The emerging role of innate immunity in protection against HIV-1 infection

Vaccine

Volumn 26, Issue 24, 2008, Pages 2997-3001

  Lehner, T ^a   Wang, Y ^a   Pido Lopez, J ^a   Whittall, T ^a   Bergmeier, L A ^a   Babaahmady, K ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

HIV; Innate immunity

Indexed keywords

ALPHA BETA INTERFERON RECEPTOR; APOLIPOPROTEIN B MESSENGER RNA EDITING ENZYME CATALYTIC POLYPEPTIDE 3G; BETA CHEMOKINE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CYTOKINE; DEFENSIN; GAMMA INTERFERON; HEAT SHOCK PROTEIN 65; HEAT SHOCK PROTEIN 70; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES; STAT4 PROTEIN; TOLL LIKE RECEPTOR; TRIPARTITE MOTIF PROTEIN 5; VIRUS PROTEIN;

ALLOIMMUNIZATION; ARTICLE; B LYMPHOCYTE; CD25+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL INTERACTION; CELL MATURATION; CELLULAR IMMUNITY; DENDRITIC CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNE RESPONSE; INNATE IMMUNITY; MACROPHAGE; MACROPHAGE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SUPPRESSOR CELL; T LYMPHOCYTE; UPREGULATION; VIRUS INFECTIVITY; VIRUS REPLICATION;

CHEMOKINES, CC; CYTIDINE DEAMINASE; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, NATURAL; INTERFERON TYPE I; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES; VACCINATION;

EID: 44649090003     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.11.060     Document Type: Article

References (60)

1. Levy J.A. The importance of the innate immune system in controlling HIV infection and disease. Trends Immunol 22 (2001) 312-316
2. Lehner T., Wang Y., Cranage M., Bergmeier L.A., Mitchell E., Tao L., et al. Protective mucosal immunity elicited by targeted iliac lymph node immunisation with a subunit SIV envelope and core vaccine in macaques. Nat Med 2 (1996) 767-775
3. Iwaskai A., and Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol (2004) 987-995
4. + T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 200 (2004) 749-759
5. + T cells. Nature 434 (2005) 1148-1152
6. + T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med 200 (2004) 761-770
7. Mattapallil J.J., Douek D.C., Hill B., Nishimura Y., Martin M., and Roederer M. Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 434 (2005) 1093-1097
8. Lehner T., Mitchell E., Bergmeier L., Singh M., Spallek R., Cranage M., et al. The role of γδ T cells in generating antiviral factors and β-chemokines in protection against mucosal simian immunodeficiency virus infection. Eur J Immunol 30 (2000) 2245-2256
9. Hussain L., and Lehner T. Comparative investigation of Langerhans cells and potential receptors for HIV in oral, genitourinary and rectal epithelia. Immunology 85 (1995) 475-484
10. Boismenu R., and Havran W.L. An innate view of γδ T cells. Curr Opin Immunol 9 (1997) 57-63
11. + T cells. J Exp Med 172 (1990) 1225-1231
12. Ferrick D.A., Schrenzel M.D., Mulvania T., Hsieh B., Ferlin W.A., and Lepper H. Differential production of IFN-γ and IL-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo. Nature 373 (1995) 255-257
13. Malkovsky M. The function and specificity of γδ T cells. Vaccine Res 1 (1992) 183-191
14. Wallace M., Bartz S.R., Chang W.-L., MacKenzie D., Pauza C.D., and Malkovsky M. γδ T lymphocyte responses to human immuno-deficiency virus. Clin Exp Immunol 103 (1996) 177-184
15. Lehner T., Wang Y., Cranage M., Tao L., Mitchell E., Bravery C., et al. Upregulation of β-chemokines and downmodulation of CCR5 co-receptors inhibit simian immunodeficiency virus transmission in non-human primates. Immunology 99 (2000) 569-577
16. + lymphocyte subsets during HIV infection. Clin Exp Immunol 75 (1989) 206-210
17. De Paoli P., Gennari D., Martelli P., Basaglia G., Crovatto M., and Battistin S. A subset of lymphocytes is increased during HIV-1 infection. Clin Exp Immunol 83 (1991) 187-191
18. De Maria A., Ferrazin A., Ferrini S., Ciconne E., Terragna A., and Moretta L. Selective increase of a subset of T cell receptor of γδ T lymphocytes in the peripheral blood of patients with HIV-1 infection. J Infect Dis 165 (1992) 917-919
19. Hinz T., Wesch D., Friese K., Reckziegel A., Arden B., and Kabelitz D. T cell γδ repertoire in HIV-1 infected individuals. Eur J Immunol 24 (1994) 3044-3049
20. + T cell expansion in the peripheral blood of HIV-infected persons. J Immunol 154 (1995) 1418-1431
21. Campbell K.S., Dessing M., Lopez-Botet M., Cella M., and Colonna M. Tyrosine phosphorylation of a human killer inhibitory receptors recruits protein tyrosine phosphatase 1C. J Exp Med 184 (1996) 93-100
22. Colonna M., Navarro F., Bellon T., Llano M., Garcia P., Samaridis J., et al. A common inhibitory receptor for MHC class I molecules on human lymphoid and myelomonocytic cells. J Exp Med 186 (1997) 1809-1818
23. Moretta L., Biassoni R., Bottino C., Mingari M.C., and Moretta A. Human NK-cell receptors. Immunol Today 21 (2000) 420-422
24. Mitchell E.A., Bergmeier L.A., Doyle C., Brookes R., Hussain L.A., Wang Y., et al. Homing of mononuclear cells from iliac lymph nodes to the genital and rectal mucosa in non-human primates. Eur J Immunol 28 (1998) 3066-3074
25. Fearon D.T., and Locksley R.M. The instructive role of innate immunity in the acquired immune response. Science 272 (1996) 50-53
26. Milone M.C., and Fitzgerald-Bocarsly P. The mannose receptor mediates induction of IFN-alpha in peripheral blood dendritic cells by enveloped RNA and DNA viruses. J Immunol 161 (1998) 2391-2399
27. Rogge L., D'Ambrosio D., Biffi M., Penna G., Minetti L.J., Presky D.H., et al. The role of STAT4 in species-specific regulation of Th cell development by type 1 IFNs. J Immunol 161 (1998) 6567-6574
28. Cho S.S., Bacon C.M., Sudarshan C., Rees R.C., Finbloom D., Pine R., et al. Activation of STAT4 by IL-12 and IFN-α. Evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J Immunol 157 (1996) 4781-4789
29. Marrack P., Kappler J., and Mitchell T. Type 1 interferons keep activated T cells alive. J Exp Med 189 (1999) 521-530
30. Herold K.C., Lu J., Rulifson I., Vezys V., Taub D., Grusby M.J., et al. Regulation of C-C chemokine production by murine T cells by CD28/B7 costimulation. J Immunol 159 (1997) 4150-4153
31. Riley J.L., Carroll R.G., Levine B.L., Bernstein W., St Louis D.C., Weislow O.S., et al. Intrinsic resistance to T cell infection with HIV type 1 induced by CD28 costimulation. J Immunol 158 (1997) 5545-5553
32. Kornbluth R.S., Kee K., and Richman D.D. CD40 ligand (CD154) stimulation of macrophages to produce HIV-1 suppressive β-chemokines. Proc Natl Acad Sci USA 95 (1998) 5205-5210
33. McDyer J.F., Dybul M., Goletz T.J., Kinter A.L., Thomas E.K., Berzofsky J.A., et al. Differential effects of CD40 ligand/trimer stimulation on the ability of dendritic cells to replicate and transmit HIV infection: evidence for CC-chemokine-dependent and independent mechanisms. J Immunol 162 (1999) 3711-3717
34. Medzhitov R.M., and Janeway Jr. C.A. Innate immunity: impact in immunology on the adaptive immune response. Curr Opin Immunol 9 (1997) 4-9
35. + T cells. Science 270 (1995) 1811-1815
36. Aubertin A.-M., Wang Y., Le Grand R., Beyer C., Tao L., Neildez O., et al. Generation of CD8-suppressor factor and β-chemokines by targeted iliac lymph node immunization in monkeys challenged with SHIV by the rectal route. AIDS Res Hum Retroviruses 16 (2000) 381-392
37. Wang Y., Tao L., Mitchell E., Bogers W.M.J.M., Doyle C., Bravery C.A., et al. Generation of CD8 suppressor factor and β chemokines, induced by xenogeneic immunization, in the prevention of simian immunodeficiency virus infection in macaques. Proc Natl Acad Sci USA 95 (1998) 5223-5228
38. Wang Y., Tao L., Mitchell E., Bravery C., Berlingieri P., Armstrong P., et al. Allo-immunization elicits CD8+ T cell-derived chemokines, HIV suppressor factors and resistance to HIV infection in women. Nat Med 5 (1999) 1004-1009
39. Amara A., Gall S.L., Schwartz O., Salamero J., Montes M., Loetscher P., et al. HIV coreceptor downregulation as antiviral principle: SDF-1 alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J Exp Med 186 (1997) 139-146
40. Mack M., Lucklow B., Nelson P.J., Cihak J., Simmons G., Clapham P.R., et al. Aminooxypentane-RANTES induced CCR5 internalization but inhibits recycling: a novel inhibitory mechanism of HIV infectivity. J Exp Med 187 (1998) 1215-1224
41. Lehner T., Wang Y., Cranage M., Tao L., Mitchell E., Bravery C., et al. Up-regulation of b-chemokines and down-modulation of CCR5 co-receptors inhibit simian immunodeficiency virus transmission in non-human primates. Immunology 99 (2000) 569-577
42. Sun L., Finnegan C.M., Kish-Catalone T., Blumenthal R., Garzino-Demo P., La Terra Maggiore G.M., et al. Human β-defensins suppress human immunodeficiency virus infection: potential role in mucosal protection. J Virol 79 (2005) 14318-14329
43. Sheehy A.M., Gaddis N.C., Choi J.D., and Malim M.H. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 418 (2002) 646-650
44. + T cells. Nature 435 (2005) 108-114
45. Marin M., Rose K.M., Kozak S.L., and Kabat D. HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation. Nat Med 9 (2003) 1398-1403
46. Sheehy A.M., Gaddis N.C., and Malim M.H. The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif. Nat Med 9 (2003) 1404-1407
47. Stopak K., de Noronha C., Yonemoto W., and Greene W.C. HIV-1 vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. Mol Cell 12 (2003) 591-601
48. Mariani R., Chen D., Schrofelbauer B., Navarro F., Konig R., Bollman B., et al. Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif. Cell 114 (2003) 21-31
49. Yap M.W., Nisole S., Lynch C., and Stoye J.P. TRIM5a protein restricts both HIV-1 and murine leukemia virus. Proc Natl Acad Sci USA 101 (2004) 10786-10791
50. Rose K.M., Marin M., Kozak S.L., and Kabat D. Transcriptional regulation of APOBEC3G, a cytidine deaminase that hypermutates human immunodeficiency virus. J Biol Chem 279 (2004) 41744-41749
51. Peng G., Lei K.J., Jin W., Greenwell-Wild T., and Wahl S.M. Induction of APOBEC3 family proteins, a defensive maneuver underlying interferon-induced anti-HIV-1 activity. J Cell Biol 203 (2006) 41-46
52. Jarmuz A., Chester A., Bayliss J., Gisbourne J., Dunham I., Scott J., et al. An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. Genomics 79 (2002) 285-296
53. Kreisberg J.F., Tonemoto W., and Greene W.C. Endogenous factors enhance HIV infection of tissue naive CD4 T cells by stimulating high molecular mass APOBEC3G complex formation. J Exp Med 203 (2006) 865-870
54. Pido-Lopez J., Whittall T., Wang Y., Bergmeier L.A., Babaahmady K., Singh M., et al. Stimulation of cell surface CCR5 and CD40 molecules by their ligands or by HSP70 upregulates APOBEC3G expression in CD4+ T cells and dendritic cells. J Immunol 178 (2007) 1671-1679
55. Wang Y., Kelly C.G., Singh M., McGowan E.G., Carrara A.-S., Bergmeier L.A., et al. Stimulation of Th1-polarizing cytokines, C-C chemokines, maturation of dendritic cells and adjuvant function by the peptide binding fragment of heat shock protein 70. J Immunol 169 (2002) 2422-2429
56. Whittall T., Wang Y., Younson J., Kelly C., Bergmeier L., Peters B., et al. Interaction between the CCR5 chemokine receptors and microbial HSP70. Eur J Immunol 36 (2006) 2304-2314
57. O'Leary J.G., Goofdarzi M., Drayton D.L., and von Andrian H. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nature 5 (2006) 507-516
58. Wang Y., Tao L., Mitchell E., Bergmeier L.A., Doyle C., and Lehner T. The effect of immunization on chemokines and CCR5 and CXCR4 coreceptor functions in SIV binding and chemotaxis. Vaccine 17 (1999) 1826-1836
59. Chen K., Huang J., Zhang C., Huang S., Nunnari G., Wang F.-X., et al. Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells. J Virol 80 (2006) 7645-7657
60. Sukuma R., Mael A.A., and Ikeda Y. Alpha interferon enhances TRIMα-mediated antiviral activities in human and rhesus monkey cells. J Virol 81 (2007) 10201-10206