HIV-1 matrix protein p17 prevents loss of CD28 expression during IL-2-induced maturation of naïve CD8+ T cells

Viral Immunology

Volumn 21, Issue 2, 2008, Pages 189-202

  Avolio, Manuela ^a   Caracciolo, Sonia ^a   Tosti, Giorgio ^a   Vollero, Luana ^a   Fiorentini, Simona ^a   Caruso, Arnaldo ^a,b  

^a UNIVERSITY OF BRESCIA   (Italy)

^b Institute of Microbiology   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CYTOKINE; INTERLEUKIN 2; MATRIX PROTEIN; MONOCLONAL ANTIBODY CD3; PROTEIN P17;

ANTIGEN EXPRESSION; CD8+ T LYMPHOCYTE; CELL MATURATION; CELL POLARITY; CONFERENCE PAPER; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOMODULATION; LYMPHOCYTE CULTURE; LYMPHOCYTE DIFFERENTIATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; POLARIZATION; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD28; ANTIGENS, CD3; CELLS, CULTURED; FLOW CYTOMETRY; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV ANTIGENS; HIV-1; HUMANS; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; T-LYMPHOCYTES, CYTOTOXIC;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 45749132169     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.2007.0095     Document Type: Conference Paper

References (47)

1. Alves NL, Arosa FA, and van Lier RA: IL-21 sustains CD28 expression on IL-15-activated human naive CD8+ T cells. J Immunol 2005;175:755-762.
2. Appay V, Nixon DF, Donahoe SM, et al.: HIV/specific CD8+ T cells produce antiviral cytokines but are impaired in cytolytic function. J Exp Med 2000;192:63-75.
3. Appay V, Dunbar PR, Callan M, et al.: Memory CD8+ T cells vary in differentiation in phenotype different persistent virus infection. Nat Med 2002;8:379-385.
4. Arosa FA: CD8+CD28- T cells: certainties and uncertainties of a prevalent T-cell subset. Immunol Cell Biol 2002;80:1-13.
5. Azuma M, Phillips JH, and Lanier LL: CD28- T lymphocytes. J Immunol 1993;150:1147-1159.
6. Baars PA, Ribeiro Do Couto LM, Leusen JH, Hooibrink B, Kuijpers TW, Lens SM, and van Lier RAW: Cytolytic mechanisms and expression of activation-regulating receptors on effector-type CD8+CD45RA+CD27- human T cells. J Immunol 2000;165:1910-1917.
7. Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer M, and Koup RA: Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation. J Immunol Methods 2003;281:65-78.
8. Bird JJ, Brown DR, Mullen AC, et al.: Helper T cell differentiation is controlled by the cell cycle. Immunity 1998;9:229-237.
9. Borthwick NJ, Bofill M, Gombert WM, Medina E, Sagawa K, Johnson MA, and Janossy G: Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cells. AIDS 1994;8:431-441.
10. Brzezinska A, Magalska A, and Sikora E: Proliferation of CD8+ in culture of human T cells derived from peripheral blood of adult donors and cord blood of newborns. Mech Ageing Dev 2003;124:379-387.
11. Burysek L, Syrovets T, and Simmet T: The serine protease plasmin triggers expression of MCP-1 and CD40 in human primary monocytes via activation of p38 MAPK and janus kinase (JAK)/STAT signaling pathways. J Biol Chem 2002;277:33509-33517.
12. Caruso A, Cantalamessa A, Licenziati S, et al.: Expression of CD28 on CD8+ and CD4+ lymphocytes during HIV infection. Scand J Immunol 1994;40:485-490.
13. Caruso A, Fiorentini S, Licenziati S, et al.: Expansion of rare CD8+CD28-CD11b- T cells with impaired effector functions in HIV-1 infected patients. J Acquired Immune Defic Syndr 2000;24:465-474.
14. Champagne P, Ogg GS, King AS, et al.: Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature 2001;410:106-111.
15. Cho JH, Boyman O, Kim HO, et al.: An intense form of homeostatic proliferation of naive CD8+ cells driven by IL-2. J Exp Med 2007;204:1787-1801.
16. Cocchi F, De Vico AL, Garzino-Demo A, Arya SK, Gallo RC, and Lusso P: Identification of RANTES, MIP-1 alpha, MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science 1995;270:1811-1815.
17. De Francesco MA, Caruso A, Fallacara F, et al.: HIV p17 enhances lymphocyte proliferation and HIV-1 replication after binding to a human serum factor. AIDS 1998; 12:245-252.
18. De Francesco MA, Baronio M, Fiorentini S, et al.: HIV-1 matrix protein p17 increases the production of proinflammatory cytokines and counteracts IL-4 activity by binding to a cellular receptor. Proc Natl Acad Sci 2002;99:9972-9977.
19. Derzic S, Slone V, Sender L: IL-2-activated cord blood mononuclear cells. Cytotherapy 2005;7:408-416.
20. Fiorentini S, Marini E, Caracciolo S, and Caruso A: Functions of the HIV-1 matrix protein p17. New Microbiol 2006;29:1-10.
21. Fiorentini S, Malacarne F, Ricotta D, et al.: Generation of CD28- cells from long-term-stimulated CD8+CD28+ T cells: a possible mechanism accounting for the increased number of CD8+CD28- T cells in HIV-1-infected patients. J Leukoc Biol 1999;65:641-648.
22. Fiorentini S, Licenziati S, Alessandri G, et al.: CD11b expression identifies CD8+CD28+ T lymphocytes with phenotype and function of both naive/memory and effector cells. J Immunol 2001;166:900-907.
23. Fiorentino S, Dalod M, Olive D, Guillet JG, and Gomard E: Predominant involvement of CD8+CD28- lymphocytes in human immunodeficiency virus-specific cytotoxic activity. J Virol 1996;70:2022-2026.
24. Hamann D, Baars PA, Rep MHG, Hooibrink B, Kerkhof-Garde SR, Klein MR, and van Lier RAW: Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med 1997;186:1407-1418.
25. June CH, Ledbetter JA, Linsley PS, Thompson CB: Role of the CD28 receptor in T-cell activation. Immunol Today 1990;11:211-216.
26. Kilpinen S, and Hurme M: Low CD3+CD28-induced interleukin-2 production correlates with decreased reactive oxygen intermediate formation in neonatal T cells. Immunology 1998;94:167-172.
27. Kryworuchko M, Pasquier V, Keller H, et al.: Defective interleukin-2-dependent STAT5 signalling in CD8 T lymphocytes from HIV-positive patients: restoration by antiretroviral therapy. AIDS 2004;18:421-426.
28. Kryworuchko M, Pasquier V, and Thäze J: Human immunodeficiency virus-1 envelope glycoproteins and anti-CD4 antibodies inhibit interleukin-2-induced Jak/STAT signalling in human CD4 T lymphocytes. Clin Exp Immunol 2003;131:422-427.
29. Labalette M, Leteurtre E, Thumerelle C, Grutzmacher C, Tourvieille B, and Dessaint JP: Peripheral human CD8+CD28+ T lymphocytes give rise to CD28- progeny, but IL-4 prevents loss of CD28 expression. Int Immunol 1999;8:1327-1335.
30. Marini E, Tiberio L, Caracciolo S, et al.: HIV-1 matrix protein p17 binds to monocytes and selectively stimulates MCP-1 secretion: role of transcriptional factor AP-1. Cell Microbiol 2008;10:655-666.
31. Popovic M, Tenner-Racz K, Pelser C, et al.: Persistence of HIV-1 structural proteins and glycoproteins in lymph nodes of patients under highly active antiretroviral therapy. Proc Natl Acad Sci 2005;102:14807-14812.
32. Posnett DN, Edinger, Manavalan JS, Invin C, and Marodon G: Differentiation of human CD8 T cells: implications for in vivo persistence of CD8+CD28- cytotoxic effector clones. Int Immunol 1999;11:229-241.
33. Powell, J.D., J.A. Ragheb, S.S. Kitagawa, R.H. Schwartz. 1998. Molecular regulation of interleukin-2 expression by CD28 co-stimulation and anergy. Immunol. Rev. 165:287-300.
34. Quaranta MG, Mattioli B, Giordani L, and Viora M: HIV-1 Nef equipped dendritic cells to reduce survival and function of CD8+ T cells: a mechanism of immune evasion. FASEB J 2004;18:1459-1461.
35. Rudd CE, and Schneider H: Unifying concepts in CD28, ICOS and CTLA4 co-receptor signalling. Nat Rev Immunol 2003;3:555-556.
36. Sad S, and Krishnan L: Cytokine deprivation of naïve CD8+ T cells promotes minimal cell cycling but maximal cytokine synthesis and autonomous proliferation subsequently: a mechanism of self-regulation. J Immunol 1999;163:2443-2451.
37. Sad S, Li L, and Mosmann TR: Cytokine-deficient CD8+ Tc1 cells induced by IL-4: retained inflammation and perforin and FAS cytotoxicity but compromised long term killing of tumor cells. J Immunol 1997;159:606-613.
38. Sad S, and Mosmann TR: Interleukin (IL) 4, in the absence of antigen stimulation, induces an anergy-like state of differentiated CD8+ Tc1 cells: loss of IL-2 synthesis and autonomous proliferation but retention of cytotoxicity and synthesis of other cytokines. J Exp Med 1995;182:1505-1515.
39. Sandberg JK, Fast NM, and Nixon DF: Functional heterogeneity of cytokines and cytolytic effector molecules in human CD8+ T lymphocytes. J Immunol 2001;167:181-187.
40. Suntharalingam G, Perry MR, Ward S, Brett SJ, Castello-Cortes A, Brunner MD, and Panoskaltsis N: Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med 2006;355:1018-1028.
41. Vallejo AB, Brandes C, Weyland CM, and Goronzy JJ: Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence. J Immunol 1999;162:6572-6579.
42. Vitale M, Caruso A, De Francesco MA, et al.: HIV-1 matrix protein p17 enhances the proliferative activity of natural killer cells and increases their ability to secrete proinflammatory cytokines. Br J Hematol 2003;120:337-343.
43. Walker CM, Chakrabarti S, Moss B, et al.: HIV-specific cytotoxic T lymphocytes in seropositive individuals. Nature 1987;328:345-348.
44. Walker CM, Moody DJ, Stites DP, and Levy JA: CD8+ T lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 1986;234:1563-1566.
45. Wang B, Maile R, Greenwood R, Collins EJ, and Frelinger JA: Naïve CD8+ T cells do not require costimulation for proliferation and differentiation into cytotoxic effector cells. J Immunol 2000;164:1216-1222.
46. Zinkernagel RM: Immunology taught by virus. Science 1996;271:173-178.
47. Zinkernagel RM., and Hengartner H: T-cell m ediated immunopathology versus direct cytolysis by virus: implications for HIV and AIDS. Immunol Today 1994;15:262-268.