Probing the dynamics of a mobile loop above the active site of L1, metallo-β-lactamase from Stenotrophomonas maltophilia, via site-directed mutagenesis and stopped-flow fluorescence spectroscopy

Journal of Biological Chemistry

Volumn 279, Issue 38, 2004, Pages 39663-39670

  Garrity, James D ^a   Pauff, James M ^a   Crowder, Michael W ^a  

^a MIAMI UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYSIS; ENZYMES; FLUORESCENCE; REACTION KINETICS; SUBSTRATES; ULTRAVIOLET RADIATION;

CATALYTIC CYCLES; FLUORESCENCE TITRATIONS; LACTAMASES; SUBSTRATE BINDING;

AMINO ACIDS;

BACTERIAL ENZYME; METALLO BETA LACTAMASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CIRCULAR DICHROISM; ENZYME STRUCTURE; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SPECTROFLUOROMETRY; STENOTROPHOMONAS MALTOPHILIA; WILD TYPE;

BETA-LACTAMASES; BINDING SITES; ENZYME ACTIVATION; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, TERTIARY; SPECTROMETRY, FLUORESCENCE; STENOTROPHOMONAS MALTOPHILIA; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); KOBUS; NEGIBACTERIA; STENOTROPHOMONAS; STENOTROPHOMONAS MALTOPHILIA;

EID: 4544346596     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406826200     Document Type: Article

References (55)

1. Neu, H. C. (1992) Science 257, 1064-1073
2. Levy, S. B. (1998) Sci. Am. 3, 47-53
3. Kotra, L. P., and Mobashery, S. (1999) Arch. Immunol Ther. Exp. 47, 211-216
4. Bush, K., and Mobashery, S. (1998) in Resolving the Antibiotic Paradox (Mobashery, R. A., ed) pp. 71-98, Kluwer Academic /Plenum Publishers, New York
5. Bush, K. (1989) Antimicrob. Agents Chemother. 33, 264-270
6. Bush, K. (1989) Antimicrob. Agents Chemother. 33, 271-276
7. Siemann, S., Evanoff, D. P., Marrone, L., Clarke, A. J., Viswanatha, T., and Dmitrienko, G. I. (2002) Antimicrob. Agents Chemother. 46, 2450-2457
8. Toney, J. H., Hammond, G. G., Fitzgerald, P. M. D., Sharma, N., Balkovec, J. M., Rouen, G. P., Olson, S. H., Hammond, M. L., Greenlee, M. L., and Gao, Y. D. (2001) J. Biol. Chem. 276, 31913-31918
9. Lee, N. L. S., Yuen, K. Y., and Kumana, C. R. (2001) J. Am. Med. Assoc. 285, 386-388
10. Bounaga, S., Galleni, M., Laws, A. P., and Page, M. I. (2001) Bioorg. Med. Chem. 9, 503-510
11. Hammond, G. G., Huber, J. L., Greenlee, M. L., Laub, J. B., Young, K., Silver, L. L., Balkovec, J. M., Pryor, K. D., Wu, J. K., Leiting, B., Pompliano, D. L., and Toney, J. H. (1999) FEMS Microbiol. Lett. 459, 289-296
12. Williams, J. D. (1999) Int. J. Antimicrob. Agents 12, Suppl. 1, 3-7
13. Walter, M. W., Valladares, M. H., Adlington, R. M., Amicosante, G., Baldwin, J. E., Frere, J. M., Galleni, M., Rossolini, G. M., and Schofield, C. J. (1999) Bioorg. Chem. 27, 35-40
14. Crowder, M. W., and Walsh, T. R. (1999) Research Signpost 3, 105-132
15. Bush, K. (2001) Clin. Infect. Dis. 32, 1085-1090
16. Rice, L. B., and Bonomo, R. A. (2000) Drug Resist. Updat. 3, 178-189
17. Bush, K. (1998) Clin. Infect. Dis. 27, Suppl. 1, 48-53
18. Galleni, M., Lamotte-Brasseur, J., Rossolini, G. M., Spencer, J., Dideberg, O., and Frere, J. M. (2001) Antimicrob. Agents Chemother. 45, 660-663
19. Payne, D. J. (1993) J. Med. Microbiol. 39, 93-99
20. Payne, D. J., Bateson, J. H., Gasson, B. C., Proctor, D., Khushi, T., Farmer, T. H., Tolson, D. A., Bell, D., Skett, P. W., Marshall, A. C., Reid, R., Ghosez, L., Combret, Y., and Marchand-Brynaert, J. (1997) Antimicrob. Agents Chemother. 41, 135-140
21. Payne, D. J., Bateson, J. H., Gasson, B. C., Khushi, T., Proctor, D., Pearson, S. C., and Reid, R. (1997) FEMS Microbiol. Lett. 157, 171-175
22. Yang, K. W. (1999) Arch. Biochem. Biophys. 368, 1-6
23. Felici, A., Perilli, M., Segatore, B., Franceschini, N., Setacci, D., Oratore, A., Stefani, S., Galleni, M., and Amicosante, G. (1995) Antimicrob. Agents Chemother. 39, 1300-1305
24. Prosperi-Meys, C., Llabres, G., de Seny, D., Soto, R. P., Valladares, M. H., Laraki, N., Frere, J. M., and Galleni, M. (1999) FEBS Lett. 443, 109-111
25. Nagano, R., Adachi, Y., Imamura, H., Yamada, K., Hashizume, T., and Morishima, H. (1999) Antimicrob. Agents Chemother. 43, 2497-2503
26. Toney, J. H., Cleary, K. A., Hammond, G. G., Yuan, X., May, W. J., Hutchins, S. M., Ashton, W. T., and Vanderwall, D. E. (1999) Bioorg. Med. Chem. Lett. 9, 2741-2746
27. Arakawa, Y., Shibata, N., Shibayama, K., Kurokawa, H., Yagi, T., Fujiwara, H., and Goto, M. (2000) J. Clin. Microbiol. 38, 40-43
28. Khardori, N., Elting, L., Wong, E., Schable, B., and Bodey, G. P. (1990) Rev. Infect. Dis. 12, 997-1003
29. Muder, R. R., Yu, V. L., Dummer, J. S., Vinson, C., and Lumish, R. M. (1987) Arch. Intern. Med. 147, 1672-1674
30. Villarino, M. E., Stevens, L. E., Schable, B., Mayers, G., Miller, J. M., Burke, J. P., and Jarvis, W. R. (1992) Infect. Control. Hosp. Epidemiol. 13, 201-206
31. Mett, H., Rosta, S., Schacher, B., and Frei, R. (1988) Rev. Infect. Dis. 10, 765-819
32. Walsh, T. R., Payne, D. J., Neville, T., Tolson, D., MacGowan, A. P., and Bennett, P. M. (1997) Antimicrob. Agents Chemother. 41, 1460-1462
33. Walsh, T. R., Hall, L., Assinder, S. J., Nichols, W. W., Cartwright, S. J., MacGowan, A. P., and Bennett, P. M. (1994) Biochim. Biophys. Acta 1218, 199-201
34. Crowder, M. W., Walsh, T. R., Banovic, L., Pettit, M., and Spencer, J. (1998) Antimicrob. Agents Chemother. 42, 921-926
35. Ullah, J. H., Walsh, T. R., Taylor, I. A., Emery, D. C., Verma, C. S., Gamblin, S. J., and Spencer, J. (1998) J. Mol. Biol. 284, 125-136
36. Carfi, A., Paul-Soto, R., Martin, L., Petillot, Y., Frere, J. M., and Dideberg, O. (1997) Acta Crystallogr. Sect. D 53, 485-487
37. Bernstein, N. J., and Pratt, R. F. (1999) Biochemistry 38, 10499-10510
38. Diaz, N., Suarez, D., and Merz, K. M. (2000) J. Am. Chem. Soc. 122, 4197-4208
39. Caselli, E., Powers, R. A., Blasczcak, L. C., Wu, C. Y. E., Prati, F., and Shoichet, B. K. (2000) Chem. Biol. 49, 1-16
40. Suarez, D., and Merz, K. M. (2001) J. Am. Chem. Soc. 123, 3759-3770
41. Concha, N. O., Rasmussen, B. A., Bush, K., and Herzberg, O. (1996) Structure 4, 823-836
42. Salsbury, F. R., Crowley, M. F., and Brooks, C. L. (2001) Proteins Struct. Fund. Genet. 44, 448-459
43. Spencer, J., Clark, A. R., and Walsh, T. R. (2001) J. Biol. Chem. 276, 33638-33644
44. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning: A Laboratory Manual, 2nd Ed., p. E39, Cold Spring Harbor Laboratory Press. Cold Spring Harbor Laboratory, NY
45. Carenbauer, A. L., Garrity, J. A., Periyannan, G., Yates, R. B., and Crowder, M. W. (2002) BMC Biochem 3, 4-10
46. Stewart, J. D., Roberts, V. A., Thomas, N. R., Getzoff, E. D., and Benkovic, S. J. (1994) Biochemistry 33, 1994-2003
47. Lobley, A., Whitmore, L., and Wallace, B. A. (2002) Bioinformatics 18, 211-212
48. Lobley, A., and Wallace, B. A. (2001) Biophys. J. 80, 1570
49. Segel, I. H. (1993) Enzyme Kinetics, pp. 44-53, John Wiley and Sons, Inc., New York
50. Fersht, A. (1985) Enzyme Structure and Mechanism, 2nd Ed., pp. 420-455, W. H. Freeman and Co., New York
51. Edelhoch, H. (1967) Biochemistry 6, 1948-1954
52. Garrity, J. D., Carenbauer, A. L., Herron, L. R., and Crowder, M. W. (2004) J. Biol. Chem. 279, 920-927
53. Orellano, E. G., Girardini, J. E., Cricco, J. A., Ceccarelli, E. A., and Vila, A. J. (1998) Biochemistry 37, 10173-10180
54. Aung, H. P., Bocola, M., Schleper, S., and Rohm, K. H. (2000) Biochim. Biophys. Acta 1481, 349-359
55. Wang, Z., Fast, W., and Benkovic, S. J. (1999) Biochemistry 38, 10013-10023