Efficient augmentation of a long-lasting immune responses in HIV-1 gag DNA vaccination by IL-15 plasmid boosting

Vaccine

Volumn 26, Issue 26, 2008, Pages 3282-3290

  Li, Wenjing ^a   Li, Shirui ^a   Hu, Yu ^a   Tang, Bixia ^a   Cui, Lianxian ^a   He, Wei ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

adjuvant; HIV 1 DNA vaccine; IL 15 plasmid

Indexed keywords

GAG PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; INTERLEUKIN 15; INTERLEUKIN 2; PLASMID DNA;

ADJUVANT THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA IMMUNIZATION; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; FOLLOW UP; GENE THERAPY; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOGENICITY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL;

AIDS VACCINES; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; FEMALE; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV ANTIBODIES; HIV INFECTIONS; IMMUNIZATION, SECONDARY; IMMUNOLOGIC MEMORY; INTERFERON TYPE II; INTERLEUKIN-15; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; T-LYMPHOCYTE SUBSETS; VACCINES, DNA;

EID: 44749088862     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2008.03.081     Document Type: Article

References (57)

1. Harty J.T., and Badovinac V.P. Shaping and reshaping CD8+ T-cell memory. Nat Rev Immunol 8 2 (2008) 107-119
2. Anderson R.J., Hannan C.M., Gilbert S.C., Laidlaw S.M., Sheu E.G., Korten S., et al. Enhanced CD8+ T cell immune responses and protection elicited against Plasmodium berghei malaria by prime boost immunization regimens using a novel attenuated fowlpox virus. J Immunol 172 5 (2004) 3094-3100
3. McConkey S.J., Reece W.H., Moorthy V.S., Webster D., Dunachie S., Butcher G., et al. Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans. Nat Med 9 6 (2003) 729-735
4. Xiao Y., Dong X., and Chen Y.H. Neutralizing antibodies mechanism of neutralization and protective activity against HIV-1. Immunol Res 25 3 (2002) 193-200
5. Letvin N.L., Barouch D.H., and Montefiori D.C. Prospects for vaccine protection against HIV-1 infection and AIDS. Annu Rev Immunol 20 (2002) 73-99
6. Hu G.J., Wang R.Y., Han D.S., Alter H.J., and Shih J.W. Characterization of the humoral and cellular immune responses against hepatitis C virus core induced by DNA-based immunization. Vaccine 17 23-24 (1999) 3160-3170
7. Sedegah M., Weiss W., Sacci Jr. J.B., Charoenvit Y., Hedstrom R., Gowda K., et al. Improving protective immunity induced by DNA-based immunization: priming with antigen and GM-CSF-encoding plasmid DNA and boosting with antigen-expressing recombinant poxvirus. J Immunol 164 11 (2000) 5905-5912
8. Kongkasuriyachai D., Bartels-Andrews L., Stowers A., Collins W.E., Sullivan J., Sattabongkot J., et al. Potent immunogenicity of DNA vaccines encoding Plasmodium vivax transmission-blocking vaccine candidates Pvs25 and Pvs28-evaluation of homologous and heterologous antigen-delivery prime-boost strategy. Vaccine 22 23-24 (2004) 3205-3213
9. Xin K.Q., Ooki T., Jounai N., Mizukami H., Hamajima K., Kojima Y., et al. A DNA vaccine containing inverted terminal repeats from adeno-associated virus increases immunity to HIV. J Gene Med 5 5 (2003) 438-445
10. Ahlers J.D., Belyakov I.M., and Berzofsky J.A. Cytokine, chemokine, and costimulatory molecule modulation to enhance efficacy of HIV vaccines. Curr Mol Med 3 3 (2003) 285-301
11. Mastroianni C.M., d'Ettorre G., Forcina G., and Vullo V. Teaching tired T cells to fight HIV: time to test IL-15 for immunotherapy?. Trends Immunol 25 3 (2004) 121-125
12. Carson W., and Caligiuri M.A. Interleukin-15 as a potential regulator of the innate immune response. Braz J Med Biol Res 31 1 (1998) 1-9
13. Waldmann T.A., and Tagaya Y. The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu Rev Immunol 17 (1999) 19-49
14. Marks-Konczalik J., Dubois S., Losi J.M., Sabzevari H., Yamada N., Feigenbaum L., et al. IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice. Proc Natl Acad Sci USA 97 21 (2000) 11445-11450
15. Munger W., DeJoy S.Q., Jeyaseelan Sr. R., Torley L.W., Grabstein K.H., Eisenmann J., et al. Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2. Cell Immunol 165 2 (1995) 289-293
16. Yajima T., Nishimura H., Wajjwalku W., Harada M., Kuwano H., and Yoshikai Y. Overexpression of interleukin-15 in vivo enhances antitumor activity against MHC class I-negative and -positive malignant melanoma through augmented NK activity and cytotoxic T-cell response. Int J Cancer 99 4 (2002) 573-578
17. Alpdogan O., Eng J.M., Muriglan S.J., Willis L.M., Hubbard V.M., Tjoe K.H., et al. Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation. Blood 105 2 (2005) 865-873
18. Naora H., and Gougeon M.L. Enhanced survival and potent expansion of the natural killer cell population of HIV-infected individuals by exogenous interleukin-15. Immunol Lett 68 2-3 (1999) 359-367
19. Mueller Y.M., Makar V., Bojczuk P.M., Witek J., and Katsikis P.D. IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells. Int Immunol 15 1 (2003) 49-58
20. Perera L.P., Goldman C.K., and Waldmann T.A. IL-15 induces the expression of chemokines and their receptors in T lymphocytes. J Immunol 162 5 (1999) 2606-2612
21. Kanai T., Thomas E.K., Yasutomi Y., and Letvin N.L. IL-15 stimulates the expansion of AIDS virus-specific CTL. J Immunol 157 8 (1996) 3681-3687
22. Agostini C., Trentin L., Sancetta R., Facco M., Tassinari C., Cerutti A., et al. Interleukin-15 triggers activation and growth of the CD8 T-cell pool in extravascular tissues of patients with acquired immunodeficiency syndrome. Blood 90 3 (1997) 1115-1123
23. Zhang X., Sun S., Hwang I., Tough D.F., and Sprent J. Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity 8 5 (1998) 591-599
24. Ku C.C., Murakami M., Sakamoto A., Kappler J., and Marrack P. Control of homeostasis of CD8+ memory T cells by opposing cytokines. Science 288 5466 (2000) 675-678
25. Mueller Y.M., Bojczuk P.M., Halstead E.S., Kim A.H., Witek J., Altman J.D., et al. IL-15 enhances survival and function of HIV-specific CD8+ T cells. Blood 101 3 (2003) 1024-1029
26. Ahmad R., Sindhu S.T., Toma E., Morisset R., and Ahmad A. Studies on the production of IL-15 in HIV-infected/AIDS patients. J Clin Immunol 23 2 (2003) 81-90
27. Kutzler M.A., Robinson T.M., Chattergoon M.A., Choo D.K., Choo A.Y., Choe P.Y., et al. Coimmunization with an optimized IL-15 plasmid results in enhanced function and longevity of CD8 T cells that are partially independent of CD4 T cell help. J Immunol 175 1 (2005) 112-123
28. Mourich D.V., Munks M.W., Murphy J.C., Willson R.C., and Hill A.B. Spermine compaction is an efficient and economical method of producing vaccination-grade DNA. J Immunol Methods 274 1-2 (2003) 257-264
29. Mata M., Travers P.J., Liu Q., Frankel F.R., and Paterson Y. The MHC class I-restricted immune response to HIV-gag in BALB/c mice selects a single epitope that does not have a predictable MHC-binding motif and binds to Kd through interactions between a glutamine at P3 and pocket D. J Immunol 161 6 (1998) 2985-2993
30. Li D., Liu Y., Zhang Y., Xu J., Hong K., Sun M., et al. Adjuvant effects of plasmid-generated hairpin RNA molecules on DNA vaccination. Vaccine 25 39-40 (2007) 6992-7000
31. Barouch D.H., Santra S., Steenbeke T.D., Zheng X.X., Perry H.C., Davies M.E., et al. Augmentation and suppression of immune responses to an HIV-1 DNA vaccine by plasmid cytokine/Ig administration. J Immunol 161 4 (1998) 1875-1882
32. Avice M.N., Demeure C.E., Delespesse G., Rubio M., Armant M., and Sarfati M. IL-15 promotes IL-12 production by human monocytes via T cell-dependent contact and may contribute to IL-12-mediated IFN-gamma secretion by CD4+ T cells in the absence of TCR ligation. J Immunol 161 7 (1998) 3408-3415
33. Sallusto F., Lenig D., Forster R., Lipp M., and Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401 6754 (1999) 708-712
34. Boyer J.D., Kim J., Ugen K., Cohen A.D., Ahn L., Schumann K., et al. HIV-1 DNA vaccines and chemokines. Vaccine 17 Suppl 2 (1999) S53-S64
35. Shrikant P., and Mescher M.F. Opposing effects of IL-2 in tumor immunotherapy: promoting CD8 T cell growth and inducing apoptosis. J Immunol 169 4 (2002) 1753-1759
36. Kovacs J.A., Vogel S., Albert J.M., Falloon J., Davey Jr. R.T., Walker R.E., et al. Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus. N Engl J Med 335 18 (1996) 1350-1356
37. Chow Y.H., Huang W.L., Chi W.K., Chu Y.D., and Tao M.H. Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2. J Virol 71 1 (1997) 169-178
38. Li X.C., Demirci G., Ferrari-Lacraz S., Groves C., Coyle A., Malek T.R., et al. IL-15 and IL-2: a matter of life and death for T cells in vivo. Nat Med 7 1 (2001) 114-118
39. Nelson B.H., and Willerford D.M. Biology of the interleukin-2 receptor. Adv Immunol 70 (1998) 1-81
40. Oh S., Berzofsky J.A., Burke D.S., Waldmann T.A., and Perera L.P. Coadministration of HIV vaccine vectors with vaccinia viruses expressing IL-15 but not IL-2 induces long-lasting cellular immunity. Proc Natl Acad Sci USA 100 6 (2003) 3392-3397
41. Bolesta E., Kowalczyk A., Wierzbicki A., Eppolito C., Kaneko Y., Takiguchi M., et al. Increased level and longevity of protective immune responses induced by DNA vaccine expressing the HIV-1 Env glycoprotein when combined with IL-21 and IL-15 gene delivery. J Immunol 177 1 (2006) 177-191
42. Weninger W., Crowley M.A., Manjunath N., and von Andrian U.H. Migratory properties of naive, effector, and memory CD8(+) T cells. J Exp Med 194 7 (2001) 953-966
43. Kaech S.M., Hemby S., Kersh E., and Ahmed R. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111 6 (2002) 837-851
44. Oh S., Perera L.P., Burke D.S., Waldmann T.A., and Berzofsky J.A. IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells. Proc Natl Acad Sci USA 101 42 (2004) 15154-15159
45. Mosmann T.R., and Coffman R.L. TH1, TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7 (1989) 145-173
46. Darrah P.A., Patel D.T., De Luca P.M., Lindsay R.W., Davey D.F., Flynn B.J., et al. Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med 13 7 (2007) 843-850
47. Bourgeois C., Rocha B., and Tanchot C. A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memory. Science 297 5589 (2002) 2060-2063
48. Sun J.C., Williams M.A., and Bevan M.J. CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection. Nat Immunol 5 9 (2004) 927-933
49. Marzo A.L., Vezys V., Klonowski K.D., Lee S.J., Muralimohan G., Moore M., et al. Fully functional memory CD8 T cells in the absence of CD4 T cells. J Immunol 173 2 (2004) 969-975
50. Hryniewicz A., Price D.A., Moniuszko M., Boasso A., Edghill-Spano Y., West S.M., et al. Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques. J Immunol 178 6 (2007) 3492-3504
51. Chong S.Y., Egan M.A., Kutzler M.A., Megati S., Masood A., Roopchard V., et al. Comparative ability of plasmid IL-12 and IL-15 to enhance cellular and humoral immune responses elicited by a SIVgag plasmid DNA vaccine and alter disease progression following SHIV(89.6P) challenge in rhesus macaques. Vaccine 25 26 (2007) 4967-4982
52. Boyer J.D., Robinson T.M., Kutzler M.A., Vansant G., Hokey D.A., Kumar S., et al. Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid. Proc Natl Acad Sci USA 104 47 (2007) 18648-18653
53. Schluns K.S., Williams K., Ma A., Zheng X.X., and Lefrancois L. Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol 168 10 (2002) 4827-4831
54. Ohteki T., Suzue K., Maki C., Ota T., and Koyasu S. Critical role of IL-15-IL-15R for antigen-presenting cell functions in the innate immune response. Nat Immunol 2 12 (2001) 1138-1143
55. Lodolce J.P., Boone D.L., Chai S., Swain R.E., Dassopoulos T., Trettin S., et al. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity 9 5 (1998) 669-676
56. Andreakos E., Williams R.O., Wales J., Foxwell B.M., and Feldmann M. Activation of NF-kappaB by the intracellular expression of NF-kappaB-inducing kinase acts as a powerful vaccine adjuvant. Proc Natl Acad Sci USA 103 39 (2006) 14459-14464
57. Kuwajima S., Sato T., Ishida K., Tada H., Tezuka H., and Ohteki T. Interleukin 15-dependent crosstalk between conventional and plasmacytoid dendritic cells is essential for CpG-induced immune activation. Nat Immunol 7 7 (2006) 740-746