The Caenorhabditis elegans Sex-determining Protein FEM-2 and Its Human Homologue, hFEM-2, Are Ca2+/Calmodulin-dependent Protein Kinase Phosphatases That Promote Apoptosis

Journal of Biological Chemistry

Volumn 276, Issue 47, 2001, Pages 44193-44202

  Tan, Karen Mei Ling ^a   Chan, Shing Leng ^a   Tan, Kuan Onn ^a   Yu, Victor C ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST ACTIVITY; CELLS; ENZYME KINETICS; MUTAGENESIS; PROTEINS;

APOPTOSIS SIGNALING; MAMMALS;

BIOCHEMISTRY;

CASPASE 9; PROTEIN BCL XL; PROTEIN FEM 1; PROTEIN FEM 2; PROTEIN FEM 3; PROTEIN KINASE (CALCIUM,CALMODULIN); UNCLASSIFIED DRUG; CAENORHABDITIS ELEGANS PROTEIN; CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN-DEPENDENT PROTEIN KINASE II; FEM 2 PROTEIN, C ELEGANS; FEM-2 PROTEIN, C ELEGANS; HELMINTH PROTEIN; PHOSPHOPROTEIN PHOSPHATASE;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; DELETION MUTANT; GENETIC ANALYSIS; HUMAN; HUMAN CELL; MAMMAL CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEX DETERMINATION; ANIMAL; CELL LINE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; PHOSPHORYLATION; SEQUENCE HOMOLOGY;

ANIMALIA; CAENORHABDITIS; CAENORHABDITIS ELEGANS; MAMMALIA; NEMATODA;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CELL LINE; HELMINTH PROTEINS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORYLATION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035941193     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M105880200     Document Type: Article

References (56)

1. Metzstein, M. M., Stanfield, G. M., and Horvitz, H. R. (1998) Trends Genet. 14, 410-416
2. Vaux, D. L., and Korsmeyer, S. J. (1999) Cell 96, 245-254
3. Hengartner, M. O. (1998) Nature 391, 440-442
4. Horvitz, H. R. (1999) Cancer Res. 59, 1701s-1706s
5. Schafer, A. J., and Goodfellow, P. N. (1996) Bioessays 18, 955-963
6. Marin, I., and Baker, B. S. (1998) Science 281, 1990-1994
7. Hansen, D., and Pilgrim, D. (1998) Genetics 149, 1353-1362
8. Hansen, D., and Pilgrim, D. (1999) Mech. Dev. 83, 3-15
9. Kimble, J., Edgar, L., and Hirsh, D. (1984) Dev. Biol. 105, 234-239
10. Doniach, T., and Hodgkin, J. (1984) Dev. Biol. 106, 223-235
11. Spence, A. M., Coulson, A., and Hodgkin, J. (1990) Cell 60, 981-990
12. Pilgrim, D., McGregor, A., Jackle, P., Johnson, T., and Hansen, D. (1995) Mol. Biol. Cell 6, 1159-1171
13. Chin-Sang, I. D., and Spence, A. M. (1996) Genes Dev. 10, 2314-2325
14. Ahringer, J., Rosenquist, T. A., Lawson, D. N., and Kimble, J. (1992) EMBO J. 11, 2303-2310
15. Chan, S. L., Tan, K. O., Zhang, L., Yee, K. S., Ronca, F., Chan, M. Y., and Yu, V. C. (1999) J. Biol. Chem. 274, 32461-32468
16. Chan, S. L., Yee, K. S., Tan, K. M., and Yu, V. C. (2000) J. Biol. Chem. 275, 17925-17928
17. Hengartner, M. O., and Horvitz, H. R. (1994) Cell 76, 665-676
18. Xue, D., Shaham, S., and Horvitz, H. R. (1996) Genes Dev. 10, 1073-1083
19. Gaudet, J., VanderElst, I., and Spence, A. M. (1996) Mol. Biol. Cell 7, 1107-1121
20. Mann, D. J., Campbell, D. G., McGowan, C. H., and Cohen, P. T. (1992) Biochim. Biophys. Acta 1130, 100-104
21. Kitani, T., Ishida, A., Okuno, S., Takeuchi, M., Kameshita, I., and Fujisawa, H. (1999) J Biochem. (Tokyo) 125, 1022-1028
22. Nairn, A. C., and Picciotto, M. R. (1994) Semin. Cancer Biol. 5, 295-303
23. Fujisawa, H. (2001) J. Biochem. (Tokyo) 129, 193-199
24. Soderling, T. R. (2000) Curr. Opin. Neurobiol. 10, 375-380
25. Soderling, T. R. (1999) Trends Biochem. 24, 232-237
26. Cohen, O., Feinstein, E., and Kimchi, A. (1997) EMBO J. 16, 998-1008
27. Wright, S. C., Schellenberger, U., Ji, L., Wang, H., and Larrick, J. W. (1997) FASEB J. 11, 843-849
28. Ishida, A., Kameshita, I., and Fujisawa, H. (1998) J. Biol. Chem. 273, 1904-1910
29. Ishida, A., Okuno, S., Kitani, T., Kameshita, I., and Fujisawa, H. (1998) Biochem. Biophys. Res. Commun. 253, 159-163
30. Yee, K. S., and Yu, V. C. (1998) J. Biol. Chem. 273, 5366-5374
31. Nomura, N., Miyajima, N., Sazuka, T., Tanaka, A., Kawarabayasi, Y., Sato, S., Nagase, T., Seki, N., Ishikawa, K., and Tabata, S. (1994) DNA Res. 1, 27-56
32. Marley, A. E., Kline, A., Crabtree, G., Sullivan, J. E., and Beri, R. K. (1998) FEBS Lett. 431, 121-124
33. Travis, S. M., and Welsh, M. J. (1997) FEBS Lett. 412, 415-419
34. Cohen, P. (1989) Annu. Rev. Biochem. 58, 453-508
35. Tewar, M., Quan, L. T., O'Rouke, K., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S., and Dixit, V. M. (1995) Cell 81, 801-809
36. Adams, J. M., and Cory, S. (1998) Science 281, 1322-1326
37. Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K. M., Krammer, P. H., and Peter, M. E. (1998) EMBO J. 17, 1675-1687
38. Boldin, M. P., Goncharov, T. M., Goltsev, Y. V., and Wallach, D. (1996) Cell 85, 803-815
39. Pan, G., O'Rourke, K., and Dixit, V. M. (1998) J. Biol. Chem. 273, 5841-5845
40. Srinivasula, S. M., Ahmad, M., Fernandes-Alnemri, T., and Alnemri, E. S. (1998) Mol. Cell 1, 949-957
41. Sheen, J. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 975-980
42. Das, A. K., Helps, N. R., Cohen, P. T., and Barford, D. (1996) EMBO J. 15, 6798-6809
43. Tan, K. O., Tan, K. M., and Yu, V. C. (1999) J. Biol. Chem. 274, 23687-23690
44. Shamloo, M., Kamme, F., and Wieloch, T. (2000) Neuroscience 96, 665-674
45. Shackelford, D. A., Yeh, R. Y., Hsu, M., Buzsaki, G., and Zivin, J. A. (1995) J. Cereb. Blood Flow Metab. 15, 450-461
46. Tombes, R. M., Grant, S., Westin, E. H., and Krystal, G. (1995) Cell Growth Differ. 6, 1063-1070
47. McGinnis, K. M., Wang, K. K., and Gnegy, M. E. (2001) Neurosci. Lett. 301, 99-102
48. See, V., Boutillier, A. L., Bito, H., and Loeffler, J. P. (2001) FASEB J. 15, 134-144
49. Eto, K., Takahashi, N., Kimura, Y., Masuho, Y., Arai, K., Muramatsu, M., and Tokumitsu, H. (1999) J. Biol. Chem. 274, 22556-22562
50. Whitfield, L. S., Lovell-Badge, R., and Goodfellow, P. N. (1993) Nature 364, 713-715
51. Tucker, P. K., and Lundrigan, B. L. (1993) Nature 364, 715-717
52. Koopman, P., Gubbay, J., Vivian, N., Goodfellow, P., and Lovell-Badge, R. (1991) Nature 351, 117-121
53. de Bono, M., and Hodgkin, J. (1996) Genetics 144, 587-595
54. Kuwabara, P. E. (1996) Genetics 144, 597-607
55. Raymond, C. S., Shamu, C. E., Shen, M. M., Seifert, K. J., Hirsch, B., Hodgkin, J., and Zarkower, D. (1998) Nature 391, 691-695
56. Smith, C. A., McClive, P. J., Western, P. S., Reed, K. J., and Sinclair, A. H. (1999) Nature 402, 601-602