메뉴 건너뛰기




Volumn 3, Issue 4, 2000, Pages 383-398

Non-steroidal ligands for steroid hormone receptors

Author keywords

Androgen receptor; Estrogen receptor; Ligand; Progesterone receptor; Steroid hormone receptors

Indexed keywords

1 (3,4 DICHLOROBENZOYL) 1,4,5,6 TETRAHYDRO 3 PHENYLPYRIDAZINE; 4 [4 METHYL 2 [4 [2 (1 PIPERIDINYL)ETHOXY]PHENYL] 7 PIVALOYLOXY 2H 1 BENZOPYRAN 3 YLPHENYL] PIVALATE; ACOLBIFENE; ARZOXIFENE; BAZEDOXIFENE; BICALUTAMIDE; CHIR 029122; DROLOXIFENE; ESTRADIOL; ESTROGEN RECEPTOR; ESTRONE; FLUTAMIDE; GW 5836; GW 5838; HYDROXYTAMOXIFEN; IDOXIFENE; LG 001447; LG 100127; LG 100128; LG 120746; LG 120830; LY 357489; MIPROXIFENE PHOSPHATE; NILUTAMIDE; PF 1092A; PROGESTERONE RECEPTOR; RALOXIFENE; STEROID HORMONE RECEPTOR BLOCKING AGENT; STEROID RECEPTOR; TAMOXIFEN; TOREMIFENE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 0033940430     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (37)

References (80)
  • 1
    • 0012473279 scopus 로고
    • The nuclear receptor superfamily: The second decade
    • Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM: 835-839.
    • Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM: The nuclear receptor superfamily: The second decade. Cell (1995) 83(6):835-839.
    • (1995) Cell , vol.83 , Issue.6
    • Mangelsdorf, D.J.1
  • 2
    • 0029618368 scopus 로고
    • Steroid hormone receptors: Many actors in search of a plot
    • Herrlich P, Schutz G: 851 -857.
    • Beato M, Herrlich P, Schutz G: Steroid hormone receptors: Many actors in search of a plot. Cell (1995) 83(6):851 -857.
    • (1995) Cell , vol.83 , Issue.6
    • Beato, M.1
  • 4
    • 0031039888 scopus 로고    scopus 로고
    • Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors a and β
    • Cartsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson J-A: 863-870.
    • Kuiper CG, Cartsson B, Grandien K, Enmark E, Haggblad J, Nilsson S, Gustafsson J-A: Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors a and β. Endocrinology (1997) 138(3):863-870.
    • (1997) Endocrinology , vol.138 , Issue.3
    • Kuiper, C.G.1
  • 6
    • 0030667676 scopus 로고    scopus 로고
    • Molecular basis of agonism and antagonism in the oestrogen receptor
    • Pike AC, Dauter Z, Hubbard RE, Bonn T, Engstrom O, Onman L, Greene GL, Gustafsson JA, Carlquist M: 753-758.
    • Brzozowski AM, Pike AC, Dauter Z, Hubbard RE, Bonn T, Engstrom O, Onman L, Greene GL, Gustafsson JA, Carlquist M: Molecular basis of agonism and antagonism in the oestrogen receptor. Nature (1997) 389{6652):753-758.
    • (1997) Nature , vol.389 , Issue.6652
    • Brzozowski, A.M.1
  • 7
    • 0032446607 scopus 로고    scopus 로고
    • The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen
    • Barstad D, Loria PM, Cheng L, Kushner PJ, Agard DA, Greene GL: 927-937. An elegant study showing the structural basis of the interaction of ERcc with a co-activator peptide and how the structural changes induced by tamoxifen eliminate this interaction.
    • Shiau AK, Barstad D, Loria PM, Cheng L, Kushner PJ, Agard DA, Greene GL: The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen. Cell (1998) 95(7):927-937. An elegant study showing the structural basis of the interaction of ERcc with a co-activator peptide and how the structural changes induced by tamoxifen eliminate this interaction.
    • (1998) Cell , vol.95 , Issue.7
    • Shiau, A.K.1
  • 8
    • 0033198735 scopus 로고    scopus 로고
    • Structure of the ligand-binding domain of oestrogen receptor βin the presence of a partial agonist and a full antagonist
    • Brzozowski AM, Hubbard RE, Bonn T, Thorsell AG, Engstrom O, Ljunggren J, Gustafsson J, Carlquist M: 4608-4618.
    • Pike AC, Brzozowski AM, Hubbard RE, Bonn T, Thorsell AG, Engstrom O, Ljunggren J, Gustafsson J, Carlquist M: Structure of the ligand-binding domain of oestrogen receptor βin the presence of a partial agonist and a full antagonist. EMBO J(1999) 18(17):4608-4618.
    • (1999) EMBO J , vol.18 , Issue.17
    • Pike, A.C.1
  • 9
    • 0031778177 scopus 로고    scopus 로고
    • Basic guide to the mechanisms of antiestrogen action
    • Jordan VC: 151-196. An extensive review of the field of anti-estrogens from the very earliest anti-estrogens to raloxifene and present day SERMs.
    • MacGregor Jl, Jordan VC: Basic guide to the mechanisms of antiestrogen action. Pharmacol Rev (1998) 50(2):151-196. An extensive review of the field of anti-estrogens from the very earliest anti-estrogens to raloxifene and present day SERMs.
    • (1998) Pharmacol Rev , vol.50 , Issue.2
    • Jl, M.1
  • 10
    • 0033552889 scopus 로고    scopus 로고
    • Emerging therapies for the prevention or treatment of postmenopausal osteoporosis
    • Grese TA, Dodge JA, Bryant HU, Turner CH: 1 :1 -24.
    • Sato M, Grese TA, Dodge JA, Bryant HU, Turner CH: Emerging therapies for the prevention or treatment of postmenopausal osteoporosis. J Med Chem (1999) 42(1 ):1 -24.
    • (1999) J Med Chem , vol.42
    • Sato, M.1
  • 11
    • 0033305454 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators: Clinical spectrum
    • Lindsay R: 418-434. Reviews the clinical effects of two SERMs, raloxifene and tamoxifen, comparing the clinical data available for both drugs.
    • Cosman F, Lindsay R: Selective estrogen receptor modulators: Clinical spectrum. Endocr Rev (1999) 20(3):418-434. Reviews the clinical effects of two SERMs, raloxifene and tamoxifen, comparing the clinical data available for both drugs.
    • (1999) Endocr Rev , vol.20 , Issue.3
    • Cosman, F.1
  • 12
    • 0031888317 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators (SERMs)
    • Dodge JA: 71-92.
    • Grese TA, Dodge JA: Selective estrogen receptor modulators (SERMs). CurrPharm Des (1998) 4(1):71-92.
    • (1998) CurrPharm Des , vol.4 , Issue.1
    • Grese, T.A.1
  • 13
    • 0345354280 scopus 로고    scopus 로고
    • Tamoxifen treatment for breast cancer: Concept to gold standard
    • 2 Suppl 1:7-13.
    • Jordan VC: Tamoxifen treatment for breast cancer: Concept to gold standard. Oncology (1997) 11(2 Suppl 1):7-13.
    • (1997) Oncology , vol.11
    • Jordan, V.C.1
  • 14
    • 0032537396 scopus 로고    scopus 로고
    • Tamoxifen for early breast cancer: An overview of the randomized trials
    • 1451-1467.
    • Early Breast Cancer Trialists1 Collaborative Group: Tamoxifen for early breast cancer: An overview of the randomized trials. J.ance/(1998) 351:1451-1467.
    • (1998) J.ance , vol.351
  • 15
    • 0033135892 scopus 로고    scopus 로고
    • Estrogen receptor as a target for the prevention of breast cancer
    • 408-414.
    • Jordan VC: Estrogen receptor as a target for the prevention of breast cancer. J Lab Clin Med (1999) 133(5):408-414.
    • (1999) J Lab Clin Med , vol.133 , Issue.5
    • Jordan, V.C.1
  • 16
    • 0032906119 scopus 로고    scopus 로고
    • Clinical pharmacology of selective estrogen receptor modulators
    • Dowsett M: 323-336.
    • Haynes B, Dowsett M: Clinical pharmacology of selective estrogen receptor modulators. Drugs Aging (1999) 14(5):323-336.
    • (1999) Drugs Aging , vol.14 , Issue.5
    • Haynes, B.1
  • 17
    • 0032537990 scopus 로고    scopus 로고
    • Tamoxifen for prevention of breast cancer: Report of the national surgical adjuvant breast and bowel project P-1 study
    • Constantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N: 1371-1388.
    • Fisher B, Constantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, Vogel V, Robidoux A, Dimitrov N, Atkins J, Daly M, Wieand S, Tan-Chiu E, Ford L, Wolmark N: Tamoxifen for prevention of breast cancer: Report of the national surgical adjuvant breast and bowel project P-1 study. J Natl Cancer Inst (1998) 90(18):1371-1388.
    • (1998) J Natl Cancer Inst , vol.90 , Issue.18
    • Fisher, B.1
  • 18
    • 0031962302 scopus 로고    scopus 로고
    • Tamoxifen and toremifene in breast cancer: Comparison of safety and efficacy
    • Hortobagyi GN: 348-353.
    • Buzdar AU, Hortobagyi GN: Tamoxifen and toremifene in breast cancer: Comparison of safety and efficacy. J Clin Onco/(1998) 16(1):348-353.
    • (1998) J Clin Onco/ , vol.16 , Issue.1
    • Buzdar, A.U.1
  • 19
    • 0027428568 scopus 로고
    • Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female CrhCD(BR) rats
    • lalropoulos MJ, Jordan K, Radi L, Kaltenberg OP, Imondi AR, Williams GM: 4534-4541.
    • Hard GC, lalropoulos MJ, Jordan K, Radi L, Kaltenberg OP, Imondi AR, Williams GM: Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female CrhCD(BR) rats. Cancer Res (1993) 53(19):4534-4541.
    • (1993) Cancer Res , vol.53 , Issue.19
    • Hard, G.C.1
  • 20
    • 0028861896 scopus 로고
    • Comparative pharmacodynamic analysis of TAT-59 and tamoxifen in rats bearing DMBA-induced mammary carcinoma
    • Shibata J, Sugimoto Y, Yamaya H, Yoshida M, Ogawa K, Matsushima E: 1-2:7-13.
    • Toko T, Shibata J, Sugimoto Y, Yamaya H, Yoshida M, Ogawa K, Matsushima E: Comparative pharmacodynamic analysis of TAT-59 and tamoxifen in rats bearing DMBA-induced mammary carcinoma. Cancer Chemother Pharmacol (1995) 37(1-2):7-13.
    • (1995) Cancer Chemother Pharmacol , vol.37
    • Toko, T.1
  • 21
    • 0032085894 scopus 로고    scopus 로고
    • Late phase II study of TAT-59 (miproxifene phosphate) in advanced or recurrent breast cancer patients (a double-blind comparative study with tamoxifen citrate)
    • Nakajima M, Tominaga T, Abe O: 1045-1063.
    • Nomura Y, Nakajima M, Tominaga T, Abe O: Late phase II study of TAT-59 (miproxifene phosphate) In advanced or recurrent breast cancer patients (a double-blind comparative study with tamoxifen citrate). Jpn J Cancer Chemother (1998) 25(7):1045-1063.
    • (1998) Jpn J Cancer Chemother , vol.25 , Issue.7
    • Nomura, Y.1
  • 22
    • 0032059042 scopus 로고    scopus 로고
    • Early phase II study of TAT59 in patients with advanced or recurrent breast cancer - A multicenter dose finding study
    • Tominaga T, Abe O: 853-865.
    • Aoyama H, Tominaga T, Abe O: Early phase II study of TAT59 in patients with advanced or recurrent breast cancer - a multicenter dose finding study. Jpn J Cancer Chemother (1998)25(6):853-865.
    • (1998) Jpn J Cancer Chemother , vol.25 , Issue.6
    • Aoyama, H.1
  • 23
    • 0030741983 scopus 로고    scopus 로고
    • Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone
    • Morris JD, Wagner BL, Asplin I, Baer P, Brown HR, Jones SA, Henke B, Sauls H, Wolfe S, Morris DC, McDonnell DP: 3901-3911.
    • Willson TM, Morris JD, Wagner BL, Asplin I, Baer P, Brown HR, Jones SA, Henke B, Sauls H, Wolfe S, Morris DC, McDonnell DP: Dissection of the molecular mechanism of action of GW5638, a novel estrogen receptor ligand, provides insights into the role of estrogen receptor in bone. Endocrinology (1997) 138(9):3901-3911.
    • (1997) Endocrinology , vol.138 , Issue.9
    • Willson, T.M.1
  • 24
    • 0028263517 scopus 로고
    • Diphenylbut-1-enylphenylacrylic acid: A non-steroidal estrogen with functional selectivity for bone over uterus in rats
    • Henke BR, Momtahen TM, Charifson PS, Batchelor KW, Lubahn, DB, Moore LB, Oliver BB, Sauls HR, Triantafillou JA, Wolfe SG, Baer PG: 3-4-{1,2- 1550-1552.
    • Willson TM, Henke BR, Momtahen TM, Charifson PS, Batchelor KW, Lubahn, DB, Moore LB, Oliver BB, Sauls HR, Triantafillou JA, Wolfe SG, Baer PG: 3-[4-{1,2-Diphenylbut-1-enyl)phenyl]acrylic acid: A non-steroidal estrogen with functional selectivity for bone over uterus in rats. J Med Chem (1994) 37(11):1550-1552.
    • (1994) J Med Chem , vol.37 , Issue.11
    • Willson, T.M.1
  • 25
    • 0030459216 scopus 로고    scopus 로고
    • Estrogenic triarylethylene acetic acids: Effect of structural variation on estrogen receptor affinity and estrogenic potency and efficacy in MCF-7 cells
    • Bourne CS, Sullivan KJ, Moore SA: 4853-4859.
    • Ruenitz PC, Bourne CS, Sullivan KJ, Moore SA: Estrogenic triarylethylene acetic acids: Effect of structural variation on estrogen receptor affinity and estrogenic potency and efficacy in MCF-7 cells. J Med Chem (1996) 39(24):4853-4859.
    • (1996) J Med Chem , vol.39 , Issue.24
    • Ruenitz, P.C.1
  • 26
    • 0033549901 scopus 로고    scopus 로고
    • Carboxylic acid analogues of tamoxifen: (2)-2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-/V,W-dimethylethylamine
    • Ruenitz PC, Bartlett MG: 3126-3133.
    • Kraft KS, Ruenitz PC, Bartlett MG: Carboxylic acid analogues of tamoxifen: (2)-2-[p-(1,2-diphenyl-1-butenyl)phenoxy]-/V,W-dimethylethylamine. Estrogen receptor affinity and estrogen antagonist effects in MCF-7 cells. J Med Chem (1999) 42(16):3126-3133.
    • (1999) Estrogen Receptor Affinity and Estrogen Antagonist Effects in MCF-7 Cells. J Med Chem , vol.42 , Issue.16
    • Kraft, K.S.1
  • 27
    • 0030664688 scopus 로고    scopus 로고
    • Effects of raloxifene on bone mineral density serum cholesterol concentrations and uterine endometrium in postmenopausal women
    • Bjamason NH, Mitlak BH, Ravoux A-C, Shah AS, Huster WJ, Draper M, Chirstiansen C: 1641-1647.
    • Delmas PD, Bjamason NH, Mitlak BH, Ravoux A-C, Shah AS, Huster WJ, Draper M, Chirstiansen C: Effects of raloxifene on bone mineral density serum cholesterol concentrations and uterine endometrium in postmenopausal women. New EnglJ Med (1997) 337(23):1641-1647.
    • (1997) New EnglJ Med , vol.337 , Issue.23
    • Delmas, P.D.1
  • 28
    • 0033989737 scopus 로고    scopus 로고
    • Uterine effects of 3-year raloxifene therapy in postmenopausal women younger than age 60
    • Watts S, Shah A, Akers R, Plouffe L Jr: 104-110.
    • Cohen FJ, Watts S, Shah A, Akers R, Plouffe L Jr: Uterine effects of 3-year raloxifene therapy in postmenopausal women younger than age 60. Obstet Gynecol (2000) 95(1):104-110.
    • (2000) Obstet Gynecol , vol.95 , Issue.1
    • Cohen, F.J.1
  • 29
    • 0033575083 scopus 로고    scopus 로고
    • The effect of raloxifene on risk of breast cancer in postmenopausal women: Results from the more randomized trial
    • Eckert S, Krueger KA, Grady D, Powles TJ, Cauley JA, Norton L, Nickelsen T, Bjamason NH, Morrow M, Lippman ME, Black D, Glusman JE, Costa A, Jordan VC: 2189-2197.
    • Cummings SR, Eckert S, Krueger KA, Grady D, Powles TJ, Cauley JA, Norton L, Nickelsen T, Bjamason NH, Morrow M, Lippman ME, Black D, Glusman JE, Costa A, Jordan VC: The effect of raloxifene on risk of breast cancer in postmenopausal women: Results from the MORE randomized trial. JAm Med Assoc (1999) 281 (23):2189-2197.
    • (1999) JAm Med Assoc , vol.281 , Issue.23
    • Cummings, S.R.1
  • 30
    • 0033552889 scopus 로고    scopus 로고
    • Emerging therapies for the prevention or treatment of postmenopausal osteoporosis
    • Grese TA, Dodge JA, Bryant HU, Turner CH: 1-24.
    • Sato M, Grese TA, Dodge JA, Bryant HU, Turner CH: Emerging therapies for the prevention or treatment of postmenopausal osteoporosis. J Med Chem (1999) 42(1):1-24.
    • (1999) J Med Chem , vol.42 , Issue.1
    • Sato, M.1
  • 31
    • 0003630405 scopus 로고    scopus 로고
    • Discovery and synthesis of [6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-(4-hydroxyphenyl)]benzo[b] thiophene: A novel, highly potent, selective estrogen receptor modulator
    • Glasebrook AL, Thrasher KJ, Hauser KL, Short LL, Phillips DL, Muehl BS, Sato M, Shetler PK, Cullinan GJ, Pell TR, Bryant HU: 1407-1416.
    • Palkowitz AD, Glasebrook AL, Thrasher KJ, Hauser KL, Short LL, Phillips DL, Muehl BS, Sato M, Shetler PK, Cullinan GJ, Pell TR, Bryant HU: Discovery and synthesis of [6-hydroxy-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-2-(4-hydroxyphenyl)]benzo[b] thiophene: A novel, highly potent, selective estrogen receptor modulator. J Med Chem (1997) 40(10):1407-1416.
    • (1997) J Med Chem , vol.40 , Issue.10
    • Palkowitz, A.D.1
  • 32
    • 0032462194 scopus 로고    scopus 로고
    • LY353381.HCI: A novel raloxifene analog with improved SERM potency and efficacy in vivo
    • Turner CH, Wang T, Adrian MD, Rowley E, Bryant HU: 1-7.
    • Sato M, Turner CH, Wang T, Adrian MD, Rowley E, Bryant HU: LY353381.HCI: A novel raloxifene analog with improved SERM potency and efficacy in vivo. J Pharmacol Exp Ther (1998)287(1):1-7.
    • (1998) J Pharmacol Exp Ther , vol.287 , Issue.1
    • Sato, M.1
  • 33
    • 85047679337 scopus 로고    scopus 로고
    • LY353381HCI: An improved benzothiophene analog with bone efficacy complementary to parathyroid hormone-(1-34)
    • Zeng GQ, Rowley E, Turner CH: 11 :4642-4651.
    • Sato M, Zeng GQ, Rowley E, Turner CH: LY353381HCI: An improved benzothiophene analog with bone efficacy complementary to parathyroid hormone-(1-34). Endocrinology (1998) 139(11 ):4642-4651.
    • (1998) Endocrinology , vol.139
    • Sato, M.1
  • 34
    • 0033583542 scopus 로고    scopus 로고
    • Stephenson GA: Synthesis and biological activity of trans-2,3dihydroraloxifene
    • Glasebrook AL, Misner JW. 1137-1140.
    • Schmid CR, Glasebrook AL, Misner JW. Stephenson GA: Synthesis and biological activity of trans-2,3dihydroraloxifene. Bioorg Med Chem Lett (1999) 9(8):1137-1140.
    • (1999) Bioorg Med Chem Lett , vol.9 , Issue.8
    • Schmid, C.R.1
  • 35
    • 15144355781 scopus 로고    scopus 로고
    • Synthesis and pharmacology of conformationally restricted raloxifene analogues: Highly potent selective estrogen receptor modulators
    • Pennington LD, Sluka JP, Adrian MD, Cole HW, Fuson TR, Magee DE, Phillips DL, Rowley ER, Shetler PK, Short LL, Venugopalan M, Yang NN, Sato M, Glasebrook AL, Bryant HU: 1272-1283.
    • Grese TA, Pennington LD, Sluka JP, Adrian MD, Cole HW, Fuson TR, Magee DE, Phillips DL, Rowley ER, Shetler PK, Short LL, Venugopalan M, Yang NN, Sato M, Glasebrook AL, Bryant HU: Synthesis and pharmacology of conformationally restricted raloxifene analogues: Highly potent selective estrogen receptor modulators. J Med Chem (1998) 41(8):1272-1283.
    • (1998) J Med Chem , vol.41 , Issue.8
    • Grese, T.A.1
  • 36
    • 0032581614 scopus 로고    scopus 로고
    • Discovery and preclinical pharmacology of a novel, potent, non-steroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene
    • Da Silva JP, Cameron KO, Thompson DD, Ke HZ, Toler SM, Brown TA, Pan LC, Ebbinghaus CF, Reinhold AR, Elliott NC, Newhouse BN, Tjoa CM, Sweetnam PM, Cde MJ, Arriola MW, Gauthier JW, Crawford DT, Nickerson DF, Pirie CM, Qi H, Simmons HA, Tkalcevic GT: 2928-2931.
    • Rosati RL, Da Silva JP, Cameron KO, Thompson DD, Ke HZ, Toler SM, Brown TA, Pan LC, Ebbinghaus CF, Reinhold AR, Elliott NC, Newhouse BN, Tjoa CM, Sweetnam PM, Cde MJ, Arriola MW, Gauthier JW, Crawford DT, Nickerson DF, Pirie CM, Qi H, Simmons HA, Tkalcevic GT: Discovery and preclinical pharmacology of a novel, potent, non-steroidal estrogen receptor agonist/antagonist, CP-336156, a diaryltetrahydronaphthalene. JMed Chem (1998) 41(16):2928-2931.
    • (1998) JMed Chem , vol.41 , Issue.16
    • Rosati, R.L.1
  • 38
    • 0001236520 scopus 로고    scopus 로고
    • Effects of CP-336,156, a new, non-steroldal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models
    • Paralkar VM, Grasser WA, Crawford DT, Qi H, Simmons HA, Pirie CM, Chidsey-Frink KL, Owen TA, Smock SL, Chen HK, Jee WS, Cameron KO, Rosati RL, Brown TA, Dasilva-Jardine P, Thompson DD: 2068-2076.
    • Ke HZ, Paralkar VM, Grasser WA, Crawford DT, Qi H, Simmons HA, Pirie CM, Chidsey-Frink KL, Owen TA, Smock SL, Chen HK, Jee WS, Cameron KO, Rosati RL, Brown TA, Dasilva-Jardine P, Thompson DD: Effects of CP-336,156, a new, non-steroldal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models. Endocrinology (1998) 139(4):2068-2076.
    • (1998) Endocrinology , vol.139 , Issue.4
    • Ke, H.Z.1
  • 39
    • 33749919225 scopus 로고    scopus 로고
    • American Chemical Society 219th National Meeting - Selective estrogen receptor modulators
    • 589-590.
    • Rotella DP: American Chemical Society 219th National Meeting - Selective estrogen receptor modulators. I Drugs (2000) 3(6):589-590.
    • (2000) I Drugs , vol.3 , Issue.6
    • Rotella, D.P.1
  • 41
    • 0030793285 scopus 로고    scopus 로고
    • S-(+)-4-[7-{2,2-dimethyl-1-oxopropoxy-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2W-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): A highly potent, specific, and orally active non-steroidal antiestrogen
    • Caron B, Cloutier J, Dory YL, Favre A, Larouche D, Mailhot J, Quellet C, Schwerdtfeger A, Leblanc G, Martel C, Simard J, Mérand Y, Bélanger A, Labrie C, Labrie F: 2117-2122.
    • Gauthier S, Caron B, Cloutier J, Dory YL, Favre A, Larouche D, Mailhot J, Quellet C, Schwerdtfeger A, Leblanc G, Martel C, Simard J, Mérand Y, Bélanger A, Labrie C, Labrie F: (S)-(+)-4-[7-{2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)- ethoxy]phenyl]-2W-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): A highly potent, specific, and orally active non-steroidal antiestrogen. J Med Chem (1997) 40(14):2117-2122.
    • (1997) J Med Chem , vol.40 , Issue.14
    • Gauthier, S.1
  • 42
    • 0030879732 scopus 로고    scopus 로고
    • Characterization of the effects of the novel nonsteroidal antiestrogen EM-800 on basal and estrogen-Induced proliferation of T-47D, ZR-75-1 and MCF-7 human breast cancer cells in vitro
    • Labrie C, Bélanger A, Gauthier S, Singh SM, Mérand Y, Labrie F: 104-112.
    • Simard J, Labrie C, Bélanger A, Gauthier S, Singh SM, Mérand Y, Labrie F: Characterization of the effects of the novel nonsteroidal antiestrogen EM-800 on basal and estrogen-Induced proliferation of T-47D, ZR-75-1 and MCF-7 human breast cancer cells In vitro. IntJ Cancer(1997) 73(1):104-112.
    • (1997) IntJ Cancer , vol.73 , Issue.1
    • Simard, J.1
  • 43
    • 0030860885 scopus 로고    scopus 로고
    • Blockade of the stimulatory effect of estrogens, OH-tamoxifen, OH-toremifene, droloxifene, and raloxifene on alkaline phosphatase activity by the antiestrogen EM-800 in human endometrial adenocarcinoma Ishikawa cells
    • Sanchez R, Poirier D, Gauthier S, Singh SM, Merand Y, Belanger A, Labrie C, Labrie F: 3494-3497.
    • Simard J, Sanchez R, Poirier D, Gauthier S, Singh SM, Merand Y, Belanger A, Labrie C, Labrie F: Blockade of the stimulatory effect of estrogens, OH-tamoxifen, OH-toremifene, droloxifene, and raloxifene on alkaline phosphatase activity by the antiestrogen EM-800 in human endometrial adenocarcinoma Ishikawa cells. Cancer Res (1997) 57(16):3494-3497.
    • (1997) Cancer Res , vol.57 , Issue.16
    • Simard, J.1
  • 44
    • 85011457699 scopus 로고    scopus 로고
    • EM800, a novel antiestrogen, acts as a pure antagonist of the transcriptional functions of estrogen receptors a and β
    • Tremblay GB, Labrie C, Labrie F, Giguère V: 1 :111 -118.
    • Tremblay A, Tremblay GB, Labrie C, Labrie F, Giguère V: EM800, a novel antiestrogen, acts as a pure antagonist of the transcriptional functions of estrogen receptors a and β. Endocrinology (1998) 139(1 ):111 -118.
    • (1998) Endocrinology , vol.139
    • Tremblay, A.1
  • 45
    • 0033214438 scopus 로고    scopus 로고
    • Effect of combined treatment with the pure antiestrogen EM-800 and radiotherapy on the growth of human ZR-75-1 breast cancer xenografts in nude mice
    • Gutman M, Labrie F, Candas B, Labrie C: 4857-4863.
    • Couillard S, Gutman M, Labrie F, Candas B, Labrie C: Effect of combined treatment with the pure antiestrogen EM-800 and radiotherapy on the growth of human ZR-75-1 breast cancer xenografts in nude mice. Cancer Res (1999) 59(19):4857-4863.
    • (1999) Cancer Res , vol.59 , Issue.19
    • Couillard, S.1
  • 46
    • 0029876149 scopus 로고    scopus 로고
    • Benzopyran selective estrogen receptor modulators (SERMS): Pharmacological effects and structural correlation with raloxifene
    • Skyja JP, Bryant HU, Cole HW, Kirn JR, Magee DE, Rowley ER, Sato M: 903-908.
    • Grese TA, Skyja JP, Bryant HU, Cole HW, Kirn JR, Magee DE, Rowley ER, Sato M: Benzopyran selective estrogen receptor modulators (SERMS): Pharmacological effects and structural correlation with raloxifene. Bioorg Med Chem Lett (1996) 6(7):903-908.
    • (1996) Bioorg Med Chem Lett , vol.6 , Issue.7
    • Grese, T.A.1
  • 47
    • 0033117680 scopus 로고    scopus 로고
    • Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens
    • Mortensen DS, Stauffer SR, Aron ZD, Katzenellenbogen JA: 205-219. Describes novel ER ligands discovered by means of rational design.
    • Fink BE, Mortensen DS, Stauffer SR, Aron ZD, Katzenellenbogen JA: Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens. Chem Biol (1999) 6(4):205-219. Describes novel ER ligands discovered by means of rational design.
    • (1999) Chem Biol , vol.6 , Issue.4
    • Fink, B.E.1
  • 48
    • 0033649601 scopus 로고    scopus 로고
    • Reproductive functions of the progesterone receptor
    • Lydon JP, De Mayo F, O'Malley BW: Suppl 1 :S25-S32.
    • Conneely OM, Lydon JP, De Mayo F, O'Malley BW: Reproductive functions of the progesterone receptor. J Soc Gynecol Investig (2000) 7(Suppl 1 ):S25-S32.
    • (2000) J Soc Gynecol Investig , vol.7
    • Conneely, O.M.1
  • 49
    • 0033374783 scopus 로고    scopus 로고
    • The a and B isoforms of the human progesterone receptor: Two functionally different transcription factors encoded by a single gene
    • McDonnell DP: 291-314. Describes the nature of the two progesterone receptor isoforms and the present theories about how they interact.
    • Giangrande PH, McDonnell DP: The A and B isoforms of the human progesterone receptor: Two functionally different transcription factors encoded by a single gene. Recent Prog Horn Res (1999) 54:291-314. Describes the nature of the two progesterone receptor isoforms and the present theories about how they interact.
    • (1999) Recent Prog Horn Res , vol.54
    • Giangrande, P.H.1
  • 50
    • 0026343481 scopus 로고
    • Transcription activation by estrogen and progesterone receptors
    • 89-123.
    • Gronemeyer H: Transcription activation by estrogen and progesterone receptors. Annu Rev Genet (1991) 25:89-123.
    • (1991) Annu Rev Genet , vol.25
    • Gronemeyer, H.1
  • 51
    • 0027427216 scopus 로고
    • Human progesterone receptor a form is a cell and promoter-specific represser of human progesterone receptor B function
    • Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP: 1244-1255.
    • Vegelo E, Shahbaz MM, Wen DX, Goldman ME, O'Malley BW, McDonnell DP: Human progesterone receptor A form is a cell and promoter-specific represser of human progesterone receptor B function. Mol Endocrinol (1993) 7(10):1244-1255.
    • (1993) Mol Endocrinol , vol.7 , Issue.10
    • Vegelo, E.1
  • 52
    • 0028952805 scopus 로고
    • Inhibitory cross talk between steroid hormone receptors: Differential targeting of estrogen receptor in the repression of its transcriptional activity by agonist- And antagonist occupied progestin receptors
    • Weis KE, Katzenellenbogen BS: 1847-1857.
    • Kraus WL, Weis KE, Katzenellenbogen BS: Inhibitory cross talk between steroid hormone receptors: Differential targeting of estrogen receptor in the repression of its transcriptional activity by agonist- and antagonist occupied progestin receptors. Mol Cell Biol (1995) 15(4):1847-1857.
    • (1995) Mol Cell Biol , vol.15 , Issue.4
    • Kraus, W.L.1
  • 53
    • 0033594377 scopus 로고    scopus 로고
    • Aryl1,2,3,4-tetrahydrochromeno[3,4-/]quinolin-3-ones as a novel class of non-steroidal progesterone receptor agonists: Effect of A-ring modification
    • Tegley CM, Marschke KB, Mais DE, Jones TK: 5- 1466-1472.
    • Zhi L, Tegley CM, Marschke KB, Mais DE, Jones TK: 5-Aryl1,2,3,4-tetrahydrochromeno[3,4-/]quinolin-3-ones as a novel class of non-steroidal progesterone receptor agonists: Effect of A-ring modification. J Med Chem (1999) 42(8):1466-1472.
    • (1999) J Med Chem , vol.42 , Issue.8
    • Zhi, L.1
  • 54
    • 0032401093 scopus 로고    scopus 로고
    • Jquinolines: A novel class of non-steroidal progesterone receptor modulators
    • Tegley CM, Edwards JP, West SJ, Marschke KB, Gottardis MM, Mais DE, Jones TK: 5-aikyl 1,2-dihydrochromeno3,4- 3365-3370.
    • Zhi L, Tegley CM, Edwards JP, West SJ, Marschke KB, Gottardis MM, Mais DE, Jones TK: 5-aikyl 1,2-dihydrochromeno[3,4-J]quinolines: A novel class of non-steroidal progesterone receptor modulators. Bioorg Med Chem Lett (1998) 8(23):3365-3370.
    • (1998) Bioorg Med Chem Lett , vol.8 , Issue.23
    • Zhi, L.1
  • 55
    • 0032561227 scopus 로고    scopus 로고
    • Aryl-1,2-dihydrochromeno3,4-Jfouinolines: A novel class of non-steroidal human progesterone receptor agonists
    • Tegley CM, Kallel EA, Marschke KB, Mais DE, Gottardis MM, Jones TK: 5- 291-302.
    • Zhi L, Tegley CM, Kallel EA, Marschke KB, Mais DE, Gottardis MM, Jones TK: 5-Aryl-1,2-dihydrochromeno[3,4-Jfouinolines: A novel class of non-steroidal human progesterone receptor agonists. J Med Chem (1998) 41(3):291-302.
    • (1998) J Med Chem , vol.41 , Issue.3
    • Zhi, L.1
  • 56
    • 0032561227 scopus 로고    scopus 로고
    • Benzylidene 1,2-dihyrochromeno[3,4-i]quinolines, a novel class of non-steroidal human progesterone receptor agonists
    • Zhi L, Marschke KB, Gottardis MM, Yang Q, Jones TK: 5- 4354-4359.
    • Tegley CM, Zhi L, Marschke KB, Gottardis MM, Yang Q, Jones TK: 5-Benzylidene 1,2-dihyrochromeno[3,4-i]quinolines, a novel class of non-steroidal human progesterone receptor agonists. J Med Chem (1998) 41 (22):4354-4359.
    • (1998) J Med Chem , vol.41 , Issue.22
    • Tegley, C.M.1
  • 57
    • 0032576698 scopus 로고    scopus 로고
    • Aryl-1,2-dihydro-5H-chromeno[3,4-r]quinolines as potent, orally active, non-steroidal progesterone receptor agonists: The effect of D-f ing substituents
    • West SJ, Marschke KB, Mais DE, Gottardis MM, Jones TK: 5- 303-310.
    • Edwards JP, West SJ, Marschke KB, Mais DE, Gottardis MM, Jones TK: 5-Aryl-1,2-dihydro-5H-chromeno[3,4-r]quinolines as potent, orally active, non-steroidal progesterone receptor agonists: The effect of D-f ing substituents. J Med Chem (1998) 41(3):303-310.
    • (1998) J Med Chem , vol.41 , Issue.3
    • Edwards, J.P.1
  • 58
    • 15144355008 scopus 로고    scopus 로고
    • Preparation, resolution and biological evaluation of 5-aryl1,2-dihydro-5W-chromeno[3,4-/]quinolines: Potent, orally active, non-steroidal progesterone receptor agonists
    • Zhi L, Pooley CL, Tegley CM, West SJ, Wang M-W, Gottardis MM, Pathirana C, Schrader WT, Jones TK: 2779-2785.
    • Edwards JP, Zhi L, Pooley CL, Tegley CM, West SJ, Wang M-W, Gottardis MM, Pathirana C, Schrader WT, Jones TK: Preparation, resolution and biological evaluation of 5-aryl1,2-dihydro-5W-chromeno[3,4-/]quinolines: Potent, orally active, non-steroidal progesterone receptor agonists. J Med Chem (1998) 41(15):2779-2785.
    • (1998) J Med Chem , vol.41 , Issue.15
    • Edwards, J.P.1
  • 59
    • 0028922593 scopus 로고
    • Non-steroidal human progesterone receptor modulators from the marine alga Cymopolia barbata
    • Stein RB, Berger TS, Fenical W, laniro T, Mais DE, Torres A, Goldman ME: 630-635.
    • Pathirana C, Stein RB, Berger TS, Fenical W, laniro T, Mais DE, Torres A, Goldman ME: Non-steroidal human progesterone receptor modulators from the marine alga Cymopolia barbata. Mol Pharmacol (1995) 47(3):630-635.
    • (1995) Mol Pharmacol , vol.47 , Issue.3
    • Pathirana, C.1
  • 60
    • 0029916422 scopus 로고    scopus 로고
    • Synthesis and biological activity of novel non-steroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether
    • Farmer LJ, Johnson MG, Bender SL, Mais DE, Wang M-W, Crombie D, Goldman ME, Jones TK: 1778-1789.
    • Hamann LG, Farmer LJ, Johnson MG, Bender SL, Mais DE, Wang M-W, Crombie D, Goldman ME, Jones TK: Synthesis and biological activity of novel non-steroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether. J Med Chem (1996) 39(9):1778-1789.
    • (1996) J Med Chem , vol.39 , Issue.9
    • Hamann, L.G.1
  • 61
    • 0032572837 scopus 로고    scopus 로고
    • Discovery and preliminary SAR studies of a novel, non-steroidal progesterone receptor antagonist pharmacophore
    • Edwards JP, Goldman ME, Wang M-W, Marschke KB, Crombie DL, Jones TK: 3461-3466.
    • Pooley CL, Edwards JP, Goldman ME, Wang M-W, Marschke KB, Crombie DL, Jones TK: Discovery and preliminary SAR studies of a novel, non-steroidal progesterone receptor antagonist pharmacophore. J Med Chem (1998) 41(18):3461-3466.
    • (1998) J Med Chem , vol.41 , Issue.18
    • Pooley, C.L.1
  • 62
    • 0032491268 scopus 로고    scopus 로고
    • Non-steroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl1,2-dihydro-2,2,4-trimethyiquinolines
    • Winn DT, Pooley CL, Tegley CM, West SJ, Farmer LJ, Zhi L, Edwards JP, Marschke KB, Mais DE, Goldman ME, Jones TK: 2731-2726.
    • Hamann LG, Winn DT, Pooley CL, Tegley CM, West SJ, Farmer LJ, Zhi L, Edwards JP, Marschke KB, Mais DE, Goldman ME, Jones TK: Non-steroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl1,2-dihydro-2,2,4-trimethyiquinolines. Bloorg Med Chem Lett (1998) 8(19):2731-2726.
    • (1998) Bloorg Med Chem Lett , vol.8 , Issue.19
    • Hamann, L.G.1
  • 63
    • 0033526930 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of new non-steroidal progesterone receptor ligands
    • Tanabe K, Yamamoto Y, Shinei R, Ajito K, Okonogi T: 1837-1842.
    • Kuriahara K, Tanabe K, Yamamoto Y, Shinei R, Ajito K, Okonogi T: Synthesis and structure-activity relationships of new non-steroidal progesterone receptor ligands. Bloorg Med Chem Lett (1999) 9(13):1837-1842.
    • (1999) Bloorg Med Chem Lett , vol.9 , Issue.13
    • Kuriahara, K.1
  • 64
    • 0030762285 scopus 로고    scopus 로고
    • Synthesis and progesterone receptor binding affinity of substituted 1-phenyl-7-benzyl-4,5,6,7-tetrahydro1-indazoles
    • Wetter SK, Beers KN, Hamel SC, Haynes-Johnson D, Koddoe M, Kraft P, Lai MT, Campen C, Palmer S, Phillips A: 2551-2556.
    • Connoliy PJ, Wetter SK, Beers KN, Hamel SC, Haynes-Johnson D, Koddoe M, Kraft P, Lai MT, Campen C, Palmer S, Phillips A: Synthesis and progesterone receptor binding affinity of substituted 1-phenyl-7-benzyl-4,5,6,7-tetrahydro1-indazoles. Bioorg Med Chem Le«(1997) 7(19):2551-2556.
    • (1997) Bioorg Med Chem Le« , vol.7 , Issue.19
    • Connoliy, P.J.1
  • 65
    • 0023901348 scopus 로고
    • Activation of programmed cell death in the rat ventral prostate after castration
    • Isaacs JT: 552-562.
    • Kyprianou N, Isaacs JT: Activation of programmed cell death in the rat ventral prostate after castration. Endocrinology (1988) 122(2):552-562.
    • (1988) Endocrinology , vol.122 , Issue.2
    • Kyprianou, N.1
  • 66
    • 84928580276 scopus 로고
    • Studies on prostate cancer: The effects of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate
    • Hodges CV: 293-297.
    • Huggins C, Hodges CV: Studies on prostate cancer: The effects of castration, of estrogen and androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res( 1941) 1:293-297.
    • (1941) Cancer Res , vol.1
    • Huggins, C.1
  • 67
    • 0033378278 scopus 로고    scopus 로고
    • Antiandrogens in prostate cancer
    • Kantoff P, Oh W: 271-284.
    • Reid P, Kantoff P, Oh W: Antiandrogens in prostate cancer. Invest New Drugs (1999) 17(3):271-284.
    • (1999) Invest New Drugs , vol.17 , Issue.3
    • Reid, P.1
  • 68
    • 0034121290 scopus 로고    scopus 로고
    • Androgen receptor antagonists (antiandrogens): Structure-activity relationships
    • Gauthier S, Labrie F: 211 -247. Describes in detail the SAR of the known classes of androgen receptor antagonists.
    • Singh SM, Gauthier S, Labrie F: Androgen receptor antagonists (antiandrogens): Structure-activity relationships. Curr Med Chem (2000) 7(2):211 -247. Describes in detail the SAR of the known classes of androgen receptor antagonists.
    • (2000) Curr Med Chem , vol.7 , Issue.2
    • Singh, S.M.1
  • 69
    • 0015377166 scopus 로고
    • A biological profile of a non-steroidal antiandrogen, SCH 13521 (4'-nitro-3'trifluoromethylisobutyranilide)
    • Rorance K, Koziol P, Van Cleave S: 427-437.
    • Neri R, Rorance K, Koziol P, Van Cleave S: A biological profile of a non-steroidal antiandrogen, SCH 13521 (4'-nitro-3'trifluoromethylisobutyranilide). Endocrinology (1972) 91(8):427-437.
    • (1972) Endocrinology , vol.91 , Issue.8
    • Neri, R.1
  • 70
    • 9444292850 scopus 로고    scopus 로고
    • Double-blind, randomized study of primary hormonal treatment of stage D2 prostate carcinoma: Flutamide versus diethylstilbestrol
    • Yeap B, Davis T, Blum R, Hahn R, Khanna O, Fisher H, Rosenthal J, Witte R, Schinella R, Trump D: 2250-2257.
    • Chang A, Yeap B, Davis T, Blum R, Hahn R, Khanna O, Fisher H, Rosenthal J, Witte R, Schinella R, Trump D: Double-blind, randomized study of primary hormonal treatment of stage D2 prostate carcinoma: Flutamide versus diethylstilbestrol. J Clin Onco/(1996) 14(8):2250-2257.
    • (1996) J Clin Onco/ , vol.14 , Issue.8
    • Chang, A.1
  • 71
    • 0033026221 scopus 로고    scopus 로고
    • Bicalutamide monotherapy versus flutamide plus goserelin in prostate cancer patients: Results of an Italian Prostate Cancer Project study
    • Rubagotti A, Barichello M, Battaglia M, Carmignani G, Comeri G, Conti G, Cruciani G, Dammino S, Delliponti U, Ditonno P, Ferraris V, Lilliu S, Montefiore F, Portoghese F, Spano G: 2027-2038.
    • Boccardo F, Rubagotti A, Barichello M, Battaglia M, Carmignani G, Comeri G, Conti G, Cruciani G, Dammino S, Delliponti U, Ditonno P, Ferraris V, Lilliu S, Montefiore F, Portoghese F, Spano G: Bicalutamide monotherapy versus flutamide plus goserelin in prostate cancer patients: Results of an Italian Prostate Cancer Project study. J Clin Onco/(1999) 17(7):2027-2038.
    • (1999) J Clin Onco/ , vol.17 , Issue.7
    • Boccardo, F.1
  • 72
    • 0029084601 scopus 로고
    • The antiandrogen withdrawal syndrome: Experience in a large cohort of unselected patients with advanced prostate cancer
    • Srinivas S: 1428-1434.
    • Small EJ, Srinivas S: The antiandrogen withdrawal syndrome: Experience in a large cohort of unselected patients with advanced prostate cancer. Cancer (1995) 76(8):1428-1434.
    • (1995) Cancer , vol.76 , Issue.8
    • Small, E.J.1
  • 73
    • 0032827195 scopus 로고    scopus 로고
    • The role of the androgen receptor in the development and progression of prostate cancer
    • 407-421.
    • Jenster G: The role of the androgen receptor in the development and progression of prostate cancer. Semin Onco/(1999) 26(4):407-421.
    • (1999) Semin Onco/ , vol.26 , Issue.4
    • Jenster, G.1
  • 74
    • 0032510051 scopus 로고    scopus 로고
    • Synthesis and biological activity of a novel series of non-steroidal, peripherally selective androgen receptor antagonists derived from 1,2-dihydropyridono[5,6-<;]quinolines
    • Higuchi Rl, Zhi L, Edwards JP, Wang XN, Marschke KB, Kong JW, Farmer LJ, Jones TK: 623-639.
    • Hamann LG, Higuchi Rl, Zhi L, Edwards JP, Wang XN, Marschke KB, Kong JW, Farmer LJ, Jones TK: Synthesis and biological activity of a novel series of non-steroidal, peripherally selective androgen receptor antagonists derived from 1,2-dihydropyridono[5,6-<;]quinolines. J Med Chem (1998) 41(4):623-639.
    • (1998) J Med Chem , vol.41 , Issue.4
    • Hamann, L.G.1
  • 75
    • 0032492668 scopus 로고    scopus 로고
    • New non-steroidal androgen receptor modulators based on 4-(trifluoromethyl)-21HJ-pyrrolidino[3,2-g]quinolinone
    • West SJ, Pooley CL, Marschke KB, Farmer LJ, Jones TK: 745-750.
    • Edwards JP, West SJ, Pooley CL, Marschke KB, Farmer LJ, Jones TK: New non-steroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1HJ-pyrrolidino[3,2-g]quinolinone. Bioorg Med Chem Lett (1998) 8(7):745-750.
    • (1998) Bioorg Med Chem Lett , vol.8 , Issue.7
    • Edwards, J.P.1
  • 76
    • 0030924642 scopus 로고    scopus 로고
    • Potent novel non-steroidal androgen antagonists with a phthalimide skeleton
    • Azuma A, Kitamoto T, Hayashi K, Kalo S, Koga M, Sato B, Hashimoto Y: 11 :1483-1488.
    • Miyachi H, Azuma A, Kitamoto T, Hayashi K, Kalo S, Koga M, Sato B, Hashimoto Y: Potent novel non-steroidal androgen antagonists with a phthalimide skeleton. Bioorg Med Chem Lett (1997) 7(11 ):1483-1488.
    • (1997) Bioorg Med Chem Lett , vol.7
    • Miyachi, H.1
  • 77
    • 0033526095 scopus 로고    scopus 로고
    • Switching androgen receptor antagonists to agonists by modifying C-ring substituents on piperidino[3,2-g]quinolinone
    • Tegley CM, Marschke KB, Jones TK: 1009-1012.
    • Zhi L, Tegley CM, Marschke KB, Jones TK: Switching androgen receptor antagonists to agonists by modifying C-ring substituents on piperidino[3,2-g]quinolinone. Bioorg Med Chem Lett (1999) 9(7):1009-1012.
    • (1999) Bioorg Med Chem Lett , vol.9 , Issue.7
    • Zhi, L.1
  • 78
    • 0033519183 scopus 로고    scopus 로고
    • Potent, non-steroidal androgen receptor agonists
    • Edwards JP, Caferro TR, Ringgenberg JD, Kong JW, Hamann LG, ArienS KL, Marschke KB, Davis RL, Farmer LJ, Jones TK: 4-alkyl- and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6-g]quinolines: 1335-1340.
    • Higuchi Rl, Edwards JP, Caferro TR, Ringgenberg JD, Kong JW, Hamann LG, ArienS KL, Marschke KB, Davis RL, Farmer LJ, Jones TK: 4-alkyl- and 3,4-dialkyl-1,2,3,4-tetrahydro-8-pyridono[5,6-g]quinolines: Potent, non-steroidal androgen receptor agonists. Bioorg Med Chem Lett (1999) 9(9):1335-1340.
    • (1999) Bioorg Med Chem Lett , vol.9 , Issue.9
    • Rl, H.1
  • 79
    • 0032906159 scopus 로고    scopus 로고
    • Discovery of a potent, orally active, nonsteroldal androgen receptor agonist: 4-ethyl-1,2,3,4-tetrahydro-6-{trifluoromethyl-8-pyridono[5,6-g]-quinolone (LG121071)
    • Mani NS, Davis RL, Wang XN, Marschke KB, Jones TK: 210-212.
    • Hamann LG, Mani NS, Davis RL, Wang XN, Marschke KB, Jones TK: Discovery of a potent, orally active, nonsteroldal androgen receptor agonist: 4-ethyl-1,2,3,4-tetrahydro-6-{trifluoromethyl)-8-pyridono[5,6-g]-quinolone (LG121071). JMedOjem(1999)42(2):210-212.
    • (1999) JMedOjem , vol.42 , Issue.2
    • Hamann, L.G.1
  • 80
    • 0032489326 scopus 로고    scopus 로고
    • Discovery of non-steroidal androgens
    • Mukherjee A, Zhu Z, Kirkovsky L, Miller DD: 1:1-4.
    • Dalton JT, Mukherjee A, Zhu Z, Kirkovsky L, Miller DD: Discovery of non-steroidal androgens. Biochem Biophys Res Comm (1998) 244{1):1-4.
    • (1998) Biochem Biophys Res Comm , vol.244
    • Dalton, J.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.