Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 18, 2004, Pages 6905-6910

  Rasouli Nia, Aghdass ^b   Karimi Busheri, Feridoun ^b   Weinfeld, Michael ^a  

^a CROSS CANCER INSTITUTE   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CAMPTOTHECIN; DNA; DOUBLE STRANDED DNA; HUMAN POLYNUCLEOTIDE KINASE; HYDROGEN PEROXIDE; MESYLIC ACID METHYL ESTER; MONOMER; OUABAIN; PHOSPHATASE; PHOSPHOTRANSFERASE; POLYNUCLEOTIDE 5' HYDROXYL KINASE; SMALL INTERFERING RNA; TOXIC SUBSTANCE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL FREE SYSTEM; CELL STRAIN; CELL STRAIN A549; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME REGULATION; GAMMA RADIATION; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; GENOTOXICITY; HUMAN; HUMAN CELL; HYPERSENSITIVITY; LUNG ADENOCARCINOMA; MUTATION RATE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RNA SILENCING; SENSITIZATION; ULTRAVIOLET C RADIATION;

DNA DAMAGE; DNA REPAIR; DOWN-REGULATION; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENS; MUTATION; POLYNUCLEOTIDE 5'-HYDROXYL-KINASE;

STROPHANTHUS GRATUS;

EID: 2342541592     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0400099101     Document Type: Article

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