PDGF-driven proliferation, migration, and IL8 chemokine secretion in human corneal fibroblasts involve JAK2-STAT3 signaling pathway

Molecular Vision

Volumn 14, Issue , 2008, Pages 1020-1027

  Vij, Neeraj ^a,e   Sharma, Ajay ^a,c   Thakkar, Mahesh ^c,d   Sinha, Sunilima ^a,c   Mohan, Rajiv R ^a,b,c  

^a University of Missouri   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF MISSOURI   (United States)

^e JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 8; JANUS KINASE 2; MESSENGER RNA; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; PLATELET DERIVED GROWTH FACTOR; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ARTICLE; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA CELL; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; FIBROBLAST CULTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIME; VALIDATION STUDY;

CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; CORNEA; FIBROBLASTS; HUMANS; INTERLEUKIN-8; JANUS KINASE 2; MODELS, BIOLOGICAL; PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS;

EID: 44949249979     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Wilson SE, Mohan RR, Mohan RR, Ambrosio R Jr, Hong J, Lee J. The corneal wound healing response: cytokine-mediated interaction of the epithelium, stroma, and inflammatory cells. Prog Retin Eye Res 2001; 20:625-37.
2. Netto MV, Mohan RR, Ambrósio R Jr, Hutcheon AE, Zieske JD, Wilson SE. Wound healing in the cornea: a review of refractive surgery complications and new prospects for therapy. Cornea 2005; 24:509-22.
3. Jester JV, Petroll WM, Cavanagh HD. Corneal stromal wound healing in refractive surgery: the role of myofibroblasts. Prog Retin Eye Res 1999; 18:311-56.
4. Hebenstreit D, Horejs-Hoeck J, Duschl A. JAK/STAT-dependent gene regulation by cytokines. Drug News Perspect 2005; 18:243-9.
5. Murray PJ. The JAK-STAT signaling pathway: input and output integration. J Immunol 2007; 178:2623-9.
6. Liang Q, Mohan RR, Chen L, Wilson SE. Signaling by HGF and KGF in corneal epithelial cells: Ras/MAP kinase and Jak-STAT pathways. Invest Ophthalmol Vis Sci 1998; 39:1329-38.
7. Yoshimura. A, Naka T, Kubo M. SOCS proteins, cytokine signaling and immune regulation. Nat Rev Immunol 2007; 7:454-65.
8. Starr I, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ. A family of cytokine-inducible inhibitors of signalling. Nature 1997; 387:917-21.
9. Nicholson SE, Willson TA, Farley A, Starr I, Zhang JG, Baca M, Alexander WS, Metcalf D, Hilton DJ, Nicola NA. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J 1999; 18:375-85.
10. YasukawaH, Misawa H, Sakamoto H, MasuharaM, Sasaki A, Wakioka T, Ohtsuka S, Imaizumi T, Matsuda T, Ihle JN, Yoshimura A. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J 1999; 18:1309-20.
11. Cohney SJ, Sanden D, Cacalano NA, Yoshimura A, Mui A, Migone TS, Johnston JA. SOCS3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol Cell Biol 1999; 19:4980-8.
12. Stevenson NJ, Haan S, McClurg AE, McGrattan MJ, Armstrong MA, Heinrich PC, Johnston JA. The Chemoattractants, IL8 and Formyl-Methionyl-Leucyl-Phenylalanine, Regulate Granulocyte Colony-Stimulating Factor Signaling by Inducing Suppressor of Cytokine Signaling-1 Expression. J Immunol 2004; 173:3243-9.
13. Mohan RR, Wilson SE. Microarray analysis of PDGF-regulated gene expression in human corneal fibroblast cells. ARVO Annual Meeting; 2004 April 25-29; Fort Lauderdale (FL)
14. Wallace GR, John Curnow S, Wloka K, Salmon M, Murray PI. The role of chemokines and their receptors in ocular disease. Prog Retin Eye Res 2004; 23:435-48.
15. Gharaee-Kermani M. Phan SH. Role of cytokines and cytokine therapy in wound healing and fibrotic diseases. Curr Pharm Des 2001; 7:1083-103.
16. Imanishi J, Kamiyama Y, Iguchi I, Kita M, Sotozono C, Kinoshita S. Growth factors: importance in wound healing and maintenance of transparency of the cornea. Prog Retin Eye Res 2000; 19:113-29.
17. Hong JW, Liu JJ, Lee JS, Mohan RR, Mohan RR, Woods DJ, He YG, Wilson SE. Proinflammatory chemokine induction in keratocytes and inflammatory cell infiltration into the cornea. Invest Ophthalmol Vis Sci 2001; 42:2795-803.
18. Matsushima K, Oppenheim JJ. Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL 1 and TNF. Cytokine 1989; 1:2-13.
19. Dobreva I, Waeber G, James RW, Widmann C. Interleukin-8 secretion by fibroblasts induced by low density lipoproteins is p38 MAPK-dependent and leads to cell spreading and wound closure. J Biol Chem 2006; 281:199-205.
20. Schröder JM.The neutrophil-activating peptide 1/interleukin 8, a novel neutrophil chemotactic cytokine. Arch Immunol Ther Exp (Warsz) 1992; 40:23-31.
21. Feugate JE, Li Q, Wong L, Martins-Green M. The exe chemokine cCAF stimulates differentiation of fibroblasts into myofibroblasts and accelerates wound closure. J Cell Biol 2002; 156:161-72.
22. Cubitt CL, Tang Q, Monteiro CA, Lausch RN, Oakes JE, IL8 gene expression in cultures of human corneal epithelial cells and keratocytes. Invest Ophthalmol Vis Sci 1993; 34:3199-206.
23. Oakes JE, Monteiro CA, Cubitt CL, Lausch RN. Induction of interleukin-8 gene expression is associated with herpes simplex virus infection of human corneal keratocytes but not human corneal epithelial cells. J Virol 1993; 67:4777-84.
24. Ross R, Raines EW, Bowen-Pope DF. The biology of platelet-derived growth factor. Cell 1986; 46:155-69.
25. Yu J, Ustach C, Kim HR. Platelet-derived growth factor signaling and human cancer. J Biochem, Mol Biol 2003; 36:49-59.
26. Alvarez RH, Kantarjian HM, Cortes JE. Biology of platelet-derived growth factor and its involvement in disease. Mayo Clin Proc 2006; 81:1241-57.
27. Kim WJ, Mohan RR, Mohan RR, Wilson SE. Effect of PDGF, IL-1alpha, and BMP2/4 on corneal fibroblast chemotaxis: expression of the platelet-derived growth factor system in the cornea. Invest Ophthalmol Vis Sci 1999; 40:1364-72.
28. Kamiyama K, Iguchi I, Wang X, Imanishi J. Effects of PDGF on the migration of rabbit corneal fibroblasts and epithelial cells. Cornea 1998; 17:315-25.
29. Chodosh J, Astley RA, Butler MG, Kennedy RC. Adenovirus Keratitis: A Role for Interleukin-8. Invest Ophthalmol Vis Sci 2000; 41:783-9.
30. Koch AE, Polverini PJ, Kunkel SL, Harlow LA, DiPietro LA, Elner VM, Elner SG, Strieter RM. Interleukin-8 as a macrophage-derived mediator of angiogenesis. Science 1992; 258;1798-801.
31. Jester IV, Huang J, Petroll WM, Cavanagh HD. TGF beta induced myofibroblast differentiation of rabbit keratocytes requires-synergisfic TGF beta, PDGF and integrin signaling. Exp Eye Res 2002; 75:645-57.
32. Nagai H, Tokumaru S, Sayama K, Shirakata Y, Hanakawa Y, Hirakawa S, Dai X, Tohyama Mi Yang L, Hashimoto K. Suppressor of cytokine signaling 3 negative regulation of signal transducer and activator of transcription 3 in platelet-derived growth factor-induced fibroblast migration. J Dermatol 2007; 34:523-30.
33. Mohan RF, Mohan RR, Kim W-J, Wilson SE. Modulation of TNF alpha-induced apoptosis in corneal fibroblasts by transcription factor NF-kB. Invest Ophthalmol Vis Sci 2000; 41:1327-36.
34. Vij N, Amoako MO, Mazur S, Zeitlin PL. CHOP transcription factor mediates IL8 signaling in cystic fibrosis bronchial epithelial cells. Am J Respir Cell Mol Biol 2008; 38:176-84.
35. Mohan RR, Wilson SE. Ex vivo human corneal epithelial cells express membrane-bound precursor and mature soluble epidermal growth factor (EGF) and transforming growth factor (TGF) alpha proteins. Exp Eye Res 1999; 68:129-31.
36. Vij N, Fang S, Zeitlin PL. Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications. J Biol Chem 2006; 281:17369-78.
37. Mohan RF, Kim WJ, Mohan RF, Chen L, Wilson SE. Bone morphogenic proteins 2 and 4 and their receptors in the adult human cornea. Invest Ophthalmol Vis Sci 1998; 39:2626-36.
38. Vignais ML, Sadowski HB, Watling D, Rogers NC, Gilman M. Platelet-derived growth factor induces phosphorylation of multiple JAK family kinases and STAT proteins. Mol Cell Biol 1996; 16:1759-69.
39. Takeda K, Akira S. STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev 2000; 11:199-207.
40. Yang J, Stark GR. Roles of unphosphorylated STATs in signaling. Cell Res 2008; 18:443-51.
41. Qi JH, Ito N, Clacsson-Welsh L. Tyrosine phosphatase SHP-2 is involved in regulation of platelet-derived growth factor-induced migration. J Biol Chem 1999; 274:14455-63.
42. Klinghoffer RA, Duckworth B, Valius M, Cantley L, Kazlauskas A. Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol Cell Biol 1996; 16:5905-14.
43. Masamune A, Satoh M, Kikuta K, Suzuki N, Shimosegawa T. Activation of JAK-STAT pathway is required for platelet-derived growth factor-induced proliferation of pancreatic stellate cells. World J Gastroenterol 2005; 11:3385-91.
44. Ebong S, Yu CR, Carper DA, Chepelinsky AB, Egwuagu CE. Activation of STAT signaling pathways and induction of suppressors of cytokine signaling (SOCS) proteins in mammalian lens by growth factors. Invest Ophthalmol Vis Sci 2004; 45:872-8.
45. Riehle KJ, Campbell JS, McMahan RS, Johnson MM, Beyer RP, Bammler TK, Fausto N. Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3. J Exp Med 2008; 205:91-103.
46. Ogata H, Chinen T, Yoshida T, Kinjyo I, Takaesu G, Shiraishi H, Iida M, Kobayashi T, Yoshimura A. Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production. Oncogene 2006; 25:2520-30.
47. Broughton G 2nd, Janis JE, Attinger CE. The basic science of wound healing. Plast Reconstr Surg 2006; 117:12S-34S.
48. Clark RAF, ed. The molecular and cellular biology of wound repair. 2nd ed. New York: Plenum Press; 1996.
49. Dell S, Peters S, Müther P, Kociok N, Joussen AM. The role of PDGF receptor inhibitors and P13-kinase signaling in the pathogenesis of corneal neovascularization. Invest Ophthalmol Vis Sci 2006; 47:1928-37.
50. Park CS, Schneider IC, Haugh JM. Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts. J Biol Chem 2003; 278:37064-72.
51. Mohan RR, Mohan RR, Kim WJ, Stark GF, Wilson SE. Defective keratocyte apoptosis in response to epithelial injury in stat I null mice. Exp Eye Res 2000; 70:485-91.
52. Akira S. Functional roles of STAT family proteins: lessons from knockout mice. Stem Cells 1999; 17:138-46.
53. Tran MT, Lausch RN, Oakes JE. Substance P differentially stimulates IL-8 synthesis in human corneal epithelial cells. Invest Ophthalmol Vis Sci 2000; 41:3871-7.