Polynucleotide kinase as a potential target for enhancing cytotoxicity by ionizing radiation and topoisomerase I inhibitors

Anti-Cancer Agents in Medicinal Chemistry

Volumn 8, Issue 4, 2008, Pages 358-367

  Bernstein, N K ^a   Karimi Busheri, F ^b   Rasouli Nia, A ^b   Mani, R ^b   Dianov, G ^c   Glover, J N Mark ^a   Weinfeld, Michael ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b CROSS CANCER INSTITUTE   (Canada)

^c MRC Radiation/Genome Stability Unit   (United Kingdom)

Author keywords

DNA damage; DNA repair; FHA; Kinase; Phosphatase; Polynucleotide kinase; Small molecule inhibitors

Indexed keywords

ANTINEOPLASTIC AGENT; BLEOMYCIN; CAMPTOTHECIN; CARMUSTINE; DACARBAZINE; DNA; DNA GLYCOSYLTRANSFERASE; DNA METHYLTRANSFERASE INHIBITOR; DNA POLYMERASE; DNA TOPOISOMERASE INHIBITOR; DOUBLE STRANDED DNA; ENDONUCLEASE; ETOPOSIDE; GYRASE INHIBITOR; IRINOTECAN; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; NANOPARTICLE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PHOSPHATASE; PHOSPHOTRANSFERASE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; POLYNUCLEOTIDE 5' HYDROXYL KINASE; SINGLE STRANDED DNA; SMALL INTERFERING RNA; TEMOZOLOMIDE; TOPOTECAN; VIRUS VECTOR; XRCC1 PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; BRAIN CANCER; CARBOXY TERMINAL SEQUENCE; CHEMOSENSITIVITY; COLORECTAL CANCER; CYTOTOXICITY; DNA BINDING; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; DOUBLE STRANDED DNA BREAK; DOWN REGULATION; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME STRUCTURE; HIGH THROUGHPUT SCREENING; HUMAN; INHIBITION KINETICS; IONIZING RADIATION; LUNG SMALL CELL CANCER; LYMPHOMA; MALIGNANT NEOPLASTIC DISEASE; MELANOMA; NONHODGKIN LYMPHOMA; OVARY CANCER; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; RNA INTERFERENCE; SINGLE STRANDED DNA BREAK; SOFT TISSUE SARCOMA; SQUAMOUS CELL CARCINOMA; STRUCTURE ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DNA DAMAGE; DNA REPAIR; DNA TOPOISOMERASES, TYPE I; HUMANS; MODELS, MOLECULAR; NEOPLASMS; POLYNUCLEOTIDE 5'-HYDROXYL-KINASE;

EID: 44449131079     PISSN: 18715206     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152008784220311     Document Type: Article

References (90)

1. Gatti, L.; Zunino, F. Methods Mol. Med., 2005, 111, 127.
2. Madhusudan, S.; Middleton, M.R. Cancer Treat. Rev., 2005, 31, 603.
3. Murray, D.B., Begg, A.C. In DNA Repair in Cancer Therapy, Panasci, L.C.; Alaoui-Jamali, M.A., Eds.; Humana Press: Totowa, 2004, pp.211-256.
4. Ding, J.; Miao, Z.H.; Meng, L.H.; Geng, M.Y. Trends Pharmacol. Sci., 2006, 27, 338.
5. Sanchez-Perez, I. Clin. Transl. Oncol., 2006, 8, 642.
6. Von Sonatag, C., Free-Radical-Induced DNA Damage and Its Repair, Springer-Verlag; Berlin, 2006.
7. Henner, W.D.; Rodriguez, L.O.; Hecht, S.M.; Haseltine, W.A. J. Biol. Chem., 1983, 258, 711.
8. Buchko, G.W.; Weinfeld, M. Biochemistry, 1993, 32, 2186.
9. Jones, G.D.; Weinfeld, M. Cancer Res., 1996, 56, 1584.
10. Coquerelle, T.; Bopp, A.; Kessler, B.; Hagen, U. Int. J. Radiat. Biol. Relat. Stud Phys. Chem. Med., 1973, 24, 397.
11. Lennartz, M.; Coquerelle, T.; Bopp, A.; Hagen, U. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med., 1975, 27, 577.
12. Ward, J.F. Int. J. Radiat. Biol., 1994, 66, 427.
13. Sutherland, B.M.; Bennett, P.V.; Sidorkina, O.; Laval, J. Proc. Natl. Acad Sci. U. S. A., 2000, 97, 103.
14. Dianov, G.L.; O'Neill, P.; Goodhead, D.T. Bioessays, 2001, 23, 745.
15. Meer, L.; Janzer, R.C.; Kleihues, P.; Kolar, G.F. Biochem. Pharmacol., 1986, 35, 3243.
16. Newlands, E.S.; Stevens, M.F.; Wedge, S.R.; Wheelhouse, R.T.; Brock, C. Cancer Treat. Rev., 1997, 23, 35.
17. Dolan, M.E.; Pegg, A.E. Clin. Cancer Res., 1997, 3, 837.
18. Lown, J.W.; McLaughlin, L.W. Biochem. Pharmacol., 1979, 28, 1631.
19. Povirk, L.F. Mutat. Res., 1996, 355, 71.
20. Claussen, C.A.; Long, E.C. Chem. Rev., 1999, 99, 2797.
21. Porter, S.E.; Champoux, J.J. Nucleic Acid Res., 1989, 17, 8521.
22. Markovits, J.; Pommier, Y.; Mattern, M.R.; Esnault C.; Roques, B.P.; Le Pecq, J.B.; Kohn, K.W. Cancer Res., 1986, 46, 5821.
23. Pommier, Y. Nat. Rev. Cancer, 2006, 6, 789.
24. Burden, D.A.; Kingma, P.S.; Froelich-Ammon, S.J.; Bjornsti, M.A.; Patchan, M.W.; Thompson, R.B.; Osheroff, N. J. Biol. Chem., 1996, 271, 29238.
25. Pheiffer, B.H.; Zimmerman, S.B. Biochem. Biophys. Res. Commun., 1982, 109, 1297.
26. Habraken, Y.; Verly, W.G. Eur. J. Biochem., 1988, 171, 59.
27. Karimi-Busheri, F.; Weinfeld, M. J. Cell Biochem., 1997, 64, 258.
28. Friedman, E.C.W., G.C.; Siede, W.; Wood, R.D.; Schultz, R.A.; Ellenberger, T., DNA Repair and Mutagenesis, ASM Press; Washington, DC, 2006.
29. Chen, D.S.; Herman, T.; Demple, B. Nucleic Acids Res., 1991, 19, 5907.
30. Wiederhold, L.; Leppard, J.B.; Kedar, P.; karimi-Busheri, F.; Rasouli-Nia, A.; Weinfeld, M.; Tomkinson, A.E.; Izumi, T.; Prasad, R.; Wilson, S.H.; Mitra, S.; Hazra, T.K. Mol. Cell, 2004, 15, 209.
31. Das, A.; Wiederhold, L.; Leppard, J.B.; Kedar, P.; Prasad, R.; Wang, H.; Boldogh, I.; Karimi-Busheri, F.; Weinfeld, M.; Tomkinson, A.E.; Wilson, S.H.; Mitra, S.; Hazra, T.K. DNA Repair (Amst), 2006, 5, 1439.
32. Karimi-Busheri, F.; Lee, J.; Tomkinson, A.E.; Weinfeld, M. Nucleic Acids Res., 1998, 26, 4395.
33. Jilani, A.; Ramotar, D.; Slack, C.; Ong, C.; Yang, X.M.; Scherer, S.W.; Lasko, D.D. J. Biol. Chem., 1999, 274, 24176.
34. Karimi-Busheri, F.; Daly, G.; Robins, P.; Canas, B.; Pappin, D.J.; Sgouros, J.; Miller, G.G.; Fakhrai H.; Davis, E.M.; Le Beau, M.M.; Weinfeld, M. J. Biol. Chem., 1999, 274, 24187.
35. Whitehouse, C.J.; Taylor, R.M.; Thistlethwaite, A.; Zhang, H.; Karimi-Busheri, F.; Lasko, D.D.; Weinfeld, M.; Caldecott, K.W. Cell, 2001, 104, 107.
36. Chappell, C.; Hanakahi, L.A.; Karimi-Busheri, F.; Weinfeld, M.; West, S.C. EMBO J., 2002, 21, 2827.
37. Koch, C.A.; Agyei, R.; Galicia, S.; Metalnikov, P.; O'Donnell, P.; Starostine, A.; Weinfeld, M.; Durocher, D. EMBO J., 2004, 23, 3874.
38. Demple, B.; DeMott, M.R. Oncogene, 2002, 21, 8926.
39. Suh, D.; Wilson, D.M., 3rd; Povirk, L.F. Nucleic Acids Res., 1997, 25, 2495.
40. Chaudhry, M.A.; Dedon, P.C.; Wilson, D.M., 3rd; Demple, B.; Weinfeld, M. Biochem. Pharmacol., 1999, 57, 531.
41. Inamdar, K.V.; Pouliot, J.J.; Zhou, T.; Lees-Miller, S.P.; Rasouli-Nia, A.; Povirk, L.F. J. Biol. Chem., 2002, 277, 27162.
42. Plo, I.; Liao, Z.Y.; Barcelo, J.M.; Kohihagen, G.; Caldecott, K.W.; Weinfeld, M.; Pommier, Y. DNA Repair (Amst), 2003, 2, 1087.
43. Loizou, J.I.; El-Khamisy, S.F.; Zlatanou, A.; Moore, D.J.; Chan, D.W.; Qin, J.; Sarno, S.; Meggio, F.; Pinna, L.A.; Caldecott, K.W. Cell, 2004, 117, 17.
44. Parsons, J.L.; Dianova, II; Boswell, E.; Weinfeld, M.; Dianov, G.L. FEBS J., 2005, 272, 5753.
45. Karimi-Busheri F.; Rasouli-Nia, A.; Allalunis-Turner, J.; Weinfeld, M. Cancer Res., 2007, 67, 6619.
46. Sekiguchi, J.M.; Ferguson, D.O. Cell, 2006, 124, 260.
47. Lees-Miller, S.P.; Meek, K. Biochimie, 2003, 85, 1161.
48. Bernstein, N.K.; Williams, R.S.; Rakovszky, M.L.; Cui, D.; Green, R.; Karimi-Busheri, F.; Mani, R.S.; Galicia, S.; Koch, C.A.; Cass, C.E.; Durocher, D.; Weinfeld, M.; Glover, J.N. Mol. Cell, 2005, 17, 657.
49. Audebert, M.; Salles, B.; Calsou, P. J. Biol. Chem., 2004, 279, 55117.
50. Audebert, M.; Salles, B.; Weinfeld, M.; Calsou, P. J. Mol. Biol., 2006, 356, 257.
51. Meijer, M.; Karimi-Busheri, F.; Huang, T.Y.; Weinfeld, M.; Young, D. J. Biol. Chem., 2002, 277, 4050.
52. Rasouli-Nia, A.; Karimi-Busheri, F.; Weinfeld, M. Proc. Natl. Acad. Sci. U. S. A., 2004, 101, 6905.
53. Dobson, C.J.; Allinson, S.L. Nucleic Acids Res., 2006, 34, 2230.
54. Amitsur, M.; Levitz, R.; Kaufmann, G. EMBO J., 1987, 6, 2499.
55. Lillehaug, J.R. Eur. J. Biochem., 1977, 73, 499.
56. Mani, R.S.; Karimi-Busheri, F.; Cass, C.E.; Weinfeld, M. Biochemistry, 2001, 40, 12967.
57. Rass, U.; Ahel, I.; West, S.C. J. Biol. Chem., 2007.
58. Abel, I.; Rass, U.; El-Khamisy, S.F.; Katyal, S.; Clements, P.M.; McKinnon, P.J.; Caldecott, K.W.; West, S.C. Nature, 2006, 443, 713.
59. Hirano, M.; Yamamoto, A.; Mori, T.; Lan, L.; Iwamoto, T.A.; Aoki, M.; Shimada, K.; Furiya, Y.; Kariya, S.; Asai, H.; Yasui, A.; Nishiwaki, T.; Imoto, K.; Kobayashi, N.; Kiriyama, T.; Nagata, T.; Konishi, N.; Itoyama, Y.; Ueno, S. Ann. Neurol., 2007, 61, 162.
60. Gueven, N.; Becherel, O.J.; Kijas, A.W.; Chen, P.; Howe, O.; Rudolph, J.H.; Gatti, R.; Date, H.; Onodera, O.; Taucher-Scholz, G.; Lavin, M.F. Hum. Mol. Genet., 2004, 13, 1081.
61. Moreira, M.C.; Barbot, C.; Tachi, N.; Kozuka, N.; Uchida, E.; Gibson, T.; Mendonca, P.; Costa, M.; Barros, J.; Yanagisawa, T.; Watanabe, M.; Ikeda, Y.; Aoki, M.; Nagata, T.; Coutinho, P.; Sequeiros, J.; Koenig, M. Nat. Genet., 2001, 29, 189.
62. Mahajan, A.; Yuan, C.; Pike, B.L.; Heierhorst, J.; Chang, C.F.; Tsai, M.D. J. Am. Chem. Soc., 2005, 127, 14572.
63. Li, J.; Williams, B.L.; Haire, L.F.; Goldberg, M.; Wilker, E.; Durocher, D.; Yaffe, M.B.; Jackson, S.P.; Smerdon, S.J. Mol. Cell, 2002, 9, 1045.
64. Stavridi, E.S.; Huyen, Y.; Loreto, I.R.; Scolnick, D.M.; Halazonetis, T.D.; Pavletich, N.P.; Jeffrey, P.D. Structure, 2002, 10, 891.
65. Liao, H.; Yuan, C.; Su, M.I.; Yongkiettrakul, S.; Qin, D.; Li, H.; Byeon, I.J.; Pei, D.; Tsai, M.D. J. Mol. Biol., 2000, 304, 941.
66. Luo, H.; Chan, D.W.; Yang, T.; Rodriguez, M.; Chen, B.P.; Leng, M.; Mu, J.J.; Chen, D.; Songyang, Z.; Wang, Y.; Qin, J. Mol. Cell Biol., 2004, 24, 8356.
67. Mani, R.S.; Karimi-Busheri, F.; Fanta, M.; Cass, C.E.; Weinfeld, M. Biochemistry, 2003, 42, 12077.
68. Eastberg, J.H.; Pelletier, J.; Stoddard, B.L. Nucleic Acids Res., 2004, 32, 653.
69. Wang, L.K.; Shuman, S. J. Biol. Chem., 2001, 276, 26868.
70. Wang, L.K.; Shuman, S. Nucleic Acids Res., 2002, 30, 1073.
71. Holm, L.; Sander, C. Trends Biochem. Sci., 1995, 20, 478.
72. Rider, M.H.; Bertrand, L.; Vertommen, D.; Michels, P.A.; Rousseau, G.G.; Hue, L. Biochem. J., 2004, 381, 561.
73. Lahirt S.D.; Zhang, G.; Dai, J.; Dunaway-Mariano, D.; Allen, K.N. Biochemistry, 2004, 43, 2812.
74. Lahiri, S.D.; Zhang, G.; Dunaway-Mariano, D.; Allen, K.N. Biochemistry, 2002, 41, 8351.
75. Cho, H.; Wang, W.; Kim, R.; Yokota, H.; Damo, S.; Kim, S.H.; Wemmer, D.; Kustu, S.; Yan, D. Proc. Natl. Acad. Sci. U. S. A., 2001, 98, 8525.
76. Deshpande, R.A.; Wilson, T.E. Biochemistry, 2004, 43, 8579.
77. Morais, M.C.; Zhang, W.; Baker, A.S.; Zhang, G.; Dunaway-Mariano, D.; Allen, K.N. Biochemistry, 2000, 39, 10385.
78. Toub, N.; Malvy, C.; Fattal, E.; Couvreur, P. Biomed. Pharmacother., 2006, 60, 607.
79. Chetty, C.; Bhoopathi, P.; Joseph, P.; Chittivelu, S.; Rao, J.S.; Lakka, S. Mol. Cancer Ther., 2006, 5, 2289.
80. Yoo, J.Y.; Kim, J.H.; Kwon, Y.G.; Kim, E.C.; Kim, N.K.; Choi, H.J.; Yuri, C.O. Mol. Ther., 2007, 15, 295.
81. Dolan, M.E.; Moschel, R.C.; Pegg, A.E. Proc. Natl. Acad. Sci. U. S. A., 1990, 87, 5368.
82. Ratnam, K.; Low, J.A. Clin. Cancer Res., 2007, 13, 1383.
83. Hardcastle, I.R.; Cockcroft, X.; Curtin, N.J.; El-Murr, M.D.; Leahy, J.J.; Stockley, M.; Golding, B.T.; Rigoreau, L.; Richardson, C.; Smith, G.C.; Griffin, R.J. J. Med. Chem., 2005, 48, 7829.
84. Madhusudan, S.; Smart, F.; Shrimpton, P.; Parsons, J.L.; Gardiner, L.; Houlbrook, S.; Talbot, D.C.; Hammond, T.; Freemont, P.A.; Sternberg, M.J.; Dianov, G.L.; Hickson, I.D. Nucleic Acids Res., 2005, 33, 4711.
85. Tang, Z.; Wang, K.; Tan, W.; Ma, C.; Li, J.; Liu, L.; Guo, Q.; Meng, X. Nucleic Acids Res., 2005, 33, e97.
86. Cogan, E.B.; Birrell, G.B.; Griffith, O.H. Anal. Biochem., 1999, 271, 29.
87. Welte, S.; Baringhaus, K.H.; Schmider, W.; Muller, G.; Petry, S.; Tennagels, N. Anal. Biochem., 2005, 338, 32.
88. Schust, J.; Berg, T. Anal. Biochem., 2004, 330, 114.
89. Schust, J.; Sperl, B.; Hollis, A.; Mayer, T.U.; Berg, T. Chem. Biol., 2006, 13, 1235.
90. Lokesh, G.L.; Rachamallu, A.; Kumar, G.D.; Natarajan, A. Anal. Biochem., 2006, 352, 135.