Anti-inflammatory effects and changes in prostaglandin patterns induced by 7β-hydroxy-epiandrosterone in rats with colitis

Journal of Steroid Biochemistry and Molecular Biology

Volumn 110, Issue 3-5, 2008, Pages 255-262

  Hennebert, Olivier ^a   Pelissier, Marie Agnès ^a   Le Mee, Sandrine ^a   Wülfert, Ernst ^b   Morfin, Robert ^a  

^a Bioinformatique et Chimie Moléculaire   (France)

^b Hunter Fleming Ltd   (United Kingdom)

Author keywords

15d PGJ2; COX 2; Inflammation; Oxidative stress; PGD2; PGE2

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; 7BETA HYDROXY EPIANDROSTERONE; CYCLOOXYGENASE 2; DEXTRAN SULFATE; EPIANDROSTERONE; HF 0220; MYELOPEROXIDASE; PROSTAGLANDIN D2; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COLITIS; COLON INJURY; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; ENZYME SYNTHESIS; GOBLET CELL; HISTOPATHOLOGY; INTRACELLULAR FLUID; MALE; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROSTAGLANDIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT;

ALGORITHMS; ANDROSTERONE; ANIMALS; ANTI-INFLAMMATORY AGENTS; COLITIS; CYCLOOXYGENASE 2; CYTOPROTECTION; DEXTRAN SULFATE; DRUG EVALUATION, PRECLINICAL; INTRAMOLECULAR OXIDOREDUCTASES; LIPOCALINS; MALE; PROSTAGLANDINS; RATS; RATS, WISTAR;

RATTUS;

EID: 45249084531     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2007.12.014     Document Type: Article

References (50)

1. Podolsky D.K. The future of IBD treatment. J. Gastroenterol. 38 Suppl. 15 (2003) 63-66
2. Pavlick K.P., Laroux F.S., Fuseler J., Wolf R.E., Gray L., Hoffman J., and Grisham M.B. Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease. Free Radic. Biol. Med. 33 (2002) 311-322
3. Blumberg R.S., Saubermann L.J., and Strober W. Animal models of mucosal inflammation and their relation to human inflammatory bowel disease. Curr. Opin. Immunol. 11 (1999) 648-656
4. Stenson W.F. Prostaglandins and epithelial response to injury. Curr. Opin. Gastroenterol. 23 (2007) 107-110
5. Murthy S., Murthy N.S., Coppola D., and Wood D.L. The efficacy of BAY y 1015 in dextran sulfate model of mouse colitis. Inflamm. Res. 46 (1997) 224-233
6. Funk C.D. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294 (2001) 1871-1875
7. Ajuebor M.N., Singh A., and Wallace J.L. Cyclooxygenase-2-derived prostaglandin D(2) is an early anti-inflammatory signal in experimental colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 279 (2000) G238-G244
8. Melgar S., Drmotova M., Rehnstrom E., Jansson L., and Michaelsson E. Local production of chemokines and prostaglandin E2 in the acute, chronic and recovery phase of murine experimental colitis. Cytokine 35 (2006) 275-283
9. Monneret G., Li H., Vasilescu J., Rokach J., and Powell W.S. 15-Deoxy-delta 12,14-prostaglandins D2 and J2 are potent activators of human eosinophils. J. Immunol. 168 (2002) 3563-3569
10. Dubuquoy L., Rousseaux C., Thuru X., Peyrin-Biroulet L., Romano O., Chavatte P., Chamaillard M., and Desreumaux P. PPARgamma as a new therapeutic target in inflammatory bowel diseases. Gut 55 (2006) 1341-1349
11. Doostzadeh J., and Morfin R. Studies of the enzyme complex responsible for pregnenolone and dehydroepiandrosterone 7 alpha-hydroxylation in mouse tissues. Steroids 61 (1996) 613-620
12. Morfin R., and Courchay G. Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice. J. Steroid Biochem. Mol. Biol. 50 (1994) 91-100
13. Dulos J., Verbraak E., Bagchus W.M., Boots A.M., and Kaptein A. Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: enhancement of dehydroepiandrosterone metabolism by interleukin-1beta. Arthritis Rheum. 50 (2004) 3346-3353
14. Dulos J., van der Vleuten M.A., Kavelaars A., Heijnen C.J., and Boots A.M. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines. Arthritis Rheum. 52 (2005) 770-778
15. Pelissier M.A., Trap C., Malewiak M.I., and Morfin R. Antioxidant effects of dehydroepiandrosterone and 7a-hydroxy-dehydroepiandrosterone in the rat colon, intestine and liver. Steroids 69 (2004) 137-144
16. Pelissier M.A., Muller C., Hill M., and Morfin R. Protection against dextran sodium sulfate-induced colitis by dehydroepiandrosterone and 7alpha-hydroxy-dehydroepiandrosterone in the rat. Steroids 71 (2006) 240-248
17. Muller C., Pompon D., Urban P., and Morfin R. Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type 1. J. Steroid Biochem. Mol. Biol. 99 (2006) 215-222
18. Hennebert O., Chalbot S., Alran S., and Morfin R. Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes. J. Steroid Biochem. Mol. Biol. 104 (2007) 326-333
19. Kim S.B., Chalbot S., Pompon D., Jo D.H., and Morfin R. The human cytochrome P4507B1: catalytic activity studies. J. Steroid Biochem. Mol. Biol. 92 (2004) 383-389
20. Chalbot S., and Morfin R. Neurosteroids: metabolism in human intestine microsomes. Steroids 70 (2005) 319-326
21. Hennebert O., Pernelle C., Ferroud C., and Morfin R. 7alpha- and 7beta-hydroxy-epiandrosterone as substrates and inhibitors for the human 11beta-hydroxysteroid dehydrogenase type 1. J. Steroid Biochem. Mol. Biol. 105 (2007) 159-165
22. 14C-labelled 5α-androstane-3β, 17β-diol. J. Steroid Biochem. 14 (1981) 663-669
23. Pringle A.K., Schmidt W., Deans J.K., Wulfert E., Reymann K.G., and Sundstrom L.E. 7-Hydroxylated epiandrosterone (7-OH-EPIA) reduces ischaemia-induced neuronal damage both in vivo and in vitro. Eur. J. Neurosci. 18 (2003) 117-124
24. Dudas B., Hanin I., Rose M., and Wulfert E. Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid. Neurobiol. Dis. 15 (2004) 262-268
25. Malik A.S., Narayan R.K., Wendling W.W., Cole R.W., Pashko L.L., Schwartz A.G., and Strauss K.I. A novel dehydroepiandrosterone analog improves functional recovery in a rat traumatic brain injury model. J. Neurotrauma 20 (2003) 463-476
26. Sun J.S., Wu C.X., Tsuang Y.H., Chen L.T., and Sheu S.Y. The in vitro effects of dehydroepiandrosterone on chondrocyte metabolism. Osteoarthritis Cartilage 14 (2006) 238-249
27. Mabley J.G., Jagtap P., Perretti M., Getting S.J., Salzman A.L., Virag L., Szabo E., Soriano F.G., Liaudet L., Abdelkarim G.E., Hasko G., Marton A., Southan G.J., and Szabo C. Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase. Inflamm. Res. 50 (2001) 561-569
28. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
29. Krawisz J.E., Sharon P., and Stenson W.F. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models. Gastroenterology 87 (1984) 1344-1350
30. Albrecht R., Pelissier M.A., Atteba S., and Smaili M. Dietary restriction decreases thiobarbituric acid-reactive substances generation in the small intestine and in the liver of young rats. Toxicol. Lett. 63 (1992) 91-96
31. Ohkawa H., Ohishi N., and Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95 (1979) 315-358
32. Levine R.L., Garland D., Oliver C.N., Amici A., Climent I., Lenz A.G., Ahn B.W., Shaltiel S., and Stadtman E.R. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 186 (1990) 464-478
33. Sedlak J., and Lindsay R.H. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 25 (1968) 192-205
34. Claveau D., Sirinyan M., Guay J., Gordon R., Chan C.C., Bureau Y., Riendeau D., and Mancini J.A. Microsomal prostaglandin E synthase-1 is a major terminal synthase that is selectively up-regulated during cyclooxygenase-2-dependent prostaglandin E2 production in the rat adjuvant-induced arthritis model. J. Immunol. 170 (2003) 4738-4744
35. Chen J., Rider D.A., and Ruan R. Identification of valid housekeeping genes and antioxidant enzyme gene expression change in the aging rat liver. J. Gerontol. A Biol. Sci. Med. Sci. 61 (2006) 20-27
36. Scher J.U., and Pillinger M.H. 15d-PGJ2: the anti-inflammatory prostaglandin?. Clin. Immunol. 114 (2005) 100-109
37. Gilroy D.W., Colville-Nash P.R., Willis D., Chivers J., Paul-Clark M.J., and Willoughby D.A. Inducible cyclooxygenase may have anti-inflammatory properties. Nat. Med. 5 (1999) 698-701
38. Belley A., and Chadee K. Prostaglandin E(2) stimulates rat and human colonic mucin exocytosis via the EP(4) receptor. Gastroenterology 117 (1999) 1352-1362
39. Cuzzocrea S., Ianaro A., Wayman N.S., Mazzon E., Pisano B., Dugo L., Serraino I., Di Paola R., Chatterjee P.K., Di Rosa M., Caputi A.P., and Thiemermann C. The cyclopentenone prostaglandin 15-deoxy-delta(12,14)-PGJ2 attenuates the development of colon injury caused by dinitrobenzene sulphonic acid in the rat. Br. J. Pharmacol. 138 (2003) 678-688
40. Cuzzocrea S., Pisano B., Dugo L., Ianaro A., Patel N.S., Di Paola R., Genovese T., Chatterjee P.K., Di Rosa M., Caputi A.P., and Thiemermann C. Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut. Br. J. Pharmacol. 140 (2003) 366-376
41. Su C.G., Wen X., Bailey S.T., Jiang W., Rangwala S.M., Keilbaugh S.A., Flanigan A., Murthy S., Lazar M.A., and Wu G.D. A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. J. Clin. Invest. 104 (1999) 383-389
42. Clark R.B. The role of PPARs in inflammation and immunity. J. Leukoc. Biol. 71 (2002) 388-400
43. Jiang C., Ting A.T., and Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391 (1998) 82-86
44. Kapoor M., Kojima F., Qian M., Yang L., and Crofford L.J. Microsomal prostaglandin E synthase-1 deficiency is associated with elevated peroxisome proliferator-activated receptor gamma: regulation by prostaglandin E2 via the phosphatidylinositol 3-kinase and Akt pathway. J. Biol. Chem. 282 (2007) 5356-5366
45. Rossi A., Kapahi P., Natoli G., Takahashi T., Chen Y., Karin M., and Santoro M.G. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 403 (2000) 103-108
46. Hinz B., Brune K., and Pahl A. 15-Deoxy-delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism. Biochem. Biophys. Res. Commun. 302 (2003) 415-420
47. Okayama M., Hayashi S., Aoi Y., Nishio H., Kato S., and Takeuchi K. Aggravation by Selective COX-1 and COX-2 Inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats. Dig. Dis. Sci. 52 (2007) 2095-2103
48. Singh V.P., Patil C.S., Jain N.K., and Kulkarni S.K. Aggravation of inflammatory bowel disease by cyclooxygenase-2 inhibitors in rats. Pharmacology 72 (2004) 77-84
49. L. Beaugerie, G. Thiefin, [Gastrointestinal complications related to NSAIDs]. Gastroenterol. Clin. Biol. 28 Spec No 3 (2004) C62-C72.
50. Baumgart D.C., and Sandborn W.J. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet 369 (2007) 1641-1657