Expansion and hyperactivity of CD1d-restricted NKT cells during the progression of systemic lupus erythematosus in (New Zealand Black × New Zealand White)F1 mice

Journal of Immunology

Volumn 175, Issue 2, 2005, Pages 763-770

  Forestier, Claire ^a   Molano, Alberto ^a   Im, Jin Seon ^a   Dutronc, Yves ^b   Diamond, Betty ^c   Davidson, Anne ^c   Illarionov, Petr A ^d   Besra, Gurdyal S ^d   Porcelli, Steven A ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b HÔPITAL DU BOCAGE   (France)

^c Och Spine at New York Presbyterian Hospitals   (United States)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CD1D ANTIGEN; GAMMA INTERFERON; T LYMPHOCYTE RECEPTOR ALPHA CHAIN;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CELL ACTIVITY; CONTROLLED STUDY; DISEASE COURSE; DISEASE MODEL; FEMALE; GENE REARRANGEMENT; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NATURAL KILLER CELL; NATURAL KILLER T CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; STRAIN DIFFERENCE; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE ACTIVATION;

EID: 23244447028     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.2.763     Document Type: Article

References (53)

1. Kronenberg, M., and L. Gapin. 2002. The unconventional lifestyle of NKT cells. Nat. Rev. Immunol. 2: 557-568.
2. Kawano, T., J. Cui, Y. Koezuka, I. Toura, Y. Kaneko, K. Motoki, H. Ueno, R. Nakagawa, H. Sato, E. Kondo, et al. 1997. CD1d-restricted and TCR-mediated activation of Vα14 NKT cells by glycosylceramides. Science 278: 1626-1629.
3. + T cells produce large amounts of IL-4 and IFN-γ upon activation by anti-CD3 or CD1. J. Immunol. 159: 2240-2249.
4. Carnaud, C., D. Lee, O. Donnars, S. H. Park, A. Beavis, Y. Koezuka, and A. Bendelac. 1999. Cutting edge; cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J. Immunol. 163: 4647-4650.
5. Mars, L. T., J. Novak, R. S. Liblau, and A. Lehuen. 2004. Therapeutic manipulation of iNKT cells in autoimmunity: modes of action and potential risks. Trends Immunol. 25: 471-476.
6. + NKT cell numbers are decreased in a wide variety of diseases that are characterized by autoreactive tissue damage. Clin. Immunol. 100: 144-148.
7. Wilson, S. B., S. C. Kent, H. F. Horton, A. A. Hill, P. L. Bollyky, D. A. Hafler, J. L. Strominger, and M. C. Byrne. 2000. Multiple differences in gene expression in regulatory Vα 24Jα Q T cells from identical twins discordant for type I diabetes. Proc. Natl. Acad. Sci. USA 97: 7411-7416.
8. Sumida, T., A. Sakamoto, H. Murata, Y. Makino, H. Takahashi, S. Yoshida. K. Nishioka, I. Iwamoto, and M. Taniguchi. 1995. Selective reduction of T cells bearing invariant Vα24 JαQ antigen receptor in patients with systemic sclerosis, J. Exp. Med. 182: 1163-1168.
9. + double-negative regulatory natural killer T cells in autoimmune diseases. Arthritis Rheum. 44: 1127-1138.
10. Illes, Z., T. Kondo, J. Newcombe, N. Oka, T. Tabira, and T. Yamamura. 2000. Differential expression of NK T cell Vα24 JαQ invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy. J. Immunol. 164: 4375-4381.
11. + T-cell deficiency and IDDM in NOD/Lt mice. Diabetes 46: 572-582.
12. Frey, A. B., and T. D. Rao. 1999. NKT cell cytokine imbalance in murine diabetes mellitus. Autoimmunity 29: 201-214.
13. Yang, Y., M. Bao, and J. W. Yoon. 2001. Intrinsic defects in the T-cell lineage results in natural killer T-cell deficiency and the development of diabetes in the nonobese diabetic mouse. Diabetes 50: 2691-2699.
14. Sharif, S., G. A. Arreaza, P. Zucker, Q. S. Mi, J. Sondhi, O. V. Naidenko, M. Kronenberg, Y. Koezuka, T. L. Delovitch, J. M. Gombert, et al. 2001. Activation of natural killer T cells by α-galactosylceramide treatment prevents the onset and recurrence of autoimmune type 1 diabetes. Nat. Med. 7: 1057-1062.
15. Hong, S., M. T. Wilson, I. Serizawa, L. Wu, N. Singh, O. V. Naidenko, T. Miura, T. Haba, D. C. Scherer, J. Wei, et al. 2001. The natural killer T-cell ligand α-galactosylceramide prevents autoimmune diabetes in non-obese diabetic mice. Nat. Med. 7: 1052-1056.
16. Singh, A. K., M. T. Wilson, S. Hong, D. Olivares-Villagomez, C. Du, A. K. Stanic, S. Joyce, S. Sriram, Y. Koezuka, and L. Van Kaer. 2001. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J. Exp. Med. 194: 1801-1811.
17. Lehuen, A., O. Lantz, L. Beaudoin, V. Laloux, C. Carnaud, A. Bendelac, J. F. Bach, and R. C. Monteiro. 1998. Overexpression of natural killer T cells protects Vα14-Jα281 transgenic nonobese diabetic mice against diabetes. J. Exp. Med. 188: 1831-1839.
18. Yang, J. Q., V. Saxena, H. Xu, L. Van Kaer, C. R. Wang, and R. R. Singh. 2003. Repeated α-galactosylceramide administration results in expansion of NK T cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice. J. Immunol. 171: 4439-4446.
19. Zeng, D., Y. Liu, S. Sidobre, M. Kronenberg, and S. Strober. 2003. Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus. J. Clin. Invest. 112: 1211-1222.
20. Kono, D. H., and A. N. Theofilopoulos. 2000. Genetics of systemic autoimmunity in mouse models of lupus. Int. Rev. Immunol. 19: 367-387.
21. Yu, K. O., J. S. Im, A. Molano, Y. Dutronc, P. A. Illarionov, C. Forestier, N. Fujiwara, I. Arias, S. Miyake, T. Yamamura, et al. 2005. Modulation of CD1d-restricted NKT cell responses by using N-acyl variants of α-galactosylceramides. Proc. Natl. Acad. Sci. USA 102: 3383-3388.
22. Matsuda, J. L., O. V. Naidenko, L. Gapin, T. Nakayama, M. Taniguchi, C. R. Wang, Y. Koezuka, and M. Kronenberg. 2000. Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers. J. Exp. Med. 192: 741-754.
23. Katz, J. B., W. Limpanasithikul, and B. Diamond. 1994. Mutational analysis of an autoantibody: differential binding and pathogenicity. J. Exp. Med. 180: 925-932.
24. Marzio, R., J. Mauel, and S. Betz-Corradin. 1999. CD69 and regulation of the immune function. Immunopharmacol. Immunotoxicol 21: 565-582.
25. Bendelac, A., P. Matzinger, R. A. Seder, W. E. Paul, and R. H. Schwartz. 1992. Activation events during thymic selection. J. Exp. Med. 175: 731-742.
26. Miyamoto, K., S. Miyake, and T. Yamamura. 2001. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 413: 531-534.
27. Hahn, B. H. 1998. Antibodies to DNA. N. Engl. J. Med. 338: 1359-1368.
28. - (NKT) thymocytes prevent insulin-dependent diabetes mellitus in nonobese diabetic (NOD)/Lt mice by the influence of interleukin (IL)-4 and/or IL-10. J. Exp. Med. 187: 1047-1056.
29. + NK T cells associated with disease development in autoimmune-prone mice. J. Immunol. 156: 4035-4040.
30. Takeda, K., and G. Dennert. 1993. The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms. J. Exp. Med. 177: 155-164.
31. Benlagha, K., A. Weiss, A. Beavis, L. Teyton, and A. Bendelac. 2000, In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers. J. Exp. Med. 191: 1895-1903.
32. Berzins, S. P., K. Kyparissoudis, D. G. Pellicci, K. J. Hammond, S. Sidobre, A. Baxter, M. J. Smyth, M. Kronenberg, and D. I. Godfrey. 2004. Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies. Immunol. Cell Biol. 82: 247-252.
33. Yang, J. Q., A. K. Singh, M. T. Wilson, M. Satoh, A. K. Stanic, J. J. Park, S. Hong, S. D. Gadola, A. Mizutani, S. R. Kakumanu, et al. 2003. Immunoregulatory role of CD1d in the hydrocarbon oil-induced model of lupus nephritis. J. Immunol. 171: 2142-2153.
34. Yang, J. Q., T. Chun, H. Liu, S. Hong, H. Bui, L. Van Kaer, C. R. Wang, and R. R. Singh. 2004. CD1d deficiency exacerbates inflammatory dermatitis in MRL-lpr/lpr mice. Eur. J. Immunol. 34: 1723-1732.
35. 1 mice. Eur. J. Immunol. 32: 2551-2561.
36. Zeng, D., M. K. Lee, J. Tung, A. Brendolan, and S. Strober. 2000. Cutting edge: a role for CD1 in the pathogenesis of lupus in NZB/NZW mice. J. Immunol. 164: 5000-5004.
37. Zeng, D., M. Dick, L. Cheng, M. Amano, S. Dejbakhsh-Jones, P. Huie, R. Sibley, and S. Strober. 1998. Subsets of transgenic T cells that recognize CD1 induce or prevent murine lupus: role of cytokines. J. Exp. Med. 187: 525-536.
38. Bendelac, A., M. Bonneville, and J. F. Kearney. 2001. Autoreactivity by design: innate B and T lymphocytes. Nat. Rev. Immunol. 1: 177-186.
39. Kaplan, M. J. 2004. Apoptosis in systemic lupus erythematosus. Clin. Immunol. 112: 210-218.
40. Mevorach, D. 2004. The role of death-associated molecular patterns in the pathogenesis of systemic lupus erythematosus. Rheum Dis. Clin. North Am. 30: 487-504.
41. Zhou, D., J. Mattner, C. Cantu III, N. Schrantz, N. Yin, Y. Gao, Y. Sagiv, K. Hudspeth, Y. P. Wu, T. Yamashita, et al. 2004. Lysosomal glycosphingolipid recognition by NKT cells. Science 306: 1786-1789.
42. Zhou, D., C. Cantu III, Y. Sagiv, N. Schrantz, A. B. Kulkami, X. Qi, D. J. Mahuran, C. R. Morales, G. A. Grabowski, K. Benlagha, et al. 2004. Editing of CD1d-bound lipid antigens by endosomal lipid transfer proteins. Science 303: 523-527.
43. Brigl, M., and M. B. Brenner. 2004. CD1: antigen presentation and T cell function. Annu. Rev. Immunol. 22: 817-890.
44. Benlagha, K., T. Kyin, A. Beavis, L. Teyton, and A. Bendelac. 2002. A thymic precursor to the NK T cell lineage. Science 296: 553-555.
45. + T cells lose NK1.1 expression upon in vitro activation. J. Immunol. 158: 5112-5119.
46. Gadue, P., and P. L. Stein. 2002. NK T cell precursors exhibit differential cytokine regulation and require Itk for efficient maturation. J. Immunol. 169: 2397-2406.
47. + CD1d-dependent precursor stage. J. Exp. Med. 195: 835-844.
48. Peng, S. L., J. Moslehi, and J. Craft. 1997. Roles of interferonγ and interleukin-4 in murine lupus. J. Clin. Invest. 99: 1936-1946.
49. 1 mice by plasmids encoding Interferon (IFN)γ but not by those encoding interleukin (IL)-4. J. Comp. Pathol 127: 1-6.
50. Theofilopoulos, A. N., S. Koundouris, D. H. Kono, and B. R. Lawson. 2001. The role of IFN-γ in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity. Arthritis Res. 3: 136-141.
51. 1 lupus-like nephritis with monoclonal antibody to γ interferon. J. Exp. Med. 166: 798-803.
52. Santiago, M. L., L. Fossati, C. Jacquet, W. Muller, S. Izui, and L. Reininger. 1997. Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J. Exp. Med. 185: 65-70.
53. Kewalramani, R., and A. K. Singh. 2002. Immunopathogenesis of lupus and lupus nephritis: recent insights. Curr. Opin. Nephrol. Hypenens. 11: 273-277.