HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation

Nature Medicine

Volumn 9, Issue 11, 2003, Pages 1398-1403

  Marin, Mariana ^a   Rose, Kristine M ^a   Kozak, Susan L ^a   Kabat, David ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B MRNA EDITING ENZYME CATALYTIC POLYPEPTIDE LIKE 3G; PROTEASOME; UNCLASSIFIED DRUG; VIF PROTEIN; VIRUS ENZYME; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME DEGRADATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; VIRION; VIRUS MUTANT;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; GENE PRODUCTS, VIF; HIV-1; HOST-PARASITE RELATIONS; HUMANS; NUCLEOSIDE DEAMINASES; PROTEINS; REPRESSOR PROTEINS;

ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0344845196     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm946     Document Type: Article

References (40)

1. + T lymphocytes. J. Virol. 66, 6489-6495 (1992).
2. Madani, N. & Kabat, D. An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the viral Vif protein. J. Virol. 72, 10251-10255 (1998).
3. Simon, J.H., Gaddis, N.C., Fouchier, R.A. & Malim, M.H. Evidence for a newly discovered cellular anti-HIV-1 phenotype. Nat. Med. 4, 1397-1400 (1998).
4. Sheehy, A.M., Gaddis, N.C., Choi, J.D. & Malim, M.H. Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature 418, 646-650 (2002).
5. Gaddis, N.C., Chertova, E., Sheehy, A.M., Henderson, L.E. & Malim, M.H. Comprehensive investigation of the molecular defect in vif-deficient human immunodeficiency virus type 1 virions. J. Virol. 77, 5810-5820 (2003).
6. Ochsenbauer, C., Wilk, T. & Bosch, V. Analysis of vif-defective human immunodeficiency virus type 1 (HIV-1) virions synthesized in 'non-permissive' T lymphoid cells stably infected with selectable HIV-1. J. Gen. Virol. 78, 627-635 (1997).
7. von Schwedler, U., Song, J., Aiken, C. & Trono, D. Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells. J. Virol. 67, 4945-4955 (1993).
8. Courcoul, M. et al. Peripheral blood mononuclear cells produce normal amounts of defective Vif-human immunodeficiency virus type 1 particles which are restricted for the preretrotranscription steps. J. Virol. 69, 2068-2074 (1995).
9. Simon, J.H. & Malim, M.H. The human immunodeficiency virus type 1 Vif protein modulates the postpenetration stability of viral nucleoprotein complexes. J. Virol. 70, 5297-5305 (1996).
10. Dettenhofer, M., Cen, S., Carlson, B.A., Kleiman, L. & Yu, X.F. Association of human immunodeficiency virus type 1 Vif with RNA and its role in reverse transcription. J. Virol. 74, 8938-8945 (2000).
11. Goncalves, J., Korin, Y., Zack, J. & Gabuzda, D. Role of Vif in human immunodeficiency virus type 1 reverse transcription. J. Virol. 70, 8701-8709 (1996).
12. Teng, B., Burant, C.F. & Davidson, N.O. Molecular cloning of an apolipoprotein B messenger RNA editing protein. Science 260, 1816-1819 (1993).
13. Harris, R.S., Petersen-Mahrt, S.K. & Neuberger, M.S. RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. Mol. Cell 10, 1247-1253 (2002).
14. Liu, H. et al. The Vif protein of human and simian immunodeficiency viruses is packaged into virions and associates with viral core structures. J. Virol. 69, 7630-7638 (1995).
15. Khan, M.A. et al. Human immunodeficiency virus type 1 Vif protein is packaged into the nucleoprotein complex through an interaction with viral genomic RNA. J. Virol. 75, 7252-7265 (2001).
16. Lecossier, D., Bouchonnet, F., Clavel, F. & Hance, A.J. Hypermutation of HIV-1 DNA in the absence of the Vif protein. Science 300, 1112 (2003).
17. Zhang, H. et al. The cytidine deaminase CEM 15 induces hypermutation in newly synthesized HIV-1 DNA. Nature 424, 94-98 (2003).
18. Mangeat, B., Turelli, P., Caron, G., Friedli, L.P. & Trono, D. Broad antiretroviral defense by human Apobec3G through lethal editing of nascent reverse transcripts. Nature 424, 99-103 (2003).
19. Harris, R.S. et al. DNA deamination mediates innate immunity to retroviral infection. Cell 113, 803-809 (2003).
20. Mariani, R. et al. Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif. Cell 114, 21-31 (2003).
21. Oberste, M.S. & Gonad, M.A. Conservation of amino-acid sequence motifs in lentivirus Vif proteins. Virus Genes 6, 95-102 (1992).
22. Page, K.A., Landau, N.R. & Littman, D.R. Construction and use of a human immunodeficiency virus vector for analysis of virus infectivity. J. Virol. 64, 5270-5276 (1990).
23. Madani, N. & Kabat, D. Cellular and viral specificities of human immunodeficiency virus type 1 vif protein. J. Virol. 74, 5982-5987 (2000).
24. Simon, J.H., Sheehy, A.M., Carpenter, E.A., Fouchier, R.A. & Malim, M.H. Mutational analysis of the human immunodeficiency virus type 1 Vif protein. J. Virol. 73, 2675-2681 (1999).
25. Garrett, E.D., Tiley, L.S. & Cullen, B.R. Rev activates expression of the human immunodeficiency virus type 1 vif and vpr gene products. J. Virol. 65, 1653-1657 (1991).
26. Gluschankof, P., Mondor, I., Gelderblom, H.R. & Sattentau, Q.J. Cell membrane vesicles are a major contaminant of gradient-enriched human immunodeficiency virus type-1 preparations. Virology 230, 125-133 (1997).
27. Verma, R. & Deshaies, R.J. A proteasome howdunit: the case of the missing signal. Cell 101, 341-344 (2000).
28. Kamura, T. et al. The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev. 12, 3872-3881 (1998).
29. Iwai, K. et al. Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proc. Natl. Acad. Sci. USA 96, 12436-12441 (1999)
30. Schubert, U. et al. CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway. J. Virol. 72, 2280-2288 (1998).
31. Margottin, F. et al. A novel human WB protein, h-beta TrCp, that interacts with HIV-1 Vpu connects CD4 to the ER degradation pathway through an F-box motif. Mol. Cell 1, 565-574 (1998).
32. Desrosiers, R.C. et al. Identification of highly attenuated mutants of simian immunodeficiency virus. J. Virol. 72, 1431-1437 (1998).
33. Barnes, W.M. PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates. Proc. Natl. Acad. Sci. USA 91, 2216-2220 (1994).
34. Sambrook, J., Fritsch, E.F. & Maniatis, T. In vitro amplification of DNA by the polymerase chain reaction, in Molecular Cloning: A Laboratory Manual 14.5-14.34 (Cold Spring Harbor Laboratory Press, New York, 1989).
35. Helseth, E. et al. Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants. J. Virol. 64, 2416-2420 (1990).
36. Page, K.A., Stearns, S.M. & Littman, D.R. Analysis of mutations in the V3 domain of gp160 that affect fusion and infectivity. J. Virol. 66, 524-533 (1992).
37. Platt, E.J., Kuhmann, S.E., Rose, P.P. & Kabat, D. Adaptive mutations in the V3 loop of gp120 enhance fusogenicity of human immunodeficiency virus type 1 and enable use of a CCR5 coreceptor that lacks the amino-terminal sulfated region. J. Virol. 75, 12266-12278 (2001).
38. Marin, M., Tailor, C.S., Nouri, A. & Kabat, D. Sodium-dependent neutral amino acid transporter type 1 is an auxiliary receptor for baboon endogenous retrovirus. J. Virol. 74, 8085-8093 (2000).
39. Klippel, A., Escobedo, J.A., Hirano, M. & Williams, L.T. The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Mol. Cell. Biol. 14, 2675-2685 (1994).
40. Tailor, C.S., Nouri, A., Lee, C.G., Kozak, C. & Kabat, D. Cloning and characterization of a cell surface receptor for xenotropic and polytropic murine leukemia viruses. Proc. Natl. Acad. Sci. USA 96, 927-932 (1999).