Inhibitors of human cytomegalovirus replication drastically reduce the activity of the viral protein kinase pUL97

Journal of General Virology

Volumn 82, Issue 6, 2001, Pages 1439-1450

  Marschall, M ^a   Stein Gerlach, M ^a   Freitag, M ^a   Kupfer, R ^a   van den Bogaard, M ^a   Stamminger, T ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; ANTIVIRUS AGENT; BENZIMIDAZOLE DERIVATIVE; CARBAZOLE DERIVATIVE; CIDOFOVIR; FOMIVIRSEN; FOSCARNET; GANCICLOVIR; GO 7874; INDOLE DERIVATIVE; LEFLUNOMIDE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; TERIFLUNOMIDE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; CATALYSIS; CELL CLONE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG RESISTANCE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ASSAY; GENE DELETION; GENETIC TRANSFECTION; HUMAN CYTOMEGALOVIRUS; IN VITRO STUDY; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SCREENING; VIRUS INHIBITION; VIRUS INTERFERENCE; VIRUS REPLICATION;

EID: 0034982838     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-82-6-1439     Document Type: Article

References (51)

1. The U69 gene of human herpesvirus 6 encodes a protein kinase which can confer ganciclovir sensitivity to baculoviruses
2. Herpes simplex virus thymidine kinase/ganciclovir-induced apoptosis involves ligand-independent death receptor aggregation and activation of caspases
3. Cytomegaloviruses
4. Human herpesvirus 8-encoded thymidine kinase and phospho-transferase homologues confer sensitivity to ganciclovir
5. Alpha-, beta- and gammaherpesviruses encode a putative phosphotransferase
6. A protein kinase associated with Epstein-Barr virus BGLF4 phosphorylates the viral early antigen EA-D in vitro
7. Development of novel benzimidazole riboside compounds for treatment of cytomegalovirus disease
8. The UL13 virion protein of herpes simplex virus type 1 is phosphorylated by a novel virus-induced protein kinase
9. Purification and characterization of the protein kinase encoded by the UL13 gene of herpes simplex virus type 2
10. Herpesviruses encode an unusual protein-serine/threonine kinase which is nonessential for growth in cultured cells
11. Resistance of human cytomegalovirus to antiviral drugs
12. The 'bystander effect': Tumor regression when a fraction of the tumor mass is genetically modified
13. Two versatile eukaryotic expression vectors permitting epitope tagging, radiolabelling and nuclear localisation of expressed proteins
14. Protein kinase C in treatment of diseases: Signal transduction pathways, inhibitors and agents in development
15. Herpes simplex virus type 1 induction of persistent NF-κB nuclear translocation increases the efficiency of virus replication
16. Antiviral agents
17. The human cytomegalovirus UL97 protein is a protein kinase that autophosphorylates on serines and threonines
18. Recent discovery and development of selective protein kinase C inhibitors
19. Eukaryotic elongation factor 1δ is hyperphosphorylated by the protein kinase encoded by the UL13 gene of herpes simplex virus 1
20. Cellular elongation factor 1δ is modified in cells infected with representative alpha-, beta-, or gammaherpesviruses
21. Multiple mechanisms are implicated in the regulation of NF-κB activity during human cytomegalovirus infection
22. Rapid and efficient site-specific mutagenesis without phenotypic selection
23. Human cytomegalovirus UL97 open reading frame encodes a protein that phosphorylates the antiviral nucleoside analogue ganciclovir
24. The ORF regulated synthesis and persistence-specific variation of influenza C viral NS1 protein
25. Recombinant green fluorescent protein-expressing human cytomegalovirus as a tool for screening antiviral agents
26. Inhibition of acute lymphoblastic leukemia by a Jak-2 inhibitor
27. Inhibition of human immunodeficiency virus type 1 replication in vitro by a novel combination of anti-tat single-chain intrabodies and NF-κB antagonists
28. The UL97 gene product of human cytomegalovirus is an early-late protein with nuclear localization but is not a nucleoside kinase
29. Function regions of the human cytomegalovirus protein pUL97 involved in nuclear localization and phosphorylation of ganciclovir and pUL97 itself
30. Amino acids of conserved kinase motifs of cytomegalovirus protein UL97 are essential for autophosphorylation
31. The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse
32. Serine protein kinase associated with varicella-zoster virus ORF 47
33. Phosphorylation of varicella-zoster virus open reading frame (ORF) 62 regulatory product by viral ORF 47-associated protein kinase
34. UL13 protein kinase of herpes simplex virus 1 complexes with glycoprotein E and mediates the phosphorylation of the viral Fc receptor: Glycoproteins E and I
35. The UL13 protein kinase and the infected cell type are determinants of post-translational modification of ICP0
36. Gene therapy for the treatment of brain tumors using intratumoral transduction with the thymidine kinase gene and intravenous ganciclovir
37. Fomivirsen
38. Advances in indolo (2,3-a)carbazole chemistry: Design and synthesis of protein kinase C and topoisomerase I inhibitors
39. A recombinant human cytomegalovirus with a large deletion in UL97 has a severe replication deficiency
40. The UL13 gene of herpes simplex virus 1 encodes the functions for posttranslational processing associated with phosphorylation of the regulatory protein α22
41. Gö6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low-level-producing reservoir cells in vitro
42. Indolocarbazoles: Potent, selective inhibitors of human cytomegalovirus replication
43. Identification of new protein kinase-related genes in three herpesviruses, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus
44. A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells
45. The human cytomegalovirus UL97 protein is phosphorylated and a component of virions
46. Novel mechanism of inhibition of cytomegalovirus by the experimental immunosuppressive agent leflunomide
47. Inhibition of cytomegalovirus in vitro and in vivo by the experimental immunosuppressive agent leflunomide
48. Characterization of the human cytomegalovirus UL97 gene product as a virion-associated protein kinase
49. Human cytomegalovirus upregulates NF-κB activity by transactivating the NF-κB p105/p50 and p65 promoters
50. The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-κB during infection
51. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase