ERβ ligands. Part 1: The discovery of ERβ selective ligands which embrace the 4-hydroxy-biphenyl template

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 16, 2003, Pages 3457-3474

  Edsall Jr , Richard J ^a   Harris, Heather A ^a   Manas, Eric S ^a   Mewshaw, Richard E ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' BIPHENYL 2,4' DIOL; 1,1' BIPHENYL 3,4' DIOL; 1,1':2',1'' TERPHENYL 4 OL; 2 CHLORO 1,1' BIPHENYL 4 OL; 2 METHYL 1,1' BIPHENYL 4 OL; 2' (TRIFLUOROMETHOXY) 1,1' BIPHENYL 4 OL; 2' CHLORO 1,1' BIPHENYL 4 OL; 2' FLUORO 1,1' BIPHENYL 4 OL; 2' METHOXY 1,1' BIPHENYL 4 OL; 2' METHYL 1,1' BIPHENYL 4 OL; 2',3' DICHLORO 1,1' BIPHENYL 4 OL; 2',4' DICHLORO 1,1' BIPHENYL 4 OL; 2',5' DICHLORO 1,1' BIPHENYL 4 OL; 3 CHLORO 1,1' BIPHENYL 4 OL; 3 METHYL 1,1' BIPHENYL 4 OL; 3' (TRIFLUOROMETHOXY) 1,1' BIPHENYL 4 OL; 3' FLUORO 1,1' BIPHENYL 4 OL; 3' METHOXY 1,1' BIPHENYL 4 OL; 3' METHYL 1,1' BIPHENYL 4 OL; 4' CHLORO 1,1' BIPHENYL 4 OL; 4' ETHYL 1,1' BIPHENYL 4 OL; 4' FLUORO 1,1' BIPHENYL 4 OL; 4' HYDROXY 1,1' BIPHENYL 3 CARBONITRILE; 4' METHOXY 1,1' BIPHENYL 4 OL; 4' METHYL 1,1' BIPHENYL 4 OL; BIPHENYL DERIVATIVE; ESTROGEN RECEPTOR BETA; FUNCTIONAL GROUP; LIGAND; UNCLASSIFIED DRUG; UNINDEXED DRUG; ESTROGEN RECEPTOR; GENISTEIN;

ARTICLE; DRUG SELECTIVITY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; HYDROXYLATION; IC 50; METABOLISM; PROTEIN CONFORMATION;

BIPHENYL COMPOUNDS; ESTROGEN RECEPTOR BETA; GENISTEIN; HYDROXYLATION; INHIBITORY CONCENTRATION 50; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN CONFORMATION; RECEPTORS, ESTROGEN; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0038149156     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(03)00303-1     Document Type: Article

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