HIV-1 matrix protein p17 binds to monocytes and selectively stimulates MCP-1 secretion: Role of transcriptional factor AP-1

Cellular Microbiology

Volumn 10, Issue 3, 2008, Pages 655-666

  Marini, Elena ^a   Tiberio, Laura ^a   Caracciolo, Sonia ^a   Tosti, Giorgio ^a   Guzman, Carlos A ^b   Schiaffonati, Luisa ^a   Fiorentini, Simona ^a   Caruso, Arnaldo ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MATRIX PROTEIN; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P17; TRANSCRIPTION FACTOR AP 1;

ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MONOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RISK FACTOR; TRANSCRIPTION INITIATION; VIRUS VIRULENCE;

BINDING SITES; CELLS, CULTURED; CHEMOKINE CCL2; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV ANTIGENS; HIV-1; HUMANS; MONOCYTES; PROMOTER REGIONS (GENETICS); SEQUENCE DELETION; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION, GENETIC; UP-REGULATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 38849114213     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2007.01073.x     Document Type: Article

References (50)

1. Alfano, M., and Poli, G. (2001) Cytokine and chemokine based control of HIV infection and replication. Curr Pharm Des 7: 993-1013.
2. Behren, A., Simon, C., Schwab, B.M., Loetzsch, E., Brodbeck, S., Huber, E., et al. (2005) Papillomavirus E2 protein induces expression of the matrix metalloproteinase-9 via the extracellular signal-regulated kinase/ activator protein-1 pathway. Cancer Res 65: 11613-11621.
3. Biggs, T.E., Cooke, S.J., Barton, C.H., Harris, M.P., Saksela, K., and Mann, D.A. (1999) Induction of activator protein 1 (AP-1) in macrophages by human immunodeficiency virus type-1 NEF is a cell-type-specific response that requires both hck and MAPK signalling events. J Mol Biol 290: 21-35.
4. Cho, N.-H., Seong, S.-Y., Huh, M.-S., Kim, N.-H., Choi, M.-S., and Kim, I.-S. (2002) Induction of the gene encoding macrophage chemoattractant protein 1 by Orientia tsutsugamushi in human endothelial cells involves activation of transcription factor activator protein 1. Infect Immun 70: 4841-4850.
5. Cinque, P., Vago, L., Mengozzi, M., Torri, V., Ceresa, D., Licenzi, E., et al. (1998) Elevated cerebrospinal fluid levels of monocyte chemotactic protein-1 correlate with HIV-1 encephalitis and local viral replication. AIDS 12: 1327-1332.
6. Conant, K., Garzino-Demo, A., Nath, A., McArthur, J.C., Halliday, W., Power, C., et al. (1998) Induction of monocyte chemoattractant protein-1 in HIV-1 tat-stimulated astrocytes and elevation in AIDS dementia. Proc Natl Acad Sci USA 95: 3117-3121.
7. De Francesco, M.A., Baronio, M., Fiorentini, S., Signorini, C., Bonfanti, C., Ponesi, C., et al. (2002) HIV-1 matrix protein p17 increases the production of proinflammatory cytokines and couteracts IL-4 activity by binding to a cellular receptor. Proc Natl Acad Sci USA 99: 9972-9977.
8. De Francesco, M.A., Caruso, A., Fallacara, F., Canaris, A.D., Dima, F., Poiesi, C., et al. (1998) HIV p17 enhances lymphocyte proliferation and HIV-1 replication after binding to a human serum factor. AIDS 12: 245-252.
9. Dhawan, L., Liu, B., Blaxall, B.C., and Taubman, M.B. (2007) A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability. J Biol Chem 282: 10146-10152.
10. Donovan, R.M., Bush, C.E., Markowitz, N.P., Baxa, D.M., and Saravolatz, L.D. (1996) Changes in viral load markers during AIDS-associated opportunistic diseases in human immunodeficiency virus-infected persons. J Infect Dis 174: 401-403.
11. Fantuzzi, L., Conti, L., Gauzzi, M.C., Eid, P., Del Corno, M., Varano, B., et al. (2000) Regulation of chemokine/cytokine network during in vitro differentiation and HIV-1 infection of human monocytes: Possible importance in the pathogenesis of AIDS. J Leukoc Biol 68: 391-399.
12. Fantuzzi, L., Spadaro, F., Vallanti, G., Canini, I., Ramoni, C., Licenzi, E., et al. (2003) Endogenous CCL2 (monocyte chemotactic protein-1) modulates human immunodeficiency virus type-1 replication and affects cytoskeleton organization in human monocyte-derived macrophages. Blood 102: 2334-2337.
13. Fiorentini, S., Marini, E., Caracciolo, S., and Caruso, A. (2006) Functions of the HIV-1 matrix protein p17. New Microbiol 29: 1-10.
14. + peripheral blood-derived monocytes in HIV dementia: Perivascular accumulation and reservoir of HIV infection. J Neurovirol 6: 528-541.
15. Gibellini, D., Re, M.C., Bassini, A., Guidotti, L., Catani, I., La Placa, M., and Zauli, G. (1999) HIV-1 gp120 induces the activation of both c-fos and c-jun immediate-early genes in HEL megakaryocytic cells. Br J Haematol 104: 81-86.
16. Glass, J.D., Fedor, H., Wesselingh, S.L., and McArthur, J.C. (1995) Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlation with dementia. Ann Neurol 38: 755-762.
17. Goletti, D., Weissman, D., Jackson, R.W., Graham, N.M., Vlahov, D., Klein, R.S., et al. (1996) Effect of Mycobacterium tuberculosis on HIV replication. Role of immune activation. J Immunol 175: 1271-1278.
18. Gonzalez, E., Rovin, R.H., Sen, L., Cooke, G., Dhanda, R., Mummidi, S., et al. (2002) HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels. Proc Natl Acad Sci USA 99: 13795-13800.
19. Hanazawa, S., Takeshita, A., Amano, S., Semba, T., Nirazuka, T., Katoh, H., and Kitano, S. (1993) Tumor necrosis factor-α induced expression of monocyte chemoattractant JE via fos and jun genes in clonal osteoblastic MC3T3-E1 cells. J Biol Chem 268: 9526-9532.
20. He, R., Leeson, A., Andonov, A., Li, Y., Bastien, N., Cao, J., et al. (2003) Activation of AP-1 signal transduction pathway by SARS coronavirus nucleocapsid protein. Biochem Biophys Res Commun 311: 870-876.
21. Herbein, G., Coaquette, A., Perez-Bercoff, D., and Pacino, G. (2002) Macrophage activation and HIV infection: Can the Trojan horse turn into a fortress? Curr Mol Med 2: 723-738.
22. Hirsch, V.M., Sharkey, M.E., Brown, C.R., Brichacek, B., Goldstein, S., Wakefield, J., et al. (1998) Vpx is required for dissemination and pathogenesis of SIV(SM) PBj: Evidence of macrophage-dependent viral amplification. Nat Med 4: 1401-1408.
23. Ho, W.Z., Cherukrui, R., and Douglas, S.D. (1994) The macrophage and HIV-1. Immunol Ser 60: 569-587.
24. Holloway, G., and Coulson, B.S. (2006) Rotavirus activates JNK and p38 signaling pathways in intestinal cells, leading to AP-1-driven transcriptional responses and enhanced virus replication. J Virol 80: 10624-10633.
25. Kedzierska, K., Crowe, S.M., Turnville, S., and Cunningham, A.L. (2003) The influence of cytokines, chemokines and their receptors on HIV-1 replication in monocytes and macrophages. Rev Med Virol 13: 39-56.
26. Kelder, W., McArthur, J.C., Nance-Sproson, T., McClernon, D., and Griffin, D.E. (1998) Beta-chemokines MCP-1 and RANTES are selectively increased in cerebrospinal fluid of patients with human immunodeficiency virus-associated dementia. Ann Neurol 44: 831-835.
27. Kieser, A., Kilger, E., Gires, O., Ueffing, M., Kolch, W., and Hammerschmidt, W. (1997) Epstein-Barr virus latent membrane protein-1 triggers AP-1 activity via the c-Jun N-terminal kinase cascade. EMBO J 16: 6478-6485.
28. Kumar, A., Manna, S.K., Dhawan, S., and Aggarwal, B.B. (1998) HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1. J Immunol 161: 776-781.
29. Kwon, D., Fuller, A.C., Palma, J.P., Choi, I.H., and Kim, B.S. (2004) Induction of chemokines in human astrocytes by picornavirus infection requires activation of both AP-1 and NF-kappa B. Glia 45: 287-296.
30. Lanzavecchia, A., Reid, P.A., and Watts, C. (1992) Irreversible association of peptides with class II MHC molecules in living cells. Nature 357: 249-252.
31. Lee, S.K., Kim, B.S., Yang, W.S., Kim, S.B., Park, S.K., and Park, J.S. (2001) High glucose induces MCP-1 expression partly via tyrosine kinase-AP-1 pathway in peritoneal mesothelial cells. Kidney Int 60: 55-64.
32. Lim, S.P., and Garzino-Demo, A. (1999) The human immunodeficiency virus type 1 tat protein up-regulates the promoter activity of the beta-chemokine monocyte chemoattractant protein 1 in the human astrocytoma cell line U-87 MG: Role of SP-1, AP-1 and NF-κB consensus sites. J Virol 74: 1632-1640.
33. Poon, M., Liu, B., and Taubman, M.B. (1999) Identification of a novel dexamethasone-sensitive RNA-destabilizing region on rat monocyte chemoattractant protein 1 mRNA. Mol Cell Biol 19: 6471-6478.
34. Popovic, M., Tenner-Racz, K., Pelser, C., Stellbrink, H.J., van Lunzen, J., Lewis, G., et al. (2005) Persistence of HIV-1 structural proteins and glycoproteins in lymph nodes of patients under highly active antiretroviral therapy. Proc Natl Acad Sci USA 102: 14807-14812.
35. Pulliam, L., Gascon, R., Stubblebine, M., McGuire, D., and McGrath, M.S. (1997) Unique monocyte subset in patients with AIDS dementia. Lancet 349: 692-695.
36. Pulliam, L., Sun, B., and Rempel, H. (2004) Invasive chronic inflammatory monocyte phenotype in subjects with high HIV-1 viral load. J Neuroimmunol 157: 93-98.
37. + T cells: A mechanism of immune evasion. FASEB J 18: 1459-1461.
38. Rabbi, M.F., Saifuddin, M., Gu, D.S., Kagnoff, M.F., and Roebuch, K.A. (1997) U5 region of the human immunodeficiency virus type 1 long terminal repeat contains TRE-like cAMP-responsive elements that bind both AP-1 and CREB/ATF proteins. Virology 233: 235-245.
39. Sadowska, B., Barrucco, R., Khalili, K., and Safak, M. (2003) Regulation of human polyomavirus JC virus gene transcription by AP-1 in glial cells. J Virol 77: 665-672.
40. Shyy, Y.J., Ly, Y.S., and Kolattukudy, P.E. (1993) Activation of MCP-1 gene expression is mediated through multiple signalling pathways. Biochem Biophys Res Commun 192: 693-699.
41. Tanaka, Y., Kanai, F., Ichimura, T., Tateishi, K., Asaoka, Y., Guleng, B., et al. (2006) The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1. Oncogene 25: 633-642.
42. Tiberio, L., Tiberio, G., Bardella, L., Cervi, E., Cerea, K., Dreano, M., et al. (2006) Mechanisms of interleukin-6 protection against ischemia-reperfusion injury in rat liver. Cytokine 34: 131-142.
43. Tiberio, G., Tiberio, L., Benetti, A., Cervi, E., Pandolfo, G., Dreano, M., et al. (2007) Interleukin-6 sustains hepatic regeneration in cirrhotic rat. Hepatogastroenterology 54: 878-883.
44. Tulp, A., Verwoerd, D., Dobberstein, B., Ploegh, H.L., and Pieters, J. (1994) Isolation and characterization of the intracellular MHC class II compartment. Nature 369: 120-126.
45. Ueda, A., Ishigatsubo, Y., Okubo, T., Yoshimura, T. (1997) Transcriptional regulation of the human monocyte chemoattractant protein-1 gene. Cooperation of two NF-kappa B sites and NF-kappa B/Rel subunit specificity. J Biol Chem 272: 31092-31099.
46. Varin, A., Decrion, A.-Z., Sabbah, E., Quivy, V., Sire, J., Van Lint, C., et al. (2005) Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-κB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages. J Biol Chem 280: 42557-42567.
47. Vitale, M., Caruso, A.M.A., De Francesco, M.A., Rodella, L., Bozzo, L., Garrafa, E., et al. (2003) HIV-1 matrix protein p17 enhances the proliferative activity of natural killer cells and increases their ability to secrete proinflammatory cytokines. Br J Haematol 120: 337-343.
48. Wahl, S.M., Greenwell-Wild, T., Peng, G., Ma, G., Orenstein, J.M., and Vazquez, N. (2003) Viral and host cofactors facilitate HIV-1 replication in macrophages. J Leukoc Biol 74: 726-735.
49. Wang, N., Verna, L., Hardy, S., Forsayeth, J., Zhu, Y., and Stemerman, M.B. (1999) Adenovirus-mediated overexpression of c-Jun and c-Fos induces intercellular adhesion molecule-1 and monocyte chemoattractant protein-1 in human endothelial cells. Arterioscler Thromb Vasc Biol 19: 2078-2084.
50. Xie, J., Pan, H., Yoo, S., and Gao, S.-J. (2005) Kaposi's sarcoma-associated herpesvirus induction of AP-1 and interleukin 6 during primary infection mediated by multiple mitogen-activated protein kinase pathways. J Virol 79: 15027-15037.