IL-6-deficient mice exhibit normal mucosal IgA responses to local immunizations and Helicobacter felis infection

Journal of Immunology

Volumn 156, Issue 11, 1996, Pages 4290-4297

  Bromander, Anna Kari ^a   Ekman, Lena ^a   Kopf, Manfred ^b   Nedrud, John G ^c   Lycke, Nils Y ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b BASEL INSTITUTE FOR IMMUNOLOGY   (Switzerland)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; IMMUNOGLOBULIN A; INTERLEUKIN 6;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; FEMALE; HELICOBACTER; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNITY; MALE; MOUSE; MUCOSA; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGENS; B-LYMPHOCYTES; CHOLERA TOXIN; FEMALE; HELICOBACTER; HELICOBACTER INFECTIONS; HEMOCYANIN; IMMUNITY, MUCOSAL; IMMUNIZATION; IMMUNOGLOBULIN A, SECRETORY; INTERLEUKIN-6; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OVALBUMIN; PEYER'S PATCHES;

EID: 0029934454     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Kishimoto, T., T. Taga, and S. Akira. 1994. Cytokine signal transduction. Cell 76:253.
2. Van Snick, J. 1995. Interleukin 6: an overview Annu. Rev. Immunol. 8:253.
3. Strober, W., and R. O. Ehrhardt. 1994. Regulation of IgA B cell development. In Handbook of Mucosal Immunology, P. L. Ogra, W. Strober, J. Mestecky, J. R. McGhee, M. E. Lamm, and J. Bienenstock, eds. Academic Press, Inc., San Diego, CA, p. 159.
4. Hilbert, D. M., M. Kopf, B. A. Mock, G. Köhler, and S. Rudikoff. 1995. Interleukin 6 is essential for in vivo development of B lineage neoplasms. J. Exp. Med. 182:243.
5. Ihle, J. N., B. A. Witthuhn, F. W. Quelle, K. Yamamoto, and O. Silvennoinen. 1995. Signaling through the hematopoietic cytokine receptors. Annu. Rev. Immunol. 13:369.
6. Beagley, K., J. Eldridge, F. Lee, H. Kiyono, M. Everson, W. Koopman, T. Hirano, T. Kishimoto, and J. McGhee. 1989. Interleukins and IgA synthesis: human and murine interleukin 6 induce high rate IgA secretion in IgA-committed B cells. J. Exp. Med 169:2133.
7. Kunimoto, D., R. Nordan, and W. Strober. 1989. IL-6 is a potent cofactor of IL-1 in IgM synthesis and of IL-5 in IgA synthesis. J. Immunol. 143:2230.
8. Cebra, J. J., and K. E. Shroff. 1994. Peyer's patches as inductive sites for IgA committment. In Handbook of Mucosal Immunology, P. L. Ogra, W. Strober, J. Mestecky, J. R. McGhee, M. E. Lamm, and J. Bienenstock, eds. Academic Press, Inc., San Diego, CA, p. 151.
9. Dunkley, M. L., and A. J. Husband. 1991. The role of non-B cells in localizing an IgA plasma cell response in the intestine. Reg. Immunol. 3:336.
10. Bao, S., S. Goldstone, and A. J. Husband. 1993. Localization of IFN-γ and IL-6 in murine intestine by in situ hybridization. Immunology 80:666.
11. Kopf, M., H. Baumann, G. Freer, M. Freudenberg, M. Lamers, T. Kishimoto, R. Zinkernagel, H. Bluethmann, and G. Köhler. 1994. Impaired immune and acute phase responses in interleukin-6-deficient mice. Nature 368:339.
12. Ramsay, A., A. Husband, I. Ramshaw, S. Bao, K. Matthaei, G. Köhler, and M. Kopf. 1994. The role of interleukin-6 in mucosal IgA antibody responses in vivo. Science 264:561.
13. Lycke, N., and J. Holmgren. 1986. Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens. Immunology 59:301.
14. Hörnquist, E., N. Lycke, C. Czerkinsky, and J. Holmgren. 1993. Cholera toxin and cholera B subunit as oral-mucosal adjuvant and antigen carrier systems. In Novel delivery systems for oral vaccines, D. T. O' Hagan, ed. CRC Press, Boca Raton, FL, p. 153.
15. Hörnquist, E., and N. Lycke. 1993. Cholera toxin adjuvant greatly promotes antigen priming by T cells. Eur. J. Immunol. 23:2136.
16. Bromander, A. K., J. Holmgren, and N. Lycke,. 1991. Cholera toxin stimulates IL-1 production and enhances antigen presentation by macrophages in vitro. J. Immunol. 146:2908.
17. Bromander, A. K., M. Kjerrulf, J. Holmgren, and N. Lycke. 1993. Cholera toxin enhances alloantigen presentation by cultured intestinal epithelial cells. Scand. J. Immunol. 37:452.
18. Lycke, N. 1986. A sensitive method for detection of specific antibody production in different isotypes from single lamina propria plasma cells. Scand. J. Immunol. 24:393.
19. Vajdy, M., M. H. Kosco-Vilbois, M. Kopf, G. Köhler, and N. Y. Lycke. 1995. Impaired mucosal immune responses in Interleukin 4-targeted mice. J. Exp. Med. 181:41.
20. Elson, C. O., W. Ealding, and J. Lefkowitz. 1984. A lavage technique allowing repeated measurement of IgA antibody in mouse intestinal secretions. J. Immunol. Methods 67:101.
21. Czinn, S. J., A. Cai, and J. Nedrud. 1993. Protection of germ-free mice from infection by Helicobacter felis after active oral or passive IgA immunization. Vaccine 11:637.
22. Lange, S., and J. Holmgren. Protective antitoxic cholera immunity in mice: influence of route and number of immunizations and mode of action of protective antibodies. Acta Pathol. Microbiol. Scand. Sect. C 86:145.
23. Fox, J. G., M. Blanco, C. Murphy, N. S. Taylor, A, Lee, Z. Kabok, and J. Pappo. 1993. Local and systemic immune responses in murine Helicobacter felis active chronic gastritis. Infect. Immun. 61:2309.
24. Butcher, E. C., R. V. Rouse, R. L. Coffman, C. N. Nottenberg, R. R. Hardy, and I. Weissman. 1982. Surface phenotype of Peyer's patch germinal centers: implications for the role of germinal centers in B cell differentiation. J. Immunol. 129:2698.
25. Kroese, F. G. M., W. Timens, and P. Nieuwenhuis. 1990. Germinal center reaction and B lymphocytes: morphology and function. Curr. Top. Pathol. 84:103.
26. Beagley, K., S. Bao, A. Ramsey, J. Eldridge, and A. Husband. 1995. IgA production by peritoneal cavity B cells is IL-6 independent: implications for intestinal IgA responses. Eur. J. Immunol. 25:2123.
27. Kroese, F. G. M., E. C. Butcher, A. M. Stall, P. A. Lalor, S. Adams, and L. A. Herzenberg. 1989. Many of the IgA producing plasma cells in murine gut are derived from self-replenishing precursors in the peritoneal cavity. Int. Immunol. 1:75.
28. Hörnquist, E., L. Ekman, D. Grdic, K. Schön, and N. Lycke. 1995. Paradoxical IgA immunity in CD4-deficient mice: lack of cholera toxin specific protective immunity despite normal gut mucosal IgA differentiation. J. Immunol. 155:2877.
29. Lebman, D., F. D. Lee, and R. L. Coffman. 1990. Mechanism for transforming growth factor β and IL-2 enhancement of IgA expression in lipopolysaccharide-stimulated B cell cultures. J. Immunol. 144:942.
30. Brandtzaeg P. 1995. Basic mechanisms of mucosal immunity. The Immunologist 3:89.
31. Xu-Amano, J,. H. Kiyono, R. Jackson, H. F. Staats, K. Fujihashi, P. D. Burrows, C. O. Elson, S. Pillai, and J. R. McGhee. 1993. Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. J. Exp. Med. 178:1309.
32. Yoshihiro, O., A. G. Rolink, S. Suematsu, T. Kishimoto, and F. Melchers. 1995. An interleukin-6 transgene expressed in B-lymphocyte lineage cells overcomes the T cell-dependent establishment of normal levels of switched immunoglobulin isotypes. Eur. J. Immunl. 25:1332.
33. Murakami, M., T. Tsubata, R. Shinkura, S. Nisitani, M. Okamoto, H. Yoshioka, T. Usui, S. Miyawak, and T. Honjo. 1994. Oral administration of lipopolysaccharides activates B-1 cells in the peritoneal cavity and lamina propria of the gut and induces autoimmune symptoms in an autoantibody transgenic mouse. J. Exp. Med. 180:111.
34. Hörnquist, C. E., K. D. Grdic, T. W. Mak and N. Y. Lycke. 1996. CD8-deficient mice exhibit augmented mucosal immune responses and intact adjuvant effects of cholera toxin. Immunology 87:220.