Post-secretion neutralization of transgene-derived effect: Soluble erythropoietin receptor/IgG1Fc expressed in liver neutralizes erythropoietin produced in muscle

Journal of Gene Medicine

Volumn 6, Issue 2, 2004, Pages 228-237

  Maruyama, Hirokim ^a   Higuchi, M ^b   Higuchi, N ^a   Kameda, S ^a   Saito, M ^b   Sugawa, M ^b   Matsuzaki, J ^b   Neichi, T ^b   Yokoyama, S ^b   Miyazaki, Y ^c   Miyazaki, J ^d   Gejyo, F ^a  

^a NIIGATA UNIVERSITY   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^c NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Erythropoietin; Hydrodynamics based transfection; IgG1Fc; In vivo electroporation; Naked DNA; Soluble erythropoietin receptor

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; MESSENGER RNA;

ANIMAL EXPERIMENT; ARTICLE; CELL GROWTH; CONTROLLED STUDY; CULTURE MEDIUM; ELECTROPORATION; ERYTHROCYTOSIS; ERYTHROPOIESIS; GENE TRANSFER; GENETIC TRANSFECTION; HEMATOCRIT; HORMONE BINDING; HYDRODYNAMICS; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL LINE; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; RETICULOCYTE COUNT; SKELETAL MUSCLE; TRANSGENE; ANIMAL; GENETICS; HUMAN; METABOLISM; MUSCLE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ERYTHROPOIETIN; HUMANS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; LIVER; MUSCLES; RATS; RECEPTORS, ERYTHROPOIETIN; RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 4644317542     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.485     Document Type: Article

References (34)

1. Gossen M, Bujard H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A 1992; 89: 5547-5551.
2. Gossen M, Freundlieb S, Bender G, et al. Transcriptional activation by tetracyclines in mammalian cells. Science 1995; 268: 1766-1769.
3. No D, Yao TP, Evans RM. Ecdysone-inducible gene expression in mammalian cells and transgenic mice. Proc Natl Acad Sci U S A 1996; 93: 3346-3351.
4. Wang Y, O'Malley BW Jr, Tsai SY, et al. A regulatory system for use in gene transfer. Proc Natl Acad Sci U S A 1994; 91: 8180-8184.
5. Ye X, Rivera VM, Zoltick P, et al. Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer. Science 1999; 283: 88-91.
6. Abruzzese RV, Godin D, Burcin M, et al. Ligand-dependent regulation of plasmid-based transgene expression in vivo. Hum Gene Ther 1999; 10: 1499-1507.
7. Abruzzese RV, Godin D, Mehta V, et al. Ligand-dependent regulation of vascular endothelial growth factor and erythropoietin expression by a plasmid-based autoinducible GeneSwitch system. Mol Ther 2000; 2: 276-287.
8. Payen E, Bettan M, Henri A, et al. Oxygen tension and a pharmacological switch in the regulation of transgene expression for gene therapy. J Gene Med 2001; 3: 498-504.
9. Werstuck G, Green MR. Controlling gene expression in living cells through small molecule-RNA interactions. Science 1998; 282 296-298.
10. Rivera VM, Wang X, Wardwell S, et al. Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science 2000; 287: 826-830.
11. Maruyama H, Sugawa M, Moriguchi Y, et al. Continuous erythropoietin delivery by muscle-targeted gene transfer using in vivo electroporation. Hum Gene Ther 2000; 11: 429-437.
12. Maruyama H, Ataka K, Gejyo F, et al. Long-term production of erythropoietin after electroporation-mediated transfer of plasmid DNA into the muscles of normal and uremic rats. Gene Ther 2001; 8: 461-468.
13. Nagao M, Inoue K, Moon SK, et al. Secretory production of erythropoietin and the extracellular domain of the erythropoietin receptor by Bacillus brevis: affinity purification and characterization. Biosci Biotechnol Biochem 1997; 61: 670-674.
14. 1 fusion protein. Gene Ther 1999; 6: 771-777.
15. 1 chimeric proteins protects from autoimmunity. J Gene Med 1999; 1: 415-423.
16. Piccirillo CA, Prud'homme GJ. Prevention of experimental allergic encephalomyelitis by intramuscular gene transfer with cytokine-encoding plasmid vectors. Hum Gene Ther 1999; 10: 1915-1922.
17. Ueno H, Sakamoto T, Nakamura T, et al. A soluble transforming growth factor β receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats. Hum Gene Ther 2000; 11: 33-42.
18. Honda M, Sakamoto T, Ishibashi T, et al. Experimental subretinal neovascularization is inhibited by adenovirus-mediated soluble VEGF/flt-1 receptor gene transfection: a role of VEGF and possible treatment for SRN in age-related macular degeneration. Gene Ther 2000; 7: 978-985.
19. Lawson BR, Prud'homme GJ, Chang Y, et al. Treatment of murine lupus with cDNA encoding IFN-γR/Fc. J Clin Invest 2000; 106: 207-215.
20. Takayama K, Ueno H, Nakanishi Y, et al. Suppression of tumor angiogenesis and growth by gene transfer of a soluble form of vascular endothelial growth factor receptor into a remote organ. Cancer Res 2000; 60: 2169-2177.
21. Nakamura H, Isaka Y, Tsujie M, et al. Electroporation-mediated PDGF receptor-IgG chimera gene transfer ameliorates experimental glomerulonephritis. Kidney Int 2001; 59 2134-2145.
22. Adachi O, Nakano A, Sato O, et al. Gene transfer of Fc-fusion cytokine by in vivo electroporation: application to gene therapy for viral myocarditis. Gene Ther 2002; 9: 577-583.
23. Liu F, Song Y, Liu D. Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA. Gene Ther 1999; 6: 1258-1266.
24. Zhang G, Budker V, Wolff JA. High levels of foreign gene expression in hepatocytes after tail vein injections of naked plasmid DNA. Hum Gene Ther 1999; 10: 1735-1737.
25. Maruyama H, Higuchi N, Nishikawa Y, et al. High-level expression of naked DNA delivered to rat liver via tail vein injection. J Gene Med 2002; 4: 333-341.
26. Niwa H, Yamamura K, Miyazaki J. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 1991; 108: 193-199.
27. Miyazaki Y, Kuriyama K, Higuchi M, et al. Establishment and characterization of a new erythropoietin-dependent acute myeloid leukemia cell line, AS-E2. Leukemia 1997; 11: 1941-1949.
28. Brown SJ, Becherer KA, Blumeyer K, et al. Expression and ligand binding assays of soluble cytokine receptor-immunoglobulin fusion proteins. Protein Expr Purif 1998; 14: 120-124.
29. Henderikx P, Coolen-van Neer N, Jacobs A, et al. A human immunoglobulin G1 antibody originating from an in vitro-selected Fab phage antibody binds avidly to tumor-associated MUC1 and is efficiently internalized. Am J Pathol 2002; 160: 1597-1608.
30. Zhang G, Song YK, Liu D. Long-term expression of human alpha1-antitrypsin gene in mouse liver achieved by intravenous administration of plasmid DNA using a hydrodynamics-based procedure. Gene Ther 2000; 7: 1344-1349.
31. Miao CH, Thompson AR, Loeb K, et al. Long-term and therapeutic-level hepatic gene expression of human factor IX after naked plasmid transfer in vivo. Mol Ther 2001; 3: 947-957.
32. Maruyama H, Ataka K, Higuchi N, et al. Skin-targeted gene transfer using in-vivo electroporation. Gene Ther. 2001; 8: 1808-1812.
33. Maruyama H, Higuchi N, Nishikawa Y, et al. Kidney-targeted naked DNA transfer by retrograde renal vein injection in rats. Hum Gene Ther 2002; 13: 455-468.
34. Casadevall N, Nataf J, Viron B, et al. Pure red-cell aplasia and antierythropoietin antibodies in patients treated with recombinant erythropoietin. N Engl J Med 2002; 346: 469-475.