Aberrant genetic control of invariant TCR-bearing NKT cell function in new zealand mouse strains: Possible involvement in systemic lupus erythematosus pathogenesis

Journal of Immunology

Volumn 180, Issue 7, 2008, Pages 4530-4539

  Tsukamoto, Kazuyuki ^a   Ohtsuji, Mareki ^a   Shiroiwa, Wakana ^a,b   Lin, Qingshun ^a,b   Nakamura, Kazuhiro ^a   Tsurui, Hiromichi ^a   Jiang, Yi ^d   Sudo, Katsuko ^c   Nishimura, Hiroyuki ^d   Shirai, Toshikazu ^a   Hirose, Sachiko ^a,e  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOKYO MEDICAL UNIVERSITY   (Japan)

^c TOIN UNIVERSITY OF YOKOHAMA   (Japan)

^d CHINA MEDICAL UNIVERSITY   (China)

^e JUNTENDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACKCROSSING; CHROMOSOME 11; CONTROLLED STUDY; CYTOKINE PRODUCTION; D11MIT14 GENE; DISEASE SEVERITY; FLOW CYTOMETRY; GENE; GENE CONTROL; GENE FREQUENCY; GENE LOCUS; GENOTYPE; IMMUNOGLOBULIN BLOOD LEVEL; LUPUS ERYTHEMATOSUS NEPHRITIS; MOUSE; MOUSE STRAIN; NATURAL KILLER T CELL; NEW ZEALAND BLACK MOUSE; NONHUMAN; ONSET AGE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROGENY; QUANTITATIVE TRAIT LOCUS; SYSTEMIC LUPUS ERYTHEMATOSUS; ANIMAL; BIOSYNTHESIS; CD4 LYMPHOCYTE COUNT; CHROMOSOME; CYTOLOGY; GENETICS; IMMUNOLOGY; METABOLISM; NEW ZEALAND; PATHOLOGY; REGULATORY T LYMPHOCYTE;

ANIMALS; CD4 LYMPHOCYTE COUNT; CHROMOSOMES; GENOTYPE; INTERFERON TYPE II; INTERLEUKIN-4; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; NEW ZEALAND; PHENOTYPE; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, REGULATORY;

EID: 44449160501     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.7.4530     Document Type: Article

References (52)

1. + T cells: development, specificity, and function. Annu. Rev. Immunol. 15: 535-562.
2. Porcelli, S. A., and R. L. Modlin. 1999. The CD1d system: antigen presenting molecules for T cell recognition of lipids and glycolipids. Annu. Rev. Immunol. 17: 297-329.
3. Kronenberg, M., and L. Gapin. 2002. The unconventional lifestyle of NKT cells. Nat. Rev. Immunol 2: 557-568.
4. Taniguchi, M., N. Harada, S. Koji, T. Nakayama, and H. Wakao. 2003. The regulatory role of Va14 NKT cells in innate and acquired immune response. Annu. Rev. Immunol. 21: 483-513.
5. Brigl, M., and M. B. Brenner. 2004. CD1: antigen presentation and T cell function. Annu. Rev. Immunol. 22: 817-890.
6. Kawano, T., J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, et al. 1997. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science 278: 1626-1629.
7. Brossary, L., M. Chioda, N. Burdin, Y. Koezula, G. Casorati, P. Dellabona, and M. Kronenberg. 1998. CD1d-mediated recognition of an α-glycosylceramide by natural killer cells is highly conserved through mammalian evolution. J. Exp. Med. 188: 1521-1528.
8. Wilson, S., S. C. Kent, H. F. Horton, A. A. Hill. P. L. Bollyky, D. A. Hafler, J. L. Strominger, and M. C. Byrne. 2000. Multiple differences in gene expression in regulatory Vα24JαQ T cells from identical twins discordant for type I diabetes. Proc. Natl. Acad. Sci. USA 97: 7411-7416.
9. Kukreja, A., G. Coat, J. Marker, C. Zhang, Z. Sun, K. Lin-Su, S. Ten, M. Sanz, M. Exley, B. Wilson, et al. 2002. Multiple immuno-regulatory defects in type-I diabetes. J. Clin. Invest. 109: 131-140.
10. Sumida, T., A. Sakamoto, H. Murata, Y. Makino, H. Takahashi, S. Yoshida, K. Nishioka, I. Iwamoto, and M. Taniguchi. 1995. Selective reduction of T cells bearing invariant Vα24JαQ antigen receptor in patients with systemic sclerosis. J. Exp. Med. 182: 1163-1168.
11. + NKT cell numbers are decreased in a wide variety of diseases that are characterized by auto- reactive tissue damage. Clin. Immunol. 100: 144-148.
12. + double-negative regulatory natural killer T cells in autoimmune diseases. Arthritis Rheum. 44: 1127-1138.
13. Illes, Z., T. Kondon, J., Newcombe, N. Oka, T. Tabira, and T. Yamamura. 2000. Differential expression of NKT cell Vα24JαQ invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. J. Immunol. 164: 4375-4381.
14. -Vα24JαQ T cells in peripheral blood of patients with relapsing-remitting multiple sclerosis. Clin. Immunol. 98: 11-17.
15. - T-cell deficiency and IDDM in NOD/Lt mice. Diabetes 46: 572-582.
16. Frey, A. B., and T. D. Rao. 1999. NKT cell cytokine imbalance in murine diabetes mellitus. Autoimmunity 29: 201-214.
17. Yang, Y., M. Bao, and J. W. Yoon. 2001. Intrinsic defects in the T-cell lineage results in natural killer T-cell deficiency and the development of diabetes in the nonobese diabetes mouse. Diabetes 50: 2691-2699.
18. Hong, S., M. T. Wilson, I. Serizawa, L. Wu, N. Singh, O. V. Naidenko, T. Miura, T. Haba, D. C. Schere, J. Wei, et al. 2001. The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 7: 1052-1056.
19. Sharif, S., G. A. Arreaza, P. Zucker, Q. S. Mi, J. Sondhi, O. V. Naidenko, M. Kronenberg, Y. Koezuka, T. L. Delovitch, J. M. Gombert, et al. 2001. Activation of natural killer T cells by a-galactosylceramide treatment prevents the onset and recurrence of autoimmune type I diabetes. Nat. Med. 7: 1057-1062.
20. Lehuen, A., O. Lantz, L. Beaudoin, V. Laloux, C. Carnaud, A. Bendelac, J. F. Bach, and R. C. Monteiro. 1998. Overexpression of natural killer T cells protects Vα14-Jα281 transgenic nonobese diabetic mice against diabetes. J. Exp. Med. 188: 1831-1839.
21. Wang, B., Y. B. Geng, and C. R. Wang. 2001. CD1-restricted NK T cells protect nonobese diabetic mice from developing diabetes. J. Exp. Med. 194: 313-320.
22. Shi, F. D., M. Flodstrom, B. Balasa, S. H. Kim, K. Van Gunst, J. L. Strominger, S. B. Wilson, and N. Sarvetnick. 2001. Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc. Natl. Acad. Sci. USA 98:6777-6782.
23. + NK T cells associated with disease development in autoimmune-prone mice. J. Immunol. 156: 4035-4040.
24. Yang, J. Q., V. Saxena, H. Xu, L. Van Kaer, C. R. Wang, and R. R. Singh. 2003. Repeated a-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice. J. Immunol. 171:4439-4446.
25. Singh, A. K., M. T. Wilson, S. Hong, D. Olivares-Villagómez. C. Du, A. K. Stanic, S. Joyce, S. Sriram, Y. Koezuka, and L. V. Kaer. 2001. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J. Exp. Med. 194: 1801-1811.
26. Miyamoto, K., S. Miyake, and T. Yamamura. 2001. A synthetic glygolipid prevents autoimmune encephalomyelitis by inducing Th2 bias of natural killer T cells. Nature 413: 531-534.
27. Chiba, A., S. Oki, K. Miyamato, H. Hashimoto, T. Yamamura, and S. Miyake. 2004. Suppression of collagen-induced arthritis by natural killer T cell activation with OCH, a sphingosine-truncated analog of α- galactosylceramide. Arthritis Rheum. 50: 305-313.
28. Ohnishi, Y., A. Tsutsumi, D. Goto, S. Itoh, I. Matsumoto, M. Taniguchi, and T. Sumida. 2005. TCR Va14 natural killer T cells function as effector T cells in mice with collagen-induced arthritis. Clin. Exp. Immunol. 141: 47-53.
29. Zeng, D., M.-K. Lee, J. Tung, A. Brendolan, and S. Stober. 2000. Cutting edge: A role for CD1 in the pathogenesis of lupus in NZB/NZW mice. J. Immunol. 164:5000-5004.
30. 1 mice. Eur. J. Immunol. 32: 2551-2561.
31. Zeng, D., Y. Liu, S. Sidobre, M. Kronenberg, and S. Strober. 2003. Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus. J. Clin. Invest. 112: 1211-1222.
32. 1 mice. J. Immunol. 175: 763-770.
33. Shirai, T., S. Hirose, T. Okada, and H. Nishimura. 1991. Immunology and im- munopathology of the autoimmune disease of NZB and related mouse strains. In Immunological Disorders in Mice.B.Ríhová and V. Vetvicka, eds. CRC Press, Boca Raton, FL, pp. 95-136.
34. + NK T lymphocytes. J. Immunol. 161: 3271-3281.
35. Knight, J. G., D. D. Adams, and H. D. Purves. 1977. The genetic contribution of the NZB mouse to the renal disease of the NZB α NZW hybrid. Clin. Exp. Immunol. 28: 352-358.
36. 1 mice. J. Exp. Med. 158: 228 -233.
37. 1 hybrid mice. Eur. J. Immunol. 16: 1631-1633.
38. Hirose, S., K. Kinoshita, S. Nozawa, H. Nishimura, and T. Shirai. 1990. Effects of major histocompatibility complex on autoimmune disease of H-2-congenic New Zealand mice. Int. Immunol. 2: 1091-1095.
39. Matsuki, N., A. K. Stanic, M. E. Embers, L. V. Kaer, L. Morel, and S. Joyce. 2003. Genetic dissection of Vα14Jα18 natural killer T cell number and function in autoimmune-prone mice. J. Immunol. 170: 5429-5437.
40. Kawamura, H., T. Kawamura, Y. Kokai, M. Mori, A. Matsuura, H. Oya, S. Handa, S. Suzuki, A. Weerashinghe, H. Watanabe, and T. Abo. 1999. Expansion of extrathymic T cells as well as granulocytes in the liver and other organs of granulocyte-colony stimulating factor transgenic mice: why they lost the ability of hybrid resistance. J. Immunol. 162: 5957-5964.
41. + NKT cells. J. Immunol. 173: 4960 -4966.
42. Gorham, J. D., M. L. Güler, R. G. Steen, A. J. Mackey, M. J. Daly, K. Fredrick, W. F. Dietrich, and K. M. Murphy. 1996. Genetic mapping of a murine locus controlling development of T helper 1/T helper 2 type responses. Proc. Natl. Acad. Sci. USA 93: 12467-12472.
43. Kuchroo, V. K., D. T. Umetsu, R. H. DeKruyff, and G. J. Freeman. 2003. The TIM gene family: emerging roles in immunity and disease. Nat. Rev. Immunol. 3:454-462.
44. Wills-Karp, M., Y. Belkaid, and C. L. Karp. 2003. I-Tim-izing the pathways of counter-regulation. Nat. Immunol. 4: 1050 -1052.
45. Shiroiwa, W., K. Tsukamoto, M. Ohtsuji, Q. Lin, A. Ida, S. Kodera, N. Ohtsuji, K. Nakamura, H. Tsurui, K. Kinoshita, et al. 2006. IL-4Ra polymorphism in regulation of IL-4 synthesis by T cells: implication in susceptibility to a subset of murine lupus. Int. Immunol. 19: 175-183.
46. Bendelac, A., M. Bonnevillw, and J. F. Kearney. 2001. Autoreactivity by design: innate B and T lymphocytes. Nat. Rev. Immunol. 1: 177-186.
47. Zhou, D., J. Mattner, C. Canti, III, N. Schrantz, N. Yin, Y. Gao, Y. Sagiv, K. Hudspeth, Y.-P. Wu, T. Yamashita, et al. 2004. Lysosomal glycosphingolipid recognition by NKT cells. Science 306: 1786-1789.
48. Bendelac, A., P. B. Savage, and L. Teyton. 2006. The biology of NKT cells. Annu. Rev. Immunol. 25: 297-336.
49. Spolski, R., and W. J. Leonard. 2007. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu. Rev. Immunol. 26: 57-79.
50. 1 mice? Int. Immunol. 1: 99-103.
51. Taki, S., S. Hirose, K. Kinoshita, H. Nishimura, T. Shimamura, J. Hamuro, and T. Shirai. 1992. Somatically mutated IgG anti-DNA antibody clonally related to germ-line encoded IgM anti-DNA antibody. Eur. J. Immunol. 22: 987-992.
52. Hirose, S., M. Wakiya, Y. Kawano-Nishi, Y. Jiang, R. Sanokawa, S. Taki, T. Shimamura, K. Kinoshita, H. Tsurui, H. Nishimura, and T. Shirai. 1993. Somatic diversification and affinity maturation of IgM and IgG anti-DNA antibodies in murine lupus. Eur. J. Immunol. 23: 2813-2820.