, Marconi PC, Bergami A, Ruffini F, Adorini L, Glorioso JC, Comi G, Martino G: Central nervous system gene therapy with interleukin-4 inhibits progression of ongoing relapsing-remitting autoimmune encephalomyelitis in Biozzi AB/H mice. Gene Ther 2001, 8:13-19
12. Constantinescu CS, Hilliard B, Ventura E, Wysocka M, Showe L, Lavi E, Fujioka T, Scott P, Trinchieri G, Rostami A: Modulation of susceptibility and resistance to an autoimmune model of multiple sclerosis in prototypically susceptible and resistant strains by neutralization of interleukin-12 and interleukin-4, respectively. Clin Immunol 2001, 98:23-30
13. Cannella B, Raine CS: Multiple sclerosis: cytokine receptors on oligodendrocytes predict innate regulation. Ann Neurol 2004, 55:46-57
14. Hulshof S, Montagne L, De Groot CJ, Van Der Valk P: Cellular localization and expression patterns of interleukin-10, interleukin-4, and their receptors in multiple sclerosis lesions. Glia 2002, 38:24-35
15. Carson MJ, Sutcliffe JG: Balancing function vs. self defense: the CNS as an active regulator of immune responses. J Neurosci Res 1999, 55:1-8
16. Moore GR, Traugott U, Raine CS: Survival of oligodendrocytes in chronic relapsing experimental autoimmune encephalomyelitis. J Neurol Sci 1984, 65:137-145
17. Moore GR, Traugott U, Farooq M, Norton WT, Raine CS: Experimental autoimmune encephalomyelitis. Augmentation of demyelination by different myelin lipids. Lab Invest 1984, 51:416-424
18. Radu DL, Noben-Trauth N, Hu-Li J, Paul WE, Bona CA: A targeted mutation in the IL-4Ralpha gene protects mice against autoimmune diabetes. Proc Natl Acad Sci USA 2000, 97:12700-12704
19. Svetić A, Jian YC, Lu P, Finkelman FD, Gause WC: Brucella abortus induces a novel cytokine gene expression pattern characterized by elevated IL-10 and IFN-gamma in CD4+ T cells. Int Immunol 1993, 5:877-883
20. Noben-Trauth N, Kropf P, Muller I: Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science 1996, 271:987-990
21. Constant S, Pfeiffer C, Woodard A, Pasqualini T, Bottomly K: Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. J Exp Med 1995, 182:1591-1596
22. Croft M, Swain SL: Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines. J Immunol 1995, 154:4269-4282
23. Jankovic D, Kullberg MC, Noben-Trauth N, Caspar P, Paul WE, Sher A: Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile. J Immunol 2000, 164:3047-3055
24. Zhao ML, Fritz RB: Acute and relapsing experimental autoimmune encephalomyelitis in IL-4- and alpha/beta T cell-deficient C57BL/6 mice. J Neuroimmunol 1998, 87:171-178
25. Kleinschek MA, Owyang AM, Joyce-Shaikh B, Langrish CL, Chen Y, Gorman DM, Blumenschein WM, McClanahan T, Brombacher F, Hurst SD, Kastelein RA, Cua DJ: IL-25 regulates Th17 function in autoimmune inflammation. J Exp Med 2007, 204:161-170
26. Cash E, Minty A, Ferrara P, Caput D, Fradelizi D, Rott O: Macrophage-inactivating IL-13 suppresses experimental autoimmune encephalomyelitis in rats. J Immunol 1994, 153:4258-4267
27. Kopf M, Le Gros G, Bachmann M, Lamers MC, Bluethmann H, Kohler G: Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 1993, 362:245-248
28. Liblau R, Steinman L, Brocke S: Experimental autoimmune encephalomyelitis in IL-4-deficient mice. Int Immunol 1997, 9:799-803
29. Khoruts A, Miller SD, Jenkins MK: Neuroantigen-specific Th2 cells are inefficient suppressors of experimental autoimmune encephalomyelitis induced by effector Th1 cells. J Immunol 1995, 155:5011-5017
30. Lafaille JJ: The role of helper T cell subsets in autoimmune diseases. Cytokine Growth Factor Rev 1998, 9:139-151
31. Nagelkerken L, Blauw B, Tielemans M: IL-4 abrogates the inhibitory effect of IL-10 on the development of experimental allergic encephalomyelitis in SJL mice. Int Immunol 1997, 9:1243-1251
32. Issazadeh S, Mustafa M, Ljungdahl A, Hojeberg B, Dagerlind A, Elde R, Olsson T: Interferon gamma, interleukin 4 and transforming growth factor beta in experimental autoimmune encephalomyelitis in Lewis rats: dynamics of cellular mRNA expression in the central nervous system and lymphoid cells. J Neurosci Res 1995, 40:579-590
33. Khoury SJ, Hancock WW, Weiner HL: Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 1992, 176:1355-1364
34. Hochrein H, O'Keeffe M, Luft T, Vandenabeele S, Grumont RJ, Maraskovsky E, Shortman K: Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells. J Exp Med 2000, 192:823-833
35. Arnett HA, Mason J, Marino M, Suzuki K, Matsushima GK, Ting JP: TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination. Nat Neurosci 2001, 4:1116-1122
36. Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M: Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci 2006, 31:149-160
37. Butovsky O, Landa G, Kunis G, Ziv Y, Avidan H, Greenberg N, Schwartz A, Smirnov I, Pollack A, Jung S, Schwartz M: Induction and blockage of oligodendrogenesis by differently activated microglia in an animal model of multiple sclerosis. J Clin Invest 2006, 116:905-915
38. Lipsky PE: Interleukin-6 and rheumatic diseases. Arthritis Res Ther 2006, 8(Suppl 2):S4,1-5
39. Willenborg DO, Fordham SA, Cowden WB, Ramshaw IA: Cytokines and murine autoimmune encephalomyelitis: inhibition or enhancement of disease with antibodies to select cytokines, or by delivery of exogenous cytokines using a recombinant vaccinia virus system. Scand J Immunol 1995, 41:31-41
40. Gijbels K, Brocke S, Abrams JS, Steinman L: Administration of neutralizing antibodies to interleukin-6 (IL-6) reduces experimental autoimmune encephalomyelitis and is associated with elevated levels of IL-6 bioactivity in central nervous system and circulation. Mol Med 1995, 1:795-805
41. Xing Z, Gauldie J, Cox G, Baumann H, Jordana M, Lei XF, Achong MK: IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 1998, 101:311-320
42. Tilg H, Dinarello CA, Mier JW: IL-6 and APPs: anti-inflammatory and immunosuppressive mediators. Immunol Today 1997, 18:428-432
43. Joyce DA, Steer JH, Abraham LJ: Glucocorticoid modulation of human monocyte/macrophage function: control of TNF-alpha secretion. Inflamm Res 1997, 46:447-451
44. Raber J, O'Shea RD, Bloom FE, Campbell IL: Modulation of hypothalamic-pituitary-adrenal function by transgenic expression of interleukin-6 in the CNS of mice. J Neurosci 1997, 17:9473-9480
45. Van Wagoner NJ, Oh JW, Repovic P, Benveniste EN: Interleukin-6 (IL-6) production by astrocytes: autocrine regulation by IL-6 and the soluble IL-6 receptor. J Neurosci 1999, 19:5236-5244
46. Van Wagoner NJ, Benveniste EN: Interleukin-6 expression and regulation in astrocytes. J Neuroimmunol 1999, 100:124-139
47. Zhang PL, Izrael M, Ainbinder E, Ben-Simchon L, Chebath J, Revel M: Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6/soluble interleukin-6 receptor fusion protein. Mol Cell Neurosci 2006, 31:387-398
48. Zhang P, Chebath J, Lonai P, Revel M: Enhancement of oligodendrocyte differentiation from murine embryonic stem cells by an activator of gp130 signaling. Stem Cells 2004, 22:344-354
49. te Velde AA, Huijbens RJ, Heije K, de Vries JE, Figdor CG: Interleukin-4 (IL-4) inhibits secretion of IL-1 beta, tumor necrosis factor alpha, and IL-6 by human monocytes. Blood 1990, 76:1392-1397
50. Diehl S, Anguita J, Hoffmeyer A, Zapton T, Ihle JN, Fikrig E, Rincon M: Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1. Immunity 2000, 13:805-815
51. Samoilova EB, Horton JL, Chen Y: Acceleration of experimental autoimmune encephalomyelitis in interleukin-10-deficient mice: roles of interleukin-10 in disease progression and recovery. Cell Immunol 1998, 188:118-124
52. Cannella B, Gao YL, Brosnan C, Raine CS: IL-10 fails to abrogate experimental autoimmune encephalomyelitis. J Neurosci Res 1996, 45:735-746
53. Stohlman SA, Pei L, Cua DJ, Li Z, Hinton DR: Activation of regulatory cells suppresses experimental allergic encephalomyelitis via secretion of IL-10. J Immunol 1999, 163:6338-6344