Protection against dextran sodium sulfate-induced colitis by dehydroepiandrosterone and 7α-hydroxy-dehydroepiandrosterone in the rat

Steroids

Volumn 71, Issue 3, 2006, Pages 240-248

  Pélissier, Marie Agnès ^a   Muller, Caroline ^a   Hill, Martin ^b   Morfin, Robert ^a  

^a Bioinformatique et Chimie Moléculaire   (France)

^b INSTITUTE OF ENDOCRINOLOGY   (Czech Republic)

Author keywords

11 HSD; 7 Hydroxy DHEA; DHEA; Goblet cells; Oxidative stress

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 7ALPHA HYDROXYPRASTERONE; ANDROSTERONE DERIVATIVE; CARBONYL DERIVATIVE; DEXTRAN SULFATE; MYELOPEROXIDASE; PRASTERONE; PROTEIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CELL COUNT; CELL INFILTRATION; COLITIS; CONTROLLED STUDY; ENZYME ACTIVITY; GOBLET CELL; HISTOPATHOLOGY; HOMOGENATE; INFLAMMATION; INTESTINE MUCOSA; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATION; OXIDATIVE STRESS; QUANTITATIVE ANALYSIS; RAT; RECTUM; RECTUM HEMORRHAGE; STEROID METABOLISM; THICKNESS; TISSUE INJURY; WEIGHT REDUCTION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIOXIDANTS; COLITIS; DEHYDROEPIANDROSTERONE; DEXTRAN SULFATE; MALE; OXIDATIVE STRESS; PEROXIDASE; RATS; RATS, WISTAR; THIOBARBITURIC ACID REACTIVE SUBSTANCES; WEIGHT LOSS;

ANIMALIA;

EID: 32144457524     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2005.10.009     Document Type: Article

References (50)

1. M.B. Grisham Oxidants and free radicals in inflammatory bowel disease Lancet 344 1994 859 861
2. N.J. Simmonds, and D.S. Rampton Inflammatory bowel disease - a radical view Gut 34 1993 865 868
3. C. Fiocchi Inflammatory bowel disease: etiology and pathogenesis Gastroenterology 115 1998 182 205
4. L. Lih-Brody, S.R. Powell, K.P. Collier, G.M. Reddy, R. Cerchia, and E. Kahn Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease Dig Dis Sci 41 1996 2078 2086
5. L. Bhaskar, B.S. Ramakrishna, and K.A. Balasubramanian Colonic mucosal antioxidant enzymes and lipid peroxide levels in normal subjects and patients with ulcerative colitis J Gastroenterol Hepatol 10 1995 140 143
6. B.S. Ramakrishna, R. Varghese, S. Jayakumar, M. Mathan, and K.A. Balasubramanian Circulating antioxidants in ulcerative colitis and their relationship to disease severity and activity J Gastroenterol Hepatol 12 1997 490 494
7. A. Tuzun, A. Erdil, V. Inal, A. Aydin, S. Bagci, and Z. Yesilova Oxidative stress and antioxidant capacity in patients with inflammatory bowel disease Clin Biochem 35 2002 569 572
8. G.D. Buffinton, and W.F. Doe Depleted mucosal antioxidant defences in inflammatory bowel disease Free Radic Biol Med 19 1995 911 918
9. I.B. Renes, J.A. Boshuizen, D.J. Van Nispen, N.P. Bulsing, H.A. Buller, and J. Dekker Alterations in Muc2 biosynthesis and secretion during dextran sulfate sodium-induced colitis Am J Physiol Gastrointest Liver Physiol 282 2002 G382 G389
10. I. Ahnfelt-Ronne, O.H. Nielsen, A. Christensen, E. Langholz, V. Binder, and P. Riis Clinical evidence supporting the radical scavenger mechanism of 5-aminosalicylic acid Gastroenterology 98 1990 1162 1169
11. D.K. Podolsky The future of IBD treatment J Gastroenterol 38 Suppl. 15 2003 63 66
12. J.A. Katz Treatment of inflammatory bowel disease with corticosteroids Gastroenterol Clin North Am 33 2004 171 189 vii
13. A. Schottelius, S. Wedel, R. Weltrich, W. Rohde, F. Buttgereit, and S. Schreiber Higher expression of glucocorticoid receptor in peripheral mononuclear cells in inflammatory bowel disease Am J Gastroenterol 95 2000 1994 1999
14. K.I. Takahashi, K. Fukushima, H. Sasano, I. Sasaki, S. Matsuno, and Z.S. Krozowski Type II 11beta-hydroxysteroid dehydrogenase expression in human colonic epithelial cells of inflammatory bowel disease Dig Dis Sci 44 1999 2516 2522
15. J. Bryndova, S. Zbankova, M. Kment, and J. Pacha Colitis up-regulates local glucocorticoid activation and down-regulates inactivation in colonic tissue Scand J Gastroenterol 39 2004 549 553
16. C.B. Whorwood, M.L. Ricketts, and P.M. Stewart Epithelial cell localization of type 2 11 beta-hydroxysteroid dehydrogenase in rat and human colon Endocrinology 135 1994 2533 2541
17. R.E. Smith, K.X. Li, R.K. Andrews, and Z. Krozowski Immunohistochemical and molecular characterization of the rat 11 beta-hydroxysteroid dehydrogenase type II enzyme Endocrinology 138 1997 540 547
18. R.H. Straub, D. Vogl, V. Gross, B. Lang, J. Scholmerich, and T. Andus Association of humoral markers of inflammation and dehydroepiandrosterone sulfate or cortisol serum levels in patients with chronic inflammatory bowel disease Am J Gastroenterol 93 1998 2197 2202
19. M. Szathmari, B. Vasarhelyi, A. Treszl, T. Tulassay, and Z. Tulassay Association of dehydroepiandrosterone sulfate and testosterone deficiency with bone turnover in men with inflammatory bowel disease Int J Colorectal Dis 17 2002 63 66
20. R. Srinivasan, and G.R. Lichtenstein Recent developments in the pharmacological treatment of Crohn's disease Expert Opin Investig Drugs 13 2004 373 391
21. T. Andus, F. Klebl, G. Rogler, N. Bregenzer, J. Scholmerich, and R.H. Straub Patients with refractory Crohn's disease or ulcerative colitis respond to dehydroepiandrosterone: a pilot study Aliment Pharmacol Ther 17 2003 409 414
22. F.H. Klebl, N. Bregenzer, G. Rogler, R.H. Straub, J. Scholmerich, and T. Andus Treatment of pouchitis with dehydroepiandrosterone (DHEA) - a case report Z Gastroenterol 41 2003 1087 1090
23. M.A. Pelissier, C. Trap, M.I. Malewiak, and R. Morfin Antioxidant effects of dehydroepiandrosterone and 7a-hydroxy-dehydroepiandrosterone in the rat colon, intestine and liver Steroids 69 2004 137 144
24. R. Morfin, and G. Courchay Pregnenolone and dehydroepiandrosterone as precursors of active 7-hydroxylated metabolites which increase the immune response in mice J Steroid Biochem Mol Biol 50 1994 91 100
25. J. Doostzadeh, and R. Morfin Studies of the enzyme complex responsible for pregnenolone and dehydroepiandrosterone 7 alpha-hydroxylation in mouse tissues Steroids 61 1996 613 620
26. I. Okayasu, S. Hatakeyama, M. Yamada, T. Ohkusa, Y. Inagaki, and R. Nakaya A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice Gastroenterology 98 1990 694 702
27. B. Robinzon, K.K. Michael, S.L. Ripp, S.J. Winters, and R.A. Prough Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases? Arch Biochem Biophys 412 2003 251 258
28. J.G. Mabley, P. Jagtap, M. Perretti, S.J. Getting, A.L. Salzman, and L. Virag Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase Inflamm Res 50 2001 561 569
29. O.H. Lowry, N.J. Rosenbrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J Biol Chem 193 1951 265 274
30. J.E. Krawisz, P. Sharon, and W.F. Stenson Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models Gastroenterology 87 1984 1344 1350
31. R. Albrecht, M.A. Pelissier, S. Atteba, and M. Smaili Dietary restriction decreases thiobarbituric acid-reactive substances generation in the small intestine and in the liver of young rats Toxicol Lett 63 1992 91 96
32. H. Ohkawa, N. Ohishi, and K. Yagi Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal Biochem 95 1979 315 358
33. R.L. Levine, D. Garland, C.N. Oliver, A. Amici, I. Climent, and A.G. Lenz Determination of carbonyl content in oxidatively modified proteins Methods Enzymol 186 1990 464 478
34. J. Sedlak, and R.H. Lindsay Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent Anal Biochem 25 1968 192 205
35. E. Gaudio, G. Taddei, A. Vetuschi, R. Sferra, G. Frieri, and G. Ricciardi Dextran sulfate sodium (DSS) colitis in rats: clinical, structural, and ultrastructural aspects Dig Dis Sci 44 1999 1458 1475
36. J.M. McCord Iron, free radicals, and oxidative injury Semin Hematol 35 1998 5 12
37. C.F. Babbs Oxygen radicals in ulcerative colitis Free Radic Biol Med 13 1992 169 181
38. K.P. Pavlick, F.S. Laroux, J. Fuseler, R.E. Wolf, L. Gray, and J. Hoffman Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease Free Radic Biol Med 33 2002 311 322
39. Z.L. Wu, K.O. Martin, N.B. Javitt, and JY.L. Chiang Structure and functions of human oxysterol 7 alpha-hydroxylase cDNAs and gene CYP7B1 J Lipid Res 40 1999 2195 2203
40. J. Dulos, E. Verbraak, W.M. Bagchus, A.M. Boots, and A. Kaptein Severity of murine collagen-induced arthritis correlates with increased CYP7B activity: enhancement of dehydroepiandrosterone metabolism by interleukin-1beta Arthritis Rheum 50 2004 3346 3353
41. J. Dulos, M.A. van der Vleuten, A. Kavelaars, C.J. Heijnen, and A.M. Boots CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines Arthritis Rheum 52 2005 770 778
42. J.R. Seckl, and B.R. Walker Minireview: 11beta-hydroxysteroid dehydrogenase type 1 - a tissue-specific amplifier of glucocorticoid action Endocrinology 142 2001 1371 1376
43. I. Dalle-Donne, R. Rossi, D. Giustarini, A. Milzani, and R. Colombo Protein carbonyl groups as biomarkers of oxidative stress Clin Chim Acta 329 2003 23 38
44. T. Grune, T. Reinheckel, and K.J. Davies Degradation of oxidized proteins in K562 human hematopoietic cells by proteasome J Biol Chem 271 1996 15504 15509
45. W.G. Siems, H. Zollner, T. Grune, and H. Esterbauer Metabolic fate of 4-hydroxynonenal in hepatocytes: 1,4-dihydroxynonene is not the main product J Lipid Res 38 1997 612 622
46. M.I. Torres, M. Garcia-Martin, M.I. Fernandez, N. Nieto, A. Gil, and A. Rios Experimental colitis induced by trinitrobenzenesulfonic acid: an ultrastructural and histochemical study Dig Dis Sci 44 1999 2523 2529
47. H.S. Cooper, S.N. Murthy, R.S. Shah, and D.J. Sedergran Clinicopathologic study of dextran sulfate sodium experimental murine colitis Lab Invest 69 1993 238 249
48. S. Chalbot, and R. Morfin Neurosteroids: metabolism in human intestine microsomes Steroids 70 2005 319 326
49. S. Chalbot, and R. Morfin Human liver S9 fractions: metabolism of dehydroepiandrosterone, epiandrosterone, and related 7-hydroxylated derivatives Drug Metab Dispos 33 2005 563 569
50. R. Lathe Steroid and sterol 7-hydroxylation: ancient pathways Steroids 67 2002 967 977