Synthesis and evaluation of nitrostyrene derivative compounds, new snake venom phospholipase A2 inhibitors

Toxicon

Volumn 51, Issue 8, 2008, Pages 1467-1478

  Villar, J A F P ^a   Lima, F T D ^b   Veber, C L ^a   Oliveira, A R M ^a   Calgarotto, A K ^c   Marangoni, S ^c   da Silva, S L ^b  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b FEDERAL UNIVERSITY OF AMAZONAS   (Brazil)

^c UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Bothrops jararacussu; Chemometrics; DFT; Nitrostyrene; PLA2

Indexed keywords

1 ( 2 NITROVINYL)BENZENE; 1 CHLORO 4 ( 2 NITROVINYL)BENZENE; 1 METHOXY 4 ( 2 NITROVINYL)BENZENE; 1 NITRO 2 ( 2 NITROVINYL)BENZENE; 1 NITRO 3 ( 2 NITROVINYL)BENZENE; 1 NITRO 4 ( 2 NITROVINYL)BENZENE; 2 (CYCLOPENTYLOXY) 1 METHOXY 4 ( 2 NITROVINYL)BENZENE; 2 METHOXY 4 ( 2 NITROVINYL)PHENOL; 2 METHOXY 4 ( 2 NITROVINYL)PHENYL ACETATE; N,N DIMETHYLAMINE 4 ( 2 NITROVINYL)BENZENE; NITROSTYRENE DERIVATIVE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; SNAKE VENOM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; DRUG STRUCTURE; DRUG SYNTHESIS; EDEMA; ENZYME ACTIVITY; ENZYME KINETICS; MALE; MOUSE; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; SNAKE; STRUCTURE ACTIVITY RELATION;

ANIMALS; BOTHROPS; CLUSTER ANALYSIS; CROTALID VENOMS; KINETICS; MALE; MICE; MICE, INBRED BALB C; PHOSPHOLIPASES A2; STYRENES;

BOTHROPS JARARACUSSU;

EID: 44949193695     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2008.03.023     Document Type: Article

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