Prevention of experimental allergic encephalomyelitis by intramuscular gene transfer with cytokine-encoding plasmid vectors

Human Gene Therapy

Volumn 10, Issue 12, 1999, Pages 1915-1922

  Piccirillo, Ciriaco A ^a,b   Prud'homme, Gérald J ^a  

^a MCGILL UNIVERSITY   (Canada)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; IMMUNOGLOBULIN G1; INTERLEUKIN 12; INTERLEUKIN 4; MYELIN BASIC PROTEIN; PLASMID VECTOR; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR;

ALLERGIC ENCEPHALITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE SEVERITY; FEMALE; GENE TARGETING; GENE TRANSFER; HELPER CELL; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION;

ANIMALS; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; IMMUNOGLOBULIN G; INJECTIONS, INTRAMUSCULAR; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MICE; MYELIN BASIC PROTEINS; PLASMIDS; POLYMERASE CHAIN REACTION; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA;

EID: 0033543127     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950017275     Document Type: Article

References (41)

1. ALLEN, J.B., WONG, H.L., COSTA, G.L., BIENKOWSKI, M.H., and WAHL, S.M. (1993). Suppression of monocyte function and differential regulation of IL-1 and IL-1ra by IL-4 contribute to resolution of experimental arthritis. J. Immunol. 151, 4344-4351.
2. ALVORD, E.G., KIES, M.W., and SUCKLING, A.J. (1984). Experimental allergic encephalomyelitis: A model for multiple sclerosis. Prog. Clin. Biol. Res. 146, 1-8.
3. BOUTARD, V., HAROUIS, R., FOUQUERAY, B., PHILIPPE, C., MOULINOUX, J.P., and BAUD, L. (1995). Transforming growth factor-β stimulates arginase activity in macrophages: Implications for the regulation of macrophage cytotoxicity. J. Immunol. 55, 2077-2084.
4. CAMERON, M.J., ARREAZA, G.A., ZUCKER, P., CHENSUE, S.W., STRIETER, R.M., CHAKRABARTI, S., and DELOVITCH, T.L. (1997). IL-4 prevents insulitis and insulin-dependent diabetes mellitus in non-obese diabetic mice by potentiation of regulatory T helper-2 cell function. J. Immunol. 159, 4686-4692.
5. CANTORNA, M.T., WOODWARD, W.D., HAYES, C.E., and DELUCA, H.F. (1998). 1,25-Dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-β1 and IL-4. J. Immunol. 160, 5315-5319.
6. DAVIS, H.L., MICHEL, M.L., and WHALEN, R.G. (1993). DNA-based immunization for hepatitis B induces continuous secretion of antigen and high levels of circulating antibody. Hum. Mol. Genet. 2, 1847-1851.
7. D'ORAZIO, T.J., and NIEDERKORN, J.Y. (1998). A novel role for TGF-β and IL-10 in the induction of immune privilege. J. Immunol. 160, 2089-2098.
8. FALCONE, M., RAJAN, A.J., BLOOM, B.R., and BROSNAN, C.F. (1998). A critical role for IL-4 in regulating disease severity in experimental allergic encephalomyelitis as demonstrated in IL-4-deficient C57BL/6 mice and BALB/c mice. J. Immunol. 160, 4822-4830.
9. GAUTAM, S., TEBO, J.M., and HAMILTON, T.A. (1992). IL-4 suppresses cytokine gene expression induced by IFN-γ and/or IL-2 in murine peritoneal macrophages. J. Immunol. 148, 1725-1730.
10. GILADI, E., RAZ, E., KARMELI, F., OKON, E., and RACHMILEWTTZ, D. (1995). Transforming growth factor-beta gene therapy ameliorates experimental colitis in rats. Eur. J. Gastroenterol. Hepatol. 7, 341-347.
11. HAN, H.S., JUN, H.S., UTSUGI, T., and YOON, J.W. (1996). A new type of CD4+ suppressor T cell completely prevents spontaneous autoimmune diabetes and recurrent diabetes in syngeneic islet-transplanted NOD mice. J. Autoimmunity 9, 331-339.
12. HARTIKKA, J., SAWDEY, M., CORNEFERT-JENSEN, F., MARGALITH, M., BARNHART, K., NOLASCO, M., VAHLSING, H.L., MEEK, J., MARQUET, M., HOBART, P., NORMAN, J., and MANTHORPE, M. (1996). An improved plasmid DNA expression vector for direct injection into skeletal muscle. Hum. Gene Ther. 7, 1205-1217.
13. INOBE, J.I., CHEN, Y., and WEINER, H.L. (1996). In vivo administration of IL-4 induces TGF-β-producing cells and protects animals from experimental autoimmune encephalomyelitis. Ann. N.Y. Acad. Sci. 778, 390-392.
14. ISHII, K.J., WEISS, W.R., ICHINO, M., VERTHELYI, D., and KLINMAN, D.M. (1999). Activity and safety of DNA plasmids encoding IL-4 and IFN gamma. Gene Ther. 6, 237-244.
15. KHOURY, S.J., HANCOCK, W.W., and WEINER, H.L. (1992). Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E expression in the brain. J. Exp. Med. 176, 1355-1364.
16. KING, C., DAVIES, J., MUELLER, R., LEE, M.S., KRAHL, T., YEUNG, B., O'CONNOR, E., and SARVETNICK, N. (1998). TGF-beta 1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotype. Immunity 8, 601-613.
17. KURUVILLA, A.P., SHAH, R., HOCHWALD, G.M., LIGGITT, H.D., PALLADINO, M.A., and THORBECKE, G.J. (1991). Protective effect of transforming growth factor β1 on experimental autoimmune diabetes in mice. Proc. Natl. Acad. Sci. U.S.A. 88, 2918-2921.
18. LENNART, D.J., FLANDERS, K.C., RANGERS, G.E., and SRIRAM, S. (1991). Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-β1. J. Immunol. 147, 1792-1796.
19. LEVY, M.Y., BARRON, L.G., MEYER, K.B., and SZOKA, F.C., JR. (1996). Characterization of plasmid DNA transfer into mouse skeletal: Evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Ther. 3, 201-211.
20. LIBLAU, R.S., SINGER, S.M., and MCDEVITT, H.O. (1995). Th1 and Th2 CD4+ T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 1, 34-38.
21. LUDOVIC-CROXFORD, J., TRIANTAPHYLLAPOULOS, K., PODHAJCER, O.L., FELDMANN, M., BAKER, D., and CHERNAJOVSKY, Y. (1998). Cytokine gene therapy in experimental allergic encephalomyelitis by injection of plasmid DNA-cationic liposome complex into the central nervous system. J. Immunol. 160, 5181-5187.
22. MARTIN, R., and McFARLAND, H.F. (1995). Immunological aspects of experimental allergic encephalomyelitis and multiple schlerosis. Crit. Rev. Clin. Lab. Sci. 2, 121-182.
23. MASON, D., and POWRIE, F. (1998). Control of immune pathology by regulatory T cells. Curr. Opin. Immunol. 10, 649-655.
24. O'GARRA, A., STEINMAN, L., and GIJBELS, K. (1997). CD4+ T-cell subsets in autoimmunity. Curr. Opin. Immunol. 9, 872-883.
25. OLSSON, T. (1995). Critical influences of the cytokine orchestration on the outcome of myelin antigen-specific T cell autoimmunity in experimental allergic encephalomyelitis and multiple sclerosis. Immunol. Rev. 144, 245-268.
26. PICCIRILLO, C.A., CHANG, Y., and PRUD'HOMME, G.J. (1998). TGF-β1 somatic gene therapy prevents autoimmune disease in non-obese diabetic mice. J. Immunol. 161, 3950-3956.
27. POWELL, M.B., MITCHELL, D., LEDERMAN, J., BUCKMEIER, J., ZAMVIL, S.S., GRAHAM, M., RUDDLE, N.H., and STEINMAN, L. (1990). Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity. Int. Immunol. 2, 539-544.
28. PRUD'HOMME, G.J., KONO, D.H., and THEOFILOPOULOS, A.N. (1995). Quantittive polymerase chain reaction analysis reveals marked overexpression of interleukin-1β, interleukin 10 and interferon γ mRNA in the lymph nodes of lupus-prone mice. Mol. Immunol. 32, 495-503.
29. RABINOVITCH, A. (1993). Immunology and diabetes mellitus: Roles of cytokines in IDDM pathogenesis and islet β-cell destruction. Diabetes Rev. 1, 215-240.
30. RACKE, M.K., CANNELLA, B., ALBERT, P., SPORN, M., RAINE, C.S., and MCFARLIN, D.E. (1992). Evidence of endogenous regulatory function of transforming growth factor-β1 in experimental allergic encephalomyelitis. Int. Immunol. 4, 615-620.
31. RACKE, M.K., BONOMO, A., SCOTT, D.E., CANNELLA, B., LEVINE, A., RAINE, C.S., SHEVACH, E.M., and ROCKEN, M. (1994). Cytokine-induced immune deviation as a therapy for inflammatory autoimmune disease. J. Exp. Med. 180, 1961-1966.
32. RAZ, E., LOTZ, M., BAIRS, S.M., BERRY, C.C., EISENBERG, R.A., and CARSON, D. (1995). Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery. Lupus 4, 286-292.
33. RENNO, T., KRAKOWSKI, M.K., PICCIRILLO, C., LIN, J., and OWENS, T. (1995). TNFα expression by resident microglia and infiltrating leukcoytes in the central nervous system of mice with experimental allergic encephalomyelitis. J. Immunol. 154, 944-953.
34. SHULL, M.M., ORMSBY, I., KIER, A.B., PAWLOWSKI, S., DIEBOLD, R.J., YIN, M., ALLEN, R., SIDMAN, C., PROETZEL, G., CALVIN, D., ANNUNZIATA, N., and DOETSCHMAN, T. (1992). Targeted disruption of the mouse TGF-β1 gene results in multifocal inflammatory disease. Nature (London) 359, 693-699.
35. SWANBORG, R.H. (1995). Animal models of human disease experimental autoimmune encephalomyelitis in rodents as a model for human demyelinating disease. Clin. Immunol. Immunopathol. 77, 4-13.
36. TAKEUCHI, M., ALARD, P., and STREILEIN, J.W. (1998). TGF-β promotes immune deviation by altering accessory signals of antigen-presenting cells. J. Immunol. 160, 1589-1597.
37. TOKUI, M., TAKEI, I., TASHIRO, F., SHIMAD, A., KUSAGA, A., ISHU, M., TAKATSU, K., SARUTA, T., and MIYAZAKI, J. (1997). Intramuscular injection of expression plasmid DNA is an effective means of long-term systemic delivery of interleukin-5. Biochem. Biophys. Res. Commun. 233, 527-531.
38. VODOVOTZ, Y., BOGDAN, C., PAIK, J., XIE, Q.W., and NATHAN, C. (1993). Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor-β. J. Exp. Med. 178, 605-613.
39. WALLICK, S.C., FIGARI, I.S., MORRIS, R.E., LEVISON, A.D., and PALLADINO, M.A. (1990). Immunoregulatory role of transforming growth factor β (TGFβ) in development of killer cells: Comparison of active and latent TGF-β1. J. Exp. Med. 172, 1777-1784.
40. WOLFF, J.A., MALONE, R.W., WILLIAMS, P., CHONG, W., ASCADI, G., JANI, A., and FELGNER, P.L. (1990). Direct gene therapy into mouse muscle in vivo. Science 247, 1465-1468.
41. WOLFF, J.A., LUDTKE, J.J., ASCADI, WILLIAMS, P., and JANI, A. (1992). Long-term persistence of plasmid DNA and foreign gene expression in mouse muscle. Hum. Mol. Genet. 1, 363-369.