메뉴 건너뛰기




Volumn 500, Issue 1-3 SPEC. ISS., 2004, Pages 243-253

Orphan G protein-coupled receptors and obesity

Author keywords

Feeding; Ghrelin; Melanin concentrating hormone; Neuropeptide B; Neuropeptide W; Orexin hypocretin

Indexed keywords

AGOUTI RELATED PROTEIN; G PROTEIN COUPLED RECEPTOR; GHRELIN; GHRELIN RECEPTOR; GHRELIN RECEPTOR ANTAGONIST; HORMONE RECEPTOR BLOCKING AGENT; LEPTIN; MELANIN CONCENTRATING HORMONE; NEUROPEPTIDE; NEUROPEPTIDE B; NEUROPEPTIDE W; OREXIN; OREXIN A; OREXIN B; RECEPTOR; UNCLASSIFIED DRUG;

EID: 4644312969     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.07.029     Document Type: Review
Times cited : (37)

References (117)
  • 3
    • 0038304457 scopus 로고    scopus 로고
    • Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
    • A. Asakawa, A. Inui, T. Kaga, G. Katsuura, M. Fujimiya, M.A. Fujino, and M. Kasuga Antagonism of ghrelin receptor reduces food intake and body weight gain in mice Gut 52 2003 947 952
    • (2003) Gut , vol.52 , pp. 947-952
    • Asakawa, A.1    Inui, A.2    Kaga, T.3    Katsuura, G.4    Fujimiya, M.5    Fujino, M.A.6    Kasuga, M.7
  • 4
    • 0037471384 scopus 로고    scopus 로고
    • Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting
    • M. Bagnasco, G. Tulipano, M.R. Melis, A. Argiolas, D. Cocchi, and E.E. Muller Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting Regul. Pept. 111 2003 161 167
    • (2003) Regul. Pept. , vol.111 , pp. 161-167
    • Bagnasco, M.1    Tulipano, G.2    Melis, M.R.3    Argiolas, A.4    Cocchi, D.5    Muller, E.E.6
  • 5
    • 0038575349 scopus 로고    scopus 로고
    • Neuropeptide W acts in brain to control prolactin, corticosterone, and growth hormone release
    • J.R. Baker, K. Cardinal, C. Bober, M.M. Taylor, and W.K. Samson Neuropeptide W acts in brain to control prolactin, corticosterone, and growth hormone release Endocrinology 144 2003 2816 2821
    • (2003) Endocrinology , vol.144 , pp. 2816-2821
    • Baker, J.R.1    Cardinal, K.2    Bober, C.3    Taylor, M.M.4    Samson, W.K.5
  • 6
    • 0032998652 scopus 로고    scopus 로고
    • Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus
    • D.G. Baskin, J.F. Breininger, and M.W. Schwartz Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus Diabetes 48 1999 828 833
    • (1999) Diabetes , vol.48 , pp. 828-833
    • Baskin, D.G.1    Breininger, J.F.2    Schwartz, M.W.3
  • 8
    • 0034801859 scopus 로고    scopus 로고
    • Opposite regulation of hypothalamic orexin and neuropeptide Y receptors and peptide expressions in obese Zucker rats
    • B. Beck, S. Richy, T. Dimitrov, and A. Stricker-Krongrad Opposite regulation of hypothalamic orexin and neuropeptide Y receptors and peptide expressions in obese Zucker rats Biochem. Biophys. Res. Commun. 286 2001 518 523
    • (2001) Biochem. Biophys. Res. Commun. , vol.286 , pp. 518-523
    • Beck, B.1    Richy, S.2    Dimitrov, T.3    Stricker-Krongrad, A.4
  • 9
    • 0034676324 scopus 로고    scopus 로고
    • Structure-function studies on the new growth hormone-releasing peptide, ghrelin: Minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a
    • M.A. Bednarek, S.D. Feighner, S.S. Pong, K.K. McKee, D.L. Hreniuk, M.V. Silva, V.A. Warren, A.D. Howard, L.H. Van Der Ploeg, and J.V. Heck Structure-function studies on the new growth hormone-releasing peptide, ghrelin: minimal sequence of ghrelin necessary for activation of growth hormone secretagogue receptor 1a J. Med. Chem. 43 2000 4370 4376
    • (2000) J. Med. Chem. , vol.43 , pp. 4370-4376
    • Bednarek, M.A.1    Feighner, S.D.2    Pong, S.S.3    McKee, K.K.4    Hreniuk, D.L.5    Silva, M.V.6    Warren, V.A.7    Howard, A.D.8    Van Der Ploeg, L.H.9    Heck, J.V.10
  • 10
    • 0032517162 scopus 로고    scopus 로고
    • Melanin-concentrating hormone and neuropeptide EI projections from the lateral hypothalamic area and zona incerta to the medial septal nucleus and spinal cord: A study using multiple neuronal tracers
    • J.C. Bittencourt, and C.F. Elias Melanin-concentrating hormone and neuropeptide EI projections from the lateral hypothalamic area and zona incerta to the medial septal nucleus and spinal cord: a study using multiple neuronal tracers Brain Res. 805 1998 1 19
    • (1998) Brain Res. , vol.805 , pp. 1-19
    • Bittencourt, J.C.1    Elias, C.F.2
  • 12
    • 0033118334 scopus 로고    scopus 로고
    • Molecular tinkering of G protein-coupled receptors: An evolutionary success
    • J. Bockaert, and J.P. Pin Molecular tinkering of G protein-coupled receptors: an evolutionary success EMBO J. 18 1999 1723 1729
    • (1999) EMBO J. , vol.18 , pp. 1723-1729
    • Bockaert, J.1    Pin, J.P.2
  • 21
    • 0032560581 scopus 로고    scopus 로고
    • Functional genomics: The search for novel neurotransmitters and neuropeptides
    • O. Civelli Functional genomics: the search for novel neurotransmitters and neuropeptides FEBS Lett. 430 1998 55 58
    • (1998) FEBS Lett. , vol.430 , pp. 55-58
    • Civelli, O.1
  • 23
    • 0036528005 scopus 로고    scopus 로고
    • Obesity therapy: Altering the energy intake-and-expenditure balance sheet
    • V.E. Crowley, G.S. Yeo, and S. O'Rahilly Obesity therapy: altering the energy intake-and-expenditure balance sheet Nat. Rev., Drug Discov. 1 2002 276 286
    • (2002) Nat. Rev., Drug Discov. , vol.1 , pp. 276-286
    • Crowley, V.E.1    Yeo, G.S.2    O'Rahilly, S.3
  • 24
    • 0035433977 scopus 로고    scopus 로고
    • A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    • D.E. Cummings, J.Q. Purnell, R.S. Frayo, K. Schmidova, B.E. Wisse, and D.S. Weigle A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans Diabetes 50 2001 1714 1719
    • (2001) Diabetes , vol.50 , pp. 1714-1719
    • Cummings, D.E.1    Purnell, J.Q.2    Frayo, R.S.3    Schmidova, K.4    Wisse, B.E.5    Weigle, D.S.6
  • 27
    • 0033679897 scopus 로고    scopus 로고
    • Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    • Y. Date, M. Kojima, H. Hosoda, A. Sawaguchi, M.S. Mondal, T. Suganuma, S. Matsukura, K. Kangawa, and M. Nakazato Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans Endocrinology 141 2000 4255 4261
    • (2000) Endocrinology , vol.141 , pp. 4255-4261
    • Date, Y.1    Kojima, M.2    Hosoda, H.3    Sawaguchi, A.4    Mondal, M.S.5    Suganuma, T.6    Matsukura, S.7    Kangawa, K.8    Nakazato, M.9
  • 30
    • 0036797774 scopus 로고    scopus 로고
    • Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats
    • O. Della-Zuana, F. Presse, C. Ortola, J. Duhault, J.L. Nahon, and N. Levens Acute and chronic administration of melanin-concentrating hormone enhances food intake and body weight in Wistar and Sprague-Dawley rats Int. J. Obes. Relat. Metab. Disord. 26 2002 1289 1295
    • (2002) Int. J. Obes. Relat. Metab. Disord. , vol.26 , pp. 1289-1295
    • Della-Zuana, O.1    Presse, F.2    Ortola, C.3    Duhault, J.4    Nahon, J.L.5    Levens, N.6
  • 31
    • 0034677966 scopus 로고    scopus 로고
    • Drug discovery: A historical perspective
    • J. Drews Drug discovery: a historical perspective Science 287 2000 1960 1964
    • (2000) Science , vol.287 , pp. 1960-1964
    • Drews, J.1
  • 32
    • 0032863991 scopus 로고    scopus 로고
    • Food intake elicited by central administration of orexins/hypocretins: Identification of hypothalamic sites of action
    • M.G. Dube, S.P. Kalra, and P.S. Kalra Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action Brain Res. 842 1999 473 477
    • (1999) Brain Res. , vol.842 , pp. 473-477
    • Dube, M.G.1    Kalra, S.P.2    Kalra, P.S.3
  • 33
    • 0023786564 scopus 로고
    • The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor
    • A. Fargin, J.R. Raymond, M.J. Lohse, B.K. Kobilka, M.G. Caron, and R.J. Lefkowitz The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor Nature 335 1988 358 360
    • (1988) Nature , vol.335 , pp. 358-360
    • Fargin, A.1    Raymond, J.R.2    Lohse, M.J.3    Kobilka, B.K.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 39
    • 0032858014 scopus 로고    scopus 로고
    • Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat
    • A.C. Haynes, B. Jackson, P. Overend, R.E. Buckingham, S. Wilson, M. Tadayyon, and J.R. Arch Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat Peptides 20 1999 1099 1105
    • (1999) Peptides , vol.20 , pp. 1099-1105
    • Haynes, A.C.1    Jackson, B.2    Overend, P.3    Buckingham, R.E.4    Wilson, S.5    Tadayyon, M.6    Arch, J.R.7
  • 42
    • 0033784980 scopus 로고    scopus 로고
    • Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats
    • A.K. Hewson, and S.L. Dickson Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats J. Neuroendocrinol. 12 2000 1047 1049
    • (2000) J. Neuroendocrinol. , vol.12 , pp. 1047-1049
    • Hewson, A.K.1    Dickson, S.L.2
  • 43
    • 0037521642 scopus 로고    scopus 로고
    • Ghrelin and the regulation of food intake and energy balance
    • H. Hosoda, M. Kojima, and K. Kangawa Ghrelin and the regulation of food intake and energy balance Mol. Interv. 2 2002 494 503
    • (2002) Mol. Interv. , vol.2 , pp. 494-503
    • Hosoda, H.1    Kojima, M.2    Kangawa, K.3
  • 46
    • 0041836225 scopus 로고    scopus 로고
    • Targeted disruption of GPR7 the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity
    • M. Ishii, H. Fei, and J.M. Friedman Targeted disruption of GPR7 the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity Proc. Natl. Acad. Sci. U. S. A. 100 2003 10540 10545
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 10540-10545
    • Ishii, M.1    Fei, H.2    Friedman, J.M.3
  • 48
    • 0035513696 scopus 로고    scopus 로고
    • Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats
    • J. Kamegai, H. Tamura, T. Shimizu, S. Ishii, H. Sugihara, and I. Wakabayashi Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats Diabetes 50 2001 2438 2443
    • (2001) Diabetes , vol.50 , pp. 2438-2443
    • Kamegai, J.1    Tamura, H.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5    Wakabayashi, I.6
  • 49
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • M. Kojima, H. Hosoda, Y. Date, M. Nakazato, H. Matsuo, and K. Kangawa Ghrelin is a growth-hormone-releasing acylated peptide from stomach Nature 402 1999 656 660
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5    Kangawa, K.6
  • 51
    • 0036144322 scopus 로고    scopus 로고
    • Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers
    • C.B. Lawrence, A.C. Snape, F.M. Baudoin, and S.M. Luckman Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers Endocrinology 143 2002 155 162
    • (2002) Endocrinology , vol.143 , pp. 155-162
    • Lawrence, C.B.1    Snape, A.C.2    Baudoin, F.M.3    Luckman, S.M.4
  • 52
    • 0036732411 scopus 로고    scopus 로고
    • Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis
    • J. LeCouter, R. Lin, and N. Ferrara Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis Nat. Med. 8 2002 913 917
    • (2002) Nat. Med. , vol.8 , pp. 913-917
    • Lecouter, J.1    Lin, R.2    Ferrara, N.3
  • 53
    • 0033020865 scopus 로고    scopus 로고
    • Two related G protein-coupled receptors: The distribution of GPR7 in rat brain and the absence of GPR8 in rodents
    • D.K. Lee, T. Nguyen, C.A. Porter, R. Cheng, S.R. George, and B.F. O'Dowd Two related G protein-coupled receptors: the distribution of GPR7 in rat brain and the absence of GPR8 in rodents Brain Res. Mol. Brain Res. 71 1999 96 103
    • (1999) Brain Res. Mol. Brain Res. , vol.71 , pp. 96-103
    • Lee, D.K.1    Nguyen, T.2    Porter, C.A.3    Cheng, R.4    George, S.R.5    O'Dowd, B.F.6
  • 55
  • 60
  • 65
    • 0035863948 scopus 로고    scopus 로고
    • Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary
    • V. Mitchell, S. Bouret, J.C. Beauvillain, A. Schilling, M. Perret, C. Kordon, and J. Epelbaum Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary J. Comp. Neurol. 429 2001 469 489
    • (2001) J. Comp. Neurol. , vol.429 , pp. 469-489
    • Mitchell, V.1    Bouret, S.2    Beauvillain, J.C.3    Schilling, A.4    Perret, M.5    Kordon, C.6    Epelbaum, J.7
  • 68
    • 0037066587 scopus 로고    scopus 로고
    • Neuroendocrine and peripheral activities of ghrelin: Implications in metabolism and obesity
    • G. Muccioli, M. Tschöp, M. Papotti, R. Deghenghi, M. Heiman, and E. Ghigo Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity Eur. J. Pharmacol. 440 2002 235 254
    • (2002) Eur. J. Pharmacol. , vol.440 , pp. 235-254
    • Muccioli, G.1    Tschöp, M.2    Papotti, M.3    Deghenghi, R.4    Heiman, M.5    Ghigo, E.6
  • 78
    • 0033566084 scopus 로고    scopus 로고
    • Molecular characterization of the melanin-concentrating-hormone receptor
    • Y. Saito, H.P. Nothacker, Z. Wang, S.H. Lin, F. Leslie, and O. Civelli Molecular characterization of the melanin-concentrating-hormone receptor Nature 400 1999 265 269
    • (1999) Nature , vol.400 , pp. 265-269
    • Saito, Y.1    Nothacker, H.P.2    Wang, Z.3    Lin, S.H.4    Leslie, F.5    Civelli, O.6
  • 79
    • 0035908285 scopus 로고    scopus 로고
    • Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain
    • Y. Saito, M. Cheng, F.M. Leslie, and O. Civelli Expression of the melanin-concentrating hormone (MCH) receptor mRNA in the rat brain J. Comp. Neurol. 435 2001 26 40
    • (2001) J. Comp. Neurol. , vol.435 , pp. 26-40
    • Saito, Y.1    Cheng, M.2    Leslie, F.M.3    Civelli, O.4
  • 80
    • 1042263152 scopus 로고    scopus 로고
    • Orexin: A link between energy homeostasis and adaptive behaviour
    • T. Sakurai Orexin: a link between energy homeostasis and adaptive behaviour Curr. Opin. Clin. Nutr. Metab. Care 6 2003 353 360
    • (2003) Curr. Opin. Clin. Nutr. Metab. Care , vol.6 , pp. 353-360
    • Sakurai, T.1
  • 85
  • 87
    • 0035143816 scopus 로고    scopus 로고
    • Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway
    • M. Shintani, Y. Ogawa, K. Ebihara, M. Aizawa-Abe, F. Miyanaga, K. Takaya, T. Hayashi, G. Inoue, K. Hosoda, M. Kojima, K. Kangawa, and K. Nakao Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway Diabetes 50 2001 227 232
    • (2001) Diabetes , vol.50 , pp. 227-232
    • Shintani, M.1    Ogawa, Y.2    Ebihara, K.3    Aizawa-Abe, M.4    Miyanaga, F.5    Takaya, K.6    Hayashi, T.7    Inoue, G.8    Hosoda, K.9    Kojima, M.10    Kangawa, K.11    Nakao, K.12
  • 89
    • 0346494433 scopus 로고    scopus 로고
    • Ghrelin levels in obesity and anorexia nervosa: Effect of weight reduction or recuperation
    • L. Soriano-Guillen, V. Barrios, A. Campos-Barros, and J. Argente Ghrelin levels in obesity and anorexia nervosa: effect of weight reduction or recuperation J. Pediatr. 144 2004 36 42
    • (2004) J. Pediatr. , vol.144 , pp. 36-42
    • Soriano-Guillen, L.1    Barrios, V.2    Campos-Barros, A.3    Argente, J.4
  • 90
    • 0242580169 scopus 로고    scopus 로고
    • Deletion of ghrelin impairs neither growth nor appetite
    • Y. Sun, S. Ahmed, and R.G. Smith Deletion of ghrelin impairs neither growth nor appetite Mol. Cell. Biol. 23 2003 7973 7981
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 7973-7981
    • Sun, Y.1    Ahmed, S.2    Smith, R.G.3
  • 91
    • 1842480284 scopus 로고    scopus 로고
    • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    • Y. Sun, P. Wang, H. Zheng, and R.G. Smith Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor Proc. Natl. Acad. Sci. U. S. A. 101 2004 4679 4684
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 4679-4684
    • Sun, Y.1    Wang, P.2    Zheng, H.3    Smith, R.G.4
  • 93
    • 0036580756 scopus 로고    scopus 로고
    • The hypocretins: Setting the arousal threshold
    • J.G. Sutcliffe, and L. de Lecea The hypocretins: setting the arousal threshold Nat. Rev., Neurosci. 3 2002 339 349
    • (2002) Nat. Rev., Neurosci. , vol.3 , pp. 339-349
    • Sutcliffe, J.G.1    De Lecea, L.2
  • 100
    • 0038176915 scopus 로고    scopus 로고
    • Peptides that regulate food intake: Regional, metabolic, and circadian specificity of lateral hypothalamic orexin a feeding stimulation
    • A.J. Thorpe, M.A. Mullett, C. Wang, and C.M. Kotz Peptides that regulate food intake: regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation Am. J. Physiol., Regul. Integr. Comp. Physiol. 284 2003 R1409 R1417
    • (2003) Am. J. Physiol., Regul. Integr. Comp. Physiol. , vol.284
    • Thorpe, A.J.1    Mullett, M.A.2    Wang, C.3    Kotz, C.M.4
  • 102
    • 0034687376 scopus 로고    scopus 로고
    • Ghrelin induces adiposity in rodents
    • M. Tschöp, D.L. Smiley, and M.L. Heiman Ghrelin induces adiposity in rodents Nature 407 2000 908 913
    • (2000) Nature , vol.407 , pp. 908-913
    • Tschöp, M.1    Smiley, D.L.2    Heiman, M.L.3
  • 106
    • 0035940750 scopus 로고    scopus 로고
    • Energy expenditure by intracerebroventricular administration of orexin to anesthetized rats
    • J. Wang, T. Osaka, and S. Inoue Energy expenditure by intracerebroventricular administration of orexin to anesthetized rats Neurosci. Lett. 315 2001 49 52
    • (2001) Neurosci. Lett. , vol.315 , pp. 49-52
    • Wang, J.1    Osaka, T.2    Inoue, S.3
  • 107
    • 0037414418 scopus 로고    scopus 로고
    • Orexin-A-sensitive site for energy expenditure localized in the arcuate nucleus of the hypothalamus
    • J. Wang, T. Osaka, and S. Inoue Orexin-A-sensitive site for energy expenditure localized in the arcuate nucleus of the hypothalamus Brain Res. 971 2003 128 134
    • (2003) Brain Res. , vol.971 , pp. 128-134
    • Wang, J.1    Osaka, T.2    Inoue, S.3
  • 116
    • 0032729636 scopus 로고    scopus 로고
    • Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight
    • A. Yamanaka, T. Sakurai, T. Katsumoto, M. Yanagisawa, and K. Goto Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight Brain Res. 849 1999 248 252
    • (1999) Brain Res. , vol.849 , pp. 248-252
    • Yamanaka, A.1    Sakurai, T.2    Katsumoto, T.3    Yanagisawa, M.4    Goto, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.