메뉴 건너뛰기




Volumn 6, Issue 4, 2003, Pages 353-360

Orexin: A link between energy homeostasis and adaptive behaviour

Author keywords

Appetite; Arousal; Lateral hypothalamus; Metabolism; Narcolepsy

Indexed keywords

ACETYLCHOLINE; DYNORPHIN; G PROTEIN COUPLED RECEPTOR; GALANIN; GHRELIN; GLUCOSE; GLUTAMIC ACID; LEPTIN; MELANIN CONCENTRATING HORMONE; MESSENGER RNA; MONOAMINE; NEUROPEPTIDE; NEUROPEPTIDE RECEPTOR; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN A; OREXIN B; UNCLASSIFIED DRUG;

EID: 1042263152     PISSN: 13631950     EISSN: None     Source Type: Journal    
DOI: 10.1097/00075197-200307000-00001     Document Type: Review
Times cited : (91)

References (54)
  • 1
    • 0032489093 scopus 로고    scopus 로고
    • Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    • Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998; 92:573-585.
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1    Amemiya, A.2    Ishii, M.3
  • 2
    • 0033580910 scopus 로고    scopus 로고
    • Structure and function of human prepro-orexin gene
    • Sakurai, T, Moriguchi, T, Furuya, K, et al. Structure and function of human prepro-orexin gene. J. Biol. Chem. 1999; 274:17771-17776.
    • (1999) J Biol Chem , vol.274 , pp. 17771-17776
    • Sakurai, T.1    Moriguchi, T.2    Furuya, K.3
  • 3
    • 0008390266 scopus 로고    scopus 로고
    • The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
    • de Lecea L, Kilduff TS, Peyron C, et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 1998; 95:322-327.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 322-327
    • De Lecea, L.1    Kilduff, T.S.2    Peyron, C.3
  • 4
    • 0035908286 scopus 로고    scopus 로고
    • Differential expression of orexin receptors 1 and 2 in the rat brain
    • Marcus JN, Aschkenasi CJ, Lee CE, et al. Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 2001; 435:6-25.
    • (2001) J Comp Neurol , vol.435 , pp. 6-25
    • Marcus, J.N.1    Aschkenasi, C.J.2    Lee, C.E.3
  • 5
    • 0032582716 scopus 로고    scopus 로고
    • Distribution of orexin receptor mRNA in the rat brain
    • Trivedi P, Yu H, MacNeil DJ, et al. Distribution of orexin receptor mRNA in the rat brain. FEBS Lett 1998; 438:71-75.
    • (1998) FEBS Lett , vol.438 , pp. 71-75
    • Trivedi, P.1    Yu, H.2    MacNeil, D.J.3
  • 6
    • 0032705117 scopus 로고    scopus 로고
    • Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade
    • Malendowicz LK, Tortorella C, Nussdorfer GG. Orexins stimulate corticosterone secretion of rat adrenocortical cells, through the activation of the adenylate cyclase-dependent signaling cascade. J Steroid Biochem Mol Biol 1999; 70:185-188.
    • (1999) J Steroid Biochem Mol Biol , vol.70 , pp. 185-188
    • Malendowicz, L.K.1    Tortorella, C.2    Nussdorfer, G.G.3
  • 7
    • 0033378162 scopus 로고    scopus 로고
    • Orexin synthesis and response in the gut
    • Kirchgessner AL, Liu M. Orexin synthesis and response in the gut. Neuron 1999; 24:941-951.
    • (1999) Neuron , vol.24 , pp. 941-951
    • Kirchgessner, A.L.1    Liu, M.2
  • 8
    • 0037221707 scopus 로고    scopus 로고
    • Glucose regulates the release of orexin-a from the endocrine pancreas
    • Ouedraogo R, Naslund E, Kirchgessner AL. Glucose regulates the release of orexin-a from the endocrine pancreas. Diabetes. Diabetes 2003; 52:111-117.
    • (2003) Diabetes. Diabetes , vol.52 , pp. 111-117
    • Ouedraogo, R.1    Naslund, E.2    Kirchgessner, A.L.3
  • 9
    • 0037222016 scopus 로고    scopus 로고
    • Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans
    • Burdyga G, Lal S, Spiller D, et al. Localization of orexin-1 receptors to vagal afferent neurons in the rat and humans. Gastroenterology 2003; 124:129-139.
    • (2003) Gastroenterology , vol.124 , pp. 129-139
    • Burdyga, G.1    Lal, S.2    Spiller, D.3
  • 10
    • 0033582175 scopus 로고    scopus 로고
    • Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
    • Date Y, Ueta Y, Yamashita H, et al. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci U S A 1999; 96:748-753.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 748-753
    • Date, Y.1    Ueta, Y.2    Yamashita, H.3
  • 11
    • 0033535747 scopus 로고    scopus 로고
    • Distribution of orexin neurons in the adult rat brain
    • Nambu T, Sakurai T, Mizukami K, et al. Distribution of orexin neurons in the adult rat brain. Brain Res 1999; 827:243-260.
    • (1999) Brain Res , vol.827 , pp. 243-260
    • Nambu, T.1    Sakurai, T.2    Mizukami, K.3
  • 12
    • 0032402181 scopus 로고    scopus 로고
    • Neurons containing hypocretin (orexin) project to multiple neuronal systems
    • Peyron C, Tighe DK, van den Pol AN, et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 1998; 18:9996-10015.
    • (1998) J Neurosci , vol.18 , pp. 9996-10015
    • Peyron, C.1    Tighe, D.K.2    Van Den Pol, A.N.3
  • 13
    • 0032527071 scopus 로고    scopus 로고
    • Distributions of leptin receptor mRNA isoforms in the rat brain
    • Elmquist JK, Bjorbaek C, Ahima RS, et al. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 1998; 395:535-547.
    • (1998) J Comp Neurol , vol.395 , pp. 535-547
    • Elmquist, J.K.1    Bjorbaek, C.2    Ahima, R.S.3
  • 14
    • 0032576536 scopus 로고    scopus 로고
    • Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: Relationship to the neuropeptide Y and agouti gene-related protein systems
    • Broberger C, De Lecea L, Sutcliffe JG, Hokfelt T. Hypocretin/orexin- and melanin-concentrating hormone-expressing cells form distinct populations in the rodent lateral hypothalamus: relationship to the neuropeptide Y and agouti gene-related protein systems. J Comp Neurol 1998; 402:460-474.
    • (1998) J Comp Neurol , vol.402 , pp. 460-474
    • Broberger, C.1    De Lecea, L.2    Sutcliffe, J.G.3    Hokfelt, T.4
  • 15
    • 0032576592 scopus 로고    scopus 로고
    • Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area
    • Elias CF, Saper CB, Maratos-Flier E, et al. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol 1998; 402:442-459.
    • (1998) J Comp Neurol , vol.402 , pp. 442-459
    • Elias, C.F.1    Saper, C.B.2    Maratos-Flier, E.3
  • 16
    • 0035136919 scopus 로고    scopus 로고
    • Orexin-A immunoreactive neurons in the rat hypothalamus do not contain neuronal nitric oxide synthase (nNOS)
    • Cutler DJ, Morris R, Evans ML, et al. Orexin-A immunoreactive neurons in the rat hypothalamus do not contain neuronal nitric oxide synthase (nNOS). Peptides 2001; 22:123-128.
    • (2001) Peptides , vol.22 , pp. 123-128
    • Cutler, D.J.1    Morris, R.2    Evans, M.L.3
  • 17
    • 4243302729 scopus 로고    scopus 로고
    • Orexin (hypocretin) neurons contain dynorphin
    • Chou TC, Lee CE, Lu J, et al. Orexin (hypocretin) neurons contain dynorphin. J Neurosci 2001; 21:RC168.
    • (2001) J Neurosci , vol.21
    • Chou, T.C.1    Lee, C.E.2    Lu, J.3
  • 18
    • 0033555609 scopus 로고    scopus 로고
    • Preprohypocretin (orexin) and prolactin-like immunoreactivity are coexpressed by neurons of the rat lateral hypothalamic area
    • Risold PY, Griffond B, Kilduff TS, et al. Preprohypocretin (orexin) and prolactin-like immunoreactivity are coexpressed by neurons of the rat lateral hypothalamic area. Neurosci Lett 1999; 259:153-156.
    • (1999) Neurosci Lett , vol.259 , pp. 153-156
    • Risold, P.Y.1    Griffond, B.2    Kilduff, T.S.3
  • 19
    • 0035847577 scopus 로고    scopus 로고
    • The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems
    • Abrahamson EE, Leak RK, Moore RY, et al. The suprachiasmatic nucleus projects to posterior hypothalamic arousal systems. Neuroreport 2001; 12:435-440.
    • (2001) Neuroreport , vol.12 , pp. 435-440
    • Abrahamson, E.E.1    Leak, R.K.2    Moore, R.Y.3
  • 20
    • 0031912090 scopus 로고    scopus 로고
    • Genetic and familial aspects of narcolepsy
    • Mignot E. Genetic and familial aspects of narcolepsy. Neurology 1998; 50 (2 Suppl. 1):S16-S22.
    • (1998) Neurology , vol.50 , Issue.2 SUPPL. 1
    • Mignot, E.1
  • 21
    • 0033529520 scopus 로고    scopus 로고
    • The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    • Lin L, Faraco J, Li R, et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 1999; 98:365-376.
    • (1999) Cell , vol.98 , pp. 365-376
    • Lin, L.1    Faraco, J.2    Li, R.3
  • 22
    • 0033588184 scopus 로고    scopus 로고
    • Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
    • Chemelli RM, Willie JT, Sinton CM, et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 1999; 98:437-451.
    • (1999) Cell , vol.98 , pp. 437-451
    • Chemelli, R.M.1    Willie, J.T.2    Sinton, C.M.3
  • 23
    • 0033826856 scopus 로고    scopus 로고
    • A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
    • Peyron C, Faraco J, Rogers W, et al. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 2000; 9:991-997.
    • (2000) Nat Med , vol.9 , pp. 991-997
    • Peyron, C.1    Faraco, J.2    Rogers, W.3
  • 24
    • 0033710848 scopus 로고    scopus 로고
    • Reduced number of hypocretin neurons in human narcolepsy
    • Thannickal TC, Moore RY, Nienhuis R, et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 2000; 27:469-474.
    • (2000) Neuron , vol.27 , pp. 469-474
    • Thannickal, T.C.1    Moore, R.Y.2    Nienhuis, R.3
  • 25
    • 0034846670 scopus 로고    scopus 로고
    • Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy
    • Nishino S, Ripley B, Overeem S, et al. Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy. Ann Neurol 2001; 50:381-388.
    • (2001) Ann Neurol , vol.50 , pp. 381-388
    • Nishino, S.1    Ripley, B.2    Overeem, S.3
  • 26
    • 0034992322 scopus 로고    scopus 로고
    • Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
    • Hara J, Beuckmann CT, Nambu T, et al. Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 2001; 30:345-354.
    • (2001) Neuron , vol.30 , pp. 345-354
    • Hara, J.1    Beuckmann, C.T.2    Nambu, T.3
  • 27
    • 0022831801 scopus 로고
    • Increased frequency of non-insulin-dependent diabetes mellitus among narcoleptic patients
    • Honda Y, Doi Y, Ninomiya R, Ninomiya C. Increased frequency of non-insulin-dependent diabetes mellitus among narcoleptic patients. Sleep 1986; 9:254-259.
    • (1986) Sleep , vol.9 , pp. 254-259
    • Honda, Y.1    Doi, Y.2    Ninomiya, R.3    Ninomiya, C.4
  • 28
    • 0030025684 scopus 로고    scopus 로고
    • Spontaneous food choice in narcolepsy
    • Lammers GJ, Pijl H, Iestra J, et al. Spontaneous food choice in narcolepsy. Sleep 1996; 19:75-76.
    • (1996) Sleep , vol.19 , pp. 75-76
    • Lammers, G.J.1    Pijl, H.2    Iestra, J.3
  • 29
    • 0034621042 scopus 로고    scopus 로고
    • Increased body-mass index in patients with narcolepsy
    • Schuld A, Hebebrand J, Geller F, Pollmacher T. Increased body-mass index in patients with narcolepsy. Lancet 2000; 355:1274-1275.
    • (2000) Lancet , vol.355 , pp. 1274-1275
    • Schuld, A.1    Hebebrand, J.2    Geller, F.3    Pollmacher, T.4
  • 30
    • 0029759523 scopus 로고    scopus 로고
    • The lateral hypothalamic area revisited: Ingestive behavior
    • Bernardis LL, Bellinger LL. The lateral hypothalamic area revisited: ingestive behavior. Neurosci Biobehav Rev 1996; 20:189-287.
    • (1996) Neurosci Biobehav Rev , vol.20 , pp. 189-287
    • Bernardis, L.L.1    Bellinger, L.L.2
  • 31
    • 0041443031 scopus 로고
    • Somnolence, akinesia, and sensory activation of motivated behavior in the lateral hypothalamic syndrome
    • Levitt DR, Teitelbaum P. Somnolence, akinesia, and sensory activation of motivated behavior in the lateral hypothalamic syndrome. Proc Natl Acad Sci USA 1975; 72:2819-2823
    • (1975) Proc Natl Acad Sci USA , vol.72 , pp. 2819-2823
    • Levitt, D.R.1    Teitelbaum, P.2
  • 32
    • 0018333645 scopus 로고
    • Dependence of sleep on nutrients' availability
    • Danguir J, Nicolaidis S. Dependence of sleep on nutrients' availability. Physiol Behav 1979; 22:735-740.
    • (1979) Physiol Behav , vol.22 , pp. 735-740
    • Danguir, J.1    Nicolaidis, S.2
  • 33
    • 0032940785 scopus 로고    scopus 로고
    • The effect of the orexins on food intake: Comparison with neuropeptide Y, melanin-concentrating hormone and galanin
    • Edwards CM, Abusnana S, Sunter D, et al. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J Endocrinol 1999; 160:R7-R12.
    • (1999) J Endocrinol , vol.160
    • Edwards, C.M.1    Abusnana, S.2    Sunter, D.3
  • 34
    • 0032858014 scopus 로고    scopus 로고
    • Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat
    • Haynes AC, Jackson B, Overend P, et al. Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides 1999; 20:1099.
    • (1999) Peptides , vol.20 , pp. 1099
    • Haynes, A.C.1    Jackson, B.2    Overend, P.3
  • 35
    • 0034708393 scopus 로고    scopus 로고
    • Orexin-induced food intake involves neuropeptide Y pathway
    • Yamanaka A, Kunii K, Nambu T, et al. Orexin-induced food intake involves neuropeptide Y pathway. Brain Res 2000; 24:404-409.
    • (2000) Brain Res , vol.24 , pp. 404-409
    • Yamanaka, A.1    Kunii, K.2    Nambu, T.3
  • 37
    • 0032729636 scopus 로고    scopus 로고
    • Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight
    • Yamanaka A, Sakurai T, Katsumoto T, et al. Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight. Brain Res 1999; 849:248-252.
    • (1999) Brain Res , vol.849 , pp. 248-252
    • Yamanaka, A.1    Sakurai, T.2    Katsumoto, T.3
  • 38
    • 0036851553 scopus 로고    scopus 로고
    • Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways
    • Zhu Y, Yamanaka A, Kunii K, et al. Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways. Physiol Behav 2002; 77:251-257.
    • (2002) Physiol Behav , vol.77 , pp. 251-257
    • Zhu, Y.1    Yamanaka, A.2    Kunii, K.3
  • 39
    • 13044249865 scopus 로고    scopus 로고
    • Orexin A activates locus coeruleus cell firing and increases arousal in the rat
    • Hagan JJ, Leslie RA, Patel S, et al. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci U S A 1999; 96:10911-10916.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 10911-10916
    • Hagan, J.J.1    Leslie, R.A.2    Patel, S.3
  • 40
    • 0034595109 scopus 로고    scopus 로고
    • Possible involvement of orexin in the stress reaction in rats
    • Ida T, Nakahara K, Murakami T, et al. Possible involvement of orexin in the stress reaction in rats. Biochem Biophys Res Commun 2000; 270:318-323.
    • (2000) Biochem Biophys Res Commun , vol.270 , pp. 318-323
    • Ida, T.1    Nakahara, K.2    Murakami, T.3
  • 41
    • 0025120247 scopus 로고
    • Effects of 24-hr fasting on methamphetamine- and apomorphine-induced locomotor activities, and on monoamine metabolism in mouse corpus striatum and nucleus accumbens
    • Itoh T, Murai S, Nagahama H, et al. Effects of 24-hr fasting on methamphetamine- and apomorphine-induced locomotor activities, and on monoamine metabolism in mouse corpus striatum and nucleus accumbens. Pharmacol Biochem Behav 1990; 35:391-396.
    • (1990) Pharmacol Biochem Behav , vol.35 , pp. 391-396
    • Itoh, T.1    Murai, S.2    Nagahama, H.3
  • 42
    • 0343742214 scopus 로고    scopus 로고
    • Effect of prolonged fasting and subsequent refeeding on free-running rhythms of temperature and locomotor activity in rats
    • Challet E, Pevet P, Malan A. Effect of prolonged fasting and subsequent refeeding on free-running rhythms of temperature and locomotor activity in rats. Behav Brain Res 1997; 84:275-284.
    • (1997) Behav Brain Res , vol.84 , pp. 275-284
    • Challet, E.1    Pevet, P.2    Malan, A.3
  • 44
    • 0034604826 scopus 로고    scopus 로고
    • Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system
    • Nakamura T, Uramura K, Nambu T, et al. Orexin-induced hyperlocomotion and stereotypy are mediated by the dopaminergic system. Brain Res 2000; 873:181-187.
    • (2000) Brain Res , vol.873 , pp. 181-187
    • Nakamura, T.1    Uramura, K.2    Nambu, T.3
  • 45
    • 0037220974 scopus 로고    scopus 로고
    • Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins
    • Korotkova TM, Sergeeva OA, Eriksson KS, et al. Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins. Neuroscience 2003; 23:7-11.
    • (2003) Neuroscience , vol.23 , pp. 7-11
    • Korotkova, T.M.1    Sergeeva, O.A.2    Eriksson, K.S.3
  • 46
    • 18444375874 scopus 로고    scopus 로고
    • Orexins activate histaminergic neurons via the orexin 2 receptor
    • Yamanaka A, Tsujino N, Funahashi H, et al. Orexins activate histaminergic neurons via the orexin 2 receptor. Biochem Biophys Res Commun 2002; 290:1237-1245.
    • (2002) Biochem Biophys Res Commun , vol.290 , pp. 1237-1245
    • Yamanaka, A.1    Tsujino, N.2    Funahashi, H.3
  • 48
    • 0033081871 scopus 로고    scopus 로고
    • Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: A novel circuit implicated in metabolic and endocrine regulations
    • Horvath TL, Diano S, van den Pol AN. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J Neurosci 1999; 19:1072-1087
    • (1999) J Neurosci , vol.19 , pp. 1072-1087
    • Horvath, T.L.1    Diano, S.2    Van Den Pol, A.N.3
  • 49
    • 0345085697 scopus 로고    scopus 로고
    • Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurons of the lateral hypothalamus
    • Hakansson M, de Lecea L, Sutcliffe JG, et al. Leptin receptor- and STAT3-immunoreactivities in hypocretin/orexin neurons of the lateral hypothalamus. J Neuroendocrinol 1999; 11:653-663.
    • (1999) J Neuroendocrinol , vol.11 , pp. 653-663
    • Hakansson, M.1    De Lecea, L.2    Sutcliffe, J.G.3
  • 50
    • 0036317682 scopus 로고    scopus 로고
    • Firing properties of neurones in the laterodorsal hypothalamic area during sleep and wakefulness
    • Koyama Y, Kodama T, Takahashi K, et al. Firing properties of neurones in the laterodorsal hypothalamic area during sleep and wakefulness. Psychiatry Clin 2002; 56:339-340.
    • (2002) Psychiatry Clin , vol.56 , pp. 339-340
    • Koyama, Y.1    Kodama, T.2    Takahashi, K.3
  • 51
    • 0033972880 scopus 로고    scopus 로고
    • Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system
    • Taheri S, Sunter D, Dakin C, et al. Diurnal variation in orexin A immunoreactivity and prepro-orexin mRNA in the rat central nervous system. Neurosci Lett 2000; 279:109-112.
    • (2000) Neurosci Lett , vol.279 , pp. 109-112
    • Taheri, S.1    Sunter, D.2    Dakin, C.3
  • 52
    • 0035282983 scopus 로고    scopus 로고
    • Fos expression in orexin neurons varies with behavioral state
    • Estabrooke IV, McCarthy MT, Ko E, et al. Fos expression in orexin neurons varies with behavioral state. J Neurosci 2001; 21:1656-1662.
    • (2001) J Neurosci , vol.21 , pp. 1656-1662
    • Estabrooke, I.V.1    McCarthy, M.T.2    Ko, E.3
  • 53
    • 0037470734 scopus 로고    scopus 로고
    • Regulation of orexin neurons by the monoaminergic and cholinergic systems
    • Yamanaka A, Muraki Y, Tsujino N, et al. (2003). Regulation of orexin neurons by the monoaminergic and cholinergic systems. Biochem Biophys Res Commun 2003; 303:120-129.
    • (2003) Biochem Biophys Res Commun , vol.303 , pp. 120-129
    • Yamanaka, A.1    Muraki, Y.2    Tsujino, N.3
  • 54
    • 0037137682 scopus 로고    scopus 로고
    • Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron - A potential mechanism for orchestrating the hypothalamic arousal system
    • Li Y, Gao XB, Sakurai T, van den Pol AN. Hypocretin/orexin excites hypocretin neurons via a local glutamate neuron - a potential mechanism for orchestrating the hypothalamic arousal system. Neuron 2002; 36:1169-1181. This work demonstrates that orexin release activates orexin neurons via glutamatergic interneurons.
    • (2002) Neuron , vol.36 , pp. 1169-1181
    • Li, Y.1    Gao, X.B.2    Sakurai, T.3    Van Den Pol, A.N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.