Studies on the phosphorylation of protein kinase B by CA2+/calmodulin- dependent protein kinases

Journal of Biochemistry

Volumn 127, Issue 6, 2000, Pages 965-970

  Okuno, Sachiko ^a   Kitani, Takako ^a   Matsuzaki, Hidenori ^b   Konishi, Hiroaki ^b   Kikkawa, Ushio ^b   Fujisawa, Hitoshi ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

Ca2+ calmodulin dependent protein kinase kinase (CaM kinase kinase), Ca2+; Calmodulin dependent protein kinase II (CaM kinase II); Protein kinase B (PKB); Signal transduction; Upstream protein kinase

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE B; THREONINE;

ARTICLE; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; NONHUMAN; SIGNAL TRANSDUCTION;

EID: 0033922003     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022712     Document Type: Article

References (39)

1. Marte, B.M. and Downward, J. (1997) PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. TIBS 22, 355-358
2. Hemmings, B.A. (1997) Akt signaling: linking membrane events to life and death decisions. Science 275, 628-630
3. Yano, S., Tokumitsu, H., and Soderling, T.R. (1998) Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 396, 584-587
4. 2+/calmodulin-dependent protein kinase kinase. J. Biochem. 122, 337-343
5. Ishida, A., Kameshita, I., Okuno, S., Kitani, T., and Fujisawa, H. (1995) A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem. Biophys. Res. Commun. 212, 806-812
6. Hashimoto, Y. and Soderling, T.R. (1987) Calcium-calmodulin-dependent protein kinase II and calcium-phospholipid-dependent protein kinase activities in rat tissues assayed with a synthetic peptide. Arch. Biochem. Biophys. 252, 418-425
7. Konishi, H., Shinomura, T., Kuroda, S., Ono, Y., and Kikkawa, U. (1994) Molecular cloning of rat RAC protein kinase α and β and their association with protein kinase C ζ. Biochem. Biophys. Res. Commun. 205, 817-825
8. 2+/calmodulin-dependent protein kinase IV kinase isoforms in rat brain. J. Biochem. 119, 1176-1181
9. 2+/calmodulin-dependent protein kinase (CaM-kinase) IV by CaM-kinase kinase. J. Biochem. 121, 804-810
10. Okuno, S. and Fujisawa, H. (1993) Requirement of brain extract for the activity of brain calmodulin-dependent protein kinase IV expressed in Escherichia coli. J. Biochem. 114, 167-170
11. 2+/EGTA. J. Biochem. 117, 1070-1075
12. 2+/calmodulin-dependent protein kinase IV (CaM-kinase IV) by changing its susceptibility to phosphorylation by CaM-kinase kinases. J. Biochem. 122, 897-900
13. 2+/calmodulin-dependent protein kinase kinase β from rat cerebellum. J. Biochem. 121, 155-160
14. Tobimatsu, T. and Fujisawa, H. (1989) Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs. J. Biol. Chem. 264, 17907-17912
15. 2+/calmodulin-dependent protein kinase FV kinase from rat brain. J. Biochem. 116, 923-930
16. 2+/calmodulin-dependent protein kinase phosphatase. J. Biochem. 125, 1022-1028
17. 2+/ calmodulin-dependent protein kinase II. J. Biol. Chem. 273, 1904-1910
18. Okuno, S. and Fujisawa, H. (1990) Stabilization, purification and crystallization of catalytic subunit of cAMP-dependent protein kinase from bovine heart. Biochim. Biophys. Acta 1038, 204-208
19. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685
20. 2+-binding, conformational changes, and phosphodiesterase activity. J. Biol Chem. 252, 8415-8422
21. 2+-binding proteins. J. Biol. Chem. 253, 343-346
22. 2+-dependent modulator protein (calmodulin) of bovine brain. J. Biol. Chem. 255, 962-975
23. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275
24. Peterson, G.L. (1977) A simplification of the protein assay method of Lowry et al. which is more generally applicable. Anal. Biochem. 83, 346-356
25. Kameshita, I. and Fujisawa, H. (1995) Preparation and characterization of calmodulin-dependent protein kinase IV (CaM-kinase FV) free of CaM-kinase IV kinase from rat cerebral cortex. J. Biochem. 117, 85-90
26. Cho, F.S., Phillips, K.S., Bogucki, B., and Weaver, T.E. (1994) Characterization of a rat cDNA clone encoding calcium/calmodulin-dependent protein kinase I. Biochim. Biophys. Acta 1224, 156-160
27. Lin, C.R., Kapiloff, M.S., Durgerian, S., Tatemoto, K., Russo, A.F., Hanson, P., Schulman, H., and Rosenfeld, M.G. (1987) Molecular cloning of a brain-specific calcium/calmodulin-dependent protein kinase. Proc. Natl. Acad. Sci. USA 84, 5962-5966
28. 2+/calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene. Mol. Cell. Biol. 11, 3960-3971
29. 2+/calmodulin-dependent protein kinase Gr and calspermin: A gene within a gene. Proc. Natl. Acad. Sci. USA 88, 5784-5788
30. Shoji, S., Ericsson, L.H., Walsh, K.A., Fischer, E.H., and Titani, K. (1983) Amino acid sequence of the catalytic subunit of bovine type II adenosine cyclic 3′,5′-phosphate dependent protein kinase. Biochemistry 22, 3702-3709
31. Roskoski, R., Jr. (1983) Assays of protein kinase. Methods Enzymol. 99, 3-6
32. Corbin, J.D. and Reimann, E.M. (1974) Assay of cyclic AMP-dependent protein kinases. Methods Enzymol. 38, 287-290
33. Okuno, S., Kitani, T., and Fujisawa, H. (1995) Full activation of brain calmodulin-dependent protein kinase IV requires phosphorylation of the amino-terminal serine-rich region by calmodulin-dependent protein kinase IV kinase. J. Biochem. 117, 686-690
34. 2+/calmodulin-dependent protein kinase kinase. Role of the Arg-Prorich insert domain. J. Biol. Chem. 274, 15803-15810
35. Alessi, D.R., Deak, M., Casamayor, A., Caudwell, F.B., Morrice, N., Norman, D.G., Gaffney, P., Reese, C.B., MacDougall, C.N., Harbison, D., Ashworth, A., and Bownes, M. (1997) 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr. Biol. 7, 776-789
36. 2+/calmodulin-dependent protein kinase phosphatase. Biochem. Biophys. Res. Commun. 253, 159-163
37. Sambrook, J., Fritsch, E.F., and Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual, 2nd ed., pp. E.37-E.38, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
38. Yamauchi, T. and Fujisawa, H. (1983) Purification and characterization of the brain calmodulin-dependent protein kinase (Kinase II), which is involved in the activation of tryptophan 5-monooxygenase. Eur. J. Biochem. 132, 15-21
39. Alessi, D.R., James, S.R., Downes, C.P., Holmes, A.B., Gaffney, P.R.J., Reese, C.B., and Cohen, P. (1997) Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr. Biol. 7, 261-269