메뉴 건너뛰기




Volumn 3, Issue 6, 2008, Pages 655-669

Update on in vitro cytotoxicity assays for drug development

Author keywords

Apoptosis; Cytostasis; Cytotoxicity; Fluorescence; High throughput; Luminescence; Multi parametric; Multiplex; Necrosis; Resazurin; Tetrazolium; Viability

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ADENOSINE TRIPHOSPHATE; ADENYLATE KINASE; FIREFLY LUCIFERASE; GLYCERALDEHYDE 3 PHOSPHATE; LACTATE DEHYDROGENASE; OXIDOREDUCTASE; PROTEINASE; REAGENT; RESAZURIN; TETRAZOLIUM;

EID: 45949085183     PISSN: 17460441     EISSN: None     Source Type: Journal    
DOI: 10.1517/17460441.3.6.655     Document Type: Review
Times cited : (117)

References (115)
  • 1
    • 0018894938 scopus 로고
    • Cytotoxicity of drugs and diverse chemical agents to cell cultures
    • Horvath S. Cytotoxicity of drugs and diverse chemical agents to cell cultures. Toyicology 1980;16:59-66
    • (1980) Toyicology , vol.16 , pp. 59-66
    • Horvath, S.1
  • 2
    • 0032029489 scopus 로고    scopus 로고
    • Direct measurement of cell numbers in microtitre plate cultures using the fluorescent dye SYBR green I
    • Myers M. Direct measurement of cell numbers in microtitre plate cultures using the fluorescent dye SYBR green I. J Immunol Methods 1998;212:99-103
    • (1998) J Immunol Methods , vol.212 , pp. 99-103
    • Myers, M.1
  • 3
    • 0024315565 scopus 로고
    • Viability measurements in mammalian cell systems
    • Cook J, Mitchell J. Viability measurements in mammalian cell systems. Anal Biochem 1989;179:1-7
    • (1989) Anal Biochem , vol.179 , pp. 1-7
    • Cook, J.1    Mitchell, J.2
  • 4
    • 0021990499 scopus 로고
    • Toxicity determined in vitro by morphological alterations and neutral red absorption
    • Borenfruend E, Puerner J. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol Lett 1985;24:119-24
    • (1985) Toxicol Lett , vol.24 , pp. 119-124
    • Borenfruend, E.1    Puerner, J.2
  • 5
    • 2342510973 scopus 로고    scopus 로고
    • Use of multiple assay endpoints to investigate the effects of incubation time, dose of toxin, and plating density in cell-based cytotoxicity assays
    • Riss T, Moravec R. Use of multiple assay endpoints to investigate the effects of incubation time, dose of toxin, and plating density in cell-based cytotoxicity assays. Assay Drug Dev Technol 2004;2:51-62
    • (2004) Assay Drug Dev Technol , vol.2 , pp. 51-62
    • Riss, T.1    Moravec, R.2
  • 6
    • 0035433420 scopus 로고    scopus 로고
    • Four deaths and a funeral: From caspases to alternative mechanisms
    • Leist M, Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat Rev 2001;2:1-10
    • (2001) Nat Rev , vol.2 , pp. 1-10
    • Leist, M.1    Jaattela, M.2
  • 7
    • 0034892623 scopus 로고    scopus 로고
    • Disruption of mitochondrial function and cellular ATP levels by amiodarone and N-desethylamiodarone in initiation of amiodarone-induced pulmonary cytotoxicity
    • Bolt M, Card J, Racz W, et al. Disruption of mitochondrial function and cellular ATP levels by amiodarone and N-desethylamiodarone in initiation of amiodarone-induced pulmonary cytotoxicity. J Pharmacol Exp Ther 2001;298:1280
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 1280
    • Bolt, M.1    Card, J.2    Racz, W.3
  • 8
    • 0031958219 scopus 로고    scopus 로고
    • Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells
    • Chen Q, Cederbaum A. Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells. Mol Pharmacol 1998;53:638
    • (1998) Mol Pharmacol , vol.53 , pp. 638
    • Chen, Q.1    Cederbaum, A.2
  • 9
    • 14344259481 scopus 로고    scopus 로고
    • Physiologically attainable concentrations of lycopene induce mitochondrial apoptosis in LNCaP human prostate cancer cells
    • Hantz H, Young L, Martin K. Physiologically attainable concentrations of lycopene induce mitochondrial apoptosis in LNCaP human prostate cancer cells. Exp Biol Med 2005;230:171-9
    • (2005) Exp Biol Med , vol.230 , pp. 171-179
    • Hantz, H.1    Young, L.2    Martin, K.3
  • 10
    • 37549063419 scopus 로고    scopus 로고
    • Is cell death a critical end point for anticancer therapies or is cytostasis sufficient?
    • Rixie O, Fojo T. Is cell death a critical end point for anticancer therapies or is cytostasis sufficient? Clin Cancer Res 2007;13:7280-7
    • (2007) Clin Cancer Res , vol.13 , pp. 7280-7287
    • Rixie, O.1    Fojo, T.2
  • 11
    • 15544363185 scopus 로고    scopus 로고
    • Calculating the probability of detection for inhibitors in enzymatic or binding reactions in high throughput screening
    • Buxser S, Vroegop S. Calculating the probability of detection for inhibitors in enzymatic or binding reactions in high throughput screening. Anal Biochem 2005;340:1-13
    • (2005) Anal Biochem , vol.340 , pp. 1-13
    • Buxser, S.1    Vroegop, S.2
  • 12
    • 33746789921 scopus 로고    scopus 로고
    • Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries
    • Inglese J, Auld D, Jadhav A, et al. Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci USA 2006;103:11473-8
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 11473-11478
    • Inglese, J.1    Auld, D.2    Jadhav, A.3
  • 13
    • 40849137783 scopus 로고    scopus 로고
    • Compound cytotoxicity profilling using quantitative high-throughput screening
    • Xia M, Huang R, Witt K, et al. Compound cytotoxicity profilling using quantitative high-throughput screening. Environ Health Perspect 2008;116:284-91
    • (2008) Environ Health Perspect , vol.116 , pp. 284-291
    • Xia, M.1    Huang, R.2    Witt, K.3
  • 14
    • 16244362671 scopus 로고    scopus 로고
    • Apoptosis, pyroptosis, and necrosis: Mechanistic description of dead and dying eukaryotic cells
    • Fink S, Cookson B. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect Immun 2005;73:1907-16
    • (2005) Infect Immun , vol.73 , pp. 1907-1916
    • Fink, S.1    Cookson, B.2
  • 15
    • 0028891783 scopus 로고
    • Apoptosis, oncosis, and necrosis: An overview of cell death
    • Majno G, Joris I. Apoptosis, oncosis, and necrosis: an overview of cell death. Am J Pathol 1995;146:3-15
    • (1995) Am J Pathol , vol.146 , pp. 3-15
    • Majno, G.1    Joris, I.2
  • 16
    • 0019225636 scopus 로고
    • Cell death: The significance of apoptosis
    • Wyllie A, Kerr J, Currie A. Cell death: the significance of apoptosis. Int Rev Cytol 1980;68:251-306
    • (1980) Int Rev Cytol , vol.68 , pp. 251-306
    • Wyllie, A.1    Kerr, J.2    Currie, A.3
  • 17
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immun Methods 1983;65:55-63
    • (1983) J Immun Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 18
    • 0035001145 scopus 로고    scopus 로고
    • Evaluation of hepatic subcellular fractions for Alamar Blue and MTT reductase activity
    • Gonzalez P, Tarloff J. Evaluation of hepatic subcellular fractions for Alamar Blue and MTT reductase activity. Toxicol In Vitro 2001;15:257-9
    • (2001) Toxicol In Vitro , vol.15 , pp. 257-259
    • Gonzalez, P.1    Tarloff, J.2
  • 19
    • 84965822602 scopus 로고
    • Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay
    • Alley M, Scudiero D, Monks A, et al. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res 1988;48:589-601
    • (1988) Cancer Res , vol.48 , pp. 589-601
    • Alley, M.1    Scudiero, D.2    Monks, A.3
  • 20
    • 0023792919 scopus 로고
    • Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines
    • Scudiero D, Shoemaker R, Paull K, et al. Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines. Cancer Res 1988;48:4827-33
    • (1988) Cancer Res , vol.48 , pp. 4827-4833
    • Scudiero, D.1    Shoemaker, R.2    Paull, K.3
  • 21
    • 84986452945 scopus 로고
    • The synthesis of XTT: A new tetrazolium reagent that is bioreducible to a water-soluble formazan
    • Paull K, Shoemaker R, Boyd M, et al. The synthesis of XTT: a new tetrazolium reagent that is bioreducible to a water-soluble formazan. J Heterocyclic Chem 1988;25:911
    • (1988) J Heterocyclic Chem , vol.25 , pp. 911
    • Paull, K.1    Shoemaker, R.2    Boyd, M.3
  • 22
    • 0025799991 scopus 로고
    • An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium, salt XTT
    • Roehm N, Rodgers G, Hatfield S, et al. An improved colorimetric assay for cell proliferation and viability utilizing the tetrazolium, salt XTT. J Immunol Methods 1991;142:257-65
    • (1991) J Immunol Methods , vol.142 , pp. 257-265
    • Roehm, N.1    Rodgers, G.2    Hatfield, S.3
  • 23
    • 0026066853 scopus 로고
    • 5-(3-carboxymethoxyphenyl)-2-(4,5-dimethylthiazoly)-3-(4-sulfophenyl) tetrazolium, inner salt (MTS) and related analogs of 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT) reducing to purple water-soluble formazans as cell-viability indicators
    • Barltrop J, Owen T. 5-(3-carboxymethoxyphenyl)-2-(4,5-dimethylthiazoly)-3-(4-sulfophenyl) tetrazolium, inner salt (MTS) and related analogs of 3-(4,5-dimethylthiazolyl)-2,5-diphenyltetrazolium bromide (MTT) reducing to purple water-soluble formazans as cell-viability indicators. Bioorg Med Chem Lett 1991;1:611-4
    • (1991) Bioorg Med Chem Lett , vol.1 , pp. 611-614
    • Barltrop, J.1    Owen, T.2
  • 24
    • 0025899234 scopus 로고
    • Use of an aqueous soluble tetrazolium/ formazan assay for cell growth assays in culture
    • Cory A, Owen T, Barltrop J, et al. Use of an aqueous soluble tetrazolium/ formazan assay for cell growth assays in culture. Cancer Commun 1991;3:207-12
    • (1991) Cancer Commun , vol.3 , pp. 207-212
    • Cory, A.1    Owen, T.2    Barltrop, J.3
  • 25
    • 0027249291 scopus 로고
    • A new sutfonated tetrazolium salt that produces a highly water soluble formazan dye
    • Ishiyama M, Masanobu S, Sasamoto K. A new sutfonated tetrazolium salt that produces a highly water soluble formazan dye. Chem Pharm Bull 1993;41:1118-22
    • (1993) Chem Pharm Bull , vol.41 , pp. 1118-1122
    • Ishiyama, M.1    Masanobu, S.2    Sasamoto, K.3
  • 26
    • 85010246221 scopus 로고
    • Investigation of resazurin as an indicator of the sanitary condition of milk
    • Ramsdell G, Johnson W, Evans F. Investigation of resazurin as an indicator of the sanitary condition of milk. J Dairy Sci 1935;18:705-17
    • (1935) J Dairy Sci , vol.18 , pp. 705-717
    • Ramsdell, G.1    Johnson, W.2    Evans, F.3
  • 27
    • 0343339309 scopus 로고    scopus 로고
    • Antibiotic and cytotoxic drug susceptibility assays using resazurin and poising agents
    • US5501959;
    • Alamar Biosciences Laboratory. Antibiotic and cytotoxic drug susceptibility assays using resazurin and poising agents. US5501959; 1996
    • (1996)
  • 28
    • 0033856957 scopus 로고    scopus 로고
    • Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
    • O'Brien J, Wilson I, Orton T, et al. Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. Eur J Biochem 2000;267:5421-6
    • (2000) Eur J Biochem , vol.267 , pp. 5421-5426
    • O'Brien, J.1    Wilson, I.2    Orton, T.3
  • 29
    • 0027249667 scopus 로고
    • A new fluorometric assay for cytotoxicity measurements in vitro
    • Page B, Page M, Noel C. A new fluorometric assay for cytotoxicity measurements in vitro. Int J Oncol 1993;3:473-6
    • (1993) Int J Oncol , vol.3 , pp. 473-476
    • Page, B.1    Page, M.2    Noel, C.3
  • 30
    • 0028997346 scopus 로고
    • Comparison of a novel redox dye cell growth assay to the ATP bioluminescence assay
    • Squatrito R, Connor J, Buller R. Comparison of a novel redox dye cell growth assay to the ATP bioluminescence assay. Gynecol Oncol 1995;58:101-5
    • (1995) Gynecol Oncol , vol.58 , pp. 101-105
    • Squatrito, R.1    Connor, J.2    Buller, R.3
  • 31
    • 3142606712 scopus 로고    scopus 로고
    • Comparison of alamar blue and MTT assays for high through-put screening
    • Hamid R, Rotshteyn Y, Rabadi L, et al. Comparison of alamar blue and MTT assays for high through-put screening. Toxicol In Vitro 2004;18:703-10
    • (2004) Toxicol In Vitro , vol.18 , pp. 703-710
    • Hamid, R.1    Rotshteyn, Y.2    Rabadi, L.3
  • 32
    • 0038433339 scopus 로고    scopus 로고
    • The mitochondrial uncoupler dicurnerol disrupts the MTT assay
    • Collier A, Pritsos C. The mitochondrial uncoupler dicurnerol disrupts the MTT assay. Biochem Pharm 2003;66:281-7
    • (2003) Biochem Pharm , vol.66 , pp. 281-287
    • Collier, A.1    Pritsos, C.2
  • 33
    • 0030600373 scopus 로고    scopus 로고
    • Growth hormone-responsive DT-diaphorase-mediated bioreduction of tetrazolium salts
    • Goodwin C, Holt S, Riley P, et al. Growth hormone-responsive DT-diaphorase-mediated bioreduction of tetrazolium salts. Biochem Biophys Res Commun 1996;226:935-41
    • (1996) Biochem Biophys Res Commun , vol.226 , pp. 935-941
    • Goodwin, C.1    Holt, S.2    Riley, P.3
  • 34
    • 0027179465 scopus 로고
    • Genistein inhibits tumour cell growth in vitro but enhances mitochondrial reduction of tetrazolitun salts: A further pitfall in the use of the MTT assay for evaluating cell growth and survival
    • Pagliacci M, Spinozzi F, Migliorati G, et al. Genistein inhibits tumour cell growth in vitro but enhances mitochondrial reduction of tetrazolitun salts: a further pitfall in the use of the MTT assay for evaluating cell growth and survival. Eur J Cancer 1993;29:1573-7
    • (1993) Eur J Cancer , vol.29 , pp. 1573-1577
    • Pagliacci, M.1    Spinozzi, F.2    Migliorati, G.3
  • 35
    • 34247156760 scopus 로고    scopus 로고
    • Comparison of results of the CellTiter Blue, the temazolium and the lactate dehydrogenase assay applied in brain cells after exposure to advanced glycation endproducts
    • Bigll K, Schmitt A, Meiners I, et al. Comparison of results of the CellTiter Blue, the temazolium and the lactate dehydrogenase assay applied in brain cells after exposure to advanced glycation endproducts. Toxicol In Vitro 2007;21:962-71
    • (2007) Toxicol In Vitro , vol.21 , pp. 962-971
    • Bigll, K.1    Schmitt, A.2    Meiners, I.3
  • 36
    • 0025738516 scopus 로고
    • Tetrazolium-based assays for cellular viability: A critical esamination of selected parameters affecting formazan production
    • Vistica D, Skehan P, Scudiero D, et al. Tetrazolium-based assays for cellular viability: a critical esamination of selected parameters affecting formazan production. Cancer Res 1991;51:2515-20
    • (1991) Cancer Res , vol.51 , pp. 2515-2520
    • Vistica, D.1    Skehan, P.2    Scudiero, D.3
  • 37
    • 0024356008 scopus 로고
    • Effects of pH dependence of 3-(4,5-dimethylthiazol-2-yl)-25-diphenyltetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay
    • Plumb J, Milroy R, Kaye S. Effects of pH dependence of 3-(4,5-dimethylthiazol-2-yl)-25-diphenyltetrazolium bromide-formazan absorption on chemosensitivity determined by a novel tetrazolium-based assay. Cancer Res 1989;49:4435-40
    • (1989) Cancer Res , vol.49 , pp. 4435-4440
    • Plumb, J.1    Milroy, R.2    Kaye, S.3
  • 38
    • 0027499070 scopus 로고
    • The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity
    • Crouch S, Kozlowski R, Slater K, et al. The use of ATP bioluminescence as a measure of cell proliferation and cytotoxicity. J Immuno Methods 1993;160:81-8
    • (1993) J Immuno Methods , vol.160 , pp. 81-88
    • Crouch, S.1    Kozlowski, R.2    Slater, K.3
  • 39
    • 0022959403 scopus 로고
    • Estimation of biomass in growing cell lines by ATP assay
    • Lundin A. Estimation of biomass in growing cell lines by ATP assay. Methods Enzymol 1986;133:27-42
    • (1986) Methods Enzymol , vol.133 , pp. 27-42
    • Lundin, A.1
  • 40
    • 0024375745 scopus 로고
    • Lymphocyte activation: Changes in intracellular adenosine triphosphate and deoxyribonucleic acid synthesis
    • White AG, Raju KT, Keddie S, Abouria GM. Lymphocyte activation: changes in intracellular adenosine triphosphate and deoxyribonucleic acid synthesis. Immunol Lett 1989;22:47-50
    • (1989) Immunol Lett , vol.22 , pp. 47-50
    • White, A.G.1    Raju, K.T.2    Keddie, S.3    Abouria, G.M.4
  • 41
    • 0018668502 scopus 로고
    • Analytical luminescence: Its potential in the clinical laboratory
    • Whitehead T, Kricka L, Carter T, et al. Analytical luminescence: its potential in the clinical laboratory. Clin Chem 1979;25:1531-46
    • (1979) Clin Chem , vol.25 , pp. 1531-1546
    • Whitehead, T.1    Kricka, L.2    Carter, T.3
  • 42
    • 45949102287 scopus 로고    scopus 로고
    • Promega Corporation. Method for detection of ATP. US7083911; 2006
    • Promega Corporation. Method for detection of ATP. US7083911; 2006
  • 43
    • 0242442191 scopus 로고    scopus 로고
    • editors, Bioluminescence and chemiluminescence, perspectives for the 21st century. John Wiley & Sons: Chichester, UK;
    • Hall M, Gruber M, Hannah R, et al. Stabilization of firefly luciferase using directed evolution. In: Roda A, Pazzagli M, Kricka L, et al. editors, Bioluminescence and chemiluminescence - perspectives for the 21st century. John Wiley & Sons: Chichester, UK; 1998. p. 392-5.
    • (1998) Stabilization of firefly luciferase using directed evolution , pp. 392-395
    • Hall, M.1    Gruber, M.2    Hannah, R.3
  • 44
    • 33846859994 scopus 로고    scopus 로고
    • Development and validation of a high-throughput screen for inhibitors of SARS CoV and its application in screening of a 100,000-compound library
    • Severson W, Shindo N, Sosa M, et al. Development and validation of a high-throughput screen for inhibitors of SARS CoV and its application in screening of a 100,000-compound library. J Biomol Screen 2007;12:33-40
    • (2007) J Biomol Screen , vol.12 , pp. 33-40
    • Severson, W.1    Shindo, N.2    Sosa, M.3
  • 45
    • 34249903654 scopus 로고    scopus 로고
    • Optimization procedure for small interfering RNA transfection in a 384-well format
    • Borawskii J, Lindeman A, Buxton F, et al. Optimization procedure for small interfering RNA transfection in a 384-well format. J Biomol Screen 2007;12:546-59
    • (2007) J Biomol Screen , vol.12 , pp. 546-559
    • Borawskii, J.1    Lindeman, A.2    Buxton, F.3
  • 46
    • 34047128107 scopus 로고    scopus 로고
    • A simple, no-wash cell adhesion-based high throughput assay for the discovery of a small-molecule regulators of the integrin CD11b/CD18
    • Park J, Arnaout M, Gupta V. A simple, no-wash cell adhesion-based high throughput assay for the discovery of a small-molecule regulators of the integrin CD11b/CD18. J Biomol Screen 2007;12:406-17
    • (2007) J Biomol Screen , vol.12 , pp. 406-417
    • Park, J.1    Arnaout, M.2    Gupta, V.3
  • 47
    • 34547811380 scopus 로고    scopus 로고
    • 2+ activated photoprotein, Photina®, and its application to high-throughput screening
    • 2+ activated photoprotein, Photina®, and its application to high-throughput screening. J Biomol Screen 2007;12:694-704
    • (2007) J Biomol Screen , vol.12 , pp. 694-704
    • Bovolenta, S.1    Foti, M.2    Lohmer, S.3
  • 48
    • 24944574525 scopus 로고    scopus 로고
    • Small interfering RNA and gene expresión análisis using a multiplex branched DNA assays without RNA purification
    • Zhang A, Pastor L, Nguyen Q, et al. Small interfering RNA and gene expresión análisis using a multiplex branched DNA assays without RNA purification. J Biomol Screen 2005;10:549-56
    • (2005) J Biomol Screen , vol.10 , pp. 549-556
    • Zhang, A.1    Pastor, L.2    Nguyen, Q.3
  • 49
    • 45949107585 scopus 로고    scopus 로고
    • Selecting cell-based assays for drug discovery screening
    • Riss T. Selecting cell-based assays for drug discovery screening. Cell Notes 2005;13:16-21
    • (2005) Cell Notes , vol.13 , pp. 16-21
    • Riss, T.1
  • 50
    • 33846865304 scopus 로고    scopus 로고
    • Three mechanistically distinct kinase assays compared: Measurement of intrinsic ATPase activity identified the most comprehensive set of ITK inhibitors
    • Kashem M, Nelson R, Yingling J, et al. Three mechanistically distinct kinase assays compared: measurement of intrinsic ATPase activity identified the most comprehensive set of ITK inhibitors. J Biomol Screen 2007;12:70-83
    • (2007) J Biomol Screen , vol.12 , pp. 70-83
    • Kashem, M.1    Nelson, R.2    Yingling, J.3
  • 51
    • 0021038289 scopus 로고
    • An enzyme-release assay for natural cytotoxicity
    • Korzeniewski C, Callewaert D. An enzyme-release assay for natural cytotoxicity. J Immunol Methods 1983;64:211-24
    • (1983) J Immunol Methods , vol.64 , pp. 211-224
    • Korzeniewski, C.1    Callewaert, D.2
  • 52
    • 0023738916 scopus 로고
    • A quick and simple method for the quantification of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity
    • Decker T, Lohmann-Matthes M. A quick and simple method for the quantification of lactate dehydrogenase release in measurements of cellular cytotoxicity and tumor necrosis factor (TNF) activity. J Immunol Methods 1988;115:61-9
    • (1988) J Immunol Methods , vol.115 , pp. 61-69
    • Decker, T.1    Lohmann-Matthes, M.2
  • 53
    • 2442453799 scopus 로고    scopus 로고
    • Introducing the CytoTox-ONE homogeneous membrane integrity assay
    • Riss T, Moravec R. Introducing the CytoTox-ONE homogeneous membrane integrity assay. Cell Notes 2002;4:6-9
    • (2002) Cell Notes , vol.4 , pp. 6-9
    • Riss, T.1    Moravec, R.2
  • 54
    • 17044427901 scopus 로고    scopus 로고
    • A high-throughput screen to identify inhibitors of amyloid β-protein precursor processing
    • Bakshi P, Liao Y-F, Gao J, et al. A high-throughput screen to identify inhibitors of amyloid β-protein precursor processing. J Biomol Screen 2005;10:1-12
    • (2005) J Biomol Screen , vol.10 , pp. 1-12
    • Bakshi, P.1    Liao, Y.-F.2    Gao, J.3
  • 55
    • 36549042842 scopus 로고    scopus 로고
    • Phage display screening of epithelial cell monolayers treated with EGTA: Identification of pepride FDFWITP that modulates tight junction activity
    • Herman R, Makeinko M, Prieve M, et al. Phage display screening of epithelial cell monolayers treated with EGTA: identification of pepride FDFWITP that modulates tight junction activity. J Biomol Screen 2007;12:1092-101
    • (2007) J Biomol Screen , vol.12 , pp. 1092-1101
    • Herman, R.1    Makeinko, M.2    Prieve, M.3
  • 56
    • 0346251031 scopus 로고    scopus 로고
    • Brucella abortus rough mutants are cytopathic for macrophages in culture
    • Pei J, Ficht T. Brucella abortus rough mutants are cytopathic for macrophages in culture. Infect Immun 2004;72:440-50
    • (2004) Infect Immun , vol.72 , pp. 440-450
    • Pei, J.1    Ficht, T.2
  • 57
    • 0041854306 scopus 로고    scopus 로고
    • The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity
    • Hasinoff B, Schroeder P, Patel D. The metabolites of the cardioprotective drug dexrazoxane do not protect myocytes from doxorubicin-induced cytotoxicity. Mol Pharmacol 2003;64:67
    • (2003) Mol Pharmacol , vol.64 , pp. 67
    • Hasinoff, B.1    Schroeder, P.2    Patel, D.3
  • 58
    • 0022481996 scopus 로고
    • Production of arachidonic acid metabolites by endothelial cells in hyperoxia
    • Jackson R, Chandler D, Fulmer J. Production of arachidonic acid metabolites by endothelial cells in hyperoxia. J Appl Physiol 1986;61:584
    • (1986) J Appl Physiol , vol.61 , pp. 584
    • Jackson, R.1    Chandler, D.2    Fulmer, J.3
  • 59
    • 0017356233 scopus 로고
    • In vitro inhibition of lactate dehydrogenases by kepone
    • Anderson B, Noble C. In vitro inhibition of lactate dehydrogenases by kepone. J Agric Food Chem 1977;25:8-31
    • (1977) J Agric Food Chem , vol.25 , pp. 8-31
    • Anderson, B.1    Noble, C.2
  • 60
    • 0025221316 scopus 로고
    • Inhibition of lactate dehydrogenase isoenzymes by sodium perchlorate evaluated
    • Sanders G, van der Neut E, Straalen J. Inhibition of lactate dehydrogenase isoenzymes by sodium perchlorate evaluated. Clin Chem 1990;36:1964-66
    • (1990) Clin Chem , vol.36 , pp. 1964-1966
    • Sanders, G.1    van der Neut, E.2    Straalen, J.3
  • 61
    • 0026695858 scopus 로고
    • Mercuric chloride-induced cytotoxicity and compensatory hypertrophy in rat kidney proximal tubular cells
    • Lash L, Zalups R. Mercuric chloride-induced cytotoxicity and compensatory hypertrophy in rat kidney proximal tubular cells. J Pharmacol Exp Ther 1992;261:819-29
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 819-829
    • Lash, L.1    Zalups, R.2
  • 62
    • 0020954049 scopus 로고
    • Leakage of adenylate kinase from stored blood cells
    • Olsson T, Gulliksson H, Palmeborn M, et al. Leakage of adenylate kinase from stored blood cells. J Appl Biochem 1983;5:437-45
    • (1983) J Appl Biochem , vol.5 , pp. 437-445
    • Olsson, T.1    Gulliksson, H.2    Palmeborn, M.3
  • 64
    • 0030880593 scopus 로고    scopus 로고
    • A very sensitive coupled luminescent assay for cytotoxicity and complement-mediated lysis
    • Corey MJ, et al. A very sensitive coupled luminescent assay for cytotoxicity and complement-mediated lysis. J Immunol Methods 1997;207:43-51
    • (1997) J Immunol Methods , vol.207 , pp. 43-51
    • Corey, M.J.1
  • 65
    • 28144456322 scopus 로고    scopus 로고
    • NK sensitivity of neuroblastoma cells determined by a highly sensitive coupled luminescent method
    • Ogbomo H, Hahn A. Geiler J, et al. NK sensitivity of neuroblastoma cells determined by a highly sensitive coupled luminescent method. Biochem Biophys Res Commun 2006;339:375-9
    • (2006) Biochem Biophys Res Commun , vol.339 , pp. 375-379
    • Ogbomo, H.1    Hahn, A.2    Geiler, J.3
  • 66
    • 41949112250 scopus 로고    scopus 로고
    • A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker
    • Cho M-H, Niles A, Huang R, et al. A bioluminescent cytotoxicity assay for assessment of membrane integrity using a proteolytic biomarker. Toxicol In Vitro 2008;22:1099-106
    • (2008) Toxicol In Vitro , vol.22 , pp. 1099-1106
    • Cho, M.-H.1    Niles, A.2    Huang, R.3
  • 67
    • 1942501739 scopus 로고    scopus 로고
    • Idendfication of GAPDH as a protein target of the saframycin antiproliferative agents
    • Xing C, LaPorte J, Barbay J. Idendfication of GAPDH as a protein target of the saframycin antiproliferative agents. Proc Natl Acad Sci USA 2004;101:5862-6
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 5862-5866
    • Xing, C.1    LaPorte, J.2    Barbay, J.3
  • 68
    • 34548101969 scopus 로고    scopus 로고
    • Involvement of glyceraldehyde-3-phosphate dehydrogenase in tumor necrosis factor-related apoptosis-inducing ligand mediated death of thyroid cancer cells
    • Du Z-X, Wang H-Q, Zhang H-Y, et al. Involvement of glyceraldehyde-3-phosphate dehydrogenase in tumor necrosis factor-related apoptosis-inducing ligand mediated death of thyroid cancer cells. Endocrinology 2007;148:4352-61
    • (2007) Endocrinology , vol.148 , pp. 4352-4361
    • Du, Z.-X.1    Wang, H.-Q.2    Zhang, H.-Y.3
  • 69
    • 0027285626 scopus 로고
    • Exogenous nitric oxide (NO) generation or IL-1β-induced intracellular NO production stimulates inhibitory auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase in RINm5F cells
    • Dimmeler S, Ankarcrona M, Nicotera P, et al. Exogenous nitric oxide (NO) generation or IL-1β-induced intracellular NO production stimulates inhibitory auto-ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase in RINm5F cells. J Immunol 1993;150:2964-71
    • (1993) J Immunol , vol.150 , pp. 2964-2971
    • Dimmeler, S.1    Ankarcrona, M.2    Nicotera, P.3
  • 70
    • 0030022523 scopus 로고    scopus 로고
    • Oxidative stress increases glyceraldehyde-3-phosphate dehydrogenase mRNA levels in isolated rabbit aorta
    • Ito Y, Pagano K, Tornheim P, et al. Oxidative stress increases glyceraldehyde-3-phosphate dehydrogenase mRNA levels in isolated rabbit aorta. Am J Physiol Heart Circ Physiol 1996;270:H81-7
    • (1996) Am J Physiol Heart Circ Physiol , vol.270
    • Ito, Y.1    Pagano, K.2    Tornheim, P.3
  • 71
    • 0031458495 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor BB-induced expression of glyceraldehyde-3-phosphate dehydrogenase by sodium butyrate in rat vascular smooth muscle cells
    • Ranganna K, Yatsu F. Inhibition of platelet-derived growth factor BB-induced expression of glyceraldehyde-3-phosphate dehydrogenase by sodium butyrate in rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 1997;17:3420-7
    • (1997) Arterioscler Thromb Vasc Biol , vol.17 , pp. 3420-3427
    • Ranganna, K.1    Yatsu, F.2
  • 72
    • 33845743957 scopus 로고    scopus 로고
    • Aurora kinases: New targets for cancer therapy
    • Carvajal R, Tse A, Schwartz G. Aurora kinases: new targets for cancer therapy. Clin Cancer Res 2006;12:6869-75
    • (2006) Clin Cancer Res , vol.12 , pp. 6869-6875
    • Carvajal, R.1    Tse, A.2    Schwartz, G.3
  • 73
    • 0037087531 scopus 로고    scopus 로고
    • Inhibition of KIT tyrosine kinase activity: A novel molecular approach to the treatment of KIT-positive malignancies
    • Heinrich M, Blanke C, Druker B, et al. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. J Clin Oncol 2002;20:1692-703
    • (2002) J Clin Oncol , vol.20 , pp. 1692-1703
    • Heinrich, M.1    Blanke, C.2    Druker, B.3
  • 74
    • 33747042577 scopus 로고    scopus 로고
    • Emerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer a review
    • Schöffski P, Dumez H, Clement A, et al. Emerging role of tyrosine kinase inhibitors in the treatment of advanced renal cell cancer a review. Ann Oncol 2006;17:1185-96
    • (2006) Ann Oncol , vol.17 , pp. 1185-1196
    • Schöffski, P.1    Dumez, H.2    Clement, A.3
  • 75
    • 34447318869 scopus 로고    scopus 로고
    • Regulation of mitosis via mitotic kinases: New opportunities for cancer management
    • Schmit T, Nihal A. Regulation of mitosis via mitotic kinases: new opportunities for cancer management. Mol Cancer Ther 2007;6:1920-31
    • (2007) Mol Cancer Ther , vol.6 , pp. 1920-1931
    • Schmit, T.1    Nihal, A.2
  • 76
    • 39049094387 scopus 로고    scopus 로고
    • Measure relative numbers of five and dead cells and normalize assay data to cell number
    • Niles A, Scurria M, Bernad L, et al. Measure relative numbers of five and dead cells and normalize assay data to cell number. Cell Notes 2007;18:15-20
    • (2007) Cell Notes , vol.18 , pp. 15-20
    • Niles, A.1    Scurria, M.2    Bernad, L.3
  • 77
    • 34250223468 scopus 로고    scopus 로고
    • A homogeneous assay to measure live and dead cells in the same sample by detecting different protease markers
    • Niles A, Moravec R, Hesselbeth P, et al. A homogeneous assay to measure live and dead cells in the same sample by detecting different protease markers. Anal Biochem 2007;366:197-206
    • (2007) Anal Biochem , vol.366 , pp. 197-206
    • Niles, A.1    Moravec, R.2    Hesselbeth, P.3
  • 78
    • 0033571424 scopus 로고    scopus 로고
    • Fluorescent molecular probes V: A sensitive caspase-3 substrate for fluorometric assays
    • Liu J, Bhalgat M, Zhang C, et al. Fluorescent molecular probes V: a sensitive caspase-3 substrate for fluorometric assays. Bioorg Med Chem Lett 1999;9:3231-6
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 3231-3236
    • Liu, J.1    Bhalgat, M.2    Zhang, C.3
  • 79
    • 0020679785 scopus 로고
    • Rhodamine-based compounds as fluorogenic substrates for serine proteinases
    • Leytus S, Melhado L, Mangel W. Rhodamine-based compounds as fluorogenic substrates for serine proteinases. Biochem J 1983;209:299-307
    • (1983) Biochem J , vol.209 , pp. 299-307
    • Leytus, S.1    Melhado, L.2    Mangel, W.3
  • 80
    • 37849029711 scopus 로고    scopus 로고
    • MultiTox-fluor multiplex cytotoxicity assay technology
    • Niles A, Moravec R, Scurria M, et al. MultiTox-fluor multiplex cytotoxicity assay technology. Cell Notes 2006;15:11-5
    • (2006) Cell Notes , vol.15 , pp. 11-15
    • Niles, A.1    Moravec, R.2    Scurria, M.3
  • 81
    • 37849002451 scopus 로고    scopus 로고
    • Multiplexed viability, cytotoxicity and apoptosis assays for cell-based screening
    • Niles A, Worzela T, Scurria M, et al. Multiplexed viability, cytotoxicity and apoptosis assays for cell-based screening. Cell Notes 2006;16:12-5
    • (2006) Cell Notes , vol.16 , pp. 12-15
    • Niles, A.1    Worzela, T.2    Scurria, M.3
  • 82
    • 45949089494 scopus 로고    scopus 로고
    • Using protease biomarkers to measure viability and cytotoxicity
    • Niles A, Scurria M, Bernad L, et al. Using protease biomarkers to measure viability and cytotoxicity. Cell Notes 2007;19:16-20
    • (2007) Cell Notes , vol.19 , pp. 16-20
    • Niles, A.1    Scurria, M.2    Bernad, L.3
  • 83
    • 45949085276 scopus 로고    scopus 로고
    • High throughput automation of multiplexed cell viability assays for viability and cytotoxicity
    • Worzella T, Busch M, Niles A. High throughput automation of multiplexed cell viability assays for viability and cytotoxicity. Cell Notes 2008;20:26-9
    • (2008) Cell Notes , vol.20 , pp. 26-29
    • Worzella, T.1    Busch, M.2    Niles, A.3
  • 84
    • 0242361619 scopus 로고    scopus 로고
    • High throughput screening (HTS) for phototoxicity hazard using the in vitro 3T3 neutral red uptake assay
    • Jones P, King A. High throughput screening (HTS) for phototoxicity hazard using the in vitro 3T3 neutral red uptake assay. Toxicol In Vitro 2003;17:703-8
    • (2003) Toxicol In Vitro , vol.17 , pp. 703-708
    • Jones, P.1    King, A.2
  • 85
    • 0003193143 scopus 로고    scopus 로고
    • Challenges in implementing high density formats for high throughput screening
    • Rose D, Lemmo T. Challenges in implementing high density formats for high throughput screening. Lab Auto News 1997;2:12-9
    • (1997) Lab Auto News , vol.2 , pp. 12-19
    • Rose, D.1    Lemmo, T.2
  • 86
    • 0033055583 scopus 로고    scopus 로고
    • Miniaturization of a mammalian cell-based assay: Luciferase reporter gene readout in a 3 microliter 1536-well plate
    • Maffia A, Kariv I, Oldenburg K Miniaturization of a mammalian cell-based assay: luciferase reporter gene readout in a 3 microliter 1536-well plate. J Biomol Screen 1999;4:137-42
    • (1999) J Biomol Screen , vol.4 , pp. 137-142
    • Maffia, A.1    Kariv, I.2    Oldenburg, K.3
  • 87
    • 0023123751 scopus 로고
    • The ATP assay is more sensitive than the succinate dehydrogenase inhibition test for predicting cell viability
    • Maehara Y, Anai H, Tamada R, et al. The ATP assay is more sensitive than the succinate dehydrogenase inhibition test for predicting cell viability. Eur J Cancer Clin Oncol 1987;23:273-6
    • (1987) Eur J Cancer Clin Oncol , vol.23 , pp. 273-276
    • Maehara, Y.1    Anai, H.2    Tamada, R.3
  • 88
    • 0035823098 scopus 로고    scopus 로고
    • Cytotoxicity tests for high-throughput drug discovery
    • Slater K. Cytotoxicity tests for high-throughput drug discovery. Cur Opin Biotechnol 2001;12:70-4
    • (2001) Cur Opin Biotechnol , vol.12 , pp. 70-74
    • Slater, K.1
  • 89
    • 0040338446 scopus 로고    scopus 로고
    • Tumor necrosis factor-α increases ATP content in metabolically inhibited L929 cells preceding cell death
    • Sanchez-Alcazar J, Ruiz-Cabello J, Hernandez-Munoz I, et al. Tumor necrosis factor-α increases ATP content in metabolically inhibited L929 cells preceding cell death. J Biol Chem 1997;272:30167-77
    • (1997) J Biol Chem , vol.272 , pp. 30167-30177
    • Sanchez-Alcazar, J.1    Ruiz-Cabello, J.2    Hernandez-Munoz, I.3
  • 91
    • 33747813539 scopus 로고    scopus 로고
    • Evaluation of the sensitivity of three sublethal cytotoxicity assays in human HepG2 cell line using water contaminants
    • Jondeau A, Dahbi I, Bani-Estivals M-H, et al. Evaluation of the sensitivity of three sublethal cytotoxicity assays in human HepG2 cell line using water contaminants. Toxicology 2006;226:218-28
    • (2006) Toxicology , vol.226 , pp. 218-228
    • Jondeau, A.1    Dahbi, I.2    Bani-Estivals, M.-H.3
  • 92
    • 11144337396 scopus 로고    scopus 로고
    • A practical note on the use of cytotoxicity assays
    • Weyermann J, Lochmann D, Zimmer A. A practical note on the use of cytotoxicity assays. Int J Pharm 2005;288:369-76
    • (2005) Int J Pharm , vol.288 , pp. 369-376
    • Weyermann, J.1    Lochmann, D.2    Zimmer, A.3
  • 93
    • 37249052319 scopus 로고    scopus 로고
    • Different viabilities and toxicity types after 6-OHDA and Ara-C exposure evaluated by four assays in five cell lines
    • Puttonen K, Lehtonen S, Lampela P, et al. Different viabilities and toxicity types after 6-OHDA and Ara-C exposure evaluated by four assays in five cell lines. Toxicol In Vitro 2008;22:182-9
    • (2008) Toxicol In Vitro , vol.22 , pp. 182-189
    • Puttonen, K.1    Lehtonen, S.2    Lampela, P.3
  • 94
    • 0027463266 scopus 로고
    • Comparison of four in vitro cytotoxicity tests: The MTT assay, NR assay, uridine incorporation and protein measurements
    • Husoy T, Syversen T, Jenssen J. Comparison of four in vitro cytotoxicity tests: the MTT assay, NR assay, uridine incorporation and protein measurements. Toxicol In Vitro 1993;7:149-54
    • (1993) Toxicol In Vitro , vol.7 , pp. 149-154
    • Husoy, T.1    Syversen, T.2    Jenssen, J.3
  • 95
    • 37249010159 scopus 로고    scopus 로고
    • The MTT assay yields a relatively lower result of growth inhibition than the ATP assay depending on the chemotherapeutic drugs tested
    • Ulukaya E, Ozdikicioglu F, Yilmaztepe-Oral A, et al. The MTT assay yields a relatively lower result of growth inhibition than the ATP assay depending on the chemotherapeutic drugs tested. Toxicol In Vitro 2008;22:232-9
    • (2008) Toxicol In Vitro , vol.22 , pp. 232-239
    • Ulukaya, E.1    Ozdikicioglu, F.2    Yilmaztepe-Oral, A.3
  • 96
    • 33846886919 scopus 로고    scopus 로고
    • High-throughput bioluminescence screening of ubiquitin-proteasome pathway inhibitors from chemical and natural sources
    • Ausseil F, Samson A, Aussagues Y, et al. High-throughput bioluminescence screening of ubiquitin-proteasome pathway inhibitors from chemical and natural sources. J Biomol Screen 2007;12:106-16
    • (2007) J Biomol Screen , vol.12 , pp. 106-116
    • Ausseil, F.1    Samson, A.2    Aussagues, Y.3
  • 97
    • 2442521478 scopus 로고    scopus 로고
    • Use of red-shifted dyes in a fluorescence polarization AKT kinase assay for detection of biological activity in natural product extracts
    • Turek-Etienne T, Lei M, Terracciano J, et al. Use of red-shifted dyes in a fluorescence polarization AKT kinase assay for detection of biological activity in natural product extracts. J Biomol Screen 2004;9:52-61
    • (2004) J Biomol Screen , vol.9 , pp. 52-61
    • Turek-Etienne, T.1    Lei, M.2    Terracciano, J.3
  • 98
    • 17044402932 scopus 로고    scopus 로고
    • Homogeneous, bioluminescent protease assays: Caspase-3 as a model
    • O'Brien M, Daily W, Hesselberth E, et al. Homogeneous, bioluminescent protease assays: caspase-3 as a model. J Biomol Screen 2005; 10: 137-48
    • (2005) J Biomol Screen , vol.10 , pp. 137-148
    • O'Brien, M.1    Daily, W.2    Hesselberth, E.3
  • 100
    • 39049149409 scopus 로고    scopus 로고
    • Bioluminescent assays for ADMET. Expert Opin Drug Metab
    • Cali J, Niles A, Valley M, et al. Bioluminescent assays for ADMET. Expert Opin Drug Metab Toxicol 2008;4:103-20
    • (2008) Toxicol , vol.4 , pp. 103-120
    • Cali, J.1    Niles, A.2    Valley, M.3
  • 101
    • 2442470467 scopus 로고    scopus 로고
    • A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen
    • Pratt S, David C, Black-Schaefer C, et al. A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen. J Biomol Screen 2004;9:3-11
    • (2004) J Biomol Screen , vol.9 , pp. 3-11
    • Pratt, S.1    David, C.2    Black-Schaefer, C.3
  • 102
    • 37749050446 scopus 로고    scopus 로고
    • Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II)
    • Schröter T, Minond D, Scampavia L, et al. Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II). J Biomol Screen 2008;13:17-28
    • (2008) J Biomol Screen , vol.13 , pp. 17-28
    • Schröter, T.1    Minond, D.2    Scampavia, L.3
  • 103
    • 37849048301 scopus 로고    scopus 로고
    • Multiplex caspase activity and cytotoxity assays
    • Niles A, Moravec R, Riss T. Multiplex caspase activity and cytotoxity assays. Methods Mol Biol 2008;414:151-62
    • (2008) Methods Mol Biol , vol.414 , pp. 151-162
    • Niles, A.1    Moravec, R.2    Riss, T.3
  • 104
    • 34547815060 scopus 로고    scopus 로고
    • An improved β-lactamase reporter assay: Multiplexing with a cytotoxicity readout for enhanced accuracy of hit identification
    • Hallis T, Kopp A, Gibson J, et al. An improved β-lactamase reporter assay: multiplexing with a cytotoxicity readout for enhanced accuracy of hit identification. J Biomol Screen 2007;12:635-44
    • (2007) J Biomol Screen , vol.12 , pp. 635-644
    • Hallis, T.1    Kopp, A.2    Gibson, J.3
  • 105
    • 0642378377 scopus 로고    scopus 로고
    • Development of novel assays for proteolytic enzymes using rhodamine-based fluorogenic substrates
    • Grant S, Sklar J, Cummings R. Development of novel assays for proteolytic enzymes using rhodamine-based fluorogenic substrates. J Biomol Screen 2002;7:531-40
    • (2002) J Biomol Screen , vol.7 , pp. 531-540
    • Grant, S.1    Sklar, J.2    Cummings, R.3
  • 106
    • 3242668951 scopus 로고    scopus 로고
    • A dual luciferase multiplexed high-throughput screening platform for protein-protein interactions
    • Nieuwenhuijsen B, Huang Y, Wang Y, et al. A dual luciferase multiplexed high-throughput screening platform for protein-protein interactions. J Biomol Screen 2003;8:676-84
    • (2003) J Biomol Screen , vol.8 , pp. 676-684
    • Nieuwenhuijsen, B.1    Huang, Y.2    Wang, Y.3
  • 107
  • 108
    • 0346158531 scopus 로고    scopus 로고
    • High content screening applied to large-scale biology
    • Abraham V, Taylor D, Haskins J. High content screening applied to large-scale biology. Trends Biotechnol 2004;22:15-22
    • (2004) Trends Biotechnol , vol.22 , pp. 15-22
    • Abraham, V.1    Taylor, D.2    Haskins, J.3
  • 109
    • 0001341562 scopus 로고    scopus 로고
    • High-content screening: A new approach to easing key bottlenecks in the drug discovery process
    • Giuliano K, DeBiasio R, Dunlay R, et al. High-content screening: a new approach to easing key bottlenecks in the drug discovery process. J Biomol Screen 1997;2:249-59
    • (1997) J Biomol Screen , vol.2 , pp. 249-259
    • Giuliano, K.1    DeBiasio, R.2    Dunlay, R.3
  • 110
    • 32844460056 scopus 로고    scopus 로고
    • Identification of a small molecule that induces mitotic arrest using a simplified high-content screening assay and data analysis method
    • Wilson C, Si Y, Thompson C, et al. Identification of a small molecule that induces mitotic arrest using a simplified high-content screening assay and data analysis method. J Biomol Screen 2006;11:21-8
    • (2006) J Biomol Screen , vol.11 , pp. 21-28
    • Wilson, C.1    Si, Y.2    Thompson, C.3
  • 111
    • 8844262805 scopus 로고    scopus 로고
    • Cellular dielectric spectroscopy: A powerful new approach to label-free cellular analysis
    • Ciambrone G, Liu V, Lin D, et al. Cellular dielectric spectroscopy: a powerful new approach to label-free cellular analysis. J Biomol Screen 2004;9:467-80
    • (2004) J Biomol Screen , vol.9 , pp. 467-480
    • Ciambrone, G.1    Liu, V.2    Lin, D.3
  • 112
    • 31944448353 scopus 로고    scopus 로고
    • Dynamic and label-free monitoring of natural killer cell cytotoxicity using electronic cell sensor arrays
    • Zhu J, Wang X, Xu X, et al. Dynamic and label-free monitoring of natural killer cell cytotoxicity using electronic cell sensor arrays. J Immunol Methods 2006;309:25-33
    • (2006) J Immunol Methods , vol.309 , pp. 25-33
    • Zhu, J.1    Wang, X.2    Xu, X.3
  • 113
    • 33745488641 scopus 로고    scopus 로고
    • Microelectric cell sensor assay for detection of cytotoxicity and prediction of acute toxicity
    • Xing J, Zhu L, Gabos S, et al. Microelectric cell sensor assay for detection of cytotoxicity and prediction of acute toxicity. Toxicol In Vitro 2006;20:995-1004
    • (2006) Toxicol In Vitro , vol.20 , pp. 995-1004
    • Xing, J.1    Zhu, L.2    Gabos, S.3
  • 115
    • 33947229534 scopus 로고    scopus 로고
    • Online monitoring of cell metabolism for studying pharmacodynamic effects
    • Thedinga E, Kob A, Holst H, et al. Online monitoring of cell metabolism for studying pharmacodynamic effects. Toxicol Appl Pharm 2007;220:33-44
    • (2007) Toxicol Appl Pharm , vol.220 , pp. 33-44
    • Thedinga, E.1    Kob, A.2    Holst, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.