Multiple Sclerosis: Cytokine Receptors on Oligodendrocytes Predict Innate Regulation

Annals of Neurology

Volumn 55, Issue 1, 2004, Pages 46-57

  Cannella, Barbara ^a   Raine, Cedric S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; DNA BINDING PROTEIN; GAMMA ACTIVATED FACTOR, 91 KD; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; GAMMA-ACTIVATED FACTOR, 91-KD; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 18; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; JANUS KINASE; JANUS KINASE 1; PROTEIN TYROSINE KINASE; STAT PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT6 PROTEIN; TRANSACTIVATOR PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; ASTROCYTE; AUTOCRINE EFFECT; BIOSYNTHESIS; BRAIN; CENTRAL NERVOUS SYSTEM; COMPARATIVE STUDY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DEMYELINATING DISEASE; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; IMMUNOREGULATION; MALE; METABOLISM; MICROGLIA; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; OLIGODENDROGLIA; PARACRINE SIGNALING; PATHOLOGY; PRIORITY JOURNAL; TH2 CELL; UPREGULATION; WESTERN BLOTTING;

ADULT; AGED; AGED, 80 AND OVER; ASTROCYTES; BLOTTING, WESTERN; BRAIN; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; JANUS KINASE 1; MALE; MICROGLIA; MIDDLE AGED; MULTIPLE SCLEROSIS; NEURODEGENERATIVE DISEASES; OLIGODENDROGLIA; PROTEIN-TYROSINE KINASES; RECEPTORS, CYTOKINE; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STAT4 TRANSCRIPTION FACTOR; STAT6 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; UP-REGULATION;

EID: 0346688788     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.10764     Document Type: Article

References (42)

1. Raine CS. The Norron Lecture: a review of the oligodendrocyte as the target in multiple sclerosis. J Neuroimmunol 1997;77: 135-152.
2. D'Souza SD, Bonetti B, Balasingam V, et al. Multiple sclerosis: fas signaling in oligodendrocyte cell death. J Exp Med 1996; 184:2361-2370.
3. Bonetti B, Raine, CS. Multiple sclerosis: oligodendrocytes display cell death-related molecules in situ but do not undergo apoptosis. Ann Neurol 1997;42:74-84.
4. Hofman FM, von Hanwehr RI, Dinarello CA, et al. Immunoregulatory molecules and IL2 receptors identified in multiple sclerosis brain. J Immunol 1986;136:3239-3245.
5. Traugott U, Lebon P. Interferon-gamma and la antigen are present on astrocytes in active chronic multiple sclerosis lesions. J Neurosci 1988;84:257-264.
6. Hofman FM, Hinton DR, Johnson K, Merrill JE. Tumor necrosis identified in multiple sclerosis brain. J Exp Med 1989; 170:607-612.
7. Selmaj K, Raine CS, Cross AH. Anti-tumor necrosis factor therapy abrogates autoimmune demyelination. Ann Neurol 1991;30:694-700.
8. Cannella B, Raine CS. The adhesion molecule/cytokine profile of multiple sclerosis lesions. Ann Neurol 1995;37:424-435.
9. Windhagen A, Newcombe J, Dangond F, et al. Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J Exp Med 1995;182:1985-1986.
10. Maimone D, Guazzi G, Annunziata P. IL-6 detection in multiple sclerosis brain. J Neurol Sci 1997;146:59-65.
11. Hulshof S, Montagne L, DeGroot CJ, Van Der Valk P. Cellular localization and expression patterns of interleukin-10, interleukin-4, and their receptors in multiple sclerosis lesions. Glia 2002;38:24-35.
12. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996;383:787-793.
13. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003;3: 133-146.
14. Okamura H, Tsutsi H, Komatsu T, et al. Cloning of a new cytokine that induces IFN-γ production by T cells. Nature 1995;378:88.
15. Prinz M, Hanisch UK. Murine microglial cells produce and respond to interleukin-18. J Neurochem 1999;72:2215-2218.
16. Gracie JA, Robertson SE, McInnes IB. Interleukin 18. J Leukocyte Biol 2003;73:213-224.
17. Strle K, Zhou JH, Shen WH, et al. Interleukin-10 in the brain. Crit Rev Immunol 2001;21:427-449.
18. Ho AS, Liu Y, Khan TA, et al. A receptor for interleukin 10 is related to interferon receptors. Proc Natl Acad Sci USA 1993; 90:11267-11271.
19. Liu Y, Wei SH-Y, Ho AS-Y, et al. Expression of cloning and characterization of a human IL-10 receptor. J Immunol 1994; 152:1821-1929.
20. Keegan AD, Nelms K, Wang LM, et al. Interleukin 4 receptor signaling mechanisms. Immunol Today 1994;15:423-432.
21. Hirano T. Interleukin 6 and its receptor: ten years later. Int Rev Immunol 1998;16:249-284.
22. Heim MH. The Jak-STAT pathway: cytokine signaling from the receptor to the nucleus. J Recept Signal Transduct Res 1999;19:75-120.
23. Carson MJ. Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis. Glia 2002;40:218-231.
24. Raine CS. Demyelinating diseases. In: Textbook of neuropathology. Davis RL, Robertson DM, eds. Baltimore: William & Wilkins, 1997:243-286.
25. Kisseleva T, Bhaltacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 2002;285:1-24.
26. Nguyen MD, Julien JP, Rivest S. Innate immunity: the missing link in neuroprotection and neurodegeneration? Nat Rev Neurosci 2002;3:216-227.
27. Raine CS, Bonetti B, Cannella C. Multiple sclerosis: expression of molecules of the tumor necrosis factor ligand and receptor families in relationship to the demyelinated plaque. Rev Neurol 1998;154:577-585.
28. Dörr J, Bechmann 1, Waiczies S, et al. Lack of tumor necrosis factor-related apoptosis-inducing ligand but presence of its receptors in the human brain. J Neurosci 2002;22:RC209:1-5.
29. Peterson JW, Bo L, Mork S, et al. VCAM-1 positive microglia target oligodendrocytes at the border of multiple sclerosis lesions. J Neuropath Exp Neurol 2002;61:539-546.
30. Bsibsi M, Rivka R, Gveric D, Van Noort JM. Broad expression of Toll-like receptors in the human central nervous system. J Neuropath Exp Neurol 2002;61:1013-1021.
31. Cannella B, Pitt D, Marchionni M, Raine CS. Neuregulin and erbB receptor expression in normal and diseased human white matter. J Neuroimmunol 1999;100:233-242.
32. Messersmith DJ, Murtie JC, Le TQ, et al. Fibroblast growth factor 2 (FGF2) and FGF receptor expression in an experimental demyelinating disease with extensive remyelination. J Neurosci Res 2000;62:241-256.
33. Deadwyler GD, Pouly S, Antel JP, DeVries GH. Neuregulins and erbB receptor expression in adult human oligodendrocytes. Glia 2000;32:304-312.
34. Mason JL, Goldman JE. A2B5+ and 04+ cycling progenitors in adult forebrain white matter respond differentially to PDGF-AA, FGF-2, and IGF-1. Mol Cell Neurosci 2002;20: 30-42.
35. Lock C, Hermans G, Pedotti R, et al. Harvest of gene microarray analysis of multiple sclerosis lesions yields new targets validated in the experimental autoimmune encephalomyelitis model. Nat Med 2002;8:500-508.
36. Mycko MP, Papoian R, Boschert U, et al. cDNA microarray analysis in multiple sclerosis: comparison between active and inactive lesions. Brain 2003;126:1048-1057.
37. Chitnis T, Najafian N, Benou C, et al. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest 2001;108: 739-747.
38. Jee Y, Kim G, Tanuma N, Matsumoto Y. STAT expression and localization in the central nervous system during autoimmune encephalomyelitis in Lewis rats. J Neuroimmunol 2001;114: 40-47.
39. + T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions. Proc Natl Acad Sci USA 1999;96:6873-6878.
40. Schonrock LM, Gawlowski G, Brück W. Interleukin-6 expression in human multiple sclerosis lesions. Neurosci Lett 2000; 294:45-48.
41. Molina-Holgado E, Vela JM, Arevalo-Martin A, Gouza C. LPS/IFN-γ cyrotoxicity in oligodendroglial cells: role of nitric oxide and protection by the anti-inflammatory cytokine IL-10. Eur J Neurosci 2000;13:493-502.
42. Matute C, Sanchez-Gomez MV, Martinez-Millan L, Miledi R. Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes. Proc Natl Acad Sci USA 1997;94:8830-8835.