A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A

Science

Volumn 280, Issue 5367, 1998, Pages 1258-1261

  Westphal, Ryan S ^a   Anderson, Kristin A ^a   Means, Anthony R ^a   Wadzinski, Brian E ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN); CALCIUM; CALMODULIN; CALMODULIN DEPENDENT PROTEIN KINASE IV; CALMODULIN-DEPENDENT PROTEIN KINASE IV; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; HYBRID PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN SERINE THREONINE PHOSPHATASE; PROTEIN-SERINE-THREONINE PHOSPHATASE; VIRUS T ANTIGEN;

ARTICLE; CALCIUM CELL LEVEL; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; ANIMAL; BRAIN; COENZYME; ENZYME ACTIVATION; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; ISOLATION AND PURIFICATION; LEUKEMIA CELL LINE; METABOLISM; MUTATION; PHOSPHORYLATION; RAT;

ANIMALS; ANTIGENS, POLYOMAVIRUS TRANSFORMING; BRAIN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CALMODULIN; COENZYMES; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; ENZYME ACTIVATION; HUMANS; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MUTATION; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC;

EID: 0032557245     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5367.1258     Document Type: Article

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38. Supported by NIH grants GM51366 (B.E.W.), GM33976 and HD07503 (A.R.M.), and NRSA F32 AI09258 (K.A.A.); by grants from the Vanderbilt Diabetes Research and Training Center (DK20593), Cancer Center (CA68485), and Center for Molecular Neuroscience (MH19732); and by the Keck Foundation (Duke University). B.E.W. is the recipient of a Faculty Development Award from the Pharmaceutical Research and Manufacturers of America Foundation. We thank R. Colbran, J. Scott, L. Limbird, D. Lovinger, L. Kerr, and S. Shenolikar for critical discussions of the data and manuscript.