Evaluation of the potential effects of ingredients added to cigarettes. Part 3: In vitro genotoxicity and cytotoxicity

Food and Chemical Toxicology

Volumn 40, Issue 1, 2002, Pages 105-111

  Roemer, E ^a   Tewes, F J ^a   Meisgen, T J ^a   Veltel, D J ^a   Carmines, E L ^b  

^a INBIFO Inst F Biol Forschung   (Germany)

^b Philip Morris USA   (United States)

Author keywords

Ames assay; Cigarette smoke; Cytotoxicity; Flavor; Genotoxicity; In vitro toxicology; Ingredient; Mutagenicity; Neutral red uptake assay; Tobacco

Indexed keywords

CIGARETTE SMOKE; FLAVORING AGENT; MENTHOL; NEUTRAL RED;

AMES TEST; ANIMAL CELL; CHEMICAL ANALYSIS; CIGARETTE SMOKING; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; EMBRYO CELL; GAS; GENOTOXICITY; IN VITRO STUDY; MUTAGENICITY; NONHUMAN; SENSITIVITY AND SPECIFICITY; VAPOR;

3T3 CELLS; ANIMALS; CELL DEATH; EMBRYO; MICE; MICE, INBRED BALB C; MUTAGENICITY TESTS; NEUTRAL RED; SMOKE; TOBACCO;

EID: 0036132804     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(01)00086-2     Document Type: Conference Paper

References (40)

1. Protective effect of hydroxychavicol, a phenolic component of betel leaf, against the tobacco-specific carcinogens
2. Cyanide induced DNA fragmentation in mammalian cell cultures
3. Neutral red assay for toxicology in vitro
4. Comparative cytotoxicity studies of smoke condensate from different types of cigarettes and tobaccos
5. Toxicity determined in vitro by morphological alterations and neutral red absorption
6. Chemically induced cell proliferation in carcinogenesis
7. Evaluation of the potential effects of ingredients added to cigarettes. Part 1: Cigarette design, testing approach, and review of results
8. Assessing the use of known mutagens to calibrate the Salmonella typhimurium mutagenicity assay: II. With exogenous activation
9. Validation and characterization of the L5178Y/TK+/- mouse lymphoma mutagen assay system
10. Genotoxicity of tobacco smoke and tobacco smoke condensate
11. Methods of collection of smoke for analytical purposes
12. Multiple range and multiple F-tests
13. Statistical methods for short-term tests in genetic toxicology: The first fifteen years
14. Predicting rodent carcinogenicity from mutagenic potency measured in the Ames Salmonella assay
15. Screening of tobacco smoke constituents for mutagenicity using the Ames test
16. 13-Week inhalation toxicity study of menthol cigarette smoke
17. Toxicologic evaluation of flavor ingredients added to cigarette tobacco: 13-Weeks inhalation exposures in rats
18. Salmonella mutagenicity test results for 250 chemicals
19. Effects of α-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
20. Comparisons of four in vitro cytotoxicity tests: The MIT assay, NR assay, uridine incorporation and protein measurements
21. Bound aroma compounds in tobacco smoke condensates
22. Determination of mutagenic heterocyclic amines in combustion smoke samples
23. Cytotoxicity, thiol depletion and inhibition of O6-methylguanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts
24. Review of the genotoxicity of formaldehyde
25. Reviewed methods for the Salmonella mutagenicity test
26. The FEMA GRAS assessment of trans-anethole used as flavouring substance
27. OECD principles of good laboratory practice (as revised in 1997)
28. Comparative cytotoxicity of phenols in vitro
29. Anlage zur langzeit-inhalation mit zigarettenrauch für kleine labortiere
30. Discrimination of cigarette mainstream smoke condensates with the Salmonella reverse mutation assay
31. Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke
32. Studies on the mutagenicity of resorcinol and hydroxy-3-(p-amino)anilino-6,N-[(p-amino)phenol]benzoquinone-monoimine-1,4 in Salmonella typhimurium
33. Discrimination of cigarette mainstream smoke with the Neutral Red Uptake cytotoxicity assay
34. Evaluation of the potential effects of ingredients added to cigarettes. Part 4: Subchronic inhalation toxicity
35. Changes in mutagenicity of protein pyrolyzates by reaction with nitrite
36. Salmonella mutagenicity tests: V. results from the testing of 311 chemicals