Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats

Digestive Diseases and Sciences

Volumn 52, Issue 9, 2007, Pages 2095-2103

  Okayama, Mitsuaki ^a   Hayashi, Shusaku ^a   Aoi, Yoko ^a   Nishio, Hikaru ^a   Kato, Shinichi ^a   Takeuchi, Koji ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Cyclooxygenase (COX); Dextran sulfate sodium induced colon lesion; Nonsteroidal anti inflammatory drug; Prostaglandin; Selective COX 1 and COX 2 inhibitors

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; CELECOXIB; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; DEXTRAN SULFATE; INDOMETACIN; MESSENGER RNA; MYELOPEROXIDASE; PROSTAGLANDIN E2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLON INJURY; CONTROLLED STUDY; DISEASE SEVERITY; DRUG EFFECT; ENZYME ACTIVITY; GENE EXPRESSION; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT; UPREGULATION; WEIGHT FLUCTUATION;

ANIMALS; CARDIOVASCULAR DISEASES; COLITIS, ULCERATIVE; COLON; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; DEXTRAN SULFATE; DINOPROSTONE; DISEASE MODELS, ANIMAL; GENE EXPRESSION; INDOMETHACIN; MALE; PEROXIDASE; PLASMA SUBSTITUTES; PYRAZOLES; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SPECTROPHOTOMETRY; SULFONAMIDES; TREATMENT OUTCOME;

EID: 34547843601     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-006-9597-z     Document Type: Article

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