trans-β-nitrostyrene derivatives as slow-binding inhibitors of protein tyrosine phosphatases

Biochemistry

Volumn 43, Issue 47, 2004, Pages 15014-15021

  Park, Junguk ^a   Pei, Dehua ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABSORPTION SPECTROSCOPY; BIOCHEMISTRY; CATALYSIS; COMPLEXATION; HYDROLYSIS; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHATES; PROTEINS;

NUCLEOPHILIC ATTACKS; PHOSPHOTYROSYL (PY); PROTEIN TYROSINE PHOSPHATASES (PTP); SIGNAL TRANSDUCTION;

ENZYMES;

IODOACETIC ACID; NITROSTYRENE; PHOSPHATE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN YOP; STYRENE DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

ABSORPTION SPECTROSCOPY; ARTICLE; CANCER; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYSIS; COMPLEX FORMATION; COVALENT BOND; DIABETES MELLITUS; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; HYDROLYSIS; INFLAMMATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM MECHANICS; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

BINDING SITES; BINDING, COMPETITIVE; ENZYME INHIBITORS; KINETICS; MODELS, CHEMICAL; MOLECULAR STRUCTURE; MUTAGENESIS, INSERTIONAL; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN-TYROSINE-PHOSPHATASE; STYRENES; SUBSTRATE SPECIFICITY;

EID: 9744283378     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0486233     Document Type: Article

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