Interleukin-15 triggers activation and growth of the CD8 T-cell pool in extravascular tissues of patients with acquired immunodeficiency syndrome

Blood

Volumn 90, Issue 3, 1997, Pages 1115-1123

  Agostini, Carlo ^a   Trentin, Livio ^a   Sancetta, Rosaria ^a   Facco, Monica ^a   Tassinari, Cristina ^a   Cerutti, Andrea ^a   Bortolin, Michela ^a   Milani, Antonella ^a   Siviero, Marta ^a   Zambello, Renato ^a   Semenzato, Gianpietro ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; CD8 ANTIGEN; HLA DR ANTIGEN; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR; INTERLEUKIN 2 RECEPTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; FEMALE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; SUPPRESSOR CELL; T LYMPHOCYTE ACTIVATION;

EID: 0030845530     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.3.1115.1115_1115_1123     Document Type: Article

References (31)

1. Itescu S, Dalton J, Zhang HZ, Winchester R: Tissue infiltration in a CD8 lymphocytosis syndrome associated with human immuno-deficiency virus-1 infection has the phenotypic appearance of an antigenically driven response. J Clin Invest 91:2216, 1993
2. Agostini C, Zambello R, Trentin L, Semenzato G: HIV and pulmonary immune responses. Immunol Today 17:359, 1996
3. Plata F, Autran B, Martins LP, Wain-Hobson S, Raphael M, Mayaud C, Denis M, Guillon JM, Debre' P: AIDS-virus specific cytotoxic T lymphocytes in lung disorders. Nature 328:348, 1987
4. Dwyer, Itescu DS, Winchester R: Characterization of the primary structure of the T-cell receptor β chain in cells infiltrating the salivary gland in the sicca syndrome of HIV-infection: Evidence of an antigen-driven clonal selection suggested by restricted combination of Vβ Jβ gene segment usage and shared somatically encoded amino acid residues. J Clin Invest 92:495, 1993
5. Trentin L, Zambello R, Facco M, Sancetta R, Cerruti A, Milani A, Tassinari C, Crivellaro C, Cipriani A, Agostini C, Semenzato G: Skewing of the T cell repertoire in the lung of patients with HIV-1 infection. AIDS 10:729, 1996
6. Grabstein KH, Eisenman J, Shanebeck K, Rauch C, Srinivasan S, Fung V, Beers C, Richardson J, Schoenborn MA, Ahdieh M, Johnson L, Alderson MR, Watson JD, Anderson DM, Giri JG: Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 264:865, 1994
7. Carson WE, Giri JG, Lindemann MJ, Linett ML, Ahdieh M, Paxton R, Anderson D, Eisenman J, Grabstein K, Caligiuri MA: Interleukin (IL)-15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J Exp Med 180:1395, 1994
8. Zambello R, Facco M, Trentin L, Sancetta R, Tassinari C, Perin A, Milani A, Pizzolo G, Rodeghiero F, Agostini C, Meazza R, Ferrini S, Semenzato G: IL-15 triggers the proliferation and the cytotoxicity of granular lymphocytes in patients with lymphoproliferative disease of granular lymphocytes. Blood 89:201, 1997
9. dim) human NK cells. J Immunol 156:3254, 1996
10. Trentin L, Cerutti A, Zambello R, Sancetta R, Tassinari C, Facco M, Adami F, Rodeghiero F, Agostini C, Semenzato G: IL-15 promotes the growth of leukemic cells of patients with B-cell chronic lymphoproliferative disorders. Blood 87:3327, 1996
11. Khan IA, Kasper LH: IL-15 augments CD8+ T cell-mediated immunity against Toxoplasma gondii infection in mice. J Immunol 157:2103, 1996
12. Mclnnes IB, Al-Mughales J, Field M, Leung BP, Huang F, Dixon R, Sturrock RD, Wilkinson PC, Liew FY: The role of interleukin-15 in T-cell migration and activation in rheumatoid arthritis. Nature Med 2:175, 1996
13. Agostini C, Trentin L, Facco M, Sancetta R, Cerutti A, Tassinari C, Cimarosto L, Adami F, Cipriani A, Zambello R, Semenzato G: Role of IL-15, IL-2 and their receptors in the development of T cell alveolitis in pulmonary sarcoidosis. J Immunol 157:910, 1996
14. Giri JG, Ahdieh M, Eisenman J, Shanebeck K. Grabstein KH, Kumaki S, Namen A, Park LS, Cosman D, Anderson D: Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J 13:2822, 1994
15. Seder RA, Grabstein KH, Berzofsky JA: Cytokine interactions in human immunodeficiency virus infected individuals: Roles of interleukin (IL)-2, IL-12, and IL-15. J Exp Med 182:1067, 1995
16. + T lymphocytes in the lung of AIDS patients harbor human immunodeficiency virus type 1. Blood 85:2308, 1995
17. Agostini C, Zambello R, Trentin L, Cerutti A, Enthammer C, Facco M, Milani A, Sancetta R, Garbisa S Semenzato G: Expression of TNF receptors by T cells and membrane TNFα by alveolar macrophages suggests a role for TNFα in the regulation of the local immune responses in the lung of HIV-1-infected patients. J Immunol 155:2928, 1995
18. Twigg HL, Iwamoto GK, Soliman DM: Role of cytokines in alveolar macrophage-T cell adherence in accessory cell function in HIV-intected individuals. J Immunol 149:1462, 1992
19. Spain BA, Soliman DM, Sidner RA, Twigg HL: Enhanced proliferation and IL-2 secretion by lung lymphocytes from HIV-infected subjects. Am J Physiol 269:L498, 1995
20. Israel-Biet D, Cadranel DJ, Beldjord K, Andrieu M, Jeffrey A, Even P: Tumor necrosis factor production in HIV-seropositive subjects. Relationship with lung opportunistic infections and HIV expression in alveolar macrophages. J Immunol 147:490, 1991
21. Doherty TM, Seder RA, Sher A: Induction and regulation of IL-15 expression in murine macrophages. J Immunol 156:735, 1996
22. Kanegane H, Tosato G: Activation of naive and memory T cells by interleukin-15. Blood 88:230, 1996
23. Carson WE, Ross ME, Baiocchi RA, Marien MJ, Boiani N, Grabstein N, Caligiuri MS: Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-γ by natural killer cells in vitro. J Clin Invest 96:2578, 1995
24. Kanai T, Thomas EK, Yasutomi Y, Letvin N: IL-15 stimulates the expansion of AIDS virus-specific CTL. J Immunol 157:3681, 1996
25. Russel SM, Keegan Y, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmnn MC, Miyajima A, Puri PK, Paul WE, Leonard WJ: Interleukin-2 receptor gamma chain: A functional component of the IL-4 receptor. Science 262:1880, 1993
26. Noguchi M, Nakamura Y, Russel SM, Ziegler SF, Tsang M, Cao X, Leonard WJ: Interleukin-2 receptor gamma chain: A functional component of the IL-7 receptor. Science 262:1877, 1993
27. Kondo M, Takeshita T, Ishii N, Nakamura Y, Watanabe S, Arai KI, Sugamura K: Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science 262:1874, 1993
28. Zurawski SM, Vega F, Huyghe B, Zurawski G: Receptors for interleukin 13 and interleukin 4 are complex and share a novel component that functions in signal transduction. EMBO J 12:2663, 1993
29. Denis M, Ghadirian E: Interleukin 13 and interleukin 4 protect bronchoalveolar macrophages from productive infection with human immunodeficiency virus type 1. AIDS Res Hum Retroviruses 10:795, 1994
30. Patki AH, Quinones-Mateu ME, Dorazio D, Yen-Lieberman B, Boom WH, Thomas EK, Lederman M: Activation of antigen-induced lympocyte proliferation by interleukin-15 without the mitogenic effect of interleukin-2 that may induce human immunodeficiency virus type 1 expression. J Clin Invest 98:616, 1996
31. Mori A, Suko M, Kaminuma O, Inoue S, Ohemura T, Nishizaki Y, Nagahori T, Asakura Y, Hoshino A, Okumura Y, Sato G, Ito K, Okudaira H: IL-15 promotes cytokine production of human helper T cells. J Immunol 156:2400, 1996