Activation of NF-κB by the intracellular expression of NF-κB-inducing kinase acts as a powerful vaccine adjuvant

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 39, 2006, Pages 14459-14464

  Andreakos, E ^a,b   Williams, R O ^a   Wales, J ^a   Foxwell, B M ^a   Feldmann, M ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b Academy of Athens Biomedical Research Foundation   (Greece)

Author keywords

Adenovirus; Antigen presentation; Dendritic cells; Immunogenicity

Indexed keywords

ADENOVIRUS VECTOR; B7 ANTIGEN; CD86 ANTIGEN; CHEMOKINE; CYTOKINE; DNA VACCINE; FREUND ADJUVANT; GAMMA INTERFERON; GREEN FLUORESCENT PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G2A; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; NUCLEAR FACTOR KAPPA B INDUCING KINASE; PROTEIN KINASE; RANTES; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VACCINE; ANTIBODY; HISTOCOMPATIBILITY ANTIGEN; HYBRID PROTEIN; NF KAPPA B KINASE; NF-KAPPA B KINASE; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; DRUG EFFICACY; DRUG MECHANISM; HUMAN; HUMAN CELL; IMMUNOGENICITY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH1 CELL; TRANSGENE; UPREGULATION; VACCINE PRODUCTION; ANIMAL; ANTIBODY PRODUCTION; BLOOD; CELL PROLIFERATION; CYTOLOGY; GENE EXPRESSION; GENE VECTOR; GENETICS; IMMUNIZATION; IMMUNOLOGY; METABOLISM; TIME;

ADENOVIRIDAE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES; ANTIBODY FORMATION; ANTIGEN PRESENTATION; CELL PROLIFERATION; CHEMOKINES; DENDRITIC CELLS; GENE EXPRESSION; GENETIC VECTORS; HISTOCOMPATIBILITY ANTIGENS; HUMANS; IMMUNIZATION, SECONDARY; MICE; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, CYTOTOXIC; TH1 CELLS; TIME FACTORS; UP-REGULATION; VACCINES;

EID: 33749240553     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0603493103     Document Type: Article

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