Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: A bio-historical perspective with updates

Carcinogenesis

Volumn 22, Issue 12, 2001, Pages 1903-1930

  Rubin, Harry ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; CARCINOGEN; CATECHOL; CIGARETTE SMOKE; CIGARETTE SMOKE CONDENSATE; COAL TAR; DIHYDROXYBENZO[A]PYRENE OXIDE; NICOTINE; POLYCYCLIC AROMATIC HYDROCARBON; TUMOR PROMOTER;

ANIMAL TISSUE; CELL HYPERPLASIA; CHEMICAL CARCINOGENESIS; CHEMICAL STRUCTURE; CIGARETTE SMOKING; CONTROLLED STUDY; DNA BINDING; GENE MUTATION; HUMAN; INHALATION; LUNG ADENOMA; LUNG CANCER; MOUSE; MUTAGENICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SKIN TUMOR; TOBACCO; TUMOR PROMOTION;

EID: 0035681327     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/22.12.1903     Document Type: Review

References (249)

1. Carcinogenic substances and their fluorescence spectra
2. The isolation of a cancer-producing hydrocarbon from coal tar
3. Fifty years of benzo(a)pyrene
4. Historical origins of current concepts of carcinogenesis
5. Chemical compounds as carcinogenic agents
6. Polynuclear aromatic hydrocarbons, steroids and carcinogenesis
7. Evidence for the binding of polynuclear aromatic hydrocarbons to the nucleic acids of mouse skin: Relation between carcinogenic power of the hydrocarbons and their binding to deoxyribonucleic acid
8. The relative potency of carcinogenic compounds
9. Binding of tritium-labeled polycyclic hydrocarbons to DNA of mouse skin
10. Metabolic conversion of benzo(a)pyrene by Syrian hamster liver microsomes and binding of metabolites to deoxyribonucleic acid
11. Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide
12. Benzo(a)pyrene diol epoxides as intermediates in nucleic acid binding in vitro and in vivo
13. A metabolite of the carcinogen 7,12-dimethylbenz (a)anthracene that reacts predominantly with adenine residues in DNA
14. Stereoselective activation of dibenzo(a.l)pyrene to (-)-anti (11R, 12S, 13S, 14R)- and (+)-syn (11S, 12R, 13S, 14R)-11,12-diol-13,14-epoxides which bind extensively to deoxyadenosine residues of DNA in the human cell line MCF-7
15. Developing factor in experimental blastogenesis
16. The role of croton oil applications associated with a single painting of a carcinogen in tumor induction of the mouse's skin
17. A new quantitative approach to the study of the stages of chemical carcinogenesis in the mouse's skin
18. An experimental study of the initiating stage of carcinogenesis and a re-examination of the somatic cell mutation theory
19. The growth potentialities of induced skin tumors in mice. The effects of different methods of chemical carcinogenesis
20. Malignant conversion of mouse skin tumors is increased by tumor initiators and unaffected by tumour promoters
21. Papillomas induced by initiation-promotion differ from those induced by carcinogen alone
22. Divergent responses in epidermal basal cells exposed to the tumor promoter 12-O-tetradecanoylphorbol-13-acetate
23. Selective nature of phorbol 12-myristate 13-acetate-induced neoplastic transformation in NIH 3T3 cells
24. The significance of mutation in relation to the origin of tumors: A review
25. Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection
26. Cell-mediated mutagenesis of mammalian cells with chemical carcinogens
27. Marked differences in the tumor-initiating activity of optically pure (+)- and (-)-trans-7,8,-dihydroxy-7,8-dihydrobenzo(a) pyrene on mouse skin
28. Carcinogenicity of benzo-ring derivatives of benzo(a)pyrene on mouse skin
29. Mutagenicity and carcinogenicity of benzo(a)pyrene and benzo(a)pyrene derivatives
30. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons
31. Carcinogenicity of 2-hydroxy-benzo(a)pyrene and 6-hydroxy-benzo(a)pyrene in newborn mice
32. Tumour initiating activities on mouse skin of dihydrodiols derived from benzo(a)pyrene
33. Skin tumor initiating ability of benzo(a)pyrene 4,5-7,8 and 7,8-diol-9,10-epoxides and 7,8-diol
34. Comparison of the tumor-initiating activities of benzo(a)pyrene arene oxides and diol-epoxides
35. Marked differences in the tumor-initiating activities of the diastereomeric benzo(a)pyrene 7,8,-diol-9,10-epoxides
36. The initiation of tumors on mouse skin by dihydrodiols derived from 7,12-dimethylbenzo(a)anthracene and 3-methylcholanthrene
37. Both (±)syn- and (±)anti-7,12-dimethylbenz(a)anthracene-3,4-diol-1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTA- mutations at codon 61 of c-H-ras
38. The importance of the 'bay-region' diol epoxide in 7,12-dimethylbenz(a)anthracene skin tumor initiation and mutagenesis
39. Synthesis and tumor-initiating activity in mouse skin of dibenz(a,l)pyrene syn- and anti-fjord-region diol epoxides
40. The approach to understanding aromatic hydrocarbon carcinogenesis. The central role of radical cations in metabolic activation
41. Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites
42. Polynuclear aromatic compounds
43. The role of hair follicles in the origin and evolution of some cutaneous neoplasms of man and experimental animals
44. The refractoriness of the skin of hairless mice to chemical carcinogenesis
45. Epidermal stem cells: Properties, markers and location
46. High mutagenicity and toxicity of a diol epoxide derived from benzo(a)pyrene
47. Mutagenicity and cytotoxicity of benzo(a)pyrene and benzo-ring epoxides
48. Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells
49. Benzo(a)pyrene 7,8-dihydrodiol is more carcinogenic than benzo(a)pyrene in newborn mice
50. Tumor-initiating activity and carcinogenicity of dibenzo(a,l)pyrene versus 7,12-dimethyl benz(a)anthracene and benzo(a)pyrene at low doses in mouse skin
51. The binding to mouse skin DNA of benzo[a]pyrene, its 7,8-diol and 7,8-diol-9,10-epoxides in relation to the tumorigenicity of these compounds
52. Comparison of levels of benzo(a)pyrene diol epoxide diastereomers covalently bound in vivo to macromolecular components of the whole epidermis versus the basal layer
53. Formation and persistence of DNA, RNA and protein adducts in mouse skin exposed to pure optical enantiomers of 7β,
54. Contrasting disposition and metabolism of topically applied benzo(a)pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene and 7β,8α-dihydroxy-9α10α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in mouse epidermis in vivo
55. Binding of benzo(a)pyrene 7,8-diol-9,10-epoxides to DNA, RNA and protein of mouse skin occurs with high stereoselectivity
56. The early stages of carcinogenesis by 20-methylcholanthrene in the skin of the mouse. I. Experimental technique and macroscopic changes
57. Mechanism of experimental tumorigenesis. I. Epidermal hyperplasia in mouse caused by locally applied tumor initiator and dipole type tumor promoter
58. Tumorigenicity studies with diol-epoxides of benzo(a)pyrene which indicate that (±) trans-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene is an ultimate carcinogen in newborn mice
59. Tumorigenicity of the optical enantiomers of the diastereomeric benzo(a)pyrene 7,8 diol-9,10 epoxides in newborn mice: Exceptional activity of the (+)-7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene
60. The effects of carcinogenic chemicals in newborn mice
61. Quantitative assay for carcinogen altered differentiation in mouse epidermal cells
62. Correlation of initiating potency of skin carcinogens with potency to induce resistance to terminal differentiation in cultured mouse keratinocytes
63. Benzo(a)pyrene-DNA adduct formation and removal in mouse epidermis in vivo and in vitro: Relationship of DNA binding to initiation of skin carcinogenesis
64. In vitro transformation of normal cells to tumor cells by carcinogenic hydrocarbons
65. Expression of transformed morphology and anchorage independent growth of hamster embryo cells
66. Electronic structure and carcinogenic activity of aromatic molecules
67. The biological significance of metabolism of polycyclic compounds
68. Interactions of the K-region epoxides of phenanthrene and dibenz(a,h)anthracene with nucleic acids and histone
69. Mutagenicity to mammalian cells of epoxides and other derivatives of polycyclic hydrocarbon
70. Epoxides of carcinogenic polycyclic hydrocarbons are frameshift mutagens
71. Low carcinogenicity of the K-region epoxides of 7-methylbenz(a)anthracene and benz(a)anthracene in the mouse and rat
72. The carcinogenic activities in mice of compounds related to 3-methylcholanthrene
73. In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons
74. Malignant transformation of cells derived from mouse prostate by epoxides and other derivatives of polycyclic hydrocarbons
75. Malignant transformation in vitro of mouse fibroblasts by 7,12-dimethylbenz(a) anthracene and 7-hydroxymethylbenz(a)anthracene and by their K-region derivatives
76. Comparison of the cellular DNA-bound products of benzo(a)pyrene with the products formed by the reaction of benzo(a)pyrene-4,5-oxide with DNA
77. In vitro malignant transformation of mouse fibroblasts by non-K-region dihydrodiols derived from 7-methylbenz(a)anthracene, 7,12 dimethylbenz(a)anthracene and benz(a)pyrene
78. Transformation of normal hamster cells by benzo(a)pyrene diol epoxide
79. Experimental study of the pathogenesis of carcinoma
80. On the mechanism of carcinogenesis by chemical compounds
81. Rate of absorption of carcinogens and local tissue reaction as factors influencing carcinogenesis
82. The rate of disappearance of 3,4-benzpyrene from the mouse after subcutaneous and intraperitoneal injection
83. The carcinogenic action of 9,10-dimethyl-1,2-benzanthracene on the skin and subcutaneous tissues of the mouse, rabbit, rat and guinea pig
84. Studies in carcinogenesis. II. The detection of dibenzanthracene in mouse tumors induced by the hydrocarbon
85. Investigation of the metabolism of 3,4,9,10-dibenzpyrene
86. A study of the metabolism of 20-methylcholanthrene
87. 14
88. Non-mutagenic carcinogens are primarily hydrophobic
89. Metabolism of benzo(a)pyrene with isolated hepatocytes and the formation and degradation of DNA-binding derivatives
90. Inverse correlation between species lifespan and capacity of cultured fibroblasts to convert benzo(a)pyrene to water-soluble metabolites
91. Fluorescence studies of carcinogens in skin. II. Mouse skin after single and multiple applications of 20-methylcholanthrene
92. Penetration of benzopyrene through the intact skin of newborn mice
93. A histological study of masked lipids
94. Uptake of hydrocarbon carcinogens by lysosomes
95. The fluorescence spectrum of 3:4-benzopyrene
96. The early stages of carcinogenesis by 20-methylcholanthrene in the skin of the mouse. II. Microscopic tissue changes
97. The first effects on mouse skin of some polycyclic hydrocarbons
98. Correlation between carcinogenic potency and the first skin reaction to certain hydrocarbons
99. Chromosomal changes in epidermal carcinogenesis
100. Aneuploidy, an early event in mouse skin tumor development
101. Chromosome breakage induced by a carcinogenic hydrocarbon in Chinese hamster cells and human leukocytes in vitro
102. Chromosome breakage induced in vivo by a carcinogenic hydrocarbon in bone marrow cells of the Chinese hamster
103. Prooxidant states and tumor production
104. Carcinogen-induced chromosomal breakage decreased by antioxidants
105. Increase of peroxidation in carcinogenesis
106. Peroxidative and radiation damage to isolated lysosomes
107. Lysosomes and disease
108. Oxidative stress causes relocation of lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal cardiomyocytes
109. An anoxia inducible endonuclease and enhanced DNA breakage as contributors to genomic instability in cancer
110. Conditioned neoplasms and subthreshold neoplastic states
111. The experimental disclosure of latent neoplastic changes in tarred skin
112. The initiating and promoting elements in tumor production
113. The genesis and growth of tumors. II. Effects of caloric restriction per se
114. The persistence of latent tumour cells induced in the mouse skin by a single application of 9:10 dimethyl-1:2-benzanthracene
115. Of mice and men: A critical reappraisal of the two-stage theory of carcinogenesis
116. Co-carcinogenic principles from the seed oil of Croton tiglium and from other Euphorbiacae
117. Studies on the promoting phase in the stages of carcinogenesis in mice, rats rabbits and guinea pigs
118. Tumor production by abrasion induced epidermal hyperplasia in the skin of mice
119. An analysis of epidermal hyperplasia produced by acetic acid, a weak promoter, in the skin of female mice initiated with dimethylbenzanthracene
120. Specificity and mechanisms of promoter inhibitors and multistage promotion
121. Cutaneous changes during prolonged application of 12-O-tetradecanoyl-phorbol-13-acetate on mouse skin and residual effects after cessation of treatment
122. Epidermal tumor promotion by regeneration
123. TPA (12-O-tetradecanoyl-phorbol-13-acetate) as a carcinogen for mouse skin
124. Effect of tumor promoting agents on mutation frequencies in cultured V79 Chinese hamster cells
125. Metabolic conversion of 12-O-tetradecanoyl-phorbol-13-acetate in adult and newborn mouse skin and mouse liver microsomes
126. Somatic spectrum of cancer-associated single basepair substitutions in the TP53 gene is determined mainly by endogenous mechanisms of mutation and by selection
127. Tumor promoters: Carcinogenesis gets more complicated
128. V-ras genes from Harvey and Balb murine sarcoma viruses can act as initiators of two-stage mouse skin carcinogenesis
129. In vitro establishment is not a sufficient prerequisite for transformation by activated ras oncogenes
130. Some biological aspects of skin carcinogenesis
131. Studies on the mechanism of skin tumor promotion: Evidence for several stages in promotion
132. Skin tumor promotion by phorbol esters is a two-stage process
133. Tumor promotion by phorbol esters in skin: Evidence for a memory effect
134. Partial inversion of multistage tumorigenesis in the skin of NMRI mice
135. DNA strand breakage in human leukocytes exposed to a tumor promoter, phorbol myristate acetate
136. Tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced chromosome aberrations in mouse keratinocyte cell lines: A possible genetic mechanism of tumor promotion
137. Cytogenetic effects caused by phorbol ester tumor promotion in primary mouse keratinocyte cultures: Correlation with the convertogenic activity of TPA in multistage skin carcinogenesis
138. Tumor induction in initiated mouse skin by phorbol esters and methyl methanesulfonate: Correlation between chromosome damage and conversion (stage 1 of tumor promotion) in vivo
139. Three stage tumorigenesis in mouse skin: DNA synthesis as a prerequisite for the conversion stage induced by TPA prior to initiation
140. Stimulatory role of transforming growth factors in multistage carcinogenesis: Possible explanation for the tumor-inducing effect of wounding in initiated NMRI mouse skin
141. Chromosomal aberrations as a contributing factor for tumor production in the mouse skin
142. Two-stage promotion in mouse skin. An alternative explanation
143. Defective responses of transformed keratinocytes to terminal differentiation stimuli: Their role in epidermal tumour promotion by phorbol esters and by deep wounding
144. The conversion stage of skin carcinogenesis
145. A course of very small doses of DMBA, each of them allegedly with no promoting tendency, acts with clear synergistic effect as a strong promoter of DMBA-initiated mouse skin carcinogenesis
146. The effects of weak or non-carcinogenic polycyclic hydrocarbons on 7,12-dimethyl-benzanthracene and benzo(a)pyrene skin tumor initiation
147. Retinoyl-phorbol-acetate is a complete skin tumor promoter in SENCAR mice
148. Correlation between sensitivity to tumor promotion and sustained epidermal hyperplasia of mice and rats treated with 12-O-tetradecanoylphorbol-13-acetate
149. Actions cancérogène et cocancérogène du 12-O-tétradécanoylphorbol-13-acétate (TPA) sur la peau de Souris
150. The tumorigenic and carcinogenic effect of TPA (12-O-tetradecanoylphorbol-13-acetate) when applied to the skin of Balb/cA mice
151. Studies on the mechanism of promotion
152. The action of croton oil in the induction of sarcomas in mice
153. Two-stage chemical oncogenesis in cultures of C3H/10T1/2 cells
154. Transforming growth factor TGFB as a potent promoter in two-stage BALB/c3T3 cell transformation
155. Evidence for the progressive and adaptive nature of spontaneous transformation in the NIH 3T3 cell line
156. Induction of pseudofoci and inhibition of density-mediated neoplastic transformation by PMA in NIH 3T3 cells after short-term exposures
157. Integration of mutant Ha-ras oncogene into C3H 10T1/2 cells and its relationship to tumorigenic transformation
158. Oncogene-mediated multistep transformation of C3H 10T1/2 cells
159. Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division
160. Spontaneous formation of foci of morphologically transformed cells in populations of C3H 10T1/2 (clone 8) cells
161. Tobacco smoking as a possible etiological factor in bronchiogenic carcinoma: A study of six hundred and eighty-four proved cases
162. Smoking and carcinoma of the lung: Preliminary report
163. A study of the aetiology of carcinoma of the lung
164. Experimental production of carcinoma with cigarette tar
165. A study of tobacco carcinogenesis. II. Dose-response studies
166. A study of tobacco carcinogenesis. V. The role of pyrolysis
167. A study of tobacco carcinogenesis. I. The primary fractions
168. Effect of concentrations of benzopyrene in skin carcinogenesis
169. A study of tobacco carcinogenesis. VII. The study of the higher polycyclic hydrocarbons
170. Summation and inhibition effects of weak and strong carcinogenic hydrocarbons: 1:2-benzanthracene, chrysene, 1:2:5:6-dibenzanthracene and 20-methylcholanthrene
171. Quantitative unterschungen zur bedeutung benzpyrens für die carcinogene wirkung von tabakrauch
172. The cocarcinogenic activity of cigarette tobacco tar
173. The tumor-promoting action of phenol and related compounds for mouse skin
174. The development of malignant tumors of mouse skin after 'initiating' and 'promoting' stimuli. III. The carcinogenic action of croton oil
175. Incomplete carcinogens in cigarette smoke condensate: Tumour-promotion by a phenol fraction
176. Tobacco carcinogenesis
177. Incomplete carcinogens: Ethyl carbamate (urethane) as an initiator of skin tumour formation in the mouse
178. Further studies on incomplete carcinogenesis: Triethylene melamine (T.E.M.), 1,2-benzanthracene and β-proprolactone as initiators of skin tumor formation in the mouse
179. A study of tobacco carcinogenesis: VIII. The role of the acidic fractions as promoters
180. A study of carcinogenesis: X. Tumor promoting activity
181. The tumor-promoting agents of tobacco leaf and tobacco smoke condensate
182. Initiators and promoters in tobacco carcinogenesis
183. Initiating action of aromatic hydrocarbons in two-stage carcinogenesis
184. Some possible exogenous factors in the causation of lung cancer
185. Tumor-producing activity of extracts of unburned tobacco
186. Tumor producing agents in unburned cigarette tobacco
187. Tumor-promoting properties of anthralin (1,8,9-anthratriol)
188. The nature of tumor-promoting agents in tobacco products
189. Carcinogenic constituents of coal tar
190. Covalent binding of polycyclic aromatic hydrocarbon components of coal tar to DNA in mouse skin
191. Polynuclear aromatic compounds: Bitumens, coal tar and derived products, shale oils and soot
192. Cocarcinogenic and tumor promoting agents in tobacco carcinogenesis
193. The carcinogenicity of environmental tobacco smoke
194. The carcinogenic potential of the gas phase of environmental tobacco smoke
195. Successful and not so successful chemoprevention of tobacco smoke-induced lung tumors
196. Preferential formation of benzo(a)pyrene adducts at lung cancer mutational hotspots in P53
197. P53 mutations, benzo(a)pyrene and lung cancer
198. Human lung cancer and p53: The interplay between mutagenesis and selection
199. Patterns of p53 G→T transversions in living cancer reflect the primary mutagenic signature of DNA damage by tobacco smoke
200. Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke
201. Tobacco smoke carcinogens and lung cancer
202. Cigarette smoke and the incidence of primary neoplasm of the lung in the albino mouse
203. Cigarette smoking and changes in the histopathology of lung cancer
204. Differential response of Snell's and C57 Black mice to chronic inhalation of cigarette smoke
205. Lung tumors in mice: Application to carcinogenesis bioassay
206. Lung tumors in Strain A mice as a bioassay for carcinogenicity of environmental chemicals
207. Primary lung tumors in mice: An experimentally manipulable model of human adenocarcinomas
208. Mechanistic linkage between DNA adducts, mutations in oncogenes and tumorigenesis of carcinogenic environmental polycyclic aromatic hydrocarbons in strain A/J mice
209. Six months exposure of strain A/J mice to cigarette smoke: Cell kinetics and lung tumor data
210. Failure of cigarette smoke to induce or promote lung cancer in the A/J mouse
211. DNA damage in human respiratory tract epithelial cells: Damage by gas phase cigarette smoke apparently involves attack by reactive nitrogen species in addition to oxygen radicals
212. Pilot studies evaluating the lung tumor yield in cigarette smoke-exposed mice
213. Comparative carcinogenicity of cigarette mainstream and sidestream smoke condensates on the mouse skin
214. Gas chromatographic determination of polycyclic hydrocarbons, azoarenes, aromatic amines in the particle and vapor phase of mainstream and sidestream smoke of cigarettes
215. Tobacco smoking
216. Investigations of the effects of chronic cigarette smoke inhalation in Syrian golden hamsters
217. Strain difference in the response of inbred Syrian hamsters to cigarette smoke inhalation
218. Cigarette smoke inhalation studies in inbred Syrian golden hamsters
219. Laboratory contributions to the tobacco-cancer problem
220. Sur la composition chimique de la fumée du tabac. I. Analyse de la fraction neutre
221. Tumor-initiating activity in mouse skin and carcinogenicity in rat mammary gland of dibenzo(a)pyrenes: The very potent environmental carcinogen dibenzo(a,l)pyrene
222. Theories of carcinogenesis
223. Carcinogenesis by cholesterol
224. Etiological factors, stages and the role of foreign body in foreign body carcinogenesis
225. Effect of dose fractionation on the enhancement by radiation or cyclophosphamide of artificial pulmonary metastases
226. Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells
227. Cancer as a dynamic developmental disorder
228. Selected cell and selective microenvironment in neoplastic development
229. Distinct spectra of somatic mutations accumulated with age in mouse heart and small intestine
230. Molecular determinants of dysplasia in colorectal lesions
231. Lessons from hereditary colorectal cancer
232. Elimination of metabolic cooperation in Chinese hamster cells by a tumor promoter
233. Phorbol ester-induced formation of clastogenic factor from human monocytes
234. Characterization of the hydroperoxide response observed in mouse skin treated with tumor promoter
235. Activity of benzo(a)pyrene and its hydroxylated metabolites in an estrogen receptor-α reporter gene assay
236. Polynuclear aromatic hydrocarbon carcinogens as antiestrogens in MCF-7 human breast cancer cells: Role of the Ah receptor
237. 2+ and cell proliferation in primary human mammary epithelial cells
238. On the origin of cancer cells
239. On respiratory impairment in cancer cells
240. On respiratory impairment in cancer cells
241. The action of steroids and streptolysin on the permeability of phospholipid structure to cations
242. Keilin's respiratory chain concept and its chemiosmotic consequences
243. The influence of carcinogenic substances on sarcomata induced by the same and other compounds
244. The mutation rate and cancer
245. A speculative review: The probable nature of promoting action and its significance in the understanding of the mechanism of carcinogenesis
246. Epidermal hyperplasia after topical application of benz(a)pyrene, benzo(a)pyrene diol epoxides and other metabolites