Identification of DNA 3′-phosphatase active site residues and their differential role in DNA binding, Mg2+ coordination, and catalysis

Biochemistry

Volumn 43, Issue 26, 2004, Pages 8579-8589

  Deshpande, Rajashree A ^a   Wilson, Thomas E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYMES; MUTAGENESIS; PHOSPHATES;

DEHALOGENASE; LESION SCANNING;

DNA;

HALOACID; MAGNESIUM; PHOSPHATASE; PHOSPHOSERINE;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; DNA BINDING; DNA STRAND BREAKAGE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME INACTIVATION; ENZYME MECHANISM; ENZYME SPECIFICITY; PHENOTYPE; PRIORITY JOURNAL; RESIDUE ANALYSIS; SACCHAROMYCES CEREVISIAE;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; BLOTTING, WESTERN; CATALYSIS; DNA; DNA DAMAGE; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLUTATHIONE TRANSFERASE; HUMANS; HYDROLYSIS; MAGNESIUM; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEIC ACID CONFORMATION; NUCLEOTIDASES; OLIGONUCLEOTIDES; PHENOTYPE; PLASMIDS; PROTEIN BINDING; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 3142654702     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049434n     Document Type: Article

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