Negative regulation of multifunctional Ca 2+/calmodulin-dependent protein kinases: Physiological and pharmacological significance of protein phosphatases

British Journal of Pharmacology

Volumn 154, Issue 4, 2008, Pages 729-740

  Ishida, A ^a   Sueyoshi, N ^b   Shigeri, Y ^c   Kameshita, I ^b  

^a HIROSHIMA UNIVERSITY   (Japan)

^b KAGAWA UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

Ca 2+ calmodulin dependent protein kinase; Chemical screening; Deactivation; Dephosphorylation; Disease; Inhibitor; Pathogenesis; Phosphorylation; Protein phosphatase

Indexed keywords

1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; BENZIDINE DERIVATIVE; CALCINEURIN; CALCIUM ION; CALYCULIN A; CANTHARIDIN; CIPERMETHRIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOSPORIN; DELTAMETHRIN; EVANS BLUE; FLUORIDE SODIUM; FOSTRIECIN; HEPARIN; LEVODOPA; MICROCYSTIN; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; NODULARIN; OKADAIC ACID; ORTHOVANADIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE (CALCIUM,CALMODULIN); SULFONIC ACID DERIVATIVE; TACROLIMUS; TAUTOMYCIN; TOLIDINE; TRANSCRIPTION FACTOR;

ALZHEIMER DISEASE; AUTOPHOSPHORYLATION; BONE DENSITY; BONE METABOLISM; BRAIN; CALCIUM CELL LEVEL; CELL CYCLE; CENTRAL NERVOUS SYSTEM; DEPHOSPHORYLATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE EXPRESSION REGULATION; HEART; HEART ARRHYTHMIA; HEART FAILURE; HEART INFARCTION; HUMAN; INSULIN RELEASE; LEARNING; LONG TERM POTENTIATION; MEMORY; NEOPLASM; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTRANSMISSION; NONHUMAN; PANCREAS ISLET BETA CELL; PARKINSONISM; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; RAT; REVIEW; SARCOPLASMIC RETICULUM; SPERMATOGENESIS; THYMUS; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION;

ANIMALS; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES; HUMANS; PHOSPHOPROTEIN PHOSPHATASES; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 44949231143     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.127     Document Type: Review

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