Critical role for tumor necrosis factor alpha in controlling the number of lumenal pathogenic bacteria and immunopathology in infectious colitis

Infection and Immunity

Volumn 69, Issue 11, 2001, Pages 6651-6659

  Goncalves N S ^a   Ghaem Maghami, M ^a   Monteleone, G ^a   Frankel, G ^a   Dougan, G ^a   Lewis, D J M ^a   Simmons, C P ^a   MacDonald, T T ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; PROTEIN P40; STAT4 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COUNT; BACTERIAL IMMUNITY; CITROBACTER; CITROBACTER RODENTIUM; COLITIS; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; FEMALE; HYPERPLASIA; IMMUNOPATHOLOGY; INFLAMMATION; INTESTINE MUCOSA; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TH1 CELL;

ANIMALS; ANTIGENS, CD; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CITROBACTER FREUNDII; COLON; COLONIC DISEASES, FUNCTIONAL; DNA-BINDING PROTEINS; ENTEROBACTERIACEAE INFECTIONS; FEMALE; GENE EXPRESSION; HYPERPLASIA; INTERLEUKIN-12; INTERLEUKIN-4; INTESTINAL MUCOSA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; STAT4 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034773205     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.11.6651-6659.2001     Document Type: Article

References (60)

1. Detection of intimins α, β, γ, and δ, four intimin derivatives expressed by attaching and effacing microbial pathogens
2. Interaction between stromal cell-derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia
3. The microbiology of transmissible murine colonic hyperplasia
4. Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease
5. Regulation of keratinocyte growth factor gene expression by interleukin 1
6. Expression of interleukin 8 and CD54 by human gastric epithelium after Helicobacter pylori infection in vitro
7. Expression of antimicrobial neutrophil defensin and lysozyme is induced in epithelial cells of active inflammatory bowel disease (IBD) mucosa
8. Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF) IL-2, interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-alpha) and IL-6 on the production of immunoreactive IL-1 and TNF-alpha by human monocytes
9. T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease
10. Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection
11. Interactions between enteropathogenic Escherichia coli and host epithelial cells
12. Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12
13. s) congenic mouse strains show similar cytokine responses following infection with salmonella Dublin
14. Activation of neutrophils by interleukin-1 and-2 and tumor necrosis factors
15. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth
16. Synergistic effects of interferon gamma and tumour necrosis factor alpha on T84 cell function
17. Intimin from enteropathogenic Escherichia coli restores murine virulence to a Citrobacter eaeA mutant: Induction of an immunoglobulin A response to intimin and EspB
18. Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis
19. Citrobacter rodentium infection in mice elicits a mucosal Thl cytokine response and lesions similar to those in murine inflammatory bowel disease
20. Role of bacterial intimin in colonic hyperplasia and inflammation
21. Inhibition of interferon-γ induced interleukin-12 production: A potential mechanism for the anti-inflammatory activities of tumor necrosis factors
22. STATs: Signal transducers and activators of transcription
23. The ultrastructure of transmissible murine colonic hyperplasia
24. A distinct array of proinflammatory cytokines is expressed in human colon epithelials cells in response to bacterial invasion
25. A large toxin from pathogenic Escherichia coli strains that inhibits lymphocyte activation
26. The function of tumour necrosis factor in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease
27. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
28. A small animal model of human Helicobacterpylori active chronic gastritis
29. Escherichia coli that cause diarrhea: Enterotoxigenic, enteropathogenic, enteroinvasive, enterohemorrhagic, and enteroadherent
30. TNF-alpha, nitric oxide and IFN-gamma are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii
31. + T-cell-dependent, interferon-γ mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii
32. Inhibition of IL-12 production in human monocyte-derived macrophages by TNF
33. The central role of chemokines (chemotactic cytokines) in the immunopathogenesis of ulcerative colitis and Crohn's disease
34. Monoclonal anti-TNF-α antibody as a probe of pathogenesis and therapy of rheumatoid disease
35. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α
36. Development of a mouse model of Helicobacter pylori infection that mimics human disease
37. Characterization of tumor necrosis factor-deficient mice
38. A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens
39. Helicobacter specific cell-mediated immune responses display a predominant Thl phenotype and promote a delayed-type hypersensitivity response in the stomachs of mice
40. From the cover: Bad bugs and beleaguered bladders: Interplay between uropathogenic Escherichia coli and innate host defenses
41. Predominant pathogenic role of tumour necrosis factor in experimental colitis in mice
42. Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium
43. The regulation and functional consequence of proinflammatory cytokine binding on human intestinal epithelial cells
44. Up-regulation of the IL-12 receptor beta 2 chain in Crohn's disease
45. A p55 TNF receptor immunoadhesin prevents T cell-mediated intestinal injury by inhibiting matrix metalloproteinase protection
46. + T cells
47. An ultrastructural study of enteropathogenic Escherichia coli infection in human infants
48. Keratinocyte growth factor in celiac disease
49. Attachment of a noninvasive enteric pathogen, enteropathogenic Escherichia coli, to cultured human intestinal epithelial monolayers induces transmigration of neutrophils
50. The eae gene of Citrobacter freundii biotype 4280 is necessary for colonization in transmissible murine colonic hyperplasia
51. Association between tumor necrosis factor-a and disease progression in patients with multiple sclerosis
52. A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn's disease
53. Enteric beta-defensin: Molecular cloning and characterization of a gene with inducible epithelial cell expression associated with Cryptosporidium parvum infection
54. Interleukin 12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T helper cells type 1 and cytotoxic lymphocytes
55. Exploitation of host cells by enteropathogenic Escherichia coli
56. Tumor necrosis factor and Crohn's disease
57. Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)
58. The pathophysiology of tumor necrosis factors
59. T cell receptor expression in intestinal intraepithelial lymphocyte subpopulations of normal and athymic mice
60. What's new about tumour necrosis factors?