E-cadherin expression in melanoma cells restores keratinocyte-mediated growth control and down-regulates expression of invasion-related adhesion receptors

American Journal of Pathology

Volumn 156, Issue 5, 2000, Pages 1515-1525

  Hsu, Mei Yu ^a   Meier, Friedegund E ^a   Nesbit, Mark ^a   Hsu, Ju Yu ^a   Van Belle, Patricia ^a   Elder, David E ^a   Herlyn, Meenhard ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA1 INTEGRIN; COMPLEMENTARY DNA; INTERCELLULAR ADHESION MOLECULE 1; UVOMORULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INVASION; CELL ADHESION; CELL GROWTH; CELL INTERACTION; CONTROLLED STUDY; DENDRITE; DOWN REGULATION; HUMAN; HUMAN CELL; KERATINOCYTE; MELANOMA CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH;

EID: 0033838767     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)65023-7     Document Type: Article

References (59)

1. E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro
2. Shifts in cadherin profiles between human normal melanocytes and melanomas
3. Expression of melanoma-associated antigens in rapidly dividing human melanocytes in culture
4. Antigenic profile of tumor progression in human melanocytic nevi and melanomas
5. Undifferentiated keratinocytes control growth, morphology, and antigen expression of normal melanocytes through cell-cell contact
6. Regulation of MeI-CAM/ MUC18 expression on melanocytic cells of different stages of tumor progression by normal keratinocytes
7. Cadherin cell adhesion receptors as a morphogenetic regulator
8. Structural basis of cell-cell adhesion by cadherins
9. Unraveling the cytoplasmic interactions of the cadherin superfamily
10. Specific proto-oncogenic tyrosine kinases of src family are enriched in cell-to-cell adherens junctions where the level of tyrosine phosphorylation is elevated
11. Dynamic interaction of PTPmu with multiple cadherins in vivo
12. The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts
13. Induction of polarized cell-cell association and retardation of growth by activation of the E-cadherin-catenin adhesion system in a dispersed carcinoma line
14. Increased cell-substratum adhesion, and decreased ge-latinase secretion and cell growth, induced by E-cadherin transfection of human colon carcinoma cells
15. Cadherin-mediated adhesion is required for normal growth regulation of human gingival epithelial cells
16. Dermal fibroblast proliferation is improved by β-catenin overexpression and inhibited by E-cadherin expression
17. Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium
18. The importance of the E-cadherin-catenin complex in the maintenance of intestinal epithelial homeostasis: More than intercellular glue?
19. Cadherins promote skeletal muscle differentiation in three-dimensional cultures
20. The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin
21. Association of the APC tumor suppressor protein with catenins
22. c-erbB-2 gene product directly associates with β-catenin and plakoglobin
23. Wnt-1-dependent regulation of local E-cadherin and alpha N-catenin expression in the embryonic mouse brain
24. The epidermal growth factor receptor modulates the interaction of E-cadherin with the actin cytoskeleton
25. The E-cadherin-mediated cell-cell adhesion system in human cancers
26. Loss of E-cadherin expression associated with lymph node metastases in small breast carcinomas
27. Reduced E-cadherin expression correlates with increased invasiveness in colorectal carcinoma cell lines
28. Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer
29. Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas
30. E-cadherin expression in renal cell cancer and its significance in metastasis and survival
31. Deletion of the E-cadherin gene in hepatitis B virus-positive Chinese hepatocellular carcinomas
32. Differential expression of the cell-cell adhesion molecule E-cadherin in ascites and solid human ovarian tumor cells
33. Loss of membranous E-cadherin expression in pancreatic cancer: Correlation with lymph node metastasis, high grade, and advanced stage
34. E-cadherin: A marker for differentiation and invasiveness in prostatic carcinoma
35. Expression of the E-cadherin-catenin cell adhesion complex in primary squamous cell carcinomas of the head and neck and their nodal metastases
36. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
37. Forced expression of E-cadherin in the mouse intestinal epithelium shows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system
38. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells
39. E-cadherin transfection down-regulates the epidermal growth factor receptor and reverses the invasive phenotype of human papilloma virus-transfected keratinocytes
40. E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model
41. Cultivation of normal human epidermal melanocytes
42. Progression-related expression of β3 integrin in melanoma and nevi
43. Isolation and functional characterization of the A32 melanoma-associated antigen
44. Methods for construction of adenovirus vectors
45. Adenovirus-mediated correction of the genetic defect in hepatocytes from patients with familial hypercholesterolemia
46. Characterization of mutants within the gene for the adenovirus E3 14.7-kilodalton protein which prevents cytolysis by tumor necrosis factor
47. Adenoviral gene transfer of β3 integrin subunit induces conversion from radial to vertical growth phase in primary human melanoma
48. Human melanoma progression in skin reconstructs: Biological significance of bFGF
49. Tumor progression and the nature of cancer
50. Regulation of gene expression and cell function by extracellular matrix
51. Assignment of the E-cadherin gene (CDH1) to chromosome 16q22.1 by radiation hybrid mapping
52. Stabilization of β-catenin by genetic defects in melanoma cell lines
53. Target genes of β-catenin-T cell factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas
54. Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation
55. Cross-talk between adhesion molecules: Control of N-cadherin activity by intracellular signals elicited by β1 and β3 integrins in migrating neural crest cells
56. Integrin and cadherin synergy regulates contact inhibition of migration and motile activity
57. Cadherin/catenin complex: A target for anti-invasive therapy?
58. Stimulation of urokinase-type plasminogen activator expression by blockage of E-cadherin dependent cell-cell adhesion