Ligand-dependent regulation of plasmid-based transgene expression in vivo

Human Gene Therapy

Volumn 10, Issue 9, 1999, Pages 1499-1507

  Abruzzese, Ronald V ^a   Godin, Debra ^a   Burcin, Mark ^b   Mehta, Vidya ^a   French, Martha ^a   Li, Yuhua ^a   O'Malley, Bert W ^b   Nordstrom, Jeffrey L ^a  

^a Urigen Pharmaceuticals Inc   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; MIFEPRISTONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE TARGETING; GENE THERAPY; GENE TRANSFER; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; TRANSGENE;

ANIMALIA; CUCUMBER MOSAIC VIRUS;

EID: 0033542389     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430349950017833     Document Type: Article

References (21)

1. ANWER, K., SHI, M., FRENCH, M. F., MULLER, S. M., CHEN, W., LIE, Q., PROCTOR, B. L., WANG, J., MUMPER, R. J., SINGHAL, A., ROLLAND, A. P., and ALILA, H. A. (1998). Systemic effect of human growth hormone after intramuscular injection of a single dose of a muscle-specific gene medicine. Hum. Gene Ther. 9, 659-670.
2. BOHL, D., SALVETTI, A., MOULLIER, P., and HEARD, J. M. (1998). Control of erythropoietin delivery by doxycycline in mice after intramuscular injection of adeno-associated vector. Blood 92, 1512-1517.
3. BRONSTEIN, I., MARTIN, C. S., FORTIN, J. J., OLESEN, C. E. M., and VOYTA, J. C. (1996). Chemilummescence: Sensitive detection technology for reporter gene assays. Clin. Chem. 42, 1542-1546.
4. BURCIN, M. M., SCHIEDNER, G., KOCHANEK, S., TSAI, S. Y., and O'MALLEY, B. W. (1999). Adenovirus-mediated regulatable target gene expression in vivo. Proc. Natl. Acad. Sci. U.S.A. 96, 355-360.
5. DHAWAN, J., RANDO, T. A., ELSON, S. L., BUJARD, H., and BLAU, H. M. (1995). Tetracycline-regulated gene expression following direct gene transfer into mouse skeletal muscle. Somat. Cell Mol. Genet. 21, 233-240.
6. FOTAKI, M. E., PINK, J. R., and MOUS, J. (1996). Tetracycline-responsive gene expression in mouse brain after amplicon-mediated gene transfer. Gene Ther. 4, 901-908.
7. GRUNBERG, S. M., WEISS, M. H., SPITZ, I. M., AHMADI, J., SADUN, A., RUSSELL, C. A., LUCCI, L., and STEVENSON, L. L. (1991). Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone. J. Neurosurg. 74, 861-866.
8. HARDING, T. C., GEDDES, B. J., MURPHY, D., KNIGHT, D., and UNEY, J. B. (1997). Switching transgene expression in the brain using an adenoviral tetracycline-regulatable system. Nature Biotechnol. 16, 553-555.
9. HO, D. Y., McLAUGHLIN, J. R., and SAPOLSKY, R. M. (1996). Inducible gene expression from defective herpes simplex virus vectors using the tetracycline-responsive promoter system. Brain Res. Mol. Brain Res. 41, 200-209.
10. LEVY, M. Y., BARRON, L. G., MEYER, K. B., and SZOKA, F. C., JR. (1996). Characterization of plasmid DNA transfer into mouse skeletal muscle: Evaluation of uptake mechanism, expression and secretion of gene products into blood. Gene Ther. 3, 201-211.
11. LIANG, X., HARTIKKA, J., SUKHU, L., MANTHORPE, M., and HOBART, P. (1996). Novel, high expressing and antibiotic-controlled plasmid vectors designed for use in gene therapy. Gene Ther. 3, 350-356.
12. OLIGINO, T., POLIANI, P. L., WANG, Y., TSAI, S. Y., O'MALLEY, B. W., FINK, D. J., and GLORlOSO, J. C. (1998). Drug inducible transgene expression in brain using a herpes simplex virus vector. Gene Ther. 5, 491-496.
13. RENDAHL, K. G., LEFF, S. E., OTTEN, G. R., SPRATT, S. K., BOHL, D., ROEY, M. V., DONAHUE, B. A., COHEN, L. K., MANDEL, R. J., DANOS, O., and SNYDER, R. O. (1998). Regulation of gene expression in vivo following transduction by two separate rAAV vectors. Nature Biotechnol. 16, 757-761.
14. SMITH, C. L., and HAGER, G. L. (1997). Transcriptional regulation of mammalian genes in vivo. A tale of two templates. J. Biol. Chem. 272, 27493-27496.
15. SPITZ, I. M., and BARDIN, C. W. (1993). Mifepristone (RU 486) -a modulator of progestin and glucocorticoid action. N. Engl. J. Med. 329, 404-412.
16. VEGETO, E., ALLAN, G. F., SCHRADER, W. T., TSAI, M. J., McDONNELL, D. P., and O'MALLEY, B. W. (1992). The mechanism of RU486 antagonism is dependent on the conformation of the carboxy-terminal tail of the human progesterone receptor. Cell 69, 703-713.
17. WANG, Y., O'MALLEY, B. W., JR., TSAI, S. Y., and O'MALLEY, B. W. (1994). A regulatory system for use in gene transfer. Proc. Natl. Acad. Sci. U.S.A. 91, 8180-8184.
18. WANG, Y., DEMAYO, F. J., TSAI, S. Y., and O'MALLEY, B. W. (1997a). Ligand-inducible and liver-specific target gene expression in transgenic mice. Nature Biotechnol 15, 239-243.
19. WANG, Y., XU, J., PIERSON, T., O'MALLEY, B. W., and TSAI, S. Y. (1997b). Positive and negative regulation of gene expression in eukaryotic cells with an inducible transcriptional regulator. Gene Ther. 4, 432-441.
20. YE, X., RIVERA, V. M., ZOLTICK, P., CERASOLI, F., JR., SCHNELL, M. A., GAO, G., HUGHES, J. V., GILMAN, M., and WILSON, J. M. (1999). Regulated delivery of therapeutic proteins after in vivo somatic cell gene transfer. Science 283, 88-91.
21. ZHANG, G., VARGO, D., BUDKER, V., ARMSTRONG, N., KNECHTLE, S., and WOLFF, J. A. (1997). Expression of naked plasmid DNA injected into the afferent and efferent vessels of rodent and dog livers. Hum. Gene Ther. 8, 1763-1772.