ERβ ligands. Part 2: Synthesis and structure-activity relationships of a series of 4-hydroxy-biphenyl-carbaldehyde oxime derivatives

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 10, 2004, Pages 2553-2570

  Yang, Cuijian ^a   Edsall Jr , Richard ^a   Harris, Heather A ^a   Zhang, Xiaochun ^a   Manas, Eric S ^a   Mewshaw, Richard E ^a  

^a PFIZER INC   (United States)

Author keywords

Biphenyl; Biphenyl oximes; ER ; Oximes

Indexed keywords

3 CHLORO 3' FLUORO 4' HYDROXYL 1,1' BIPHENYL 4 CARBALDEHYDE OXIME; 3,5 DICHLORO 3' FLUORO 4' HYDROXY 1,1' BIPHENYL 4 CARBALDEHYDE OXIME; ESTROGEN RECEPTOR BETA; GENISTEIN; HISTIDINE; OXIME DERIVATIVE; UNCLASSIFIED DRUG; 4 HYDROXY BIPHENYL CARBALDEHYDE OXIME; 4-HYDROXY-BIPHENYL-CARBALDEHYDE OXIME; BIPHENYL DERIVATIVE; ESTROGEN RECEPTOR ALPHA; KERATIN; LIGAND; MESSENGER RNA; OXIME;

ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; MOLECULAR MODEL; RADIOASSAY; STRUCTURE ACTIVITY RELATION; BINDING COMPETITION; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG ANTAGONISM; DRUG POTENTIATION; GENE EXPRESSION REGULATION; GENETICS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

BINDING, COMPETITIVE; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; GENE EXPRESSION REGULATION; HUMANS; KERATINS; LIGANDS; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; OXIMES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RADIOLIGAND ASSAY; RNA, MESSENGER;

EID: 2142814284     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.03.028     Document Type: Article

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