Allo-immunization elicits CD8+ T cell-derived chemokines, HIV suppressor factors and resistance to HIV infection in women

Nature Medicine

Volumn 5, Issue 9, 1999, Pages 1004-1009

  Wang, Yufei ^a   Tao, Louisa ^a   Mitchell, Elaine ^a   Bravery, Christopher ^a   Berlingieri, Pasqule ^a   Armstrong, Paul ^a   Vaughan, Robert ^c   Underwood, Jenny ^b   Lehner, Thomas ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b ST MARY S HOSPITAL   (United Kingdom)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; SUPPRESSOR FACTOR;

ALLOIMMUNIZATION; ARTICLE; DOWN REGULATION; FEMALE; HELPER CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RESISTANCE; MONOCYTE; PRIORITY JOURNAL; RECURRENT ABORTION; SPONTANEOUS ABORTION; T LYMPHOCYTE SUBPOPULATION; VACCINE PRODUCTION;

ABORTION, HABITUAL; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; CHEMOKINES, CC; FEMALE; GENE EXPRESSION REGULATION; HIV INFECTIONS; HIV-1; HUMANS; IMMUNIZATION; ISOANTIBODIES; LEUKOCYTES, MONONUCLEAR; MACROPHAGE INFLAMMATORY PROTEIN-1; MALE; PREGNANCY; RANTES; RECEPTORS, CCR5; RECEPTORS, CXCR4; SUPPRESSOR FACTORS, IMMUNOLOGIC; VIRUS REPLICATION;

EID: 0032847128     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/12440     Document Type: Article

References (37)

1. + cell anti-HIV activity: Nonlytic suppression of virus replication. AIDS Res. Hum. Retro. 8, 629-640 (1992).
2. + T cells. Science 270, 1811-1815 (1995).
3. Lehner, T. et al. Protective mucosal immunity elicited by targeted iliac lymph node immunization with a subunit SIV envelope and core vaccine in macaques. Nature Med. 2, 767-775 (1996).
4. Heeney, J. et al. β-chemokines and neutralizing antibody titers correlate with sterilizing immunity generated in HIV vaccinated macaques. Proc. Notl. Acad. Sci. USA 95, 10803-10808 (1998).
5. Desrosiers, R.C. et al. Vaccine protection against simian immunodeficiency virus infection, Proc. Natl. Acad. Sci. USA 8, 6353-6357 (1989).
6. Murphey-Corb, M. et al. Inactivated whole SIV vaccine confers protection in macaques. Science 246, 1293-1247 (1989).
7. Carlson, J.K. et al. Vaccine protection of rhesus macaques against simian immunodeficiency virus infection. AIDS Res. Hum. Retroviruses 336, 1239-1246 (1990).
8. Stott, E.J. et al. Preliminary report: protection of cynomolgus macaques against simian immunodeficiency virus by whole fixed cell vaccine. Lancet 336, 1538-1541 (1990).
9. Langlois, A.J., Weinhold, K.J., Matthews, T.J., Greenberg, M.L. & Bolognes, D.P. The ability of certain SIV vaccines to provoke reactions against normal cells. Science 255, 292-293 (1992).
10. Arthur, L.O. et al. Cellular proteins bound to immunodeficiency viruses: implications for pathogenesis and vaccines. Science 258, 1935-1938 (1992).
11. Stott, E.J. et al. Anti-cell antibody in macaques. Nature 353, 393 (1991).
12. Stott J. et al. Protection against simian immunodeficiency virus infection of macaques by cellular or viral antigens. Neuvieme Colloque des Cent Gardes 1994, 219-224 (1994).
13. Wang, Y. et al. Generation of CD8-SF and β-chemokines, induced by xenogeneic immunization, in the prevention of SIV infection in macaques. Proc. Natl. Acad. Sci. USA 95, 5223-5228 (1998).
14. Shearer, G.M., Clerici, M. & Dalgleish, A. Alloimmunization as an AIDS vaccine? Science 262, 161-162 (1993).
15. Clerici, M. et al. Alloactivated cytotoxic T cells recognize the carboxy-terminal domain of human immunodeficiency virus-1 gp120 envelope glycoprotein. Eur. J. Immunol. 23, 2022-2025 (1993).
16. Bruhl, P., Kerschbaum, A., Zimmermann, K., Eibl, M.M. & Mannhalter, J.W. Allostimulated lymphocytes inhibit replication of HIV type 1. AIDS Res. Hum. Retrovirus 12, 31-37 (1996).
17. Mowbray, J.F., Underwood, J.L., Michel, M., Forbes, P.B. & Beard, R.W. Immunization with paternal lymphocytes in women with recurrent miscarriage. Lancet II, 679-680 (1987).
18. Bunce, M., Barnardo, M.C., Procter, J., Marsh, S.C., Vilches, C. & Welsh, K.I. High resolution HLA-C typing by PCR-SSP: identification of allelic frequencies and linkage disequilibria in 604 unrelated random UK Caucasoids and a comparison with serology. Tissue Antigens 50, 100-111 (1997).
19. Kishore, R., Agarrwal, S., Halder, A., Das, V., Shukla, B.R. & Agarwal, S.S. HLA sharing, anti-paternal cytotoxic antibodies and MLR blocking factors in women with recurrent spontaneous abortion. J. Obstet. Cynaecol. Res. 22, 177-183 (1996).
20. Cocchi, F., DeVico, A.L., Garzino-Demo, A., Cara, A., Callo, R.C. & Lusso, P. The V3 domain of the HIV gp120 envelope glycoprotein is critical for chemokine- mediated blockade of infection. Nature Med. 2, 1244-1247 (1996).
21. + cells is mediated by the chemokine receptor CC-CKR-5. Nature 381, 667-673 (1996).
22. Deng, H. et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381, 661 -666 (1996).
23. Feng, Y., Broder, C.C., Kennedy, P.E. & Berger, E.A. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 272, 872-877 (1996).
24. Dean, M. et al. Genetic restriction of HIV infection and progression to AIDS by a deletion allele of the CKR5 structual gene. Science 273, 1856-1862 (1996).
25. Liu, R. et al. Homozygous defect in HIV-1 co-receptor accounts for resistance of some multiply-exposed individuals to HIV infection. Cell 86, 367-377(1996).
26. Samson, M. et al. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382, 722-725 (1996).
27. Amara, A. et al. HIV coreceptor downregulation as antiviral principle: SDF-1α-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. J. Exp. Med. 186, 139-146 (1997).
28. Wu, J. et al. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. J. Exp. Med. 186, 1681-1691 (1997).
29. Simmons, G. et al. Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry. J. Virol. 70, 8355-8360 (1996).
30. Paxton, W. et al. Relative resistant to HIV-1 infection of CD4 lymphocytes from persons who remain uninfected despite multiple high-risk sexual exposures. Nature Med. 2, 412-417 (1996).
31. Pinto, L.A., Sharpe, S., Cohen, D.I. & Shearer, G.M. Alloantigen-stimulated anti-HIV activity. Blood 92, 3346-3354 (1998).
32. Moriuchi, H., Moriuchi, M. & Fauci, A.S. Induction of HIV-1 replication by allogeneic stimulation. J. Immunol. 162, 7543-7548 (1999).
33. Tachibana K. et al. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature 393, 591-594 (1998).
34. Zhou, Y., Kottmann, A.H., Kuroda, M., Taniuchi, I. & Littman D.R. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature 393, 595-599 (1998).
35. Plummer, F.A. et al. Evidence of resistance to HIV among continuously exposed prostitutes in Nairobi, Kenya. Program and Abstracts: IXth Int. Conf. AIDS/HIV STD World Congress Abstract WS, A07-3 (Berlin, 1993).
36. Celum, C.L. et al. Risk factors for repeatedly reactive HLA-1 EIA and indeterminate western blot. A population-based case-control study. Arch. Intern. Med. 154, 1129-1137 (1994).
37. Kind, C. Mother-to-child transmission of human immunodeficiency virus type 1: influence of parity and mode of delivery. Eur. J. Pediatr. 154, 542-545 (1995).